Chemico-Biological Interactions

Article	Citations
Editorial Board	815
Characterization of a novel porcine carbonyl reductase activated by glutathione: Relationship to carbonyl reductase 1, 3α/β-hydroxysteroid dehydrogenase and prostaglandin 9-ketoreductase	197
Anti-inflammatory effects of β-ionone-curcumin hybrid derivatives against ulcerative colitis	194
Low levels of endogenous cholinesterases support the choice of cows, sheep and goats for the transgenic expression of human butyrylcholinesterase in milk	163
Discovery and characterization of the flavonoids in Cortex Mori Radicis as naturally occurring inhibitors against intestinal nitroreductases	128
Editorial Board	113
HIF-1α: A potential therapeutic opportunity in renal fibrosis	108
Drug-drug interaction potentials of tucatinib inhibition of human UDP-glucuronosyltransferases	103
Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the hippo signaling pathways in emphysema	94
Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like	88
Exosomal miR-181a-2-3p derived from citreoviridin-treated hepatocytes activates hepatic stellate cells trough inducing mitochondrial calcium overload	83
Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells	80
Modeling of a near-attack conformation of oxime in phosphorylated acetylcholinesterase via a reactivation product, a phosphorylated oxime	77
In vitro and in vivo anti-inflammatory effects of 5-hydroxyconiferaldehyde via NF-κB, MAPK/AP-1, and Nrf2 modulation	76
Preconception paternal exposure to zearalenone impairs male fertility and IVF embryo survival in mice	74
Inflammatory response and DNA damage induced by dry tobacco exposure in rural workers: A study on complex mixtures and their health impacts	73
Alternative splicing affects synapses in the hippocampus of offspring after maternal fructose exposure during gestation and lactation	64
Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4	63
Retraction notice to “Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity” [Chem. Biol. Interact. 153–154 (2005) 147–157]	61
Aspirin alleviates cisplatin-induced acute kidney injury through the AMPK-PGC-1α signaling pathway	60
Computational study to find the goat serum albumin (GSA) binding site as A-esterase	58
Copper homeostasis and its dysregulation in diseases: A focus on cuproptosis	58
Benzo[a]pyrene treatment modulates Nrf2/Keap1 axis and changes the metabolic profile in rat lung cancer	58
Thymol ameliorates ethanol-induced hepatotoxicity via regulating metabolism and autophagy	57
ER stress-enhanced HMGA2 plays an important role in Cr (VI)-induced glycolysis and inhibited oxidative phosphorylation by targeting the transcription of ATF4	56

Equol promotes osteogenic differentiation of hPDLSCs by inhibiting oxidative stress via IL1B/NF-κB/CXCL1 signaling axis	56
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication	56
Honokiol inhibits interleukin-induced angiogenesis in the NSCLC microenvironment through the NF-κB signaling pathway	55
BjussuMP-II, a venom metalloproteinase, induces the release and cleavage of pro-inflammatory cytokines and disrupts human umbilical vein endothelial cells	55
F–53B triggers ovarian granulosa cell senescence and ovarian dysfunction by triggering mitochondrial dysfunction	53
Molecular mechanisms underlying the effects of beta-sitosterol on TGF-β1/Nrf2/SIRT1/p53-mediated signaling in the kidney of a high-fat diet and sucrose-induced type-2 diabetic rat	51
The influence of alkyl substitution on the in vitro metabolism and mutagenicity of benzo[a]pyrene	51
Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approaches	50
Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity	50
Inhibition of AT1R/IP3/IP3R-mediated Ca2+ release protects against calcium oxalate crystals-induced renal oxidative stress	48
Wnt/β-catenin antagonist pyrvinium rescues high dose isoproterenol induced cardiotoxicity in rats: Biochemical and immunohistological evidences	48
Recalling the reported toxicity assessment of deoxynivalenol, mitigating strategies and its toxicity mechanisms: Comprehensive review	47
HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation	47
Aristolochic acid I abnormally activates the wnt7b/β-catenin signaling pathway and affects the repair of renal tubules	46
