Chemico-Biological Interactions

Article	Citations
Editorial Board	1015
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4	320
The influence of alkyl substitution on the in vitro metabolism and mutagenicity of benzo[a]pyrene	230
Computational study to find the goat serum albumin (GSA) binding site as A-esterase	228
Editorial Board	203
Retraction notice to “Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity” [Chem. Biol. Interact. 153–154 (2005) 147–157]	146
Low levels of endogenous cholinesterases support the choice of cows, sheep and goats for the transgenic expression of human butyrylcholinesterase in milk	141
F–53B triggers ovarian granulosa cell senescence and ovarian dysfunction by triggering mitochondrial dysfunction	111
Characterization of a novel porcine carbonyl reductase activated by glutathione: Relationship to carbonyl reductase 1, 3α/β-hydroxysteroid dehydrogenase and prostaglandin 9-ketoreductase	111
Implications of early-life BPS-induced thyroid disruption on adult female reproductive disorders	109
Thymol ameliorates ethanol-induced hepatotoxicity via regulating metabolism and autophagy	107
Synergistic kidney toxicity of polylactic acid nanoplastics and Cr(VI): Ferroptosis aggravated by mitophagy	100
Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer	96
Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approaches	94
Inflammatory response and DNA damage induced by dry tobacco exposure in rural workers: A study on complex mixtures and their health impacts	85
Corrigendum to “Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy” [Chem. Biol. Interact. 345 (2021) 109534]	82
Alternative splicing affects synapses in the hippocampus of offspring after maternal fructose exposure during gestation and lactation	80
BjussuMP-II, a venom metalloproteinase, induces the release and cleavage of pro-inflammatory cytokines and disrupts human umbilical vein endothelial cells	76
Modeling of a near-attack conformation of oxime in phosphorylated acetylcholinesterase via a reactivation product, a phosphorylated oxime	73
Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells	71
Recalling the reported toxicity assessment of deoxynivalenol, mitigating strategies and its toxicity mechanisms: Comprehensive review	70
Potent genotoxicity of phenytoin in adult male C57BL/6J mice, an effect requiring metabolic activation (possibly by Cyp2c enzymes)	67
Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like	67
Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases	66
Anti-inflammatory effects of β-ionone-curcumin hybrid derivatives against ulcerative colitis	64

In vitro and in vivo anti-inflammatory effects of 5-hydroxyconiferaldehyde via NF-κB, MAPK/AP-1, and Nrf2 modulation	62
Aspirin alleviates cisplatin-induced acute kidney injury through the AMPK-PGC-1α signaling pathway	60
Metabolic reprogramming by baicalein disrupts fibroblast–macrophage crosstalk in idiopathic pulmonary fibrosis	60
Structure-dependent inhibition of human carboxylesterase 1 by organophosphate esters: integrated in vitro profiling and 3D-QSAR interpretation	59
Drug-drug interaction potentials of tucatinib inhibition of human UDP-glucuronosyltransferases	58
Differences between human and rat 5α-Reductase 1 inhibition by phenolic disinfectants: Comparative kinetics and binding modes for neurosteroid synthesis	58
Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4	56
Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice	56
HIF-1α: A potential therapeutic opportunity in renal fibrosis	56
Inhibition of AT1R/IP3/IP3R-mediated Ca2+ release protects against calcium oxalate crystals-induced renal oxidative stress	55
Molecular mechanisms underlying the effects of beta-sitosterol on TGF-β1/Nrf2/SIRT1/p53-mediated signaling in the kidney of a high-fat diet and sucrose-induced type-2 diabetic rat	54
Copper homeostasis and its dysregulation in diseases: A focus on cuproptosis	53
Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment through the NF-κB signaling pathway	53
