Chemical & Pharmaceutical Bulletin

Papers
(The TQCC of Chemical & Pharmaceutical Bulletin is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)
ArticleCitations
Development of Ethylcellulose Microparticles for Taste Masking of Fexofenadine25
Foreword25
Errata for Chemical and Pharmaceutical Bulletin22
Concise and Highly Stereoselective Synthesis of <i>β</i>,<i>β</i>-Disubstituted <i>α</i>,<i>β</i>-Unsaturated Esters19
2-Azanorbornane-Based Amino Amide Organocatalysts for Asymmetric Michael Addition of <i>β</i>-Keto Esters with Nitroolefins15
Design, Synthesis and Radioprotective Activity Evaluation of Novel <i>N</i>-Phenyl-2<i>H</i>-chromene-3-carboxamides Derived from Ex-RAD15
Clinical Pipelines for Alzheimer’s Disease Psychosis and Agitation14
Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction14
Syntheses of Aryl Thioethers <i>via</i> Aromatic Substitution of Aryl Halides at 0 to 25 °C14
Teleocidin Analogs Isolated from <i>Streptomyces eurocidicus</i> as Membrane-Vesicle-Regulated Natural Products13
Sprayable Intranasal Powder Formulation of Ionic Liquid-Associated Mesoporous Silica13
Synthesis and Evaluation of Novel Triaryl Derivatives with Readthrough-Inducing Activity13
Protective Effect of Apple Polyphenols on H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress Damage in Human Colon Adenocarcinoma Caco-2 Cells13
Rapid Determination of Dapagliflozin in Rat Plasma by UHPLC-Q-Orbitrap MS and Its Application to a Pharmacokinetic Study11
Near-Infrared Metabolic Profiling for Discrimination of Apricot and Peach Kernels11
Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups11
Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation <i>via</i> Attachment of <i>N</i>-Methylpyrrole at the 2-Position11
Design, Synthesis, and Characterization of 1-(Anthracen-9-ylmethyl)-1,5,9-triazacyclododecane (Ant-[12]aneN3) and Its DNA Photocleavage Activity11
Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA11
Anti-hepatitis C Virus Activity of Juglorubin Derivatives11
Unusual Enzymatic C–C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis11
Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V)10
Aminoalkylation of Alkenes for Modular Pyrrolidine Synthesis <i>via</i> Electron Donor–Acceptor Complexes Generated from Alkenes and Amine-Tethered <i>N</i>-Hydroxyphthalimide 10
Molecular Modeling, Synthesis, and Preliminary Cytotoxicity Evaluation of New Indole-Based Molecules as Possible Sirtuin Inhibitors10
Natural Compounds with BMI1 Promoter Inhibitory Activity from <i>Mammea siamensis</i> and <i>Andrographis paniculata</i>10
Optimization and Advantages of Molded Tablets Using Trehalose as a Binder10
<i>In Vitro</i> Study on Combined Effect of Drugs for Hyperphosphatemia on Phosphorus Adsorption Capacity10
Synthesis of Coumarin-Conjugated Oligonucleotides <i>via</i> Knoevenagel Condensation to Prepare an Oligonucleotide Library10
Terminalagin, a New Ellagitannin from Kakadu Plum (<i>Terminalia ferdinandiana</i>)10
Synthesis of 2-Substituted Indoles <i>via</i> Migration Reaction of 3-Substituted Indoles with Triflic Acid9
Oxygen-Fueled Iterative Hydride Transfer Driven by a Rigid Planar Architecture9
Effectively Determining Dopamine Based on Dopamine Self-polymerization through Fluorescent Method Using Silicon Quantum Dots as Probe9
Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine9
Functions, Structures, and Engineering of the Teleocidin Biosynthetic Enzymes9
Substituent Effects at the <i>N</i>-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser9
Development of Efficient Synthetic Reactions Using Enamines and Enamides Carrying Oxygen Atom Substituent on Nitrogen Atom9
Liquid Chromatographic Determination of <i>o</i>-Phosphoethanolamine in Human Plasma Using Fluorescent Derivatization8
Solid Fat Content and Relaxation Time Measurement of Petrolatum Using Time-Domain NMR, and the Correlation with Viscosity and Crystallinity8
Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction8
