Chemistry of Heterocyclic Compounds

Article	Citations
3-Nitro-1,2,4-triazol-5-one (NTO): High Explosive Insensitive Energetic Material	35
Biologically active compounds and drugs in the tetrazole series	34
Recent advances on heterocyclic compounds with antiviral properties	32
Antiviral nucleoside analogs	27
Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds	25
The main directions and recent trends in the synthesis and use of isoxazoles	23
Eco-friendly and sustainable synthetic approaches to biologically significant fused N-heterocycles	21
Good pyridine hunting: a biomimic compound, a modifier and a unique pharmacophore in agrochemicals	20
Isomerization and changes of the properties of spiropyrans by mechanical stress: advances and outlook	20
Favipiravir – a Modern Antiviral Drug: Synthesis and Modifications	19
Indolo[2,3-a]carbazoles: diversity, biological properties, application in antitumor therapy	18
A perspective on environmentally benign protocols of thiazole synthesis	17
On the influence of weak intermolecular interactions on the molecular crystal density of 1,3,5-triazine trinitroalkyl derivatives	16
Antiviral activity of 1,2,4-triazole derivatives (microreview)	15
Magnetic silica nanoparticle-supported copper complex as an efficient catalyst for the synthesis of novel triazolopyrazinylacetamides with improved antibacterial activity	14
Methods of Synthesis for the Azolo[1,2,4]Triazines	13
Recent advances in the C(1)-functionalization of tetrahydroisoquinolines via multicomponent reactions	13
Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use	13
Synthetic strategies for pyrrolo[2,1-f][1,2,4]triazine: the parent moiety of antiviral drug remdesivir	12
Cage-Like Amines in the Green Protocol of Transannular Thieno[2,3-d]Pyrimidinone Formation as Promising Anticancer Agents	12
Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction	12
Synthesis of biologically active derivatives of 2-aminobenzothiazole	12
Ion exchange resin-catalyzed synthesis of bridged tetraoxanes possessing in vitro cytotoxicity against HeLa cancer cells	12
Metal-Free Functionalization of Azine N-Oxides with Electrophilic Reagents	12
Indole Derivatives of Fusidane Triterpenoids: Synthesis and the Antibacterial Activity	11

Spiropyrans: molecules in motion	11
Hypervalent iodine in the structure of N-heterocycles: synthesis, structure, and application in organic synthesis	11
Green synthetic strategies toward thiazoles: a sustainable approach	11
Synthesis and Evaluation of Biological Activity of Homodrimane Sesquiterpenoids Bearing 1,3,4-Oxadiazole or 1,3,4-Thiadiazole Units	11
Synthesis of novel 3-arylated 2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component domino reaction and evaluation of their cytotoxic activity	10
Thematic issue “Heterocyclic Compounds in Medicinal Chemistry”	10
Regioisomeric 3,5-di(nitropyrazolyl)-1,2,4-oxadiazoles and their energetic properties	10
Two approaches toward the regio- and stereoselective synthesis of N-unsubstituted 3-aryl-4-(trifluoromethyl)-4H-spiro-[chromeno[3,4-c]pyrrolidine-1,3'-oxindoles]	10
2H-Azirines in medicinal chemistry	9
Synthesis of 1,3-Oxazine Derivatives Based on (–)-Isopulegol using the Ritter Reaction and Study of their Analgesic Activity	9
Synthesis and Evaluation of the Cytotoxicity of Indeno[1,2-c]Isoquinoline Derivatives Bearing Ester Functional Group and 1,2,3-Triazole Moiety	9