Interaction between ethanol and flunitrazepam in rats: Pharmacokinetic mechanisms and toxicological implications	52
HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation	50
Equol promotes osteogenic differentiation of hPDLSCs by inhibiting oxidative stress via IL1B/NF-κB/CXCL1 signaling axis	48
Exposure to polyethylene microplastics induces a male testosterone synthesis disorder via oxidative stress-mediated ferroptosis	47
Involvement of esterases in the pulmonary metabolism of beclomethasone dipropionate and the potential influence of cannabis use	47
In memoriam of Professor Eugenio Vilanova	46
Bone–muscle crosstalk following exercise plus Ursolic acid by myomiR-133a/Cx43-Runx2 axis in aged type 2 diabetes rat models	46
Diagnosis of drug-induced liver injury in model mice by studying the inhibitory effect of serum components on P450 inhibition assay	46
Editorial Board	46
Editorial Board	46
Aristolochic acid I abnormally activates the wnt7b/β-catenin signaling pathway and affects the repair of renal tubules	45
Proton pump inhibitor-induced risk of chronic kidney disease is associated with increase of indoxyl sulfate synthesis via inhibition of CYP2E1 protein degradation	45
Gold(I) N-heterocyclic carbene complexes show strong proapoptotic, antioxidant and anti-inflammatory effects in A2780 and endothelial cells	44
Computational Investigation of Hardwickiic Acid-Derived Amides as Potential Cholinesterase Inhibitors: Molecular Docking and ADME/Tox Predictions	44
Role of selenoprotein S downregulation in T-2 toxin-induced endoplasmic reticulum stress and myocardial injury	43
High incidence of sebaceous gland inflammation in aldose reductase-deficient mice	43
Environmental concentrations of Acetamiprid exposure induced innate immunotoxicity in zebrafish larvae via crosstalk between the TLR4/MYD88/NF-κB and JAK-STAT signaling pathways	43
Induced pluripotent stem cells-podocytes promote repair in acute kidney injury is dependent on Mafb/CCR5/Nampt axis-mediated M2 macrophage polarization	43
Collaboration of bacterial consortia for biodegradation of high concentration phenol and potential application of machine learning	42
Cytochrome P450-mediated detoxification and NF-κB/NLRP3 pathway-driven hepatotoxicity of emodin: Multiomics and laboratory evidence	41
Particle-induced osteolysis is mediated by endoplasmic reticulum stress-associated osteoblast apoptosis	41
Dieckol induces vasodilation via endothelial–smooth muscle crosstalk in co-culture and in vivo zebrafish models	40
Multiple endogenous aldehydes amplify acetaminophen-induced liver injury	40
The JNK/P38 signalling pathway activated by testin protects the intestinal epithelial barrier against Crohn's disease-like colitis	40
Selenomethionine protects against Escherichia coli-induced endometritis by inhibiting inflammation and necroptosis via regulating the PPAR-γ/NF-κB pathway	40
Capsaicin toxicity to the yeast Saccharomyces cerevisiae is not due to oxidative stress but to disruption of membrane structure	39
Cytochrome c - silver nanoparticle interactions: Spectroscopy, thermodynamic and enzymatic activity studies	38
Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways	38
Editorial Board	38
Substrate-dependent inactivation of recombinant paraoxonase 1 during catalytic dihydrocoumarin turnover and the protective properties of surfactants	38
Toluidine blue O attenuates tau phosphorylation in N2a-APPSwe cells	37
Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy	37
Synthesis, cytotoxicity, oxidative stress, anti-metastatic and anti-inflammatory effects of novel 2-methylene-1H-indene-1,3-dione tethered 2-(2-methoxyphenoxy)-N-arylacetamide: induction of apoptosis	37
Unveiling the molecular interactions between alkyl imidazolium ionic liquids and human serum albumin: Implications for toxicological significance	37
Preliminary prediction of toxicologically relevant physicochemical properties of Novichoks: the first comparative in silico studies	37
Mechanism of testicular injury induced by Di-ethylhexyl phthalate and its protective agents	36
Naphthalimide derivatives as fluorescent probes for imaging endogenous gasotransmitters	35

Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice	35
Metabolomic profiling reveals ADB-BUTINACA-induced long-term hepatotoxicity	35
The interactive toxic effect of homocysteine and copper on cardiac microvascular endothelial cells during ischemia-reperfusion injury	35
Erianin reverses 5-FU resistance by targeting CALM1/CAMKK2 and activating autophagy in colorectal cancer	34
Fragment-based discovery, dynamics simulation and pharmacological study of 2-amino-pyrimidine derivative as HIPK2 inhibitor	34
Solvent isotope and mutagenesis studies on the proton relay system in yeast alcohol dehydrogenase 1	33
Old molecules, new hope: A scoping review and bibliometric analysis of drug repurposing for lung cancer	33
Evaluation of agonistic and antagonistic effects of unprenylated and prenylated flavonoids on estrogen receptor–α	33
Computational modeling of the effect of five mutations on the structure of the ACE2 receptor and their correlation with infectivity and virulence of some emerged variants of SARS-CoV-2 suggests mechan	33
Genistein-3′-sodium sulfonate promotes brain functional rehabilitation in ischemic stroke rats by regulating astrocytes polarization through NF-κB signaling pathway	33
Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases	33
SIRT1 regulates osteoblast senescence through SOD2 acetylation and mitochondrial dysfunction in the progression of Osteoporosis caused by Cadmium exposure	32
Triptolide induced spermatogenesis dysfunction via ferroptosis activation by promoting K63-linked GPX4 polyubiquitination in spermatocytes	32
Metabolism-dependent inhibition of CYP2E1 by isoniazid, a mediator of idiosyncratic liver injury	32
Reproductive toxicity and action mechanism of the estrogen zearalenone: A review	32
Tangeretin and 4′-demethyltangeretin prevent damage to mouse hepatocytes from oxidative stress by activating the Nrf2-related antioxidant pathway via an epigenetic mechanism	32
Naphthoquinones and derivatives as potential anticancer agents: An updated review	32
Increased nociceptive sensitivity is associated with periodontal inflammation and expression of chronic pain genes in gingival tissues of male rats	32
Ilimaquinone induces apoptosis in gastric cancer cells by inhibiting the signal transducer and activator of the transcription 3 pathway	31
Imine-metal complexes showing remarkable antiparasitic activity against Trypanosoma cruzi: different modes of action modulated by the ligand and the metal ion	30
Cannabidiol induces ERK activation and ROS production to promote autophagy and ferroptosis in glioblastoma cells	30
In vivo upstream factors of mouse hepatotoxic mechanism with sustained hepatic glutathione depletion: Acetaminophen metabolite-erythrocyte adducts and splenic macrophage-generated reactive oxygen spec	30
Enzyme kinetics-guided evaluation of thiazine hybrids targeting α-amylase and α-glucosidase with in vivo validation	30
Demethoxycurcumin induces metabolic crisis and ATF4/ATF3/CHOP-dependent cell death in hepatocellular carcinoma	30
Arsenic exposure accelerates type 1 diabetes mellitus progression via pyroptosis pathway in mice	30
Warning on the inhalation of silica nanoparticles: Experimental evidence for its easy passage through the air-blood barrier, resulting in systemic distribution and pathological injuries	30
Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study	29
Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation	29
Editorial Board	29
Neurotoxic effects of 2,4-DCP in adult zebrafish: A behavioral, biochemical, and genetic approach	29
T-2 toxin inhibits osteoblastic differentiation and mineralization involving mutual regulation between Wnt signaling pathway and autophagy	29
Regulation of PKC/TLR-4/NF-kB signaling by sulbutiamine improves diabetic nephropathy in rats	28
A novel HMGA2/MPC-1/mTOR signaling pathway promotes cell growth via facilitating Cr (VI)-induced glycolysis	28
A microfluidic human blood–brain barrier model reveals neurovascular toxicity and barrier disruption induced by E-cigarette additives	28