The Effect of Iontophoresis with and without Electroporation on the Penetration of High Molecular Compounds into the Stratum Corneum8
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence8
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite8
<i>p</i>-Methoxy- and 2,4-Dimethoxybenzyl <i>N</i>-Acetylcarbamate Potassium Salts: Versatile Reagents for <i>N</i>-Alkylacetamide and <i>p</i>-Methoxy-8
Flip-Flop Promotion Mechanisms by Model Transmembrane Peptides8
Dynamic Dialysis Method for Characterizing Ammonia-Driven Drug Release from Liposomal Doxorubicin: Applicability and Kinetic Modeling8
Total Synthesis of (+)-Silybin A7
Estimation for Raw Material Plants of a Henna Product Using LC-High Resolution MS and Multivariate Analysis7
Self-assembly of Urea Derivatives into Supramolecular Gels7
Development of a Novel TLC Identification Test for “Rosemary Oil” and “Rosemary Water” Listed in the Japanese Standards of Quasi-Drug Ingredients7
Simultaneous Overcoming Approach for Poor Wettability and Low Stability in Stomach by Simple Methods; Formulation Design and Development of Monoacylglycerol Acyltransferase 2 Inhibitor, S-3093097
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine7
Evaluation of the Mechanism of Phosphate Removal Using Oyster Shell Powder in Aqueous Environments7
8-Iodoisoquinolinone, a Conformationally Rigid Highly Reactive 2-Iodobenzamide Catalyst for the Oxidation of Alcohols by Hypervalent Iodine7
C21 Steroidal Glycosides from the Roots of <i>Oxypetalum caeruleum</i>7
Chlorocyclization of Alkenoic Thioester7
Tantalum-Catalyzed Peptide Elongation of Unprotected Amino Acids Using <i>N</i>-Trimethylsilylimidazole7
Enteric Microcapsules Encapsulation of Roxithromycin-PVP Composite Core Particles to Inhibit Drug Crystallization upon Fluidized Bed Method for Oral Administration7
Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster7
Identification of a Functionally Efficient and Thermally Stable Outward Sodium-Pumping Rhodopsin (<i>Be</i>NaR) from a Thermophilic Bacterium7
Preparation of Model Intercellular Membrane Using Low-Toxic Solvent Ethanol7
Two New Halimanes with a <i>γ</i>-Lactone from <i>Croton argyratus</i>7
Theoretical Study of the Substituent Effect on the Diradical Character of <i>α</i>-Substituted <i>α</i>,3-Didehydrotoluenes7
Optimized Molecular Weight of Hydroxypropyl Cellulose in Inhaled Spray-Freeze-Dried Powders for High Deagglomeration and Pulmonary Retention Abilities6
Effects of Physicochemical Properties of Constituent Ions of Ionic Liquid on Its Permeation through a Silicone Membrane6
Antiproliferative Activities of Diterpenes from Leaves of <i>Isodon trichocarpus</i> against Cancer Stem Cells6
Effects of pH and 5-Substitution of Templated Thymine on Metal-Mediated Primer Extension Reaction by DNA Polymerases: Insights into Base Selectivity of Metal Ions6
Organocatalyzed Amine-Free <i>O</i>-Phosphorylation of Alcohols with 4-Methylpyridine <i>N</i>-Oxide6
PEO-Reinforced Hydrogel-Forming PVA Nanofibrous Mats Prepared by Coaxial Electrospinning: A Physicochemical Basis for Biomedical Evaluation6
Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity6
First Total Syntheses of Natural Phenanthrene Alkaloids, Uvariopsamine, Noruvariopsamine, 8-Hydroxystephenanthrine, 8-Methoxyuvariopsine, Thalihazine, and Secophoebine, and Their Potential as Antimala6
Novel Pharmaceutical Cocrystals and Solvate Crystals of Nobiletin, a Citrus Flavonoid with Potent Pharmacological Activity6
Toward the Synthesis of Strychnos Alkaloids: Effective Construction of Fused Cyclohexane and Pyrrolidine Portion of the Strychnos Skeleton <i>via</i> Domino Intermolecular and Intramolecul6
Synthesis and Evaluation of DHMEQ Derivatives with Tertiary Hydroxyl Group Instead of Secondary Hydroxyl Group6
Synthesis, Duplex-Forming Ability, and Nuclease Resistance of Oligonucleotides Containing a Thymidine Derivative with a 1-Oxaspiro[4.5]decane Skeleton5
Effect of Solubility Improvement <i>via</i> Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability5
Methylene Blue Removal from the Aqueous Phase Using a Magnetic-Calcined Bamboo Composite Adsorbent5
