Chemico-Biological Interactions

Article	Citations
Essential metals in health and disease	338
Nuclear factor-kappa B and its role in inflammatory lung disease	140
Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties	113
Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish	100
Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications	97
Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways	97
Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice	86
Colon cancer and colorectal cancer: Prevention and treatment by potential natural products	82
Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis	81
Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis	70
Transforming growth factor-β signaling: From tissue fibrosis to therapeutic opportunities	63
Galangin as an inflammatory response modulator: An updated overview and therapeutic potential	55
Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells	54
Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19	53
A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer	52
Exploring the binding mechanism and adverse toxic effects of persistent organic pollutant (dicofol) to human serum albumin: A biophysical, biochemical and computational approach	51
Artesunate induces autophagy dependent apoptosis through upregulating ROS and activating AMPK-mTOR-ULK1 axis in human bladder cancer cells	51
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes	49
In silico analysis of selected alkaloids against main protease (Mpro) of SARS-CoV-2	48
Alcohol consumption and risk of stomach cancer: A meta-analysis	48
2D materials, synthesis, characterization and toxicity: A critical review	47
Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation	47
Effects of low-level imidacloprid oral exposure on cholinesterase activity, oxidative stress responses, and primary DNA damage in the blood and brain of male Wistar rats	46
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer	46
Erythrocytes as model cells for biocompatibility assessment, cytotoxicity screening of xenobiotics and drug delivery	46

Fluoride regulates chondrocyte proliferation and autophagy via PI3K/AKT/mTOR signaling pathway	45
Resveratrol protects against cisplatin-induced ovarian and uterine toxicity in female rats by attenuating oxidative stress, inflammation and apoptosis	44
Neuroprotective effects of protocatechuic acid on sodium arsenate induced toxicity in mice: Role of oxidative stress, inflammation, and apoptosis	44
Nuclear factor-κB signaling inhibitors revert multidrug-resistance in breast cancer cells	44
Alcohol consumption. A leading risk factor for cancer	43
Aptamer-conjugated carbon-based nanomaterials for cancer and bacteria theranostics: A review	43
Asperuloside suppressing oxidative stress and inflammation in DSS-induced chronic colitis and RAW 264.7 macrophages via Nrf2/HO-1 and NF-κB pathways	41
Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE/RhoA/ROCK signaling pathway	41
Artificial neural networks in contemporary toxicology research	41
2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease	40
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines	39
Polysaccharides from Dendrobium officinale ameliorate colitis-induced lung injury via inhibiting inflammation and oxidative stress	39
Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses	38
Potent toxic effects of Taroxaz-104 on the replication of SARS-CoV-2 particles	38
Metabolic reprograming confers tamoxifen resistance in breast cancer	37
GLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1β-induced metabolic disturbance and mitochondrial dysfunction	36
In vitro and in vivo anticancer effects of syringic acid on colorectal cancer: Possible mechanistic view	36
Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin–angiotensin-aldosterone system (RAAS) dysregulation	35
Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice	34
Evodiamine induces ROS-Dependent cytotoxicity in human gastric cancer cells via TRPV1/Ca2+ pathway	34
Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases	34
Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation	34
Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α/CHOP pathway and miR-211-5p	33
Interplay between reactive oxygen and nitrogen species in living organisms	33
Naphthoquinones and derivatives as potential anticancer agents: An updated review	33
Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma	32
The alkaloid, soyauxinium chloride, displays remarkable cytotoxic effects towards a panel of cancer cells, inducing apoptosis, ferroptosis and necroptosis	32
Trabectedin induces ferroptosis via regulation of HIF-1α/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells	32
Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence	32
Multidrug resistant tuberculosis – Diagnostic challenges and its conquering by nanotechnology approach – An overview	32
Promoted inhibition of TLR4/miR-155/ NFkB p65 signaling by cannabinoid receptor 2 agonist (AM1241), aborts inflammation and progress of hepatic fibrosis induced by thioacetamide	31
