Chemical & Pharmaceutical Bulletin

Article	Citations
Development of Ethylcellulose Microparticles for Taste Masking of Fexofenadine	50
Advances in Preparation of Peptide and Protein Thioesters Aiming to Use in Medicinal Sciences	35
Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA	34
Foreword	17
Concise and Highly Stereoselective Synthesis of <i>β</i>,<i>β</i>-Disubstituted <i>α</i>,<i>β</i>-Unsaturated Esters	17
Rapid Determination of Dapagliflozin in Rat Plasma by UHPLC-Q-Orbitrap MS and Its Application to a Pharmacokinetic Study	17
Errata for Chemical and Pharmaceutical Bulletin	16
MiR-135a Protects against Myocardial Injury by Targeting TLR4	16
Clinical Pipelines for Alzheimer’s Disease Psychosis and Agitation	16
<i>In Vitro</i> and <i>in Silico</i> Studies of Potential Coronavirus-Specific 3C-Like Protease Inhibitors	15
Syntheses of Aryl Thioethers <i>via</i> Aromatic Substitution of Aryl Halides at 0 to 25 °C	14
Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction	14
CBDPS 1.0: A Python GUI Application for Machine Learning Models to Predict Bitter-Tasting Children’s Oral Medicines	14
Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway	13
Protective Effect of Apple Polyphenols on H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress Damage in Human Colon Adenocarcinoma Caco-2 Cells	13
Optimization and Advantages of Molded Tablets Using Trehalose as a Binder	12
Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation <i>via</i> Attachment of <i>N</i>-Methylpyrrole at the 2-Position	12
Synthesis and Evaluation of Novel Triaryl Derivatives with Readthrough-Inducing Activity	12
Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups	12
Photoinduced Atom Transfer Radical Addition Reaction of Olefins with α-Bromo Carbonyls	12
Development of Efficient Synthetic Reactions Using Enamines and Enamides Carrying Oxygen Atom Substituent on Nitrogen Atom	11
Functions, Structures, and Engineering of the Teleocidin Biosynthetic Enzymes	11
Substituent Effects at the <i>N</i>-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser	11
Design, Synthesis, and Characterization of 1-(Anthracen-9-ylmethyl)-1,5,9-triazacyclododecane (Ant-[12]aneN3) and Its DNA Photocleavage Activity	10
Synthesis of 2-Substituted Indoles <i>via</i> Migration Reaction of 3-Substituted Indoles with Triflic Acid	10

Natural Compounds with BMI1 Promoter Inhibitory Activity from <i>Mammea siamensis</i> and <i>Andrographis paniculata</i>	10
<i>In Vitro</i> Study on Combined Effect of Drugs for Hyperphosphatemia on Phosphorus Adsorption Capacity	10
Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V)	9
Unusual Enzymatic C–C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis	9
Synthesis of Coumarin-Conjugated Oligonucleotides <i>via</i> Knoevenagel Condensation to Prepare an Oligonucleotide Library	9
Anti-hepatitis C Virus Activity of Juglorubin Derivatives	9
Flip-Flop Promotion Mechanisms by Model Transmembrane Peptides	8
Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine	8
Liquid Chromatographic Determination of <i>o</i>-Phosphoethanolamine in Human Plasma Using Fluorescent Derivatization	8
Transport Characteristics of Placenta-Derived Extracellular Vesicles and Their Relevance to Placenta-to-Maternal Tissue Communication	8
The Effect of Iontophoresis with and without Electroporation on the Penetration of High Molecular Compounds into the Stratum Corneum	8
Near-Infrared Metabolic Profiling for Discrimination of Apricot and Peach Kernels	8
Oxygen-Fueled Iterative Hydride Transfer Driven by a Rigid Planar Architecture	8
Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster	8
Bromine K-Edge X-Ray Absorption Near-Edge Structure Analysis on Hydrobromide-Salt Crystals and the Solid Dispersion of Active Pharmaceutical Ingredients	8
Molecular Modeling, Synthesis, and Preliminary Cytotoxicity Evaluation of New Indole-Based Molecules as Possible Sirtuin Inhibitors	8
<i>p</i>-Methoxy- and 2,4-Dimethoxybenzyl <i>N</i>-Acetylcarbamate Potassium Salts: Versatile Reagents for <i>N</i>-Alkylacetamide and <i>p</i>-Methoxy-	8
