Chemico-Biological Interactions

Article	Citations
Roles of flavonoids against coronavirus infection	233
Essential metals in health and disease	187
Mechanism and regulation of pyroptosis-mediated in cancer cell death	161
High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms	118
Nuclear factor-kappa B and its role in inflammatory lung disease	111
The role of reactive oxygen species in the biological activity of antimicrobial agents: An updated mini review	85
Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways	84
Salidroside: A review of its recent advances in synthetic pathways and pharmacological properties	77
Polystyrene microplastics induce apoptosis via ROS-mediated p53 signaling pathway in zebrafish	76
Sodium butyrate ameliorates the impairment of synaptic plasticity by inhibiting the neuroinflammation in 5XFAD mice	72
Thymoquinone suppresses invasion and metastasis in bladder cancer cells by reversing EMT through the Wnt/β-catenin signaling pathway	66
Triaryl dicationic DNA minor-groove binders with antioxidant activity display cytotoxicity and induce apoptosis in breast cancer	60
Cytochrome P450 2E1 and its roles in disease	59
Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis	58
Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications	52
Colon cancer and colorectal cancer: Prevention and treatment by potential natural products	51
Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis	50
Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19	47
Exploring the binding mechanism and adverse toxic effects of persistent organic pollutant (dicofol) to human serum albumin: A biophysical, biochemical and computational approach	46
Perspectives and advancements in the design of nanomaterials for targeted cancer theranostics	45
In silico analysis of selected alkaloids against main protease (Mpro) of SARS-CoV-2	44
Molecular and cellular basis of the anticancer activity of the prenylated flavonoid icaritin in hepatocellular carcinoma	43
Artesunate induces autophagy dependent apoptosis through upregulating ROS and activating AMPK-mTOR-ULK1 axis in human bladder cancer cells	41
Modulation of TRPV1 channel function by natural products in the treatment of pain	40
Alcohol consumption and risk of stomach cancer: A meta-analysis	40

Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells	39
Plants derived therapeutic strategies targeting chronic respiratory diseases: Chemical and immunological perspective	39
Catalpol ameliorates endothelial dysfunction and inflammation in diabetic nephropathy via suppression of RAGE/RhoA/ROCK signaling pathway	39
Transforming growth factor-β signaling: From tissue fibrosis to therapeutic opportunities	39
Alcohol consumption. A leading risk factor for cancer	37
Neuroprotective effects of protocatechuic acid on sodium arsenate induced toxicity in mice: Role of oxidative stress, inflammation, and apoptosis	37
A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer	37
Taxifolin ameliorates iron overload-induced hepatocellular injury: Modulating PI3K/AKT and p38 MAPK signaling, inflammatory response, and hepatocellular regeneration	37
p-Coumaric acid attenuates alcohol exposed hepatic injury through MAPKs, apoptosis and Nrf2 signaling in experimental models	37
Targeting cell cycle by β-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer	36
Erythrocytes as model cells for biocompatibility assessment, cytotoxicity screening of xenobiotics and drug delivery	36
Nuclear factor-κB signaling inhibitors revert multidrug-resistance in breast cancer cells	35
Galangin as an inflammatory response modulator: An updated overview and therapeutic potential	35
Cytotoxicity of a naturally occuring spirostanol saponin, progenin III, towards a broad range of cancer cell lines by induction of apoptosis, autophagy and necroptosis	35
Resveratrol protects against cisplatin-induced ovarian and uterine toxicity in female rats by attenuating oxidative stress, inflammation and apoptosis	35
Aptamer-conjugated carbon-based nanomaterials for cancer and bacteria theranostics: A review	34
2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease	34
Effects of low-level imidacloprid oral exposure on cholinesterase activity, oxidative stress responses, and primary DNA damage in the blood and brain of male Wistar rats	34
Polysaccharides from Dendrobium officinale ameliorate colitis-induced lung injury via inhibiting inflammation and oxidative stress	33