Short Chain Fatty Acids: Fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases	31
Anticancer peptides mechanisms, simple and complex	31
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells	31
Review of anticancer activity of monoterpenoids: Geraniol, nerol, geranial and neral	31
Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation	30
Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contami	30
Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis	30
Astaxanthin protects mesenchymal stem cells from oxidative stress by direct scavenging of free radicals and modulation of cell signaling	30
Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454–3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC	30
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells	29
Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators	29
Advances in designing of polymeric micelles for biomedical application in brain related diseases	29
Exploring the role of ferroptosis in the doxorubicin-induced chronic cardiotoxicity using a murine model	28
Understanding immune-modulatory efficacy in vitro	28
Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway	28
Silver nanoparticles instigate physiological, genotoxicity, and ultrastructural anomalies in midgut tissues of beetles	28
Role of phytoconstituents in the management of COVID-19	28
Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways	27
An overview of epithelial growth factor receptor (EGFR) inhibitors in cancer therapy	27

Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes	27
Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via autophagy activation	26
Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis	26
Protein and peptide delivery to lungs by using advanced targeted drug delivery	26
Synthesis, characterization, DFT calculation, antioxidant activity, ADMET and molecular docking of thiosemicarbazide derivatives and their Cu (II) complexes	26
The anti-Zika virus and anti-tumoral activity of the citrus flavanone lipophilic naringenin-based compounds	25
Silymarin prevents iron overload induced bone loss by inhibiting oxidative stress in an ovariectomized animal model	25
TRP channels in COVID-19 disease: Potential targets for prevention and treatment	25
ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice	25
Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced Parkinson's disease model in rats	25
A review on genotoxicity in connection to infertility and cancer	25
Development of a conduit of PLGA-gelatin aligned nanofibers produced by electrospinning for peripheral nerve regeneration	25
Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice	25
Selenium nanoparticles: Properties, preparation methods, and therapeutic applications	25
Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals	25
Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity	25
Gut Microbiota Disruption in COVID-19 or Post-COVID Illness Association with severity biomarkers: A Possible Role of Pre / Pro-biotics in manipulating microflora	24
The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line	24
1H-benzimidazole-2-yl hydrazones as tubulin-targeting agents: Synthesis, structural characterization, anthelmintic activity and antiproliferative activity against MCF-7 breast carcinoma cells and mole	24
Systematic review of the scientific evidence on ethylene oxide as a human carcinogen	23
mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test	23
Label-free identification and differentiation of different microplastics using phasor analysis of fluorescence lifetime imaging microscopy (FLIM)-generated data	23
Immunosuppressive role of Benzo[a]pyrene in induction of lung cancer in mice	23
TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway	23
Xanthosine, a purine glycoside mediates hepatic glucose homeostasis through inhibition of gluconeogenesis and activation of glycogenesis via regulating the AMPK/ FoxO1/AKT/GSK3β signaling cascade	23
Apigenin suppresses tumor angiogenesis and growth via inhibiting HIF-1α expression in non-small cell lung carcinoma	22
Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response	22
Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways	22
Promises of phytochemical based nano drug delivery systems in the management of cancer	21
Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy	21
Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracell	21
Nanotechnology based advanced therapeutic strategies for targeting interleukins in chronic respiratory diseases	21
Harnessing the therapeutic potential of fisetin and its nanoparticles: Journey so far and road ahead	21
Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cyt	21
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro	21
Application of artificial intelligence for detection of chemico-biological interactions associated with oxidative stress and DNA damage	21