Total Synthesis of (+)-Silybin A	7
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence	7
Evaluation of the Mechanism of Phosphate Removal Using Oyster Shell Powder in Aqueous Environments	7
Enteric Microcapsules Encapsulation of Roxithromycin-PVP Composite Core Particles to Inhibit Drug Crystallization upon Fluidized Bed Method for Oral Administration	7
Toward the Synthesis of Strychnos Alkaloids: Effective Construction of Fused Cyclohexane and Pyrrolidine Portion of the Strychnos Skeleton <i>via</i> Domino Intermolecular and Intramolecul	7
Construction of 7-Diethylaminocoumarins Promoted by an Electron-Withdrawing Group	7
Chlorocyclization of Alkenoic Thioester	7
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite	7
Amino Acids and Their <i>N</i>-Acetylated Derivatives Maintain the Skin’s Barrier Function	7
Emerging Separation Techniques in Supercritical Fluid Chromatography	7
Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction	7
Two New Halimanes with a <i>γ</i>-Lactone from <i>Croton argyratus</i>	7
Theoretical Study of the Mechanism of Ribosomal Peptide Bond Formation Using the ONIOM Method	7
<i>N</i>-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride	7
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine	7
Solid Fat Content and Relaxation Time Measurement of Petrolatum Using Time-Domain NMR, and the Correlation with Viscosity and Crystallinity	7
Development of Low Molecular Weight Ligands for Integrin α<sub>v</sub>β<sub>3</sub>	7
Antiproliferative Activities of Diterpenes from Leaves of <i>Isodon trichocarpus</i> against Cancer Stem Cells	7
Optimization of the Hydrothermal Activation Treatment with Sodium Hydroxide Solution for the Conversion of Coal Fly Ash to Zeolite and Its Adsorption Capability of Lead (II) Ions from the Liquid Phase	7
Effects of Physicochemical Properties of Constituent Ions of Ionic Liquid on Its Permeation through a Silicone Membrane	7
Exosome-Hijacking Drug Delivery System with Branched Arginine Linker Effectively Deliver Antisense Oligonucleotides into Lung Adenocarcinoma Cells	6
Novel Pharmaceutical Cocrystals and Solvate Crystals of Nobiletin, a Citrus Flavonoid with Potent Pharmacological Activity	6
Organocatalyzed Amine-Free <i>O</i>-Phosphorylation of Alcohols with 4-Methylpyridine <i>N</i>-Oxide	6
A Review on the Foodomics Based on Liquid Chromatography Mass Spectrometry	6
Identification of a Functionally Efficient and Thermally Stable Outward Sodium-Pumping Rhodopsin (<i>Be</i>NaR) from a Thermophilic Bacterium	6
First Total Syntheses of Natural Phenanthrene Alkaloids, Uvariopsamine, Noruvariopsamine, 8-Hydroxystephenanthrine, 8-Methoxyuvariopsine, Thalihazine, and Secophoebine, and Their Potential as Antimala	6
Foreword	6
8-Iodoisoquinolinone, a Conformationally Rigid Highly Reactive 2-Iodobenzamide Catalyst for the Oxidation of Alcohols by Hypervalent Iodine	6
Functional Peptides That Target Biomembranes: Design and Modes of Action	6
Simultaneous Overcoming Approach for Poor Wettability and Low Stability in Stomach by Simple Methods; Formulation Design and Development of Monoacylglycerol Acyltransferase 2 Inhibitor, S-309309	6
Magnetic Field-Responsive Pulsatile Drug Release Using A Magnetic Fluid	6
A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus <i>Curvularia aeria</i>	6
Synthesis and Evaluation of DHMEQ Derivatives with Tertiary Hydroxyl Group Instead of Secondary Hydroxyl Group	6

Estimation for Raw Material Plants of a Henna Product Using LC-High Resolution MS and Multivariate Analysis	6
Site-Selective Molecular Transformation: Acylation of Hydroxy Groups and C–H Amination	6
C21 Steroidal Glycosides from the Roots of <i>Oxypetalum caeruleum</i>	6
<i>N</i>-Acyltriazinedione; a Novel Acylating Reagent Synthesized from a Triazinone-Type Condensing Reagent	6
Errata for Chemical and Pharmaceutical Bulletin	5
Application of Quantitative NMR (qHNMR) towards Establishment of Pharmaceutical Reference Standard; A Case of a Ticagrelor Process Impurity	5