Gold(I) N-heterocyclic carbene complexes show strong proapoptotic, antioxidant and anti-inflammatory effects in A2780 and endothelial cells	45
Arsenic exposure accelerates type 1 diabetes mellitus progression via pyroptosis pathway in mice	44
Editorial Board	44
Involvement of esterases in the pulmonary metabolism of beclomethasone dipropionate and the potential influence of cannabis use	44
The JNK/P38 signalling pathway activated by testin protects the intestinal epithelial barrier against Crohn's disease-like colitis	43
Editorial Board	43
Particle-induced osteolysis is mediated by endoplasmic reticulum stress-associated osteoblast apoptosis	43
Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy	42
Computational Investigation of Hardwickiic Acid-Derived Amides as Potential Cholinesterase Inhibitors: Molecular Docking and ADME/Tox Predictions	42
Evaluation of agonistic and antagonistic effects of unprenylated and prenylated flavonoids on estrogen receptor–α	42
Induced pluripotent stem cells-podocytes promote repair in acute kidney injury is dependent on Mafb/CCR5/Nampt axis-mediated M2 macrophage polarization	41
In memoriam of Professor Eugenio Vilanova	41
Cytochrome c - silver nanoparticle interactions: Spectroscopy, thermodynamic and enzymatic activity studies	39
Erianin reverses 5-FU resistance by targeting CALM1/CAMKK2 and activating autophagy in colorectal cancer	39
Selected herbicides screened for toxicity and analysed as inhibitors of both cholinesterases	39
Preliminary prediction of toxicologically relevant physicochemical properties of Novichoks: the first comparative in silico studies	39
Capsaicin toxicity to the yeast Saccharomyces cerevisiae is not due to oxidative stress but to disruption of membrane structure	38
Substrate-dependent inactivation of recombinant paraoxonase 1 during catalytic dihydrocoumarin turnover and the protective properties of surfactants	38
p-Phenylenediamine induces immediate contact allergy and non-histaminergic itch via MRGPRX2	37
Diagnosis of drug-induced liver injury in model mice by studying the inhibitory effect of serum components on P450 inhibition assay	37
Substituent effects of sulfonamide derivatives of metformin that can dually improve cellular glucose utilization and anti-coagulation	37
Toluidine blue O attenuates tau phosphorylation in N2a-APPSwe cells	37
Proton pump inhibitor-induced risk of chronic kidney disease is associated with increase of indoxyl sulfate synthesis via inhibition of CYP2E1 protein degradation	37
Computational modeling of the effect of five mutations on the structure of the ACE2 receptor and their correlation with infectivity and virulence of some emerged variants of SARS-CoV-2 suggests mechan	36
Tangeretin and 4′-demethyltangeretin prevent damage to mouse hepatocytes from oxidative stress by activating the Nrf2-related antioxidant pathway via an epigenetic mechanism	36
EGPI-1, a novel eIF4E/eIF4G interaction inhibitor, inhibits lung cancer cell growth and angiogenesis through Ras/MNK/ERK/eIF4E signaling pathway	35
Metabolomic profiling reveals ADB-BUTINACA-induced long-term hepatotoxicity	35
Demethoxycurcumin induces metabolic crisis and ATF4/ATF3/CHOP-dependent cell death in hepatocellular carcinoma	35
Therapeutic targeting of hepatocellular carcinoma cells with antrocinol, a novel, dual-specificity, small-molecule inhibitor of the KRAS and ERK oncogenic signaling pathways	35
Unveiling the molecular interactions between alkyl imidazolium ionic liquids and human serum albumin: Implications for toxicological significance	35
The interactive toxic effect of homocysteine and copper on cardiac microvascular endothelial cells during ischemia-reperfusion injury	34
Warning on the inhalation of silica nanoparticles: Experimental evidence for its easy passage through the air-blood barrier, resulting in systemic distribution and pathological injuries	34
High incidence of sebaceous gland inflammation in aldose reductase-deficient mice	34
Eicosapentaenoic acid enhanced apoptotic and oxidant effects of cisplatin via activation of TRPM2 channel in brain tumor cells	34