Plant defence mechanisms against mycotoxin Fumonisin B1	21
Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis	21
Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism	21
Effects of high-dose uric acid on cellular proteome, intracellular ATP, tissue repairing capability and calcium oxalate crystal-binding capability of renal tubular cells: Implications to hyperuricosur	21
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication	21
Chronic exposure to nonylphenol induces oxidative stress and liver damage in male zebrafish (Danio rerio): Mechanistic insight into cellular energy sensors, lipid accumulation and immune modulation	20
PP9, a steroidal saponin, induces G2/M arrest and apoptosis in human colorectal cancer cells by inhibiting the PI3K/Akt/GSK3β pathway	20
Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury	20
Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer	20
Advances in therapeutic applications of silver nanoparticles	20
Ellagic acid blocks RANKL–RANK interaction and suppresses RANKL-induced osteoclastogenesis by inhibiting RANK signaling pathways	20
Caffeic acid attenuates gastric mucosal damage induced by ethanol in rats via nitric oxide modulation	20
Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-κB and MAPK mediated apoptosis signaling pathways in mice	20
Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs	20
Selenite induced breast cancer MCF7 cells apoptosis through endoplasmic reticulum stress and oxidative stress pathway	20
Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway	20
Elucidating of oxidative distress in COVID-19 and methods of its prevention	20
Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology	20
A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice	20
Neuropharmacological effect of risperidone: From chemistry to medicine	20
Control of ER-positive breast cancer by ERα expression inhibition, apoptosis induction, cell cycle arrest using semisynthetic isoeugenol derivatives	20
Dental resin monomers induce early and potent oxidative damage on human odontoblast-like cells	19
Triazole based novel molecules as potential therapeutic agents: Synthesis, characterization, biological evaluation, in-silico ADME profiling and molecular docking studies	19
E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice	19
Exposure to zinc oxide nanoparticles (ZnO-NPs) induces cardiovascular toxicity and exacerbates pathogenesis – Role of oxidative stress and MAPK signaling	19
PINK1/Parkin-mediated mitophagy is activated to protect against AFB1-induced kidney damage in mice	19
Knockdown of TRIM26 inhibits the proliferation, migration and invasion of bladder cancer cells through the Akt/GSK3β/β-catenin pathway	19
Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy	19
Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance	18
Tris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases	18
Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice	18
Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis	18
Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress	18
Taurine loaded chitosan-pectin nanoparticle shows curative effect against acetic acid-induced colitis in rats	18
Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues	18
Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives	18
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds	18
MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke	18
The emerging potential of SIRT-3 in oxidative stress-inflammatory axis associated increased neuroinflammatory component for metabolically impaired neural cell	18
Oleanolic acid induces HCT116 colon cancer cell death through the p38/FOXO3a/Sirt6 pathway	18
Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway	17
Role of oxidative stress-mediated cell death and signaling pathways in experimental fluorosis	17
Zinc normalizes hepatic lipid handling via modulation of ADA/XO/UA pathway and caspase 3 signaling in highly active antiretroviral therapy-treated Wistar rats	17
Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague–Dawley rats	17

IL-33 regulates M1/M2 chemokine expression via mitochondrial redox-related mitophagy in human monocytes	17
Acute toxic effects of new synthetic cannabinoid on brain: Neurobehavioral and Histological: Preclinical studies	17
Male reproductive toxicity of inorganic nanoparticles in rodent models: A systematic review	17
The multifaceted role of ferroptosis in kidney diseases	17
The SPATA2/CYLD pathway contributes to doxorubicin-induced cardiomyocyte ferroptosis via enhancing ferritinophagy	17
Hypoxia increases the apoptotic response to betulinic acid and betulin in human non-small cell lung cancer cells	17
Diosgenin inhibits ER stress-induced inflammation in aorta via iRhom2/TACE mediated signaling in experimental diabetic rats: An in vivo and in silico approach	17
ROS and DRP1 interactions accelerate the mitochondrial injury induced by polystyrene nanoplastics in human liver HepG2 cells	17
