OOIR: Observatory of International Research

Papers

(The TQCC of Chemical & Pharmaceutical Bulletin is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Smart Strategies for Therapeutic Agent Delivery into Brain across the Blood–Brain Barrier Using Receptor-Mediated Transcytosis	54
Production Mechanisms of Black Tea Polyphenols	45
Recent Advances in Drug–Antibody Ratio Determination of Antibody–Drug Conjugates	33
Co-delivery Systems of Multiple Drugs Using Nanotechnology for Future Cancer Therapy	26
Effect of the Molecularly Imprinted Polymer Component Ratio on Analytical Performance	25
Bone-Targeted Drug Delivery Systems and Strategies for Treatment of Bone Metastasis	24
Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity	23
The New Delivery Strategy of Albumin Carrier Utilizing the Interaction with Albumin Receptors	21
Temperature-Dependent Formation of <i>N</i>-Nitrosodimethylamine during the Storage of Ranitidine Reagent Powders and Tablets	19
Recent Strategies for Targeted Brain Drug Delivery	18
Fluorofunctionalizations of C–C Multiple Bonds and C–H Bonds	18
A Comprehensive Review on Ulvan Based Hydrogel and Its Biomedical Applications	18
Herba <i>Cistanche</i> (Rou Cong Rong): A Review of Its Phytochemistry and Pharmacology	15
Arctigenin Triggers Apoptosis and Autophagy <i>via</i> PI3K/Akt/mTOR Inhibition in PC-3M Cells	14
Development of Lipid Nanoparticles for the Delivery of Macromolecules Based on the Molecular Design of pH-Sensitive Cationic Lipids	14
Development of Transition-Metal-Catalysed Cross-Coupling Reactions through Ammonium C–N Bond Cleavage	14
Design, Synthesis and Evaluation of 3-Substituted Coumarin Derivatives as Anti-inflammatory Agents	14
Impact of COVID-19 Outbreak on the Long-Range Transport of Common Air Pollutants in KUWAMS	13
Chemical Research on Antitumor Isoquinoline Marine Natural Products and Related Compounds	13
Collaborative Study to Validate Purity Determination by <sup>1</sup>H Quantitative NMR Spectroscopy by Using Internal Calibration Methodology	13
Photoinduced Atom Transfer Radical Addition Reaction of Olefins with α-Bromo Carbonyls	13
<i>N</i>-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride	12
Nonheme Iron- and 2-Oxoglutarate-Dependent Dioxygenases in Fungal Meroterpenoid Biosynthesis	11
Progress in Chiral Stationary Phases Based on Proteins and Glycoproteins	11
Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α,β-Unsaturated Amide and Azomethine Imine	11

Cobalt-Catalyzed Hydroamination of Alkenes with 5-Substituted Tetrazoles: Facile Access to 2,5-Disubstituted Tetrazoles and Asymmetric Intermolecular Hydroaminations	11
A New Inhibitor of ADAM17 Composed of a Zinc-Binding Dithiol Moiety and a Specificity Pocket-Binding Appendage	11
Design, Synthesis and Biological Evaluation of the Quinazoline Derivatives as L858R/T790M/C797S Triple Mutant Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors	11
Preliminary Evaluation of Astatine-211-Labeled Bombesin Derivatives for Targeted Alpha Therapy	10
Present Situation and Future Progress of Inhaled Lung Cancer Therapy: Necessity of Inhaled Formulations with Drug Delivery Functions	10
Dioscin Protects against Aβ1–42 Oligomers-Induced Neurotoxicity <i>via</i> the Function of SIRT3 and Autophagy	10
Theoretical Study on the Mechanism of Spirocyclization in Spiroviolene Biosynthesis	10
Functional Peptides That Target Biomembranes: Design and Modes of Action	10
Drug Delivery System for Refractory Cancer Therapy <i>via</i> an Endogenous Albumin Transport System	10