Identification of a new class of potent aldose reductase inhibitors: Design, microwave-assisted synthesis, in vitro and in silico evaluation of 2-pyrazolines	33
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes	32
Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin–angiotensin-aldosterone system (RAAS) dysregulation	32
Potent toxic effects of Taroxaz-104 on the replication of SARS-CoV-2 particles	32
2D materials, synthesis, characterization and toxicity: A critical review	31
Fluoride regulates chondrocyte proliferation and autophagy via PI3K/AKT/mTOR signaling pathway	31
Graphene oxide enhances β-amyloid clearance by inducing autophagy of microglia and neurons	31
Asperuloside suppressing oxidative stress and inflammation in DSS-induced chronic colitis and RAW 264.7 macrophages via Nrf2/HO-1 and NF-κB pathways	31
Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses	31
GLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1β-induced metabolic disturbance and mitochondrial dysfunction	31
Novel benzimidazole derivatives: Synthesis, in vitro cytotoxicity, apoptosis and cell cycle studies	31
The newly synthesized compounds (NCHDH and NTHDH) attenuates LPS-induced septicemia and multi-organ failure via Nrf2/HO1 and HSP/TRVP1 signaling in mice	31
Nicotinamide and its metabolite N1-Methylnicotinamide alleviate endocrine and metabolic abnormalities in adipose and ovarian tissues in rat model of Polycystic Ovary Syndrome	31
In vitro and in vivo anticancer effects of syringic acid on colorectal cancer: Possible mechanistic view	30
The alkaloid, soyauxinium chloride, displays remarkable cytotoxic effects towards a panel of cancer cells, inducing apoptosis, ferroptosis and necroptosis	30
Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation	30
Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor	29
Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice	29
Cytotoxicity of juglone and thymoquinone against pancreatic cancer cells	29
Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer	28
Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454–3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC	28
Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence	28
Promoted inhibition of TLR4/miR-155/ NFkB p65 signaling by cannabinoid receptor 2 agonist (AM1241), aborts inflammation and progress of hepatic fibrosis induced by thioacetamide	27
Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine-based compounds on β-amyloid aggregation	27
Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation	26
Interplay between reactive oxygen and nitrogen species in living organisms	26
3-O-(E)-p-Coumaroyl betulinic acid possess anticancer activity and inhibit Notch signaling pathway in breast cancer cells and mammosphere	26
Artificial neural networks in contemporary toxicology research	26
Gallic acid and ferulic acid protect the liver from thioacetamide-induced fibrosis in rats via differential expression of miR-21, miR-30 and miR-200 and impact on TGF-β1/Smad3 signaling	26
Astaxanthin protects mesenchymal stem cells from oxidative stress by direct scavenging of free radicals and modulation of cell signaling	25
Ferroptosis is involved in the benzene-induced hematotoxicity in mice via iron metabolism, oxidative stress and NRF2 signaling pathway	25

Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation	25
Metabolic reprograming confers tamoxifen resistance in breast cancer	25
Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling pathways	25
Multidrug resistant tuberculosis – Diagnostic challenges and its conquering by nanotechnology approach – An overview	24
Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases	24
Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma	24
The anti-Zika virus and anti-tumoral activity of the citrus flavanone lipophilic naringenin-based compounds	24
Role of phytoconstituents in the management of COVID-19	24
Transcriptomic analysis suggested the involvement of impaired lipid droplet biogenesis in graphene oxide-induced cytotoxicity in human umbilical vein endothelial cells	24
Naphthoquinones and derivatives as potential anticancer agents: An updated review	24
Evodiamine induces ROS-Dependent cytotoxicity in human gastric cancer cells via TRPV1/Ca2+ pathway	24
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells	23
Empagliflozin alleviates endoplasmic reticulum stress and augments autophagy in rotenone-induced Parkinson's disease in rats: Targeting the GRP78/PERK/eIF2α/CHOP pathway and miR-211-5p	23
Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators	23
Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis	23
The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway	23
ROS-mediated mitophagy and apoptosis are involved in aluminum-induced femoral impairment in mice	22
Oxidative stress, DNA damage and apoptosis induced by tebuconazole in the kidney of male Wistar rat	22
Protein and peptide delivery to lungs by using advanced targeted drug delivery	22
Stachydrine attenuates IL-1β-induced inflammatory response in osteoarthritis chondrocytes through the NF-κB signaling pathway	22
Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells	22
Gut Microbiota Disruption in COVID-19 or Post-COVID Illness Association with severity biomarkers: A Possible Role of Pre / Pro-biotics in manipulating microflora	22
Zingerone reduces sodium arsenite-induced nephrotoxicity by regulating oxidative stress, inflammation, apoptosis and histopathological changes	21
Anticancer peptides mechanisms, simple and complex	21
Advances in designing of polymeric micelles for biomedical application in brain related diseases	21
Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contami	21
mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test	21
Development of a conduit of PLGA-gelatin aligned nanofibers produced by electrospinning for peripheral nerve regeneration	21
Silver nanoparticles instigate physiological, genotoxicity, and ultrastructural anomalies in midgut tissues of beetles	21
Anti-inflammation of Erianin in dextran sulphate sodium-induced ulcerative colitis mice model via collaborative regulation of TLR4 and STAT3	21
Plant defence mechanisms against mycotoxin Fumonisin B1	21
An overview of epithelial growth factor receptor (EGFR) inhibitors in cancer therapy	20
1H-benzimidazole-2-yl hydrazones as tubulin-targeting agents: Synthesis, structural characterization, anthelmintic activity and antiproliferative activity against MCF-7 breast carcinoma cells and mole	20
Multifunctional memantine nitrate significantly protects against glutamate-induced excitotoxicity via inhibiting calcium influx and attenuating PI3K/Akt/GSK3beta pathway	20
Anti-inflammatory and anti-gouty-arthritic effect of free Ginsenoside Rb1 and nano Ginsenoside Rb1 against MSU induced gouty arthritis in experimental animals	20
Lead-induced cardiomyocytes apoptosis by inhibiting gap junction intercellular communication via autophagy activation	20
Short Chain Fatty Acids: Fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases	20
The modulator action of thiamine against pentylenetetrazole-induced seizures, apoptosis, nitric oxide, and oxidative stress in rats and SH-SY5Y neuronal cell line	20
Exploring the role of ferroptosis in the doxorubicin-induced chronic cardiotoxicity using a murine model	19
Application of artificial intelligence for detection of chemico-biological interactions associated with oxidative stress and DNA damage	19
Immunosuppressive role of Benzo[a]pyrene in induction of lung cancer in mice	19
TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway	19
Pulchinenoside B4 exerts the protective effects against cisplatin-induced nephrotoxicity through NF-κB and MAPK mediated apoptosis signaling pathways in mice	19
Review of anticancer activity of monoterpenoids: Geraniol, nerol, geranial and neral	19
TRP channels in COVID-19 disease: Potential targets for prevention and treatment	19
Melatonin regulates the expression of inflammatory cytokines, VEGF and apoptosis in diabetic retinopathy in rats	19
Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway	19
Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis	19
Exposure to a mixture of cigarette smoke carcinogens disturbs gut microbiota and influences metabolic homeostasis in A/J mice	19
Understanding immune-modulatory efficacy in vitro	19
Label-free identification and differentiation of different microplastics using phasor analysis of fluorescence lifetime imaging microscopy (FLIM)-generated data	18
Systematic analysis of modulating activities of native human urinary Tamm-Horsfall protein on calcium oxalate crystallization, growth, aggregation, crystal-cell adhesion and invasion through extracell	18
Synthesis, characterization, DFT calculation, antioxidant activity, ADMET and molecular docking of thiosemicarbazide derivatives and their Cu (II) complexes	18
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds	18