Nucleoside Analogs with Fleximer Nucleobase	9
Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines	9
3-Nitro-2-phenyl-2-trifluoromethyl-2H-chromenes in reactions with azomethine ylides from isatins and (thia)proline: synthesis of spiro[chromeno(thia)pyrrolizidine-11,3'-oxindoles]	9
Photochemical synthesis of novel naphtho[1,2-b]benzofuran derivatives from 2,3-disubstituted benzofurans	9
Green alternatives for the synthesis of tetrazolic acids	9
Synthesis of 5-arylmethylidene-3-(arylmethylideneamino)thiazolidine-2,4-diones via triazine ring cleavage of tetrahydroimidazothiazolotriazinediones and their reactions with azomethine ylides	9
Acyclic Enaminodiones in the Synthesis of Heterocyclic Compounds	9
Synthesis and stability of thermally labile 1,2-oxaphosphetane 2-oxides and 1,2-thiaphosphetane 2-sulfides (microreview)	8
Iodine Acetate as a Mild Selective Agent for the Wagner–Meerwein Rearrangement in 3a,6-Epoxyisoindoles	8
Synthesis of functionalized oxazolidines by multicomponent reactions of 1,2-amino alcohols (microreview)	8
3-Cyanoazolo[5,1-c][1,2,4]triazines: synthesis and antiviral activity	8
Preparation of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles via chemoselective сyclocondensation of electrophilically activated nitroalkanes to (thio)semicarbazides or thiohydrazides	8
Recent Advances in the Synthesis and Biological Applications of Nortopsentin Analogs	8
Study of the methylation reaction of 2,4-dinitroimidazole and potassium 2,4,5-trinitroimidazol-1-ide with dimethyl sulfate	8
N-Propargylation and Copper(I)-Catalyzed Azide-Alkyne Cycloaddition as a Convenient Strategy for Directed Post-Synthetic Modification of 4-Oxo-1,4-Dihydrocinnoline Derivatives	8
Reactions of naphthalen-2-ol Mannich bases with β-aminoacrylonitriles and methyl 3-morpholinoacrylate	7
Regio- and Stereoselective 1,3-dipolar Cycloaddition of Azomethine Ylides Based on Isatins and (thia)proline to 3-nitro-2-(trifluoro(trichloro)methyl)-2H-chromenes: Synthesis and Cytotoxic Activity of	7
Modeling the binding of protoporphyrin IX, verteporfin, and chlorin e6 to SARS-CoV-2 proteins	7
Highly efficient phosphine-catalyzed routes to α-imidoacrylates and 2,3-diimidopropanoates	7
Novel purine conjugates with N-heterocycles: synthesis and anti-influenza activity	7
The Dimroth Rearrangement in the Synthesis of Condensed Pyrimidines – Structural Analogs of Antiviral Compounds	7
Electrophile-Induced Reactions of Cross-Conjugated Enynones in the Synthesis of Heterocycles	7
Reactions of perfluoroacylchromenes with aromatic amines: synthesis of perfluoroalkylchromene carbaldehydes	7
Synthesis and antiherpetic activity of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine	7
Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties	6
Tandem Reactions of Thermolysis and [3+2] Cycloaddition in the Synthesis of 3-Hetaryl-4-Nitrofuroxans from 4-Nitrofuroxannitrolic Acid	6
Imidazo[A]Quinoxalines: New Approaches to Synthesis and Biological Activity	6
New methods for the synthesis of phosphono-δ-lactones (microreview)	6
Benzobischalcogenadiazoles: synthesis and applications (microreview)	6
Recent advances in green synthesis of chromones	6
Three-component condensation of cyclic 1,3-dicarbonyl compounds, N-phenacylpyridinium salts, and isatins or aromatic aldehydes as a method for the synthesis of novel condensed 2-aroyl-2,3-dihydrofuran	6