T-2 toxin inhibits osteoblastic differentiation and mineralization involving mutual regulation between Wnt signaling pathway and autophagy	34
Ilimaquinone induces apoptosis in gastric cancer cells by inhibiting the signal transducer and activator of the transcription 3 pathway	34

Reproductive toxicity and action mechanism of the estrogen zearalenone: A review	33
Metabolism-dependent inhibition of CYP2E1 by isoniazid, a mediator of idiosyncratic liver injury	33
Selenomethionine protects against Escherichia coli-induced endometritis by inhibiting inflammation and necroptosis via regulating the PPAR-γ/NF-κB pathway	33
Mechanism of testicular injury induced by Di-ethylhexyl phthalate and its protective agents	33
In vivo upstream factors of mouse hepatotoxic mechanism with sustained hepatic glutathione depletion: Acetaminophen metabolite-erythrocyte adducts and splenic macrophage-generated reactive oxygen spec	33
Solvent isotope and mutagenesis studies on the proton relay system in yeast alcohol dehydrogenase 1	32
Bone–muscle crosstalk following exercise plus Ursolic acid by myomiR-133a/Cx43-Runx2 axis in aged type 2 diabetes rat models	32
Triptolide induced spermatogenesis dysfunction via ferroptosis activation by promoting K63-linked GPX4 polyubiquitination in spermatocytes	32
Dieckol induces vasodilation via endothelial–smooth muscle crosstalk in co-culture and in vivo zebrafish models	32
Genistein-3′-sodium sulfonate promotes brain functional rehabilitation in ischemic stroke rats by regulating astrocytes polarization through NF-κB signaling pathway	32
Synthesis, cytotoxicity, oxidative stress, anti-metastatic and anti-inflammatory effects of novel 2-methylene-1H-indene-1,3-dione tethered 2-(2-methoxyphenoxy)-N-arylacetamide: induction of apoptosis	32
Fragment-based discovery, dynamics simulation and pharmacological study of 2-amino-pyrimidine derivative as HIPK2 inhibitor	31
Naphthalimide derivatives as fluorescent probes for imaging endogenous gasotransmitters	31
SIRT1 regulates osteoblast senescence through SOD2 acetylation and mitochondrial dysfunction in the progression of Osteoporosis caused by Cadmium exposure	31
Multiple endogenous aldehydes amplify acetaminophen-induced liver injury	31
Increased nociceptive sensitivity is associated with periodontal inflammation and expression of chronic pain genes in gingival tissues of male rats	31
Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice	31
Collaboration of bacterial consortia for biodegradation of high concentration phenol and potential application of machine learning	30
Editorial Board	30
Cannabidiol induces ERK activation and ROS production to promote autophagy and ferroptosis in glioblastoma cells	30
Corrigendum to ‟Andrographolide inhibits the growth of human osteosarcoma cells by suppressing Wnt/β-catenin, PI3K/AKT and NF-κB signaling pathways” [Chem. Biol. Interact. 365 (2022) 110068]	30
Naphthoquinones and derivatives as potential anticancer agents: An updated review	30
Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study	29
The inhibitory kinetics of vitamins B9, C, E, and D3 on bovine xanthine oxidase: Gout treatment	29
Study of the naturally occurring lignan brachangobinan A as antiplasmodial agent: Synthesis, biological evaluation, and in silico prediction	29
Cardioprotective effect of the quercetin on cardiovascular remodeling and atherosclerosis in rodents fed a high-fat diet: A systematic review	29
RETRACTED: Potential of β-elemene induced ferroptosis through Pole2-mediated p53 and PI3K/AKT signaling in lung cancer cells	28
Quassinoids from Eurycoma longifolia and their bone formation evaluation in zebrafish, C3H10 cells and silico	28
Sulfonamide-chalcone hybrid compound suppresses cellular adhesion and migration: Experimental and computational insight	28
Transcriptome profiling and DNA methylation analysis of human hepatocyte cell line HHL-16 in response to aflatoxin B1	28
The synthesis and influence of the novel bispyridinium compound LB1 on the effectiveness of the standard antidotal treatment of organophosphorus nerve agent intoxicated mice and some structure-activit	28
A novel benzofuran derivative of β-elemene (ZT-22) inhibits hepatocellular carcinoma cell growth via directly targeting HSPA6	28
