OOIR: Observatory of International Research

Papers

(The TQCC of Chemical & Pharmaceutical Bulletin is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Development of Ethylcellulose Microparticles for Taste Masking of Fexofenadine	30
Foreword	26
Concise and Highly Stereoselective Synthesis of <i>β</i>,<i>β</i>-Disubstituted <i>α</i>,<i>β</i>-Unsaturated Esters	19
Design, Synthesis and Radioprotective Activity Evaluation of Novel <i>N</i>-Phenyl-2<i>H</i>-chromene-3-carboxamides Derived from Ex-RAD	17
Synthesis and Evaluation of Novel Triaryl Derivatives with Readthrough-Inducing Activity	15
Clinical Pipelines for Alzheimer’s Disease Psychosis and Agitation	15
2-Azanorbornane-Based Amino Amide Organocatalysts for Asymmetric Michael Addition of <i>β</i>-Keto Esters with Nitroolefins	15
Rapid Determination of Dapagliflozin in Rat Plasma by UHPLC-Q-Orbitrap MS and Its Application to a Pharmacokinetic Study	14
Teleocidin Analogs Isolated from <i>Streptomyces eurocidicus</i> as Membrane-Vesicle-Regulated Natural Products	14
Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA	14
Syntheses of Aryl Thioethers <i>via</i> Aromatic Substitution of Aryl Halides at 0 to 25 °C	13
Sprayable Intranasal Powder Formulation of Ionic Liquid-Associated Mesoporous Silica	13
Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups	12
Design, Synthesis, and Biological Evaluation of Potent Cognition-Improved Compounds Targeting AMPA Receptor Based on CX717	12
Protective Effect of Apple Polyphenols on H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress Damage in Human Colon Adenocarcinoma Caco-2 Cells	12
Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction	12
Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation <i>via</i> Attachment of <i>N</i>-Methylpyrrole at the 2-Position	11
Anti-hepatitis C Virus Activity of Juglorubin Derivatives	11
Natural Compounds with BMI1 Promoter Inhibitory Activity from <i>Mammea siamensis</i> and <i>Andrographis paniculata</i>	11
Unusual Enzymatic C–C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis	11
Design, Synthesis, and Characterization of 1-(Anthracen-9-ylmethyl)-1,5,9-triazacyclododecane (Ant-[12]aneN3) and Its DNA Photocleavage Activity	11
Synthesis of Coumarin-Conjugated Oligonucleotides <i>via</i> Knoevenagel Condensation to Prepare an Oligonucleotide Library	11
Near-Infrared Metabolic Profiling for Discrimination of Apricot and Peach Kernels	11
<i>In Vitro</i> Study on Combined Effect of Drugs for Hyperphosphatemia on Phosphorus Adsorption Capacity	11
Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V)	11