Identification of α-amanitin effector proteins in hepatocytes by limited proteolysis-coupled mass spectrometry	28
Mefenamic acid exhibits antitumor activity against osteosarcoma by impeding cell growth and prompting apoptosis in human osteosarcoma cells and xenograft mice model	28
Quassinoids from Eurycoma longifolia and their bone formation evaluation in zebrafish, C3H10 cells and silico	27
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease	27
Antimetastatic activity of (arene)ruthenium(II) complex of 4-aryl-4H-naphthopyran	27
The synthesis and influence of the novel bispyridinium compound LB1 on the effectiveness of the standard antidotal treatment of organophosphorus nerve agent intoxicated mice and some structure-activit	27
A novel benzofuran derivative of β-elemene (ZT-22) inhibits hepatocellular carcinoma cell growth via directly targeting HSPA6	27
Novel MicroRNA biomarkers revealed in the serum and bile of thioacetamide induced cholangiocarcinoma	27
Transcriptome profiling and DNA methylation analysis of human hepatocyte cell line HHL-16 in response to aflatoxin B1	27
Liposomal nanoformulations with trans-caryophyllene and caryophyllene oxide: do they have an inhibitory action on the efflux pumps NorA, Tet(K), MsrA, and MepA?	27
Non-coding RNA therapeutics: Towards a new candidate for arsenic-induced liver disease	26
Sulfonamide-chalcone hybrid compound suppresses cellular adhesion and migration: Experimental and computational insight	26
Corrigendum to ‟Andrographolide inhibits the growth of human osteosarcoma cells by suppressing Wnt/β-catenin, PI3K/AKT and NF-κB signaling pathways” [Chem. Biol. Interact. 365 (2022) 110068]	26
(4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7	26
Study of the naturally occurring lignan brachangobinan A as antiplasmodial agent: Synthesis, biological evaluation, and in silico prediction	26
Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro	26
Aldose reductase is a potential therapeutic target for neurodegeneration	26
Targeting IGF2BP1 alleviated benzene hematotoxicity by reprogramming BCAA metabolism and fatty acid oxidation	26
Protein adduct formation between RuBisCO and V-type organophosphorus nerve agents	26
RETRACTED: Potential of β-elemene induced ferroptosis through Pole2-mediated p53 and PI3K/AKT signaling in lung cancer cells	26
Adverse effects of 2-Methoxyestradiol on mouse oocytes during reproductive aging	26
Bisphenol S induced endothelial dysfunction via mitochondrial pathway in the vascular endothelial cells, and detoxification effect of albumin binding	25
Targeted delivery of doxorubicin via cholesteryl-modified cyclodextrin: Antitumor activity in breast, ovarian, and cervical cancer cell lines	25
Interaction of 3,9-disubstituted acridine with single stranded poly(rA), double stranded poly(rAU) and triple stranded poly(rUAU): molecular docking – A spectroscopic tandem study	25
Inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase/Δ5,4-isomerase activities by insecticides and fungicides: Mode action by docking analysis	25
Involvement of ductal reaction in Di-(2-ethylhexyl)-phthalate-caused hepatic fibrosis: Molecular mechanisms and potential intervention strategies	25
Differential effects of thiamethoxam and clothianidin exposure on their tissue distribution and chronic toxicity in mice	25
Ellagic acid promotes osteoblasts differentiation via activating SMAD2/3 pathway and alleviates bone mass loss in OVX mice	25
D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity	25
Parabacteroides distasonis regulates PPARɑ to alleviate colchicine-induced colonic injury through p-cresol sulfate	24
Safety pharmacology of sibutramine analogues evaluated by in silico and in vitro biological target screening	24
Reproductive toxicity induced by a repeated 28-day oral exposure to a commercial mixture of the herbicides S-metolachlor and flumioxazin in male rats	24
The prognostic gene CRABP2 affects drug sensitivity by regulating docetaxel-induced apoptosis in breast invasive carcinoma: A pan-cancer analysis	24
Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis	24