Structure based design, synthesis, and evaluation of anti-CML activity of the quinolinequinones as LY83583 analogs	18
A review on genotoxicity in connection to infertility and cancer	18
Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes	18
Upregulation of Nrf2 signaling and suppression of ferroptosis and NF-κB pathway by leonurine attenuate iron overload-induced hepatotoxicity	18
Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress	17
Elucidating of oxidative distress in COVID-19 and methods of its prevention	17
Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced Parkinson's disease model in rats	17
Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues	17
Control of ER-positive breast cancer by ERα expression inhibition, apoptosis induction, cell cycle arrest using semisynthetic isoeugenol derivatives	17
The protective effects of dulaglutide against advanced glycation end products (AGEs)-induced degradation of type Ⅱ collagen and aggrecan in human SW1353 chondrocytes	17
Tempol reduces inflammation and oxidative damage in cigarette smoke-exposed mice by decreasing neutrophil infiltration and activating the Nrf2 pathway	17
Knockdown of TRIM26 inhibits the proliferation, migration and invasion of bladder cancer cells through the Akt/GSK3β/β-catenin pathway	17
The emerging potential of SIRT-3 in oxidative stress-inflammatory axis associated increased neuroinflammatory component for metabolically impaired neural cell	17
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication	17
Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response	17
Oxidopamine and oxidative stress: Recent advances in experimental physiology and pharmacology	17
Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism	17
Effects of high-dose uric acid on cellular proteome, intracellular ATP, tissue repairing capability and calcium oxalate crystal-binding capability of renal tubular cells: Implications to hyperuricosur	17
Roles of peroxisome proliferator-activated receptor α in the pathogenesis of ethanol-induced liver disease	17
Selenite induced breast cancer MCF7 cells apoptosis through endoplasmic reticulum stress and oxidative stress pathway	16
Sphingolipids and the link between alcohol and cancer	16
Ellagic acid blocks RANKL–RANK interaction and suppresses RANKL-induced osteoclastogenesis by inhibiting RANK signaling pathways	16
Toosendanin and isotoosendanin suppress triple-negative breast cancer growth via inducing necrosis, apoptosis and autophagy	16
Trabectedin induces ferroptosis via regulation of HIF-1α/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells	16
Induction of oxidative stress as a possible mechanism by which geraniol affects the proliferation of human A549 and HepG2 tumor cells	16
Biological activities of pyrazoline-indole based Re(I) carbonyls: DNA interaction, antibacterial, anticancer, ROS production, lipid peroxidation, in vivo and in vitro cytotoxicity studies	16

E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice	16
Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway	16
Caffeic acid attenuates gastric mucosal damage induced by ethanol in rats via nitric oxide modulation	16
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro	16
Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives	16
The SPATA2/CYLD pathway contributes to doxorubicin-induced cardiomyocyte ferroptosis via enhancing ferritinophagy	16
CEES-induced ROS accumulation regulates mitochondrial complications and inflammatory response in keratinocytes	16
Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cyt	16
PP9, a steroidal saponin, induces G2/M arrest and apoptosis in human colorectal cancer cells by inhibiting the PI3K/Akt/GSK3β pathway	16
Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway	16
Promises of phytochemical based nano drug delivery systems in the management of cancer	15
Exposure to zinc oxide nanoparticles (ZnO-NPs) induces cardiovascular toxicity and exacerbates pathogenesis – Role of oxidative stress and MAPK signaling	15
Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance	15
β-elemonic acid inhibits growth and triggers apoptosis in human castration-resistant prostate cancer cells through the suppression of JAK2/STAT3/MCL-1 and NF-ĸB signal pathways	15
Thresholds for carcinogens	15
Chronic exposure to nonylphenol induces oxidative stress and liver damage in male zebrafish (Danio rerio): Mechanistic insight into cellular energy sensors, lipid accumulation and immune modulation	15
Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways	15
IL-33 regulates M1/M2 chemokine expression via mitochondrial redox-related mitophagy in human monocytes	15
A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice	15
PINK1/Parkin-mediated mitophagy is activated to protect against AFB1-induced kidney damage in mice	15
Systematic review of the scientific evidence on ethylene oxide as a human carcinogen	15
Taurine loaded chitosan-pectin nanoparticle shows curative effect against acetic acid-induced colitis in rats	15
AOC4P suppresses viability and invasion and induces apoptosis in NSCLC cells by inhibiting the Wnt/β-catenin pathway	15
Sevoflurane reduces inflammatory factor expression, increases viability and inhibits apoptosis of lung cells in acute lung injury by microRNA-34a-3p upregulation and STAT1 downregulation	14
Improved skin decontamination efficacy for the nerve agent VX	14
Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer	14
Carvedilol attenuates l-arginine induced acute pancreatitis in rats through modulation of oxidative stress and inflammatory mediators	14
Geraniol isolated from lemon grass to mitigate doxorubicin-induced cardiotoxicity through Nrf2 and NF-κB signaling	14
A novel nano therapeutic using convalescent plasma derived exosomal (CPExo) for COVID-19: A combined hyperactive immune modulation and diagnostics	14
Hypoxia increases the apoptotic response to betulinic acid and betulin in human non-small cell lung cancer cells	14
Therapeutic potential of beta-caryophyllene against aflatoxin B1-Induced liver toxicity: biochemical and molecular insights in rats	14
Dental resin monomers induce early and potent oxidative damage on human odontoblast-like cells	14
Male reproductive toxicity of inorganic nanoparticles in rodent models: A systematic review	14
MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke	14
Linear non-threshold (LNT) fails numerous toxicological stress tests: Implications for continued policy use	14
Bisphenol A and genistein have opposite effects on adult chicken ovary by acting on ERα/Nrf2-Keap1-signaling pathway	14
Diphenyl diselenide ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats via suppressing oxidative stress and inflammation	14
Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, induces apoptosis in melanoma cells	14
Nitric oxide and Ca2+-activated high-conductance K+ channels mediate nothofagin-induced endothelium-dependent vasodilation in the perfused rat kidney	14
Sirt1 inhibits kidney stones formation by attenuating calcium oxalate-induced cell injury	14
The multifaceted role of ferroptosis in kidney diseases	14
Nanotechnology based advanced therapeutic strategies for targeting interleukins in chronic respiratory diseases	14
Harnessing the therapeutic potential of fisetin and its nanoparticles: Journey so far and road ahead	14
Dipyridophenazine iridium(III) complex as a phototoxic cancer stem cell selective, mitochondria targeting agent	14
3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole ameliorates long-lasting depression- and anxiogenic-like behaviors and cognitive impairment in post-septic mice: Involvement of neuroimmune and oxidative	14
Dietary vitamin D equilibrium in serum ameliorates direct bilirubin associated diabetes mellitus	14
Vitamin D alleviates liver fibrosis by inhibiting histidine-rich calcium binding protein (HRC)	13
Tris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases	13
Triterpenoids with modified A-ring as modulators of P-gp-dependent drug-resistance in cancer cells	13
Cyclosporine A induces testicular injury via mitochondrial apoptotic pathway by regulation of mir-34a and sirt-1 in male rats: The rescue effect of curcumin	13
Interaction of silver nanoparticles with plasma transport proteins: A systematic study on impacts of particle size, shape and surface functionalization	13
Anticancer and antibacterial potential of robust Ruthenium(II) arene complexes regulated by choice of α-diimine and halide ligands	13
Harnessing the dual role of polysaccharides in treating gastrointestinal diseases: As therapeutics and polymers for drug delivery	13
Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague–Dawley rats	13
Combined 3-O-acetylbetulin treatment and carbonic anhydrase IX inhibition results in additive effects on human breast cancer cells	13
Gamabufotalin suppressed osteosarcoma stem cells through the TGF-β/periostin/PI3K/AKT pathway	13
Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway	13
Binding interaction of protoberberine alkaloids against acetylcholinesterase (AChE) using molecular dynamics simulations and QM/MM calculations	13
Dual role of eugenol on chronic gastric ulcer in rats: Low-dose healing efficacy and the worsening gastric lesion in high doses	13
Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems	13
Natural soluble epoxide hydrolase inhibitors from Inula britanica and their potential interactions with soluble epoxide hydrolase: Insight from inhibition kinetics and molecular dynamics	13
Evaluation of acacetin inhibition potential against cytochrome P450 in vitro and in vivo	13
Methyl gallate: Selective antileishmanial activity correlates with host-cell directed effects	13
Revisiting the intersection of microglial activation and neuroinflammation in Alzheimer's disease from the perspective of ferroptosis	13
Apigenin suppresses tumor angiogenesis and growth via inhibiting HIF-1α expression in non-small cell lung carcinoma	13
A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways	13
Therapeutic potential of marine macrolides: An overview from 1990 to 2022	13
STIP1 knockdown suppresses colorectal cancer cell proliferation, migration and invasion by inhibiting STAT3 pathway	13
Long non-coding RNAs: A double-edged sword in aging kidney and renal disease	13
Critical discovery and synthesis of novel antibacterial and resistance-modifying agents inspired by plant phytochemical defense mechanisms	13
The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3β and apoptosis in ma	12
Diosgenin inhibits ER stress-induced inflammation in aorta via iRhom2/TACE mediated signaling in experimental diabetic rats: An in vivo and in silico approach	12
Lysionotin induces apoptosis of hepatocellular carcinoma cells via caspase-3 mediated mitochondrial pathway	12
Hormesis and dental apical papilla stem cells	12
Long-term administration of low-dose selenium nanoparticles with different sizes aggravated atherosclerotic lesions and exhibited toxicity in apolipoprotein E-deficient mice	12
Numb ameliorates necrosis and inflammation in acute kidney injury induced by cisplatin	12
Lauric acid alleviates deoxynivalenol-induced intestinal stem cell damage by potentiating the Akt/mTORC1/S6K1 signaling axis	12
A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway	12
Irreversible disruption of the cytoskeleton as induced by non-cytotoxic exposure to titanium dioxide nanoparticles in lung epithelial cells	12
DNA-BINDING and DNA-protecting activities of small natural organic molecules and food extracts	12
Decreasing sperm quality in mice subjected to chronic cannabidiol exposure: New insights of cannabidiol-mediated male reproductive toxicity	12
Blood-brain barrier integrity is the primary target of alcohol abuse	12
Dapagliflozin attenuates diabetic cardiomyopathy through erythropoietin up-regulation of AKT/JAK/MAPK pathways in streptozotocin-induced diabetic rats	12
Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice	12
3,3′,5,5′-tetramethoxybiphenyl-4,4′diol induces cell cycle arrest in G2/M phase and apoptosis in human non-small cell lung cancer A549 cells	12
BAY60-2770 attenuates doxorubicin-induced cardiotoxicity by decreased oxidative stress and enhanced autophagy	12
Rutin-Zn(II) complex promotes bone formation - A concise assessment in human dental pulp stem cells and zebrafish	12
Açaí seed extract (ASE) rich in proanthocyanidins improves cardiovascular remodeling by increasing antioxidant response in obese high-fat diet-fed mice	12
Amentoflavone from Selaginella tamariscina as a potent inhibitor of gut bacterial β-glucuronidase: Inhibition kinetics and molecular dynamics stimulation	12
Differential mutation profile of SARS-CoV-2 proteins across deceased and asymptomatic patients	12
Cardioprotective effect of cinnamaldehyde pretreatment on ischemia/ reperfusion injury via inhibiting NLRP3 inflammasome activation and gasdermin D mediated cardiomyocyte pyroptosis	12
Glycyrrhizic acid suppresses early stage of adipogenesis through repression of MEK/ERK-mediated C/EBPβ and C/EBPδ expression in 3T3-L1 cells	12
Significance of aldo-keto reductase 1C3 and ATP-binding cassette transporter B1 in gain of irinotecan resistance in colon cancer cells	12
Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19	12
Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level	11