(4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7	28
Differential effects of thiamethoxam and clothianidin exposure on their tissue distribution and chronic toxicity in mice	28
D-limonene complexed with hydroxypropyl-β-cyclodextrin prevents impaired cardiac excitation-contraction coupling by reducing oxidative stress and cardiac apoptosis in an animal model of cardiotoxicity	28
Bisphenol S induced endothelial dysfunction via mitochondrial pathway in the vascular endothelial cells, and detoxification effect of albumin binding	27
Matrine-induced nephrotoxicity via GSK-3β/nrf2-mediated mitochondria-dependent apoptosis	27
Identification of α-amanitin effector proteins in hepatocytes by limited proteolysis-coupled mass spectrometry	27
Inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase/Δ5,4-isomerase activities by insecticides and fungicides: Mode action by docking analysis	27
Regulation of PKC/TLR-4/NF-kB signaling by sulbutiamine improves diabetic nephropathy in rats	27
Sirtuin 1/3 regulates p53 deacetylation to inhibit iron poisoning-induced alveolar epithelial cell death and contributes to Rapamycin-mediated protection against limb ischemia/reperfusion-induced lung	26
Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro	26
Bis-nor-diterpene from Cnidoscolus quercifolius (Euphorbiaceae) induces tubulin depolymerization-mediated apoptosis in BRAF-mutated melanoma cells	25
Ellagic acid promotes osteoblasts differentiation via activating SMAD2/3 pathway and alleviates bone mass loss in OVX mice	25
Obeticholic acid orchestrates the crosstalk between ileal autophagy and tight junctions in non-alcoholic steatohepatitis: Role of TLR4/TGF-β1 axis	25
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease	25
Liposomal nanoformulations with trans-caryophyllene and caryophyllene oxide: do they have an inhibitory action on the efflux pumps NorA, Tet(K), MsrA, and MepA?	25
Adverse effects of 2-Methoxyestradiol on mouse oocytes during reproductive aging	25
Novel insights into male reproductive toxicity: autophagy-dependent ferroptosis triggered by polylactic acid nanoplastics and copper sulfate	24
The involvement of gut microbiota in the anti-tumor effect of carnosic acid via IL-17 suppression in colorectal cancer	24
A novel HMGA2/MPC-1/mTOR signaling pathway promotes cell growth via facilitating Cr (VI)-induced glycolysis	24
The prognostic gene CRABP2 affects drug sensitivity by regulating docetaxel-induced apoptosis in breast invasive carcinoma: A pan-cancer analysis	24
Isolation and anticancer activity evaluation of rare Bisaryl anthraquinone antibiotics from novel Streptomyces sp. strain of NW Himalayan region	24
Targeting IGF2BP1 alleviated benzene hematotoxicity by reprogramming BCAA metabolism and fatty acid oxidation	24
Protein adduct formation between RuBisCO and V-type organophosphorus nerve agents	24
Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway	24
Involvement of ductal reaction in Di-(2-ethylhexyl)-phthalate-caused hepatic fibrosis: Molecular mechanisms and potential intervention strategies	24
Safety pharmacology of sibutramine analogues evaluated by in silico and in vitro biological target screening	24
Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis	24
Non-coding RNA therapeutics: Towards a new candidate for arsenic-induced liver disease	24
EGCG inactivates a pore-forming toxin by promoting its oligomerization and decreasing its solvent-exposed hydrophobicity	23
Design and synthesis of thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen as potential MetAP (type II) inhibitors	23
Inhibitory effects of black phosphorus nanosheets on tumor cell proliferation through downregulation of ADIPOQ and downstream signaling pathways	23
Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression	23
Interaction of 3,9-disubstituted acridine with single stranded poly(rA), double stranded poly(rAU) and triple stranded poly(rUAU): molecular docking – A spectroscopic tandem study	23
Editorial Board	23
Critical considerations for co-administering rivaroxaban and vonoprazan: Unveiling potential pharmacokinetic interactions	23
A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages	23
Editorial Board	23