Imbuing an Old Heterocycle with the Power of Modern Catalysis: An Isoxazolidin-5-one Story	10
Cellular Uptake and Transport Characteristics of FL118 Derivatives in Caco-2 Cell Monolayers	9
Revisiting 2-Alkoxy-3-bromoindolines: Control C-2 <i>vs</i>. C-3 Elimination for Regioselective Synthesis of Alkoxyindoles	9
Organocatalytic Synthesis of Highly Functionalized Heterocycles by Enantioselective aza-Morita–Baylis–Hillman-Type Domino Reactions	9
UHPLC/MS and NMR-Based Metabolomic Analysis of Dried Water Extract of Citrus-Type Crude Drugs	9
Thiamine Protects Glioblastoma Cells against Glutamate Toxicity by Suppressing Oxidative/Endoplasmic Reticulum Stress	9
The Endocytic Mechanism and Cytotoxicity of Boron-Containing Vesicles	9
A Review on the Phytochemical and Pharmacological Properties of <i>Rosa laevigata</i>: A Medicinal and Edible Plant	9
MiR-135a Protects against Myocardial Injury by Targeting TLR4	9
Numerical Study on Particle Adhesion in Dry Powder Inhaler Device	9
Syntheses and Evaluation of 2- or 3-(<i>N</i>-Cyclicamino)chromone Derivatives as Monoamine Oxidase Inhibitors	9
Design and Synthesis of 2-(1-Alkylaminoalkyl)pyrazolo[1,5-a]pyrimidines as New Respiratory Syncytial Virus Fusion Protein Inhibitors	9
Discovery of 1,3-Disubstituted 2,5-Diketopiperazine Derivatives as Potent Class I HDACs Inhibitors	9
μ-Oxo-Hypervalent-Iodine-Catalyzed Oxidative C–H Amination for Synthesis of Benzolactam Derivatives	8
Determination of Absolute Purities of Hygroscopic Substances by Quantitative NMR Analysis for the Standardization of Quantitative Reagents in the Japanese Pharmacopoeia (Part 2)	8
Development of Novel Methodology Using Diazo Compounds and Metal Catalysts	8
Chiral Bifunctional Selenide Catalysts for Asymmetric Iodolactonizations	8
Nitrate Ion Adsorption Characteristics of Activated Carbon Fibers with and without Quaternary Nitrogen Effective for Anion Adsorption	8
Magnolin Inhibits Proliferation and Invasion of Breast Cancer MDA-MB-231 Cells by Targeting the ERK1/2 Signaling Pathway	8
Absolute Purity Determination of a Hygroscopic Substance, Indocyanine Green, Using Quantitative NMR (qNMR)	8
Ring-Opening Cyclization of Spirocyclopropanes Using Sulfoxonium Ylides	8
A Review on the Foodomics Based on Liquid Chromatography Mass Spectrometry	8
Synthesis of Hydroxybenzofuranyl-pyrazolyl and Hydroxyphenyl-pyrazolyl Chalcones and Their Corresponding Pyrazoline Derivatives as COX Inhibitors, Anti-inflammatory and Gastroprotective Agents	8
Structure–Activity Relationship of Phytoestrogen Analogs as ERα/β Agonists with Neuroprotective Activities	8
Environmental Risk Assessment of Active Human Pharmaceutical Ingredients in Urban Rivers in Japan	7
Synthesis and Evaluation of Gallotannin Derivatives as Antioxidants and α-Glucosidase Inhibitors	7
Development of Photoswitchable Estrogen Receptor Ligands	7
Isolation and Characterization of Neuroprotective Components from Citrus Peel and Their Application as Functional Food	7
Fragment-Based Discovery of Irreversible Covalent Inhibitors of Cysteine Proteases Using Chlorofluoroacetamide Library	7
2-Thioxothiazolidin-4-one Analogs as Pan-PIM Kinase Inhibitors	7
Method to Improve Azo-Compound (AAPH)-Induced Hemolysis of Erythrocytes for Assessing Antioxidant Activity of Lipophilic Compounds	7
Asymmetric Total Syntheses of Mitragynine, Speciogynine, and 7-Hydroxymitragynine	7
Synthesis and Evaluation of 2-Hydroxy-1,4-naphthoquinone Derivatives as Potent Antimalarial Agents	7