A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus <i>Curvularia aeria</i>5
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities5
Exosome-Hijacking Drug Delivery System with Branched Arginine Linker Effectively Deliver Antisense Oligonucleotides into Lung Adenocarcinoma Cells5
Side-Chain Fluorine Engineering of Vitamin D<sub>3</sub> Derivatives for VDR-Silent SREBP Inhibitors5
Physical Properties for Novel Cilostazol Co-amorphous; Effect of Preparation Method and Molar Ratio on the Co-amorphous5
C–H▪▪▪S Hydrogen Bonds in Ampicillin and Amoxicillin Crystals Investigated by Sulfur K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy and Single-Crystal X-Ray Structure Analysis5
Sulfonate Derivatives Containing a Kakuol Moiety as Potential Fungicidal Candidates: Design, Synthesis and Antifungal Activity Evaluation5
Development of Highly Sensitive Method for Sugar Determination in Herbal Medicine; Application of Monosaccharides and Oligosaccharides in Japanese Angelica Root and Rehmannia Root5
Guided Isolation of Isopentenyl Flavonoids from <i>Daphne giraldii</i> Based on the Combination of GNPS and SMART5
Structure–Activity Relationship Study of Affinity Peptides for the Fc Site of Human Immunoglobulin G5
Electrochemical Characterization of a Novel Organoelectrocatalyst, 7-Azabicyclo[2.2.1]heptan-7-ol (ABHOL), and Its Application to Electrochemical Sensors5
Errata for Chemical and Pharmaceutical Bulletin5
Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain5
Inhaled Biologics: Overcoming Challenges and Recent Advances5
Design, Synthesis and Cytotoxicity Evalufation of Substituted Benzimidazole Conjugated 1,3,4-Oxadiazoles5
Comparison of Phosphate and Bicarbonate Buffer Solutions as Dissolution Test Media for Predicting Bioequivalence of Febuxostat Formulation5
Lewis Acid-Conjugated Pyrene Photoredox Catalyst Promoting the Addition Reaction of α-Silyl Amines with Benzalmalononitriles5
Structural Characterization of Zinc(II)/Cobalt(II) Complexes of Chiral <i>N</i>-(Anthracen-9-yl)methyl-<i>N</i>,<i>N</i>-bis(2-picolyl)amine and Evaluation of DNA P5
Comparison of Growth in <i>Hydrangea macrophylla</i> var. <i>thunbergii</i> Grown in Different Soil pH and Quantitative Analysis of Its Sweetness-Related Constituents5
A Twin-Fluid Atomization Method for Fabricating Ovalbumin-Loaded Gelatin Microcapsules5
New Candidate Preservative in Ophthalmic Solution Instead of Benzalkonium Chloride: 1,3-Didecyl-2-methyl Imidazolium Chloride5
Eurycomanoic Acids A–C: Three New Quassinoid Carboxylic Acids from <i>Eurycoma longifolia</i> (Simaroubaceae)5
Foreword5
Structure-Guided Engineering of 2-Oxoglutarate-Dependent Oxygenases: Principles, Case Studies, and Emerging Opportunities5
Effects of Membrane Cholesterol on Stability of Transmembrane Helix Associations5
Highly Precise Anomaly Detection Using Multivariate Statistical Process Control with Appropriate Scaling of Input Variables in Pharmaceutical Continuous Manufacturing4
Influence of Surfactants on the Stability of Cannabidiol, Formulated as a Water-Soluble Product, in Simulated Gastric Fluid4
Two New 12-Membered Macrolides from Endophytic Fungi <i>Cladosporium tenuissimum</i> and Their Bioactivities4
An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery4
Elucidating the Light-Emitting Species Generated from Aminoluciferin in Firefly/Beetle Bioluminescence4
Synthesis of Formononetin Derivatives and Cardioprotective Effects4
Determination of the Absolute Configuration of 2′-Amino-3′-methylacetophenone Based on the Modified Mosher and Microcrystal Electron Diffraction Methods4
Compounds Designs of CK2α Inhibitors Derived from Virtual Screening Hit Compounds by Computational Chemistry with Crystallography4
GMP-Compliant Automated Radiolabeling and Quality Controls of [<sup>68</sup>Ga]Ga-FAPI-46 for Fibroblast Activation Protein-Targeted PET Imaging in Clinical Settings4
Effects of Substituting Disubstituted Amino Acids into the Amphipathic Cell Penetrating Peptide Pep-14