Remarkable Solvent Effect of Fluorinated Alcohols on Azo–Ene Reactions	5
Effects of Membrane Cholesterol on Stability of Transmembrane Helix Associations	5
μ-Oxo-Hypervalent-Iodine-Catalyzed Oxidative C–H Amination for Synthesis of Benzolactam Derivatives	5
Sulfonate Derivatives Containing a Kakuol Moiety as Potential Fungicidal Candidates: Design, Synthesis and Antifungal Activity Evaluation	5
Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers	5
Comparison of Growth in <i>Hydrangea macrophylla</i> var. <i>thunbergii</i> Grown in Different Soil pH and Quantitative Analysis of Its Sweetness-Related Constituents	5
Physical Properties for Novel Cilostazol Co-amorphous; Effect of Preparation Method and Molar Ratio on the Co-amorphous	5
C–H▪▪▪S Hydrogen Bonds in Ampicillin and Amoxicillin Crystals Investigated by Sulfur K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy and Single-Crystal X-Ray Structure Analysis	5
Comparison of Phosphate and Bicarbonate Buffer Solutions as Dissolution Test Media for Predicting Bioequivalence of Febuxostat Formulation	5
Design, Synthesis and Cytotoxicity Evalufation of Substituted Benzimidazole Conjugated 1,3,4-Oxadiazoles	5
Development of Highly Sensitive Method for Sugar Determination in Herbal Medicine; Application of Monosaccharides and Oligosaccharides in Japanese Angelica Root and Rehmannia Root	5
Errata for Chemical and Pharmaceutical Bulletin	5
New Candidate Preservative in Ophthalmic Solution Instead of Benzalkonium Chloride: 1,3-Didecyl-2-methyl Imidazolium Chloride	5
Synthesis, Duplex-Forming Ability, and Nuclease Resistance of Oligonucleotides Containing a Thymidine Derivative with a 1-Oxaspiro[4.5]decane Skeleton	5
Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity	5
Effect of Solubility Improvement <i>via</i> Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	5
Selective Synthesis of the Aminobutadiene Intermediate and Mechanistic Analysis of 1,4-Dihydropyridine Formation Reaction in Water	5
Lewis Acid-Conjugated Pyrene Photoredox Catalyst Promoting the Addition Reaction of α-Silyl Amines with Benzalmalononitriles	5
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities	5
Triflimide-Promoted Nucleophilic <i>C</i>-Arylation of Halopurines to Access <i>N</i><sup>7</sup>-Substituted Purine Biaryls	4
Improved Dissolution Properties of Co-amorphous Probucol with Atorvastatin Calcium Trihydrate Prepared by Spray-Drying	4
Bivalent β-Carbolines Inhibit Colorectal Cancer Growth through Inducing Autophagy	4
Quantification of Risperidone Contained in Precipitates Produced by Tea Catechins Using Nuclear Magnetic Resonance	4
Manufacturability and Properties of Granules and Tablets Using the Eco-Friendly Granulation Method Green Fluidized Bed Granulation Compared to Direct Compression	4
Electrochemical Characterization of a Novel Organoelectrocatalyst, 7-Azabicyclo[2.2.1]heptan-7-ol (ABHOL), and Its Application to Electrochemical Sensors	4
Methylene Blue Removal from the Aqueous Phase Using a Magnetic-Calcined Bamboo Composite Adsorbent	4
Construction of <i>N</i>-Heterocycles Fused with a Highly Substituted Benzene Ring by a Benzyne-Mediated Cyclization/Functionalization Cascade Reaction and Its Application to the Total Syn	4
Novel Strategies for Enantio- and Site-Selective Molecular Transformations	4
Cyclosporin A Inhibits the Activation of Membrane-Bound Guanylate Cyclase GC-A of Atrial Natriuretic Factor <i>via</i> NAD(P)H Oxidase	4
Effect of Equipment Parameters on Amount and Dispersion of Wetting Liquid in Planetary Centrifugal Granulation	4
Synthesis of Novel Pseudo-Enantiomeric Phase-Transfer Catalysts from <i>Cinchona</i> Alkaloids and Application to the Hydrolytic Dynamic Kinetic Resolution of Racemic 3-Phenyl-2-oxetanone	4
GMP-Compliant Automated Radiolabeling and Quality Controls of [<sup>68</sup>Ga]Ga-FAPI-46 for Fibroblast Activation Protein-Targeted PET Imaging in Clinical Settings	4
Pyrrolactams from Marine Sponge <i>Stylissa massa</i> Collected from Myanmar and Their Anti-Vpr Activities	4