Synthesis of cyclic D-(+)-camphoric acid imides and study of their antiviral activity	6
Synthesis and analgesic activity of 1-[(1,2,3-triazol-1-yl)methyl]quinolizines based on the alkaloid lupinine	6
Microwave-assisted synthesis of pyrazolo[3,4-b]pyridine derivatives (microreview)	6
Synthesis of unsymmetrical cage phosphonates from heterocyclic systems based on 2H-1,2-benzoxaphosphinine	6
Highly diastereoselective four-component synthesis of polysubstituted 1,4,5,6-tetrahydropyridines	6
Application of BF3·Et2O in the synthesis of cyclic organic peroxides (microreview)	6
Green synthesis of new sulfanyl derivatives of ampyrone and prediction of their anti-inflammatory activity	6
Multicomponent Reactions Based on In Situ Generated Isocyanides for the Construction of Heterocycles	6

Synthesis and Antiviral Activity of N-Heterocyclic Hydrazine Derivatives of Camphor and Fenchone	6
8-Ethynylxanthines as promising antiproliferative agents, angiogenesis inhibitors, and calcium channel activity modulators	6
A three-component condensation of cyclic enamino ketones, phenylglyoxal hydrate, and ethyl cyanoacetate	6
Synthesis and photophysical properties of 2-azolyl-6-piperidinylpurines	6
Expanding the chemical space of 3(5)-functionalized 1,2,4-triazoles	6
Stepwise, zwitterionic course of hetero-Diels–Alder reaction between 1,2,4-triazine molecular systems and 2-cyclopropylidene-1,3-dimethylimidazoline	6
Methods for the Preparation of 3-Nitrobenzofurans	6
Reactions of β-Carbonyl-Substituted 4H-chromenes and 1H-benzo[f]Chromenes with 5-aminopyrazoles	6
Synthesis of 3(5)-aryl-5(3)-pyrazolyl-1,2,4-oxadiazole nitro derivatives	6
Synthesis of new 2-substituted 6,8-dinitro[1,2,4]triazolo[1,5-a]pyridines	6
Synthesis of 1,8-naphthyridines: a recent update (microreview)	5
Synthesis and fungicidal activity of novel 6H-benzimidazo[1,2-c][1,3]benzoxazin-6-ones	5
Imidazolone-activated donor-acceptor cyclopropanes with a peripheral stereocenter. A study on stereoselectivity of cycloaddition with aldehydes	5
Aryltellurium Trihalides in the Synthesis of Heterocyclic Compounds (Microreview)	5
Cycloaddition of nitrones to 1,3-diarylpropenones and subsequent transformations of the resulting isoxazolidines	5
Group-assisted purification chemistry principles to access highly substituted zwitterionic furans via fast, concise, and efficient one-pot three-component assembly	5
NaSCN–(NH4)2Ce(NO3)6 system in heterocycle thiocyanation: synthesis of novel highly potent broad-spectrum fungicides for crop protection	5
Synthesis of 1,2-Dihydroisoquinoline-1-Carboxylates Under Cobalt Catalysis	5
Novel Approach to the Synthesis of 3-amino-4-arylpyridin-2(1H)-one Derivatives	5
Palladium-catalyzed amino group arylation of 1,3-disubstituted 1H-pyrazol-5-amine based on Buchwald–Hartwig reaction	5
The Nenitzescu Reaction in the Synthesis of New Abietane Diterpene Indoles	5
Construction and Characterization of 3,7-Dichloro-N-(2,6-Diethylphenyl)-N-(2-Propoxyethyl)Quinolone-8-Carboxamide: A Potential Novel Pesticide Compound	5
Oxaborine Derivatives: Synthesis and Therapeutic Potential	5
Synthesis via the Mannich Reaction and Biological Activity of Novel Fluorinated Camptothecin Derivatives	5
Michael Adducts of Levoglucosenone with α-Ethoxycarbonyl- and α-Nitrocyclododecanones: Transformation into Chiral Macrolides	5
