OOIR: Observatory of International Research

Papers

(The TQCC of Chemistry of Heterocyclic Compounds is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Mechanochemical synthesis of halogenated heterocyclic compounds	49
Regioselective [3+2] cycloaddition of nitrile oxides to 1Н-pyrrole-2,3-diones: synthesis of spiro[pyrroledioxazoles]	16
Nina Nikolaevna Makhova (31.07.1938–22.06.2021)	14
Synthesis and neuroprotective activity of a (–)-cytisine-isoflavone conjugate	13
Method for the synthesis of chromenopyrimidine-fused azoles by copper-catalyzed intramolecular hetero-Diels–Alder reaction	13
The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework	11
Intramolecular Diels–Alder reaction in the synthesis of 5-arylisoxazolylmethyl- and 4,5-dichloroisothiazolylmethyl-3a,6-epoxyisoindol-3-ones	11
Structural and chemical reactivity insights of a benzimidazolidinone-based N-heterocycle: a multiapproach quantum-chemical study	11
An AgOAc-catalyzed reaction of 3-nitro-2H-chromenes with ethyl diazoacetate: an efficient one-pot synthesis of ethyl 3,4-dihydrochromeno[3,4-c]pyrazole-1-carboxylates	11
An intramolecular Diels–Alder reaction in the synthesis of N-aroyl-3a,6-epoxyisoindole-2-carbothioamides	10
A method for the synthesis of spiro-1,3,4-thiadiazolines	9
A simple method for the synthesis of isoindoline derivatives	9
New methods for the synthesis of pyrrolo[1,2-x][1,4]diazepines and their (het)arene-annulated analogs (microreview)	9
Marina Abramovna Yurovskaya (1.03.1940–21.05.2021)	8
Recent progress in the synthesis of nitroisoxazoles and their hydrogenated analogs via [3+2] cycloaddition reactions (microreview)	8
3-Cyanothiete 1,1-dioxide: synthesis and cycloaddition reactions	8
Synthetic approaches toward 2,3-dihydroquinazolinones (microreview)	8
Stereoselective synthesis of tetrahydropyrimidin-2(1H)-ones (minireview)	8
Tetrahydroazepines with an annulated five-membered heteroaromatic ring	7
Unexpected ANRORC rearrangement in pyran ring	7
Selenium-containing azoles: synthesis and possibilities of application	7
Synthesis of N,N-dimethyl-3,5-dinitro-1H-pyrazol-4-amine and its energetic derivatives as promising melt-castable explosives	7
Selective synthesis of a novel glycoluril-based hybrid compound with high application potential	7
Synthesis of novel isoxazole derivatives bearing kojic acid moiety and evaluation of their antimicrobial activity	7
Coumarin-based homoisoflavonoids as precursors in the synthesis of 8-heteroarylmethylcoumarins	7

A MEDT study of the mechanism and selectivity of the hetero-Diels–Alder reaction between 3-benzoylpyrrolo[1,2-c][1,4]-benzoxazine-1,2,4-trione and vinyl acetate	7
Synthesis, structure, and biological activity of 4-hetaryl-2-pyrrolidones containing a pyrazole ring	7
Highly functionalized pyrazolines from symmetric and asymmetric 1,2-disulfonylhydrazines: a combination of experimental and DFT perspectives	7
A novel method for the synthesis of 2-arylquinolin-4(1H)-ones	7
Convenient synthesis of imidazo[1,5-a]pyrimidine derivatives and their unusual recyclization into 3H-imidazo[4,5-b]pyridine derivatives	6
Boron-substituted 1,2,3-triazoles (microreview)	6
Intramolecular Friedel–Crafts alkylation by electrochemical carbenium ion generation	6
Chemo- and regioselective oxidation of substituted 2,3,4,9-tetrahydro-1H-carbazoles	6
Synthesis, Cytotoxicity, and α-glucosidase Inhibitory Activity of Triterpenic and Sitosterol Tetrazole Derivatives	6
Synthesis of 5,11-dialkyl-5,6,11,12-tetrahydro-6,12-epoxydibenzo[b,f][1,5]diazocines from 2-alkylaminobenzaldehydes	6
Synthesis of Alkaloid Sinomenine Derivatives Containing a Pyrimidine Substituent in Ring A	6
A novel approach to obtain 3-amino-1-benzothiophene-2-carbonitriles	6
Hexamethyldisilazane as a versatile organosilicon reagent for the synthesis of heterocycles (microreview)	6
Nitrolysis of N-alkylurotropinium Salts	6
The synthesis of salts of five-membered heterocyclic compounds based on N-containing cations/anions (microreview)	6