Compounds Designs of CK2α Inhibitors Derived from Virtual Screening Hit Compounds by Computational Chemistry with Crystallography	4
Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication <i>via</i> Inflammation and Fibrosis Inhibition in Mice	4
Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site	4
2-Thioxothiazolidin-4-one Analogs as Pan-PIM Kinase Inhibitors	4
Effects of Substituting Disubstituted Amino Acids into the Amphipathic Cell Penetrating Peptide Pep-1	4
Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain	4
Guided Isolation of Isopentenyl Flavonoids from <i>Daphne giraldii</i> Based on the Combination of GNPS and SMART	4
Synthesis of Formononetin Derivatives and Cardioprotective Effects	4
Development and Validation of an LC–MS/MS-Based Method for Quantifying Urinary Endogenous 6-Hydroxymelatonin	4
Exploring the Effectiveness of Carboxymethylated and Crosslinked <i>Albizia procera</i> Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis	4
Application of Quantitative NMR Spectroscopy to the Quality Evaluation of Diclofenac Gargles as Hospital Preparations	4
Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)	4
Structure–Activity Relationships of Thiophene Carboxamide Annonaceous Acetogenin Analogs: Shortening the Alkyl Chain in the Tail Part Significantly Affects Their Growth Inhibitory Activity against Hum	4
Importance of the Azole Moiety of Cimetidine Derivatives for the Inhibition of Human Multidrug and Toxin Extrusion Transporter 1 (hMATE1)	4
Preparation and <i>in Vitro</i> Evaluation of Osmotic-Pump Lorcaserin-hydrochloride Controlled-Release Tablets	4
A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity	4
Protein Chemical Modification Using Highly Reactive Species and Spatial Control of Catalytic Reactions	4
Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents	4
Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge <i>Psammocinia</i> sp.	4
Structural Characterization of Zinc(II)/Cobalt(II) Complexes of Chiral <i>N</i>-(Anthracen-9-yl)methyl-<i>N</i>,<i>N</i>-bis(2-picolyl)amine and Evaluation of DNA P	4
Purity Determination of Cyclophosphamide Hydrate by Quantitative <sup>31</sup>P-NMR and Method Validation	4
Dissolution Profiles of Oral Disintegrating Tablet with Taste Masking Granule Polymer Coating in Biorelevant Bicarbonate Buffer	4
Uric Acid as a Photosensitizer in the Reaction of Deoxyribonucleosides with UV Light of Wavelength Longer than 300 nm: Identification of Products from 2′-Deoxycytidine	4
Aqueous Dispersion Polymerization for the Development of Lamivudine-Polyacrylonitrile Nanoparticles through Quality by Design Approach	4
Chemical Components in <i>Hedera rhombea</i> Leaves and Their Cytotoxicity	4
An Update Mini-Review on the Progress of Azanucleoside Analogues	4
An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery	4
Development of Fluorescent Estrogen Receptor Ligands with pH Sensor Functionality	3
Development of an Antigen Delivery System for a B Cell-Targeted Vaccine as an Alternative to Dendritic Cell-Targeted Vaccines	3
Palladium-Catalyzed C–H Arylation of [1,1′-Biphenyl]-2-ols with Chloroarenes	3
Oxidative Functionalization of Catechol Derivatives Substituted with Electron-Withdrawing Groups	3
Foreword	3
Effect of Sample Concentration on Nanoparticle Tracking Analysis of Small Extracellular Vesicles and Liposomes Mimicking the Physicochemical Properties of Exosomes	3
Bioequivalence Dissolution Test Criteria for Formulation Development of High Solubility-Low Permeability Drugs	3
Development of Naturally Inspired Peptide and Protein Chemistry	3
Fragment Molecular Orbital Based Affinity Prediction toward Pyruvate Dehydrogenase Kinases: Insights into the Charge Transfer in Hydrogen Bond Networks	3
Evaluation of Time-Dependent Deformation Behavior of Pharmaceutical Excipients in the Tableting Process	3
Chemical Constituents of the Leaves of <i>Thujopsis dolabrata</i> and Their Cytotoxicity	3