Nanocarrier design–function relationship: The prodigious role of properties in regulating biocompatibility for drug delivery applications	17
Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics	17
Decreasing sperm quality in mice subjected to chronic cannabidiol exposure: New insights of cannabidiol-mediated male reproductive toxicity	16
Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis	16
Anticancer and antibacterial potential of robust Ruthenium(II) arene complexes regulated by choice of α-diimine and halide ligands	16
Microplastics- and copper-induced changes in neurogenesis and DNA methyltransferases in the early life stages of zebrafish	16
Diphenyl diselenide ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats via suppressing oxidative stress and inflammation	16
Identification and biotin receptor-mediated activity of a novel seleno-biotin compound that inhibits viability of and induces apoptosis in ovarian cancer cells	16
Triterpenoids with modified A-ring as modulators of P-gp-dependent drug-resistance in cancer cells	16
Cathepsin B is a potential therapeutic target for coronavirus disease 2019 patients with lung adenocarcinoma	16
β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways	16
Beneficial effects of apigenin on the transgenic Drosophila model of Alzheimer's disease	16
Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems	16
Bisphenol A and genistein have opposite effects on adult chicken ovary by acting on ERα/Nrf2-Keap1-signaling pathway	16
Cardiac sirtuin1 deficiency exacerbates ferroptosis in doxorubicin-induced cardiac injury through the Nrf2/Keap1 pathway	16
Lauric acid alleviates deoxynivalenol-induced intestinal stem cell damage by potentiating the Akt/mTORC1/S6K1 signaling axis	16
OGT as potential novel target: Structure, function and inhibitors	16
Blood-brain barrier integrity is the primary target of alcohol abuse	16
Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway	16
Linear non-threshold (LNT) fails numerous toxicological stress tests: Implications for continued policy use	16
Synthesis, anticancer activity and mechanism of action of new phthalimido-1,3-thiazole derivatives	16
Phytochemistry, biological activities, industrial and traditional uses of fig (Ficus carica): A review	16
A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway	16
An investigation of bacteriocin nisin anti-cancer effects and FZD7 protein interactions in liver cancer cells	15
Therapeutic potential of beta-caryophyllene against aflatoxin B1-Induced liver toxicity: biochemical and molecular insights in rats	15
A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways	15
Thresholds for carcinogens	15
STIP1 knockdown suppresses colorectal cancer cell proliferation, migration and invasion by inhibiting STAT3 pathway	15
Combined 3-O-acetylbetulin treatment and carbonic anhydrase IX inhibition results in additive effects on human breast cancer cells	15
Amentoflavone from Selaginella tamariscina as a potent inhibitor of gut bacterial β-glucuronidase: Inhibition kinetics and molecular dynamics stimulation	15
A new class of half-sandwich ruthenium complexes containing Biginelli hybrids: anticancer and anti-SARS-CoV-2 activities	15
The chemical composition of ethanolic extracts from six genotypes of medical cannabis (Cannabis sativa L.) and their selective cytotoxic activity	15
Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent	15
Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19	15
Gamabufotalin suppressed osteosarcoma stem cells through the TGF-β/periostin/PI3K/AKT pathway	15
Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPARα pathway	15
Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling by increasing antioxidant response in obese high-fat diet-fed mice	15
Therapeutic potential of marine macrolides: An overview from 1990 to 2022	15
Geraniol isolated from lemon grass to mitigate doxorubicin-induced cardiotoxicity through Nrf2 and NF-κB signaling	15
Doping gadolinium versus lanthanum into hydroxyapatite particles for better biocompatibility in bone marrow stem cells	15
Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway	14
Hepatoprotective effect of anemoside B4 against sepsis-induced acute liver injury through modulating the mTOR/p70S6K-mediated autophagy	14
Dual role of eugenol on chronic gastric ulcer in rats: Low-dose healing efficacy and the worsening gastric lesion in high doses	14
Harnessing the dual role of polysaccharides in treating gastrointestinal diseases: As therapeutics and polymers for drug delivery	14
The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3β and apoptosis in ma	14
3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole ameliorates long-lasting depression- and anxiogenic-like behaviors and cognitive impairment in post-septic mice: Involvement of neuroimmune and oxidative	14
Dietary vitamin D equilibrium in serum ameliorates direct bilirubin associated diabetes mellitus	14