Methods for the preparation of 2-nitrobenzofurans	6
Cyclopent-4-ene-1,3-diones fused with heterocycles as promising anchor groups in non-fullerene acceptors (microreview)	6
Synthesis of pyrrolizidine derivatives (microreview)	6
Characterization and structure analysis of triclinic γ-cyclodextrin hydrate methanol solvate	6
Recent progress in the synthesis of N7(N9)-alkyl(aryl)purines (microreview)	5
Synthesis of fluorinated six-membered nitrogen heterocycles using microwave irradiation	5
Synthetic approaches to phosphonylpyridazines: an overview	5
A Structural Modification of Berberine Using CH Acids and Ethoxyethylenes Based on Them	5
Proton- and iodine-induced cyclization of 2-(pent-4-en-1-yl)quinazolin-4(3H)-ones: synthesis of pyrrolo[2,1-b]quinazolinone and pyrido[1,2-a]quinazolinone derivatives	5
2H-Azirines in medicinal chemistry	5
Methods for the Preparation of 3-Nitrobenzofurans	5
Synthesis of azidopropargylamino-substituted 1,3,5-triazines – novel monomers for the production of energetic polymers	5
A synthesis of novel 5-methylsulfanylazolo[1,5-a]pyrimidin-7(4H)-ones and investigation of their chemical and cytotoxic properties	5
Synthesis of 2H-[1,2]oxazino[3,4-c]quinoline-2,5(6H)-diones from 6-oxo-6H-1,2-oxazine-3-carboxylates	5
Exploring the factors controlling the mechanism and the high stereoselectivity of the polar [3+2] cycloaddition reaction of the N,N'-cyclic azomethine imine with 3-nitro-2-phenyl-2H-chromene. A molecu	5
Recent progress in the direct phosphorylation of parent heterocycles to construct phosphorylated heterocycles	5
Recent developments in the synthesis of spirobenzosultams (microreview)	5
Synthesis of new pyrido[2,3-d]pyrimidin-5-ones and pyrido[2,3-d]pyrimidin-7-ones functionalized at position 4 from 5-acetyl-6-amino-4-methylsulfanyl-2-phenylpyrimidine	5
The synthesis and antitumor activity of novel 1-alkyl-3-phenyland 3-alkyl-1-phenylimidazothiazolotriazines	5
The synthesis of 1-oxa-9-azaspiro[5.5]undecane derivatives and optimization of antituberculosis activity thereof	5
A simple method for the synthesis of diarylamines containing a nitroso group in the ortho position based on the SNH arylamination of 5-nitroisoquinoline	4
[3+3] Annulation of diethyl 2,3-dicyanofumarate and cyclic 1,3-dicarbonyl compounds: synthesis of fused diethyl 2-amino-4-cyano-4H-pyran-3,4-dicarboxylates	4
Synthesis and NMR spectra of [15N]indole	4
Pyridine-2-selanyl chloride in the synthesis of condensed heterocycles (microreview)	4
Analgesic and Antidepressant Activity of 8-Substituted Harmine Derivatives	4
A convenient approach to the synthesis of 1-halomethyl-substituted 2,4,5,6-tetrahydro-1H-imidazo[1,2-a][1]benzazepines	4
Some properties of 1-hydroxy-1H-imidazole-2-carboxylic acid esters	4
Influence of bicyclic anhydride structure on the outcome of the Castagnoli–Cushman reaction	4
Pyrazoles, isoxazoles, and 1,2,3-triazoles as analogs of the natural cytostatic combretastatin A-4: efficient routes of synthesis, tubulin inhibition, and cytotoxicity	4
The synthesis of ortho-stilbazoles (2-styrylpyridines) (microreview)	4
The effect of substituents on carbon–carbon double bond isomerization in heterocyclic hydrazine derivatives	4
Pseudopeptides based on nicotinic acid with 4-amidoxime unit	4
Expanding the isoflavone, pyrazole, and oxazole chemical space through 2'-carboxamido-2-hydroxydeoxybenzoin precursors	4
A regioselective synthesis of 5-difluoromethyl- and 7-difluoromethyl-substituted pyrazolo[1,5-a]pyrimidines	4
A synthesis of triacetyl-substituted 1,2,3,4-tetrahydropyridine by the reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with aniline	4

Quantum evaluation of novel epoxides: molecular docking, dynamics simulation, pharmacokinetics, stereoselectivity, and mechanistic insights into cis-himachalone and cis-himachalol epoxidation	4
Unveiling the exclusive stereo and site selectivity in [3+2] cycloaddition reactions of a tricyclic strained alkene with nitrile oxides from the molecular electron density theory perspective	4