Evaluation of Complex Formation between Aminated Polyrotaxane and Proteins Using FRET4
Cyclosporin A Inhibits the Activation of Membrane-Bound Guanylate Cyclase GC-A of Atrial Natriuretic Factor <i>via</i> NAD(P)H Oxidase4
Effect of Cultivation Conditions on Components of <i>Ephedra</i> sp. Using Liquid Chromatography-Mass Spectrometry and Multivariate Analysis4
Elucidating the Factors Affecting the Patient-Centric Usability of Blister Packs for Spherical Capsules4
Amide-Directed C–H Acetoxylation of Cubanes4
Comparison of Technetium-99m-Labeled Pentapeptides as Bone Imaging Agents: Influence of Different Types of Acidic Amino Acids4
Mild and Efficient Preparation of Arylphosphonium and Arylammonium Salts under Aqueous Conditions at Room Temperature Using Pseudocyclic Arylbenziodoxaboroles as Aryne Precursors4
Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site4
Synthesis of Novel Pseudo-Enantiomeric Phase-Transfer Catalysts from <i>Cinchona</i> Alkaloids and Application to the Hydrolytic Dynamic Kinetic Resolution of Racemic 3-Phenyl-2-oxetanone4
Insights on Molecular Interaction between Polymer and Poorly Water-Soluble Loratadine in Solid Dispersion from Molecular Dynamics and Experiments4
Novel Strategies for Enantio- and Site-Selective Molecular Transformations4
Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents4
Effect of Particle Size of Powdered Cellulose Nanofibers as an Additive in the Production of Orally Disintegrating Mini-Tablets by Direct Powder Compression4
An Update Mini-Review on the Progress of Azanucleoside Analogues4
A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity4
Effect of Equipment Parameters on Amount and Dispersion of Wetting Liquid in Planetary Centrifugal Granulation4
Exploring the Effectiveness of Carboxymethylated and Crosslinked <i>Albizia procera</i> Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis4
Prediction of Intra-individual Variability in Bioequivalence Studies of 278 Formulations: Comprehensive Analysis Using Physicochemical and Pharmacokinetic Parameters4
Three-Step Synthesis of 1-Azabicyclo[1.1.0]butanes from Azetidinone and Theoretical Study of Their Stability4
Quantification of Risperidone Contained in Precipitates Produced by Tea Catechins Using Nuclear Magnetic Resonance4
Development of Fluorescent Estrogen Receptor Ligands with pH Sensor Functionality4
Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication <i>via</i> Inflammation and Fibrosis Inhibition in Mice4
Synthesis of [1-<sup>13</sup>C]2-Oxoglutaric Acid and <sup>13</sup>C Breath Tests Designed to Assess TCA Cycle Flux4
Regioselectivity Inversion in the Cycloaddition Reaction between Stable Nitrile Oxides and Acylalkyne Derivatives4
Dissolution Profiles of Oral Disintegrating Tablet with Taste Masking Granule Polymer Coating in Biorelevant Bicarbonate Buffer4
Aqueous Dispersion Polymerization for the Development of Lamivudine-Polyacrylonitrile Nanoparticles through Quality by Design Approach4
Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge <i>Psammocinia</i> sp.4
Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)4
Improved Dissolution Properties of Co-amorphous Probucol with Atorvastatin Calcium Trihydrate Prepared by Spray-Drying4
Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from <i>Streptomyces niveoruber</i>4
Crystalline Phase Transitions of 5′-<i>O</i>-Triethylsilyl-2′-deoxy-5-azacytidine under Varying Temperature and Humidity Conditions and Its Closed Storage Stability4
Substrate Flexibilities of Norbelladine Synthase and Noroxomaritidine/Norcraugsodine Reductase for Hydroxylated and/or Methoxylated Aldehydes3
Colloidal Particle in Suspensions of Maobushisaishinto Extract Granules Enhances Drug Intestinal Penetration3
Chemical Constituents of the Leaves of <i>Thujopsis dolabrata</i> and Their Cytotoxicity3
Hyaluronan Tetrasaccharides Penetrate into the Skin by Passive Diffusion and Contribute to Skin Health3
Peptide Drug Discovery through Secondary Structure Control3
Heasquinazolinone, a New Heat-Shock Metabolite Produced by Thermotolerant <i>Streptomyces</i> sp. HR413