Sirtuin 1/3 regulates p53 deacetylation to inhibit iron poisoning-induced alveolar epithelial cell death and contributes to Rapamycin-mediated protection against limb ischemia/reperfusion-induced lung	24
Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region	24
The involvement of gut microbiota in the anti-tumor effect of carnosic acid via IL-17 suppression in colorectal cancer	24
Matrine-induced nephrotoxicity via GSK-3β/nrf2-mediated mitochondria-dependent apoptosis	24
Cardioprotective effect of the quercetin on cardiovascular remodeling and atherosclerosis in rodents fed a high-fat diet: A systematic review	24
Novel insights into male reproductive toxicity: autophagy-dependent ferroptosis triggered by polylactic acid nanoplastics and copper sulfate	24
Neurotoxicity and mechanism of metal and metal oxide nanoparticles	24
Has PdCu@GO effect on oxidant/antioxidant balance? Using zebrafish embryos and larvae as a model	23
Critical considerations for co-administering rivaroxaban and vonoprazan: Unveiling potential pharmacokinetic interactions	23
Editorial Board	23
p-CREB and p-DARPP-32 orchestrating the modulatory role of cAMP/PKA signaling pathway enhanced by Roflumilast in rotenone-induced Parkinson's disease in rats	23
STIM1 N-linked glycosylation promotes arsenic-induced malignant phenotype by activating SOCE in bladder epithelial cells	23

Editorial Board	23
Potent carbonic anhydrase inhibition by ruthenium(II)-acetazolamide conjugates uncoupled from antiproliferative activity in vitro	23
Microsynthesis, mass spectrometry data and acetylcholinesterase inhibition studies of carbamates related to the OPCW 1.A.16 Scheduled Chemicals	23
Exploring the role of ferroptosis in the doxorubicin-induced chronic cardiotoxicity using a murine model	23
EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity	23
Editorial Board	23
Corrigendum to “Rno_circRNA_006061 participates in apoptosis induced by formaldehyde via activating p38/ATF3 pathway” [Chem. Biol. Interact. 381 (2023) 110584]	23
Aluminum exposure disturbs epigenetic modification and organelle function during early embryo development	23
Apocynin loaded silver nanoparticles displays potent in vitro biological activities and mitigates pyrogallol-induced hepatotoxicity	22
Review of triazole scaffolds for treatment and diagnosis of Alzheimer's disease	22
Sex-specific aggressive and emotional behavior in myostatin-deficient mice: Ratio of acylated versus unacylated ghrelin is reduced, but not correlated with butyrylcholinesterase activity level, howeve	22
How did Hermann Muller publish a paper absent any data in the journal Science? Ethical questions and implications of Muller's Nobel Prize	22
Cu(II)-acylhydrazone complex, a potent and selective antitumor agent against human osteosarcoma: Mechanism of action studies over in vitro and in vivo models	22
Laccaic acid restores epigenetic alterations responsible for high fat diet induced insulin resistance in C57BL/6J mice	22
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65	22
Melatonin's paradox: From therapeutic benefits to toxicity warnings	22
A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages	22
Salinomycin, a potent inhibitor of XOD and URAT1, ameliorates hyperuricemic nephropathy by activating NRF2, modulating the gut microbiota, and promoting SCFA production	22
Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells	22
Species differences in cholinesterase expression and their translational impact	22
Inhibitory effects of black phosphorus nanosheets on tumor cell proliferation through downregulation of ADIPOQ and downstream signaling pathways	22
Calycosin-7-glucoside promotes mitochondria-mediated apoptosis in hepatocellular carcinoma by targeting thioredoxin 1 to regulate oxidative stress	22
Fenofibrate induces liver enlargement in aging mice via activating the PPARα-YAP signaling pathway	22
Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway	21
Oleic acid reduces oxidative stress in rat brain induced by some anticancer drugs	21