Synthesis of novel γ-butyrolactone-based phenazine compounds via microwave-assisted multicomponent domino reactions	5
Synthesis, Biological Activity and Photophysical Studies of Ellipticine and its Derivatives: State of the Art	5
Conformations of saturated five-membered heterocycles evaluated by MP2 calculations	5
Synthesis, Cytotoxicity, and α-glucosidase Inhibitory Activity of Triterpenic and Sitosterol Tetrazole Derivatives	5
Synthesis and Biological Activities of 4H-3,1-Benzothiazin-4-Ones	5
Quadruple Bond Forming Multicomponent Approach to 5-(3-chromenyl)-5H-chromeno[2,3-b]pyridines and Its Interaction with the Neuropeptide Y1 Receptor	5
Heterocyclic analogs of 5,12-naphthacenequinone 16*. Synthesis and properties of new DNA ligands based on 4,11-diaminoanthra[2,3-b]thiophene-5,10-dione	5
6-Nitro-4,7-dihydroazolo [1,5-a]pyrimidines: an alternative mechanism of formation and studies of alkylation	5
Design, synthesis, and anti-breast-cancer activity evaluation of pyrrolo(pyrido)[2,3-d]pyrimidine derivatives	5
Synthesis, X-ray and DFT Studies of 6-halo-3-(hydroxymethyl)cinnolin-4(1H)-ones	5
3-Amino-4-(1-amino-2-cyanovinyl)furazans: synthesis and cyclization	5
An efficient one-pot synthesis of indolyl-4H-chromene derivatives	5
Electrophilic Fluorination of Heterocyclic Compounds with NF Reagents in Unconventional Media	5
Synthesis of five-membered heterocycles by [3+2] cycloaddition reactions of sulfur-containing 3,3,3-trifluoropropene derivatives	5
Alkaloid-like annulated pyrano[4,3-b]pyrroles: antiviral activity and hydrolysis	5
Reaction of 3-[(alkylsulfanyl)methyl]pentane-2,4-diones with nicotinic hydrazide	5
Reactions of thiiranes with NH-heterocycles 1. An investigation of the reaction of 2-chloromethylthiirane with 3,5-dibromo-4-nitropyrazole	5
Synthesis and application of haloisoxazoles	5
Regio- and stereoselectivity of [3+2] cycloaddition reactions between (Z)-1-(anthracen-9-yl)-N-methyl nitrone and analogs of trans-β-nitrostyrene on the basis of MEDT computational study	5
Nucleophilic Dearomatization of 3-nitrobenzofurans by the Action of 2-(1-arylethylidene)Malononitriles	5
Coumarin synthesis via Pechmann condensation: toward a greener era (microreview)	5
Green synthesis of novel phosphonate derivatives using ultrasonic irradiation	5
Synthesis and chemical properties of 3-alkoxycarbonylchromones and 3-alkoxalylchromones	5
Synthesis of 4,4'-Bis[3-(Fluorodinitromethyl)-1H-1,2,4-triazol-5-Yl]azofurazan	5
Synthesis of Sulfur-Containing Heterocycles by Electrophilic Addition Reactions of Disulfur Dichloride	5
Unsaturated carboxylic acids in the one-pot synthesis of novel derivatives of 3,4-dihydro-2H-thiopyran	5
Synthesis of functionalized azolo(azino)quinazolines by electrophilic cyclization (microreview)	5
Synthesis of new pyrido[2,3-d]pyrimidin-5-one, pyrido[2,3-d]pyrimidin-7-one, and pyrimidino[4,5-d][1,3]oxazine derivatives from 5-acetyl-4-aminopyrimidines	4
Formation of five- and six-membered nitrogen-containing heterocycles on the basis of hydrazones derived from α-dicarbonyl compounds (microreview)	4
Atom-efficient synthesis of hybrid molecules combining fragments of triazolopyrimidines and 3-ethoxycarbonyl-1-ethyl-6-fluoroquinolin-4(1H)-one through 1,2,3-triazole linker	4
Formation of five-membered nitrogen-containing heterocycles based on 1-bromo-1-nitroalkenes (microreview)	4
Synthesis of 1,2-azole derivatives on the basis of α,β-unsaturated triterpene aldehydes	4