Palladium-Catalyzed C–H Arylation of [1,1′-Biphenyl]-2-ols with Chloroarenes3
Comprehensive Synthesis of Side-Chain Fluorinated 2<i>α</i>-[2-(Tetrazol-2-yl)ethyl]-1<i>α</i>,25-dihydroxyvitamin D<sub>3</sub> Analogs and Preliminary Biological 3
Experimental and DFT Studies of Intermolecular Interaction-Assisted Oxindole Cyclization Reaction of Di-<i>t</i>-butyl 2-Aminophenyl-2-methyl Malonate3
Foreword3
Model Synthetic Study of Tutin, a Picrotoxane-Type Sesquiterpene: Stereoselective Construction of a <i>cis</i>-Fused 5,6-Ring Skeleton3
P(III)-Mediated Formal Reductive N–H Bond Insertion Reaction of Hydrazones to α-Keto Esters3
Study of Polymer Nanofilms Using for High-Throughput Screening in the Development of Transdermal Therapeutic System3
Synergistic Activation of TLR7 and 8 Mediated by Reduction of Electrostatic Repulsion3
12,20-Epoxypregnane Glycosides from the Roots of <i>Oxypetalum caeruleum</i>3
Analysis of Powder Properties of Pharmaceutical Excipients Using a Constant-Volume Shear Tester3
Peptide Tool-Driven Functional Elucidation of Biomolecules Related to Endocrine System and Metabolism3
Extremely Simple and Rapid HPLC Analysis of Tocilizumab in Human Serum with Selective Precipitation Using Alkylamine3
Development of a Standard-Free Analytical Quantitative Method Based on Liquid Chromatography Using Relative Molar Sensitivity for Chlorogenic Acid in Apple Juice3
Foreword3
Functional Characterization of Late-Stage Biosynthetic and Transporter Genes within the Biosynthetic Gene Cluster of the Organoarsenic Natural Product Bisenarsan3
From 1,4- to 1,5-Disubstituted Triazoles: Enhanced Three-Dimensionality and Aqueous Solubility3
Ion-Pair Extraction with Tetracyanocyclopentadienides: A Method for Estimating Extraction Efficiency3
Bioequivalence Dissolution Test Criteria for Formulation Development of High Solubility-Low Permeability Drugs3
Enhanced Physical Stability of L-Ascorbic Acid in an Ionic Liquid3
Bicarbonate Buffer Dissolution Test Using the Floating Lid Method: Inter-Laboratory Reproducibility of pH Maintenance3
Oxidative Functionalization of Catechol Derivatives Substituted with Electron-Withdrawing Groups3
Determination of Hardness of a Pharmaceutical Oral Jelly by Using <i>T</i><sub>2</sub> Relaxation Behavior Measured by Time-Domain NMR3
Development of Highly Sensitive Chemiluminescence Enzyme Immunostaining Assay to Determine Glycyrrhizin Content Using Anti-glycyrrhizin Monoclonal Antibody3
Determination of the Solid Content of Active Pharmaceutical Ingredient Powders in Suspension-Type Pharmaceutical Oral Jelly Using Time-Domain NMR3
Theoretical Framework for Novel Catalytic Biomolecules Composed of Multiple Peptides3
Discovery of a Fungal HR-PKS Cluster Encoding Biosynthetic Pathways for Macrolides with Two Distinct Ring Sizes3
Evaluation of STAT3 Inhibition by Cancer Chemopreventive Trichothecenes Derived from Metabolites of <i>Trichothecium roseum</i>3
Isolation and Identification of Three New Iridoid Glucosides from the Aerial Parts of <i>Paederia scandens</i>3
Development of Drug Discovery Platforms Using Artificial Intelligence and Cheminformatics3
Fragment Molecular Orbital Based Affinity Prediction toward Pyruvate Dehydrogenase Kinases: Insights into the Charge Transfer in Hydrogen Bond Networks3
Evaluation of Time-Dependent Deformation Behavior of Pharmaceutical Excipients in the Tableting Process3
Total Synthesis and Antibacterial Activity of 5-Geranyloxy-7-hydroxycoumarin and Murrayacoumarin A3
Development of Naturally Inspired Peptide and Protein Chemistry3
Electrochemical Analysis for Total Alkalinity of Water by the Measurement of Cathodic Prepeak of Quinone Caused by Surplus Acid3
Selection of Short 5′-UTR of Chemically Synthesized mRNA to Improve Translation Efficiency3
Identification of Guanine-Quadruplex-Binding Peptides from the RGG3 Domain of TLS/FUS3
Foreword3
Asymmetric Total Syntheses of Mitragynine, Speciogynine, and 7-Hydroxymitragynine3
Foreword3
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