Corrigendum to “Rno_circRNA_006061 participates in apoptosis induced by formaldehyde via activating p38/ATF3 pathway” [Chem. Biol. Interact. 381 (2023) 110584]	23
Antimetastatic activity of (arene)ruthenium(II) complex of 4-aryl-4H-naphthopyran	23
Aldose reductase is a potential therapeutic target for neurodegeneration	23
Editorial Board	23
Has PdCu@GO effect on oxidant/antioxidant balance? Using zebrafish embryos and larvae as a model	23
Editorial Board	23
Mefenamic acid exhibits antitumor activity against osteosarcoma by impeding cell growth and prompting apoptosis in human osteosarcoma cells and xenograft mice model	23
A new cyclin-dependent kinase-9 inhibitor A09-003 induces apoptosis in acute myeloid leukemia cells with reduction of myeloid cell leukemia sequence-1 protein	23
Dehydroandrographolide ameliorates doxorubicin-mediated cardiotoxicity by regulating autophagy through the mTOR-TFEB pathway	22
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65	22
Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells	22

Microsynthesis, mass spectrometry data and acetylcholinesterase inhibition studies of carbamates related to the OPCW 1.A.16 Scheduled Chemicals	22
Identification of potential antileishmanial 1,3-disubstituted-4-hydroxy-6-methylpyridin-2(1H)-ones, in vitro metabolic stability, cytotoxicity and molecular modeling studies	22
Review of triazole scaffolds for treatment and diagnosis of Alzheimer's disease	22
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6	22
NMDA receptor-mediated modulation on glutamine synthetase and glial glutamate transporter GLT-1 is involved in the antidepressant-like and neuroprotective effects of guanosine	22
Fenofibrate induces liver enlargement in aging mice via activating the PPARα-YAP signaling pathway	22
Fenbendazole and its synthetic analog interfere with HeLa cells’ proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway	22
The effects of agomelatine on endoplasmic reticulum stress related to mitochondrial dysfunction in hippocampus of aging rat model	22
How did Hermann Muller publish a paper absent any data in the journal Science? Ethical questions and implications of Muller's Nobel Prize	22
Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin	22
Aluminum exposure disturbs epigenetic modification and organelle function during early embryo development	21
Oleic acid reduces oxidative stress in rat brain induced by some anticancer drugs	21
Discovery of acylated isoquercitrin derivatives as potent anti-neuroinflammatory agents in vitro and in vivo	21
Potent carbonic anhydrase inhibition by ruthenium(II)-acetazolamide conjugates uncoupled from antiproliferative activity in vitro	21
Calycosin-7-glucoside promotes mitochondria-mediated apoptosis in hepatocellular carcinoma by targeting thioredoxin 1 to regulate oxidative stress	21
Exposure-response analysis of recent epidemiological data: Proposed risk based occupational exposure limits for various mineral types of asbestos	21
Immunomodulatory evaluation of caffeic acid and its quinic acid derivatives using Th1/Th2 cytokine secretion profiles and principal component analysis	21
Knockout of TRPM2 protects against cyclophosphamide-induced premature ovarian failure via inhibiting AMPK/p53 signaling pathway	21
Exploring the role of ferroptosis in the doxorubicin-induced chronic cardiotoxicity using a murine model	21
STIM1 N-linked glycosylation promotes arsenic-induced malignant phenotype by activating SOCE in bladder epithelial cells	21
Sex-specific aggressive and emotional behavior in myostatin-deficient mice: Ratio of acylated versus unacylated ghrelin is reduced, but not correlated with butyrylcholinesterase activity level, howeve	21
Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS/Caspase 1 signaling pathway	21
Melatonin's paradox: From therapeutic benefits to toxicity warnings	20
Cu(II)-acylhydrazone complex, a potent and selective antitumor agent against human osteosarcoma: Mechanism of action studies over in vitro and in vivo models	20
Metabolomics with gut microbiota analysis of podophyllotoxin-mediated cardiotoxicity in mice based on the toxicological evidence chain (TEC) concept	20
Sodium butyrate blocks the growth of colorectal cancer by inhibiting the aerobic glycolysis mediated by SIRT4/HIF-1α	20
Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells	20
Cadmium-promoted thyroid hormones disruption mediates ROS, inflammation, Aβ and Tau proteins production, gliosis, spongiosis and neurodegeneration in rat basal forebrain	20
Uro-protective role of chrysin against cyclophosphamide-induced hemorrhagic cystitis in rats involving the turning-off NF-κB/P38-MAPK, NO/PARP-1 and STAT-3 signaling cascades	20
6:2 chlorinated polyfluoroalkyl ether sulfonate (F–53B) induced nephrotoxicity associated with oxidative stress, inflammation and fibrosis in mice	20
Laccaic acid restores epigenetic alterations responsible for high fat diet induced insulin resistance in C57BL/6J mice	20
Additive cell protective and oxidative stress reducing effects of combined treatment with cromolyn sodium and masitinib on MPTP-induced toxicity in SH-SY5Y neuroblastoma cells	20
Salinomycin, a potent inhibitor of XOD and URAT1, ameliorates hyperuricemic nephropathy by activating NRF2, modulating the gut microbiota, and promoting SCFA production	20
Apocynin loaded silver nanoparticles displays potent in vitro biological activities and mitigates pyrogallol-induced hepatotoxicity	20
Exposure to zinc oxide nanoparticles (ZnO-NPs) induces cardiovascular toxicity and exacerbates pathogenesis – Role of oxidative stress and MAPK signaling	20
Enhanced potency of a chloro-substituted polyaromatic platinum(II) complex and its platinum(IV) prodrug against lung cancer	20
Fumonisins alone or mixed with other fusariotoxins increase the C22–24:C16 sphingolipid ratios in chicken livers, while deoxynivalenol and zearalenone have no effect	19
Integrated single-cell RNA-seq analysis revealed podocyte injury through activation of the BMP7/AMPK/mTOR mediated autophagy pathway	19
Species differences in cholinesterase expression and their translational impact	19
Effective parallel evaluation of molecular design, expression and bioactivity of novel recombinant butyrylcholinesterase medical countermeasures	19
Farnesoid X receptor regulates CYP1A1 and CYP1B1 and estradiol metabolism in mouse and human cell lines	19
Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy	19
Carbon nanotubes: Structural defects as stressors inducing lung cell toxicity	19
p-CREB and p-DARPP-32 orchestrating the modulatory role of cAMP/PKA signaling pathway enhanced by Roflumilast in rotenone-induced Parkinson's disease in rats	19
Editorial Board	19
Oxidative stress and ferroptosis involved in 2-ethylhexyl diphenyl phosphate -induced hepatotoxicity in chicken	19
Formaldehyde exacerbates asthma in mice through the potentiation of HIF-1α-mediated pro-inflammatory responses in pulmonary macrophages	19
Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice	19
Oxidative stress induces inflammation of lens cells and triggers immune surveillance of ocular tissues	19
A simple quinoline salt derivative is active in vitro against Plasmodiumf alciparum asexual blood stages and inhibits the development of cerebral malaria in murine model	19
Exploring the potential hypothalamic role in mediating cisplatin-induced negative energy balance	19
Artemisinin toxicity in HepG2 liver carcinoma cells is linked to protein network in host and molecular interactions with cellular drug targets	19
Exposure risks to phthalates by cosmetics and personal care products in pregnant women and early life: Urinary levels, mechanisms, biomarkers, and mitigation strategies: a review	18
Novel hybrids of quinoline with pyrazolylchalcones as potential antimalarial agents: Synthesis, biological evaluation, molecular docking and ADME prediction	18
Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling by increasing antioxidant response in obese high-fat diet-fed mice	18
Silver nanoparticles instigate physiological, genotoxicity, and ultrastructural anomalies in midgut tissues of beetles	18
GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes	18
Pachymic acid suppresses proliferation and invasion in colon cancer by inhibiting glycolysis via PPARγ/ENO1 pathway	18
Withaferin-A induced vimentin S56 phosphorylation dissociates NEDD9 signaling loop to regress progressive metastatic melanoma into lung adenocarcinoma	18