Synthesis of novel isoxazole derivatives bearing kojic acid moiety and evaluation of their antimicrobial activity	4
N-Alkylation of Nitrogen Heterocycles with α-Diazocarbonyl Compounds	4
Synthesis and antiproliferative activity characterization of new imidazothiazolotriazine oxindolylidene derivatives containing various substituents in the oxindole ring	4
Cyclic Isothiourea in Drug Design	4
Synthesis of 3-substituted tetrahydroindol-4-one	4
Synthesis of 3-Silylated 3-Sulfolenes from Propargylsilanes and their Reductive Desulfitation	4
Facile Synthesis and Spectral Properties of Novel Isomeric Nitrile-Rich Bipyridine Derivatives	4
Synthesis of Fluorinated Octahydro-2H-Chromenes in the Presence of the BF3·Et2O–H2O Catalytic System	4
Imidazothiazoles and their Hydrogenated Analogs: Methods of Synthesis and Biomedical Potential	4
Synthesis of Novel 3-(Pyridin-4-yl)-1,2,4-Triazines, their Analogs and Study of the Activity Against Vaccinia Virus	4
Synthesis, structure, and antiviral properties of novel 2-adamantyl-5-aryl-2H-tetrazoles	4
Synthesis of 3-Amino-6,7-Dihydroferroceno[a]Quinolizin-4-One Derivatives via the Reaction of 3,4-Dihydroferroceno[c]Pyridines with Azlactones	4
Heterocycles Based on 1-((Z)-1,4-dibromobut-2-en-2-yl)adamantane	4
Synthesis of 2H-pyrano[3,2-g]quinolin-2-ones containing a pyrimidinone moiety and characterization of their anticoagulant activity via inhibition of blood coagulation factors Xa and XIa	4
Synthesis of 2-aminopyridopyrimidinones and their plasmepsin I, II, IV inhibition potency	4
Synthesis of tetrazole derivatives through conversion of amide and thioamide functionalities	4
Improved Synthesis and Thermochemical Properties of Amino- and Hydrazino-1,2,4,5-Tetrazines	4
The Dimroth rearrangement of 5-amino-1-aryl-1,2,3-triazole-4-carbothioamides	4
Synthesis of azidopropargylamino-substituted 1,3,5-triazines – novel monomers for the production of energetic polymers	4
Synthesis and photophysical investigation of AIEgen dyes bearing quinoline and BODIPY scaffolds	4
Nitrolysis of N-alkylurotropinium Salts	4
Effective Synthesis of Hard-To-Reach 3,4-Disubstituted Thiophene Derivatives Based on bis(2-chloropropenyl) Sulfide	4
Synthesis of isoxazolylpyrrolones by three-component reaction of α-ketoglutaric acid or its diethyl ester with 3-amino-5-methylisoxazole and aromatic aldehydes	4

Diazapyrenes: interaction with nucleic acids and biological activity	4
Synthesis of spiro[imidazole-4,3'-quinolin]ones from [2-(dimethylamino)benzylidene]-2-(methylsulfanyl)imidazolones	4
Recent developments in the synthesis of piperazines (microreview)	4
Ring-closure reactions of functionalized vinyl sulfonamides (microreview)	4
Recent synthetic approaches to 1H- and 2H-indazoles (microreview)	4
Electrocatalytic tandem assembly of aldehydes with 2-thiobarbituric acid into 5,5'-(arylmethylene)bis(1,3-diethyl-2-thiobarbituric acids) and evaluation of their interaction with catalases	4
Synthesis of imidazo[2,1-b][1,3]thiazoles – potential anticancer agents derived from γ-bromodipnones	4
Synthesis of new pyrido[2,3-d]pyrimidin-5-ones and pyrido[2,3-d]pyrimidin-7-ones functionalized at position 4 from 5-acetyl-6-amino-4-methylsulfanyl-2-phenylpyrimidine	4
α-Functionalized ketene N,S-acetals as two-carbon synthons in the reaction with 1,2-naphthoquinone 1-methide. Synthesis of 3-amino-1H-benzo[f]chromenes	4