Janus kinase/signal transducers and activator of transcription (JAK/STAT) and its role in Lung inflammatory disease	14
Dapagliflozin attenuates diabetic cardiomyopathy through erythropoietin up-regulation of AKT/JAK/MAPK pathways in streptozotocin-induced diabetic rats	14
Impact of prenatal arsenic exposure on the testes and epididymides of prepubertal rats	14
Kaempferol alleviates the inflammatory response and stabilizes the pulmonary vascular endothelial barrier in LPS-induced sepsis through regulating the SphK1/S1P signaling pathway	14
A novel nano therapeutic using convalescent plasma derived exosomal (CPExo) for COVID-19: A combined hyperactive immune modulation and diagnostics	14
Ameliorating effect of continuous alpha-glycosyl isoquercitrin treatment starting from late gestation in a rat autism model induced by postnatal injection of lipopolysaccharides	14
GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes	14
Natural alkaloids targeting EGFR in non-small cell lung cancer: Molecular docking and ADMET predictions	14
Glycyrrhizic acid suppresses early stage of adipogenesis through repression of MEK/ERK-mediated C/EBPβ and C/EBPδ expression in 3T3-L1 cells	14
Toxic blister agents: Chemistry, mode of their action and effective treatment strategies	14
Critical discovery and synthesis of novel antibacterial and resistance-modifying agents inspired by plant phytochemical defense mechanisms	14
Down-regulation of hepatic cytochromes P450 1A1 and 1A2 by arsenic trioxide (ATO) in vivo and in vitro: A role of heme oxygenase 1	14
Bioactive sulfonyl hydrazones with alkyl derivative: Characterization, ADME properties, molecular docking studies and investigation of inhibition on choline esterase enzymes for the diagnosis of Alzhe	14
N-acetylcysteine delayed cadmium-induced chronic kidney injury by activating the sirtuin 1–P53 signaling pathway	14
Lysionotin induces apoptosis of hepatocellular carcinoma cells via caspase-3 mediated mitochondrial pathway	14
Therapeutic nanoreactors for detoxification of xenobiotics: Concepts, challenges and biotechnological trends with special emphasis to organophosphate bioscavenging	13
Proapoptotic and proautophagic activity of 20-hydroxyecdysone in breast cancer cells in vitro	13
Antioxidation, anti-hyperlipidaemia and hepatoprotection of polysaccharides from Auricularia auricular residue	13
The involvement of gut microbiota in the anti-tumor effect of carnosic acid via IL-17 suppression in colorectal cancer	13
Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo	13
Binding interaction of protoberberine alkaloids against acetylcholinesterase (AChE) using molecular dynamics simulations and QM/MM calculations	13
In vitro and in vivo studies reveal the beneficial effects of chlorogenic acid against ER stress mediated ER-phagy and associated apoptosis in the heart of diabetic rat	13
Vitamin D alleviates liver fibrosis by inhibiting histidine-rich calcium binding protein (HRC)	13
Skin decontamination procedures against potential hazards substances exposure	13
Dl-3-n-butylphthalide activates Nrf2, inhibits ferritinophagy, and protects MES23.5 dopaminergic neurons from ferroptosis	13
Hormesis and dental apical papilla stem cells	13
Differential mutation profile of SARS-CoV-2 proteins across deceased and asymptomatic patients	13
Cinobufagin restrains the growth and triggers DNA damage of human hepatocellular carcinoma cells via proteasome-dependent degradation of thymidylate synthase	13
Long-term administration of low-dose selenium nanoparticles with different sizes aggravated atherosclerotic lesions and exhibited toxicity in apolipoprotein E-deficient mice	13
Interaction of silver nanoparticles with plasma transport proteins: A systematic study on impacts of particle size, shape and surface functionalization	13
Long non-coding RNAs: A double-edged sword in aging kidney and renal disease	13
Protective role of naringin loaded solid nanoparticles against aflatoxin B1 induced hepatocellular carcinoma	13
Investigation of the multi-targeted protection potential of tannic acid against doxorubicin-induced kidney damage in rats	13
Structural improvement of new thiazolyl-isatin derivatives produces potent and selective trypanocidal and leishmanicidal compounds	13
The effects of agomelatine on endoplasmic reticulum stress related to mitochondrial dysfunction in hippocampus of aging rat model	13
Treatment with crocin suppresses diabetic nephropathy progression via modulating TGF-β1 and oxidative stress in an experimental model of pinealectomized diabetic rats	13
A mechanism of perhexiline's cytotoxicity in hepatic cells involves endoplasmic reticulum stress and p38 signaling pathway	13
1,2,3-Triazole derivatives: synthesis, docking, cytotoxicity analysis and in vivo antimalarial activity	13
Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation	13
Taxifolin and gastro-adhesive microparticles containing taxifolin promotes gastric healing in vivo, inhibits Helicobacter pylori in vitro and proton pump reversibly in silico	13