General methods for the synthesis of styrylpyridinium salts (microreview)	4
Three-component synthesis of 2-acyl-2,3-dihydro-4H-thiochromeno[4,3-b]furan-4-ones and their reductive rearrangement into 4H,5H-thiochromeno[4,3-b]pyran-5-ones	4
Synthesis of new class of trithiadiazacycloalkane 1,1-dioxides using Yb(Sm)-contaning catalysts and conformational analysis of the macroheterocycles	4
Synthesis of optically active 5-thioxotetrahydro-5H-oxazolo[3,2-c]pyrimidin-2(3H)ones	4
Synthesis of 3-substituted tetrahydroindol-4-one	4
A study of the reactivity of 2,4-diphenylfuran	3
Synthesis of functionalized polyhalogenated thiophene derivatives	3
Synthesis and structure of 3-substituted 1,5-dinitro-1,3,5-triazepanes	3
In memoriam Boris Veniaminovich Ioffe (1921–1997)	3
Divergent synthesis of 1,5-benzodiazepines and benzimidazoles via a BiCl3-catalyzed one-pot condensation–cyclization process	3
Di-, tetra-, and perhydropyrrolo[1,2-a]imidazoles: The Methods of Synthesis and Some Aspects of Application	3
4H-Chromenes as 1,3-bielectrophiles in the reaction with 2-aminobenzimidazole: synthesis of pyrimido[1,2-a]benzimidazoles	3
Synthesis of alkenyl- and alkynyloxazoles and –oxazolines using tosylmethyl isocyanide as a key building block (microreview)	3
Fused chiral azaheterocycles based on monosubstituted ferrocenes	3
Tandem Synthesis of Novel thiazole-substituted pyrrolo[1,2-d][1,2,4]triazin-4(3H)-one Derivatives and their Theoretical Pharmacokinetic Profiles	3
Synthesis of the First Dithiaaza-17-Crown-5 Ethers Containing Piperidin-4-One Subunit	3
Synthetic application of oxiranecarbonitriles (microreview)	3
Conformationally restricted hydantoins derived from bridgehead functionalized camphorquinones	3
The reactions of electron-deficient 1Н-benzo[f]chromenes with 2,3-dimethylbenzothiazol-3-ium iodide	3
Synthesis of β-vinyl-substituted 4H-chromenes and [4+2] cycloaddition reactions involving them	3
Synthesis of 6,7-dihydro-5H-benzo[c]-1,2,4-triazolo[3,4-a]azepines and 6,7-dihydro-5H-benzo[c]tetrazolo[5,1-a]azepines	3
New oxazole to oxazole recyclization	3
Multicomponent Reactions Based on In Situ Generated Isocyanides for the Construction of Heterocycles	3
Ring expansion strategy to access functionalized 2-oxazolines (microreview)	3
Synthesis of isoxazolo[4,5-b]pyridine derivatives (microreview)	3
Synthesis of 2-arylquinazolines by Chan–Evans–Lam coupling of 2-formylphenylboronic acids with amidines	3
A General Approach to 4-unsubstituted and 4-alkyl-substituted 5-acyl-1,2,3,4-tetrahydropyrimidine-2-thiones(ones) via α-(thio)ureidoalkylation of 1,3-diketones or β-oxoesters	3
Synthesis of Dihydrobenzothiazepines Based On 1-acyl-2-heteryl-1-nitroethenes	3
Synthesis and modulatory activity of 3-acetyl-7-(benzofuran-5-carbonyl)-1,5-dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-one on AMPA receptors	3
Hydroarylation of carbon–carbon double bond of furanic conjugated enones by arenes under superelectrophilic activation: synthesis and evaluation of antimicrobial activity of novel furan derivatives	3
The synthesis and study of carbonic anhydrase activity of sulfonamide-containing dibenzo[1,4]thiazepines	3
Highly diastereoselective four-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines	3
[2+1] Cycloaddition reaction of α-atlantone with m-CPBA in the light of experimental and MEDT quantum-chemical study	3
The synthesis and antiproliferative activity of isatin-7-sulfonamides	3
A regioselective synthesis of imidazothiazolotriazines based on the cyclization of imidazotriazinethiones with phenacyl bromides	3
Synthesis of 3-Amino-6,7-Dihydroferroceno[a]Quinolizin-4-One Derivatives via the Reaction of 3,4-Dihydroferroceno[c]Pyridines with Azlactones	3
Synthesis of tellurium-substituted azoles (microreview)	3
Synthesis and structural characterization of N,N',N'',N'''-tetrasubstituted cyclams	3
3-Spiroandrostene-substituted 1,3,4-thiadiazolines	3