Evaluation of Weight Variation in Mini-Tablets Manufactured by a Multiple-Tip Tool	7
Biomimetic Nanoparticle Drug Delivery Systems to Overcome Biological Barriers for Therapeutic Applications	7
Preparation of Biodegradable PLGA-Nanoparticles Used for pH-Sensitive Intracellular Delivery of an Anti-inflammatory Bacterial Toxin to Macrophages	7
Highly Sensitive Determination of Amino Acids by LC-MS under Neutral Conditions	6
Systems Pharmacology Dissection of Mechanisms of Dengzhan Xixin Injection against Cardiovascular Diseases	6
Application of Acoustic Ejection MS System to High-Throughput Screening for SARS-CoV-2 3CL Protease Inhibitors	6
Effects of Manufacturing Conditions on Pharmaceutical Properties of Petrolatum Ointment—Distribution of Hydrocarbon—	6
Bromine K-Edge X-Ray Absorption Near-Edge Structure Analysis on Hydrobromide-Salt Crystals and the Solid Dispersion of Active Pharmaceutical Ingredients	6

Discovery of C-9 Modified Berberine Derivatives as Novel Lipid-Lowering Agents	6
Constituents of the Fruiting Body of Poisonous Mushroom <i>Omphalotus japonicus</i>	6
Effect of Sample Concentration on Nanoparticle Tracking Analysis of Small Extracellular Vesicles and Liposomes Mimicking the Physicochemical Properties of Exosomes	6
Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator	6
Screening, Synthesis, and Evaluation of Novel Isoflavone Derivatives as Inhibitors of Human Golgi β-Galactosidase	6
Study on the Changes of Chemical Constituents in Different Compatibilities of Ginseng-Prepared Rehmannia Root and Their Effects on Bone Marrow Inhibition after Chemotherapy	6
Distribution of Domains Formed by Lateral Packing of Intercellular Lipid in the Stratum Corneum	6
Design, Synthesis and Pharmacological Evaluation of Some C<sub>3</sub> Heterocyclic-Substituted Ciprofloxacin Derivatives as Chimeric Antitubercular Agents	6
Monitoring Analysis of Perfluoroalkyl Substances and F-53B in Bottled Water, Tea and Juice Samples by LC-MS/MS	6
Evaluating the Sun Protection Factor of Cosmetic Formulations Containing Afzelin	6
A New Glycosidic Acid, Muricatic Acid D, and Resin Glycosides, Muricatins X and XI, from the Crude Resin Glycoside Fraction of the Seeds of <i>Ipomoea muricata</i>	6
Synthesis of 4,4-Disubstituted 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones and -thiones, the Corresponding Products of Biginelli Reaction Using Ketone, and Their Antiproliferative Effect on HL-	6
Design, Synthesis, Biological Evaluation and Inhibition Mechanism of 3-/4-Alkoxy Phenylethylidenethiosemicarbazides as New, Potent and Safe Tyrosinase Inhibitors	6
Monitoring of Cocrystal Dissociation during the Wet Granulation Process in the Presence of Disintegrants by Using Low-Frequency Raman Spectroscopy	6
Facile Fluorescence Dopamine Detection Strategy Based on Acid Phosphatase (ACP) Enzymatic Oxidation Dopamine to Polydopamine	6
Paeonol Pretreatment Attenuates Anoxia-Reoxygenation Induced Injury in Cardiac Myocytes <i>via</i> a BRCA1 Dependent Pathway	5
Improvement of Pharmaceutical Properties of Zerumbone, a Multifunctional Compound, Using Cyclodextrin Derivatives	5
Near-Infrared Metabolic Profiling for Discrimination of Apricot and Peach Kernels	5
CBDPS 1.0: A Python GUI Application for Machine Learning Models to Predict Bitter-Tasting Children’s Oral Medicines	5
C–H▪▪▪S Hydrogen Bonds in Ampicillin and Amoxicillin Crystals Investigated by Sulfur K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy and Single-Crystal X-Ray Structure Analysis	5