Carbon nanotubes: Structural defects as stressors inducing lung cell toxicity	21
Sex-specific cardiac responses to subacute exposure to tributyltin in rats	21
Integrated single-cell RNA-seq analysis revealed podocyte injury through activation of the BMP7/AMPK/mTOR mediated autophagy pathway	21
NMDA receptor-mediated modulation on glutamine synthetase and glial glutamate transporter GLT-1 is involved in the antidepressant-like and neuroprotective effects of guanosine	21
Design and synthesis of thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen as potential MetAP (type II) inhibitors	21
Metabolomics with gut microbiota analysis of podophyllotoxin-mediated cardiotoxicity in mice based on the toxicological evidence chain (TEC) concept	21
Fumonisins alone or mixed with other fusariotoxins increase the C22–24:C16 sphingolipid ratios in chicken livers, while deoxynivalenol and zearalenone have no effect	21
Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain	21
Uro-protective role of chrysin against cyclophosphamide-induced hemorrhagic cystitis in rats involving the turning-off NF-κB/P38-MAPK, NO/PARP-1 and STAT-3 signaling cascades	21
Cyclophosphamide-induced iron homeostasis imbalance triggers ovarian toxicity through ferroptosis of ovarian granulosa cells in a mitophagy crosstalk manner	21
Multi-dimensional analysis revealing the mechanism of T-2 toxin driving liver fibrosis: integration of network toxicology, machine learning, experimental verification, and molecular docking	21
Enhanced potency of a chloro-substituted polyaromatic platinum(II) complex and its platinum(IV) prodrug against lung cancer	21
Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice	21
Formaldehyde exacerbates asthma in mice through the potentiation of HIF-1α-mediated pro-inflammatory responses in pulmonary macrophages	21
6:2 chlorinated polyfluoroalkyl ether sulfonate (F–53B) induced nephrotoxicity associated with oxidative stress, inflammation and fibrosis in mice	20
Discovery of acylated isoquercitrin derivatives as potent anti-neuroinflammatory agents in vitro and in vivo	20
Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS/Caspase 1 signaling pathway	20
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6	20
Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin	20
Knockout of TRPM2 protects against cyclophosphamide-induced premature ovarian failure via inhibiting AMPK/p53 signaling pathway	20
A new cyclin-dependent kinase-9 inhibitor A09-003 induces apoptosis in acute myeloid leukemia cells with reduction of myeloid cell leukemia sequence-1 protein	20
Neurotoxicity of myclobutanil in zebrafish larvae via thyroid disruption and neuronal apoptosis	20
Sodium butyrate blocks the growth of colorectal cancer by inhibiting the aerobic glycolysis mediated by SIRT4/HIF-1α	20
Cytotoxic and oxidative stress–related effects of N2O2-type Ni(II)-thiosemicarbazone complexes: Experimental and computational studies	20
Exposure-response analysis of recent epidemiological data: Proposed risk based occupational exposure limits for various mineral types of asbestos	20
Revolutionizing lung health: Exploring the latest breakthroughs and future prospects of synbiotic nanostructures in lung diseases	20
Editorial Board	20
Immunomodulatory evaluation of caffeic acid and its quinic acid derivatives using Th1/Th2 cytokine secretion profiles and principal component analysis	20
Trojan horse tactics: Naphthalimide polyamine conjugates revolutionize cancer treatment	19
Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells	19
Effective parallel evaluation of molecular design, expression and bioactivity of novel recombinant butyrylcholinesterase medical countermeasures	19
Editorial Board	19
Alkaloid-based modulators of the PI3K/Akt/mTOR pathway for cancer therapy: Understandings from pharmacological point of view	19
Artemisinin toxicity in HepG2 liver carcinoma cells is linked to protein network in host and molecular interactions with cellular drug targets	19
Withaferin-A induced vimentin S56 phosphorylation dissociates NEDD9 signaling loop to regress progressive metastatic melanoma into lung adenocarcinoma	19