Synergistic Activation of TLR7 and 8 Mediated by Reduction of Electrostatic Repulsion	3
Determination of the Solid Content of Active Pharmaceutical Ingredient Powders in Suspension-Type Pharmaceutical Oral Jelly Using Time-Domain NMR	3
Effect of Cultivation Conditions on Components of <i>Ephedra</i> sp. Using Liquid Chromatography-Mass Spectrometry and Multivariate Analysis	3

Shanpanootols G and H, Diterpenoids from the Rhizomes of <i>Kaempferia pulchra</i> Collected in Myanmar and Their Vpr Inhibitory Activities	3
The New Delivery Strategy of Albumin Carrier Utilizing the Interaction with Albumin Receptors	3
A Facile Method for the Quantification of Urinary Uracil Concentration by a Uracil-Specific Fluorescence Derivatization Reaction	3
Evaluation of STAT3 Inhibition by Cancer Chemopreventive Trichothecenes Derived from Metabolites of <i>Trichothecium roseum</i>	3
Study of Polymer Nanofilms Using for High-Throughput Screening in the Development of Transdermal Therapeutic System	3
12,20-Epoxypregnane Glycosides from the Roots of <i>Oxypetalum caeruleum</i>	3
Foreword	3
Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes	3
Extremely Simple and Rapid HPLC Analysis of Tocilizumab in Human Serum with Selective Precipitation Using Alkylamine	3
Hyaluronan Tetrasaccharides Penetrate into the Skin by Passive Diffusion and Contribute to Skin Health	3
Highly Precise Anomaly Detection Using Multivariate Statistical Process Control with Appropriate Scaling of Input Variables in Pharmaceutical Continuous Manufacturing	3
Elaboration of Non-naturally Occurring Helical Tripeptides as p53–MDM2/MDMX Interaction Inhibitors	3
Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from <i>Streptomyces niveoruber</i>	3
Analysis of Powder Properties of Pharmaceutical Excipients Using a Constant-Volume Shear Tester	3
Formulation of Biopharmaceutical Dry Powder Inhaler Using the Void Forming Index (VFI) to Detect and Avoid Powder Caking in Dry Powder Inhaler Formulations	3
Synthesis and Evaluation of Quinone Derivatives for Activity against <i>Trypanosome cruzi</i>	3
Development of Drug Discovery Platforms Using Artificial Intelligence and Cheminformatics	3
Prediction of Intra-individual Variability in Bioequivalence Studies of 278 Formulations: Comprehensive Analysis Using Physicochemical and Pharmacokinetic Parameters	3
Determination of Hardness of a Pharmaceutical Oral Jelly by Using <i>T</i><sub>2</sub> Relaxation Behavior Measured by Time-Domain NMR	3
Peptide Tool-Driven Functional Elucidation of Biomolecules Related to Endocrine System and Metabolism	3
A Stereoselective Synthesis of Fused Carbocycles with a <i>cis</i>-1,2-Diol Moiety by Desymmetrization: SmI<sub>2</sub>-Mediated Pinacol Coupling of <i>meso</i>-Cyc	3
Development and Full Validation of a Bioanalytical Method for Quantifying Letermovir in Human Plasma Using Ultra-Performance Liquid Chromatography Coupled with Mass Spectrometry	3
Construction of 2,2-Dimethyloxepane Frameworks from Ene-Diols Catalyzed by Metal Catalyst or Brønsted Acid <i>via</i> 7-<i>Endo</i>-<i>Trig</i> Cyclization	3
P(III)-Mediated Formal Reductive N–H Bond Insertion Reaction of Hydrazones to α-Keto Esters	3
Crystalline Phase Transitions of 5′-<i>O</i>-Triethylsilyl-2′-deoxy-5-azacytidine under Varying Temperature and Humidity Conditions and Its Closed Storage Stability	3
Ion-Pair Extraction with Tetracyanocyclopentadienides: A Method for Estimating Extraction Efficiency	3
Elucidating the Factors Affecting the Patient-Centric Usability of Blister Packs for Spherical Capsules	3
Isolation and Identification of Three New Iridoid Glucosides from the Aerial Parts of <i>Paederia scandens</i>	3
Synthesis of Tetrahydrofuro[2,3-<i>d</i>]oxazoles and Oxazoles by Hypervalent Iodine (III)-Promoted [2 + 2 + 1] Annulation	3
Ruthenium-on-Carbon-Catalyzed Facile Solvent-Free Oxidation of Alcohols: Efficient Progress under Solid–Solid (Liquid)–Gas Conditions	3
Structure–Activity Relationships of UTX-121 Derivatives for the Development of Novel Matrix Metalloproteinase-2/9 Inhibitors	3