Structure and Stereochemistry of Amphidinolide N Congeners from Marine Dinoflagellate <i>Amphidinium</i> Species	5
Effects of Manufacturing Process Variables on the Tablet Weight Variation of Mini-tablets Clarified by a Definitive Screening Design	5
Three New C<sub>19</sub>-Diterpenoid Alkaloids from <i>Aconitum novoluridum</i>	5
Determination of Mineral Elements in Nanyang Mugwort (<i>Artemisia argyi</i>) Leaves Harvested from Different Crops by Inductively Coupled Plasma Mass Spectrometry and Inductively Coupled	5
Structure–Activity Relationships of Thiophene Carboxamide Annonaceous Acetogenin Analogs: Shortening the Alkyl Chain in the Tail Part Significantly Affects Their Growth Inhibitory Activity against Hum	5
LC-MS/MS Assay for the Measurement of Cannabidiol Profiling in CBD Oil from Japanese Market and Application for Convertible Tetrahydrocannabinol in Acetic Acid Condition	5
Phase Separation in Lipid Lamellae Result from Ceramide Conformations and Lateral Packing Structure	5
Leonurine Preconditioning Attenuates Ischemic Acute Kidney Injury in Rats by Promoting Nrf2 Nuclear Translocation and Suppressing TLR4/NF-κB Pathway	5
An Update Mini-Review on the Progress of Azanucleoside Analogues	5
A Series of Novel HDAC Inhibitors with Anthraquinone as a Cap Group	5
Elaboration of non-naturally occurring helical tripeptides as p53-MDM2/MDMX interaction inhibitors	5
Structure–Activity Relationship Studies of Antimicrobial Naphthoquinones Derived from Constituents of <i>Tabebuia avellanedae</i>	5
Immunochromatography—Application Example and POCT Type Genetic Testing	5
MiR-509-3p Induces Apoptosis and Affects the Chemosensitivity of Cervical Cancer Cells by Targeting the RAC1/PAK1/LIMK1/Cofilin Pathway	5
Flip-Flop Promotion Mechanisms by Model Transmembrane Peptides	5
A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines	5
The Novel Synthetic Triterpene Methyl 3β-<i>O</i>-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth <i>in</i> <i>Vitro</i>	5
Isolation of Three New Diterpenes from <i>Dodonaea viscosa</i>	5
Determination of Phenolic Compounds in Beverages by Three-Flow Channel Isocratic HPLC with Electrochemical Detections Using a Column-Switching Technique	5
Development of Catalytic Reactions for Precise Control of Chemoselectivity	5
Utilization of Diluted Compendial Media as Dissolution Test Solutions with Low Buffer Capacity for the Investigation of Dissolution Rate of Highly Soluble Immediate Release Drug Products	5
Asymmetric Nitrogen-Containing Dimer from Aerial Parts of <i>Mercurialis leiocarpa</i> and Its Synthesis by Mimicking Generation Process through Radical Intermediates	5
DFT Study on the Biosynthesis of Preasperterpenoid A: Role of Secondary Carbocations in the Carbocation Cascade	5
Effect of Disintegrants on Prolongation of Tablet Disintegration Induced by Immersion in Xanthan Gum-Containing Thickening Solution: Contribution of Disintegrant Interactions with Disintegration Fluid	5
Miroestrol Quantification in <i>Pueraria mirifica</i> Crude Drugs and Products by Single-Reference UPLC/PDA/MS Using Relative Molar Sensitivities to Kwakhurin	4
Development of Nitrolactonization Mediated by Iron(III) Nitrate Nonahydrate	4
<i>In Vitro</i> and <i>in Silico</i> Studies of Potential Coronavirus-Specific 3C-Like Protease Inhibitors	4
Biosynthesis of Bioactive Natural Products Derived from Theonellidae Family Marine Sponges	4
Development of Highly Sensitive Method for Sugar Determination in Herbal Medicine; Application of Monosaccharides and Oligosaccharides in Japanese Angelica Root and Rehmannia Root	4