Exploring the potential hypothalamic role in mediating cisplatin-induced negative energy balance	19
Untargeted and targeted metabolomics reveal bile acid profile changes in rats with ethylene glycol-induced calcium oxalate nephrolithiasis	19
Editorial Board	19
The mechanism of acrolein exposure inhibited the release of neutrophil extracellular traps: By reducing respiratory burst and Raf/MEK/ERK pathway and promote cell apoptosis	19
Acute toxic effects of new synthetic cannabinoid on brain: Neurobehavioral and Histological: Preclinical studies	19
Toxicological profile of Acovenoside A as an active pharmaceutical ingredient – prediction of missing key toxicological endpoints using in silico toxicology methodology	19
Simulating the interactions between per- and polyfluoroalkyl substances and kidney transporters for understanding their half-life and renal bioaccumulation	19
Investigation of ponatinib metabolism and drug-drug interactions with lycopene and shikonin in vitro and in vivo	19
m6A methylation dependent autophagy activation is required for anti-tumor effects of artesunate through ferroptosis in hepatocellular carcinoma	19
New insights into the interaction between duodenal toxicity and microbiota disorder under copper exposure in chicken: Involving in endoplasmic reticulum stress and mitochondrial toxicity	19
Oxidative stress and ferroptosis involved in 2-ethylhexyl diphenyl phosphate -induced hepatotoxicity in chicken	18
Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis	18
The role of age and sex in paraoxonase 1 activity in patients with Alzheimer's dementia	18
Neurotoxic risks of long-term environmental exposure to pesticides: a review	18
GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes	18
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis	18
Silver nanoparticles instigate physiological, genotoxicity, and ultrastructural anomalies in midgut tissues of beetles	18
Targeting neuroblastoma with 3β,5α-tetrahydrocorticosterone: Activation of aryl hydrocarbon receptor inhibits tumor growth, metastasis, and stemness while promoting neural differentiation	18
Mild hyperhomocysteinemia alters oxidative stress profile via Nrf2, inflammation and cholinesterases in cardiovascular system of aged male rats	18
Discovery of inhibitors against SARS-CoV-2 main protease using fragment-based drug design	18
Fusobacterium nucleatum-derived 3-indolepropionic acid promotes colorectal cancer progression via aryl hydrocarbon receptor activation in macrophages	18
Novel hybrids of quinoline with pyrazolylchalcones as potential antimalarial agents: Synthesis, biological evaluation, molecular docking and ADME prediction	18
Editorial Board	18
Farnesoid X receptor regulates CYP1A1 and CYP1B1 and estradiol metabolism in mouse and human cell lines	18
Exposure risks to phthalates by cosmetics and personal care products in pregnant women and early life: Urinary levels, mechanisms, biomarkers, and mitigation strategies: a review	18
Pachymic acid suppresses proliferation and invasion in colon cancer by inhibiting glycolysis via PPARγ/ENO1 pathway	18
Ferritinophagy-mediated ferroptosis of spermatogonia is involved in busulfan-induced oligospermia in the mice	18
Selenium nanoparticles: Properties, preparation methods, and therapeutic applications	18
Editorial Board	18
Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its’ potential against glioblastoma in cellular mod	17
Molecular and toxicological mechanisms behind the effects of chromium (VI) on the male reproductive system of Mytilus galloprovincialis: First evidence for poly-ADP-ribosylation of protamine-like II	17
Insights into the diagnostic and prognostic value of paraoxonase 1-related variables and inflammatory markers in community-acquired pneumonia	17
Impact of cuproptosis in gliomas pathogenesis with targeting options	17
A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells	17
Small-molecular cyclic peptide exerts viability suppression effects on HepG2 cells via triggering p53 apoptotic pathways	17