Targeting neuroblastoma with 3β,5α-tetrahydrocorticosterone: Activation of aryl hydrocarbon receptor inhibits tumor growth, metastasis, and stemness while promoting neural differentiation	18
Untargeted and targeted metabolomics reveal bile acid profile changes in rats with ethylene glycol-induced calcium oxalate nephrolithiasis	18
New insights into the interaction between duodenal toxicity and microbiota disorder under copper exposure in chicken: Involving in endoplasmic reticulum stress and mitochondrial toxicity	18
Fusobacterium nucleatum-derived 3-indolepropionic acid promotes colorectal cancer progression via aryl hydrocarbon receptor activation in macrophages	18
Discovery of microtubule stabilizers with novel scaffold structures based on virtual screening, biological evaluation, and molecular dynamics simulation	18
Toxicological profile of Acovenoside A as an active pharmaceutical ingredient – prediction of missing key toxicological endpoints using in silico toxicology methodology	18
Ferritinophagy-mediated ferroptosis of spermatogonia is involved in busulfan-induced oligospermia in the mice	18
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis	18
Neurotoxic risks of long-term environmental exposure to pesticides: a review	18
Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells	18
Discovery of inhibitors against SARS-CoV-2 main protease using fragment-based drug design	18
Revolutionizing lung health: Exploring the latest breakthroughs and future prospects of synbiotic nanostructures in lung diseases	18
The mechanism of acrolein exposure inhibited the release of neutrophil extracellular traps: By reducing respiratory burst and Raf/MEK/ERK pathway and promote cell apoptosis	18
The role of age and sex in paraoxonase 1 activity in patients with Alzheimer's dementia	18
Selenium nanoparticles: Properties, preparation methods, and therapeutic applications	17
Corrigendum to Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway [Chem. Biol. Interact. 2021 May 2	17
Protosappanin B activates the Wnt pathway to protect against glucocorticoid-induced osteoblast inhibition and enhance bone formation	17
Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate	17
Ameliorating effect of continuous alpha-glycosyl isoquercitrin treatment starting from late gestation in a rat autism model induced by postnatal injection of lipopolysaccharides	17
Epirubicin toxicity in rat's ovary and uterus: A protective role of 3-Indolepropionic acid supplementation	17
Editorial Board	17
Mild hyperhomocysteinemia alters oxidative stress profile via Nrf2, inflammation and cholinesterases in cardiovascular system of aged male rats	17
Investigation of ponatinib metabolism and drug-drug interactions with lycopene and shikonin in vitro and in vivo	17
Investigation of microcystin conformation and binding towards PPP1 by molecular dynamics simulation	17
Impact of cuproptosis in gliomas pathogenesis with targeting options	17
TET2 promotes UVB-induced cell death by activating RIPK3-MLKL-necroptosis signaling	17
DMSO-soluble smoking particles up-regulate the vascular endothelin receptors through AMPK-SIRT1 and MAPK pathways	17
How do different bile acid derivatives affect rat macrophage function – Friends or foes?	17
CGS-21680 defers cisplatin-induced AKI-CKD transition in C57/BL6 mice	17
Acute toxic effects of new synthetic cannabinoid on brain: Neurobehavioral and Histological: Preclinical studies	17
Modeling skin sensitization: hierarchical support vector regression−based prediction of lysine depletion in DPRA	17
Effects of acidic non-steroidal anti-inflammatory drugs on human cytochrome P450 4A11 activity: Roles of carboxylic acid and a sulfur atom in potent inhibition by sulindac sulfide	17
Interaction between cigarette smoke exposure and physical training on inflammatory and oxidative profile in mice muscle	17
Growth differentiation factor 7 pretreatment enhances the therapeutic capacity of bone marrow-derived mesenchymal stromal cells against cerebral ischemia-reperfusion injury	17
A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells	17
Alkaloid-based modulators of the PI3K/Akt/mTOR pathway for cancer therapy: Understandings from pharmacological point of view	17