Large-Scale Isolation of Three <i>O</i>-Methyl Anthocyanins from Bilberry (<i>Vaccinium myrtillus</i> L.) Extract	4
Formal Aerobic Oxidative Cross-Coupling of Benzofuranones with Azo Compounds Using Pd-μ-hydroxo Complex	4
Labeling of Peroxide-Induced Oxidative Stress Hotspots by Hemin-Catalyzed Tyrosine Click	4
Secorubenine, a Monoterpenoid Indole Alkaloid Glycoside from <i>Adina rubescens</i>: Isolation, Structure Elucidation, and Enantioselective Total Synthesis	4
Emerging Separation Techniques in Supercritical Fluid Chromatography	4
Site-Selective α-Alkylation of 1,3-Butanediol Using a Thiophosphoric Acid Hydrogen Atom Transfer Catalyst	4
Instrument-Dependent Factors Affecting the Precision in the Atomic Force Microscopy Stiffness Measurement of Nanoscale Liposomes	4
Syntheses of C2′-Fluorinated Analogs of Solamin	4
Impact of Magnesium Stearate Content: Modeling of Drug Degradation Using a Modified Arrhenius Equation	4
Four Novel Pharmaceutical Cocrystals of Oxyresveratrol, Including a 2 : 3 Cocrystal with Betaine	4
Chemical Constituents from the Leaves of <i>Pachyrhizus erosus</i> Collected in Vietnam	4
Flavanones from the Twigs and Barks of <i>Artocarpus lakoocha</i> Having Antiplasmodial and Anti-TB Activities	4
Determination of Mogroside V in Luohanguo Extract for Daily Quality Control Operation Using Relative Molar Sensitivity to Single-Reference Caffeine	4
Formylation Reaction of Amines Using <i>N</i>-Formylcarbazole	4
Synthesis of Non-canonical Amino Acids and Peptide Containing Them for Establishment of the Template for Drug Discovery	4
Iriomoteolides-14a and 14b, New Cytotoxic 15-Membered Macrolides from Marine Dinoflagellate <i>Amphidinium</i> Species	4
Application of Quantitative NMR Spectroscopy to the Quality Evaluation of Diclofenac Gargles as Hospital Preparations	4
Biological Synergy and Antimicrobial Mechanism of Hydroxypropyltrimethyl Ammonium Chloride Chitosan with Benzalkonium Chloride	4
Importance of the Azole Moiety of Cimetidine Derivatives for the Inhibition of Human Multidrug and Toxin Extrusion Transporter 1 (hMATE1)	4
Design of the N-Terminus Substituted Curvature-Sensing Peptides That Exhibit Highly Sensitive Detection Ability of Bacterial Extracellular Vesicles	4
Sequence-Independent Traceless Method for Preparation of Peptide/Protein Thioesters Using CPaseY-Mediated Hydrazinolysis	4
Facile Synthesis of Kwakhurin, a Marker Compound of <i>Pueraria mirifica</i> and Its Quantitative NMR Analysis for Standardization as a Reagent	4
Elucidation of Degradation Behavior of Tricyclic Antidepressant Amoxapine in Artificial Gastric Juice	4
Identification of Phenolic Constituents and Inhibitory Activity of Persimmon Calyx and Shiteito against Tumor Cell Proliferation	4
Potent Antibacterial Activity of Synthetic Peptides Designed from Salusin-β and HIV-1 Tat(49–57)	4
Hepatoprotective Effects of Phloridzin against Isoniazid-Rifampicin Induced Liver Injury by Regulating CYP450 and Nrf2/HO-1 Pathway in Mice	4
Prediction of Anti-proliferation Effect of [1,2,3]Triazolo[4,5-<i>d</i>]pyrimidine Derivatives by Random Forest and Mix-Kernel Function SVM with PSO	4
The Effect of Iontophoresis with and without Electroporation on the Penetration of High Molecular Compounds into the Stratum Corneum	4
Design, Synthesis and Activity Evaluation of New Phthalazinone PARP Inhibitors	4
Crystal Structure of Catechol <i>O</i>-Methyltransferase Complexed with Nitecapone	4