Molecular Modeling, Synthesis, and Preliminary Cytotoxicity Evaluation of New Indole-Based Molecules as Possible Sirtuin Inhibitors	10
Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine	10
Substituent Effects at the <i>N</i>-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser	10
Optimization and Advantages of Molded Tablets Using Trehalose as a Binder	10
Effectively Determining Dopamine Based on Dopamine Self-polymerization through Fluorescent Method Using Silicon Quantum Dots as Probe	10
Functions, Structures, and Engineering of the Teleocidin Biosynthetic Enzymes	10
Terminalagin, a New Ellagitannin from Kakadu Plum (<i>Terminalia ferdinandiana</i>)	10
Oxygen-Fueled Iterative Hydride Transfer Driven by a Rigid Planar Architecture	10
Liquid Chromatographic Determination of <i>o</i>-Phosphoethanolamine in Human Plasma Using Fluorescent Derivatization	9
Development of Efficient Synthetic Reactions Using Enamines and Enamides Carrying Oxygen Atom Substituent on Nitrogen Atom	9
Solid Fat Content and Relaxation Time Measurement of Petrolatum Using Time-Domain NMR, and the Correlation with Viscosity and Crystallinity	9
Aminoalkylation of Alkenes for Modular Pyrrolidine Synthesis <i>via</i> Electron Donor–Acceptor Complexes Generated from Alkenes and Amine-Tethered <i>N</i>-Hydroxyphthalimide	9
<i>p</i>-Methoxy- and 2,4-Dimethoxybenzyl <i>N</i>-Acetylcarbamate Potassium Salts: Versatile Reagents for <i>N</i>-Alkylacetamide and <i>p</i>-Methoxy-	9
Synthesis of 2-Substituted Indoles <i>via</i> Migration Reaction of 3-Substituted Indoles with Triflic Acid	9
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence	8
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite	8
Dynamic Dialysis Method for Characterizing Ammonia-Driven Drug Release from Liposomal Doxorubicin: Applicability and Kinetic Modeling	8
Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction	8
Enteric Microcapsules Encapsulation of Roxithromycin-PVP Composite Core Particles to Inhibit Drug Crystallization upon Fluidized Bed Method for Oral Administration	8
Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster	8
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine	8
Flip-Flop Promotion Mechanisms by Model Transmembrane Peptides	8
C21 Steroidal Glycosides from the Roots of <i>Oxypetalum caeruleum</i>	7
Tantalum-Catalyzed Peptide Elongation of Unprotected Amino Acids Using <i>N</i>-Trimethylsilylimidazole	7
Toward the Synthesis of Strychnos Alkaloids: Effective Construction of Fused Cyclohexane and Pyrrolidine Portion of the Strychnos Skeleton <i>via</i> Domino Intermolecular and Intramolecul	7
Chlorocyclization of Alkenoic Thioester	7
Total Synthesis of (+)-Silybin A	7
Self-assembly of Urea Derivatives into Supramolecular Gels	7
Preparation of Model Intercellular Membrane Using Low-Toxic Solvent Ethanol	7
Novel Pharmaceutical Cocrystals and Solvate Crystals of Nobiletin, a Citrus Flavonoid with Potent Pharmacological Activity	7
PEO-Reinforced Hydrogel-Forming PVA Nanofibrous Mats Prepared by Coaxial Electrospinning: A Physicochemical Basis for Biomedical Evaluation	7
Estimation for Raw Material Plants of a Henna Product Using LC-High Resolution MS and Multivariate Analysis	7
Theoretical Study of the Substituent Effect on the Diradical Character of <i>α</i>-Substituted <i>α</i>,3-Didehydrotoluenes	7
Simultaneous Overcoming Approach for Poor Wettability and Low Stability in Stomach by Simple Methods; Formulation Design and Development of Monoacylglycerol Acyltransferase 2 Inhibitor, S-309309	7
Optimized Molecular Weight of Hydroxypropyl Cellulose in Inhaled Spray-Freeze-Dried Powders for High Deagglomeration and Pulmonary Retention Abilities	7
Organocatalyzed Amine-Free <i>O</i>-Phosphorylation of Alcohols with 4-Methylpyridine <i>N</i>-Oxide	7
Evaluation of the Mechanism of Phosphate Removal Using Oyster Shell Powder in Aqueous Environments	7
8-Iodoisoquinolinone, a Conformationally Rigid Highly Reactive 2-Iodobenzamide Catalyst for the Oxidation of Alcohols by Hypervalent Iodine	7
Effects of Physicochemical Properties of Constituent Ions of Ionic Liquid on Its Permeation through a Silicone Membrane	6
Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity	6
Antiproliferative Activities of Diterpenes from Leaves of <i>Isodon trichocarpus</i> against Cancer Stem Cells	6
Foreword	6
New Candidate Preservative in Ophthalmic Solution Instead of Benzalkonium Chloride: 1,3-Didecyl-2-methyl Imidazolium Chloride	6
Effects of pH and 5-Substitution of Templated Thymine on Metal-Mediated Primer Extension Reaction by DNA Polymerases: Insights into Base Selectivity of Metal Ions	6
Development of a Novel TLC Identification Test for “Rosemary Oil” and “Rosemary Water” Listed in the Japanese Standards of Quasi-Drug Ingredients	6
Synthesis and Evaluation of DHMEQ Derivatives with Tertiary Hydroxyl Group Instead of Secondary Hydroxyl Group	6
Physical Properties for Novel Cilostazol Co-amorphous; Effect of Preparation Method and Molar Ratio on the Co-amorphous	6
Sulfonate Derivatives Containing a Kakuol Moiety as Potential Fungicidal Candidates: Design, Synthesis and Antifungal Activity Evaluation	6
Comparison of Phosphate and Bicarbonate Buffer Solutions as Dissolution Test Media for Predicting Bioequivalence of Febuxostat Formulation	6
Two New Halimanes with a <i>γ</i>-Lactone from <i>Croton argyratus</i>	6

Identification of a Functionally Efficient and Thermally Stable Outward Sodium-Pumping Rhodopsin (<i>Be</i>NaR) from a Thermophilic Bacterium	6
A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus <i>Curvularia aeria</i>	6
Exosome-Hijacking Drug Delivery System with Branched Arginine Linker Effectively Deliver Antisense Oligonucleotides into Lung Adenocarcinoma Cells	6
Inhaled Biologics: Overcoming Challenges and Recent Advances	6
Comparison of Growth in <i>Hydrangea macrophylla</i> var. <i>thunbergii</i> Grown in Different Soil pH and Quantitative Analysis of Its Sweetness-Related Constituents	5
Lewis Acid-Conjugated Pyrene Photoredox Catalyst Promoting the Addition Reaction of α-Silyl Amines with Benzalmalononitriles	5
Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)	5
Evaluation of the Effect of the Introduction of Disubstituted Amino Acids Aib on the Lipid Membrane into Amphipathic Helical Peptides K9L9	5
Electrochemical Characterization of a Novel Organoelectrocatalyst, 7-Azabicyclo[2.2.1]heptan-7-ol (ABHOL), and Its Application to Electrochemical Sensors	5
C–H▪▪▪S Hydrogen Bonds in Ampicillin and Amoxicillin Crystals Investigated by Sulfur K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy and Single-Crystal X-Ray Structure Analysis	5
Structural Characterization of Zinc(II)/Cobalt(II) Complexes of Chiral <i>N</i>-(Anthracen-9-yl)methyl-<i>N</i>,<i>N</i>-bis(2-picolyl)amine and Evaluation of DNA P	5
Synthesis, Duplex-Forming Ability, and Nuclease Resistance of Oligonucleotides Containing a Thymidine Derivative with a 1-Oxaspiro[4.5]decane Skeleton	5
Errata for Chemical and Pharmaceutical Bulletin	5
Side-Chain Fluorine Engineering of Vitamin D<sub>3</sub> Derivatives for VDR-Silent SREBP Inhibitors	5
Effect of Particle Size of Powdered Cellulose Nanofibers as an Additive in the Production of Orally Disintegrating Mini-Tablets by Direct Powder Compression	5
A Twin-Fluid Atomization Method for Fabricating Ovalbumin-Loaded Gelatin Microcapsules	5
Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents	5
Effects of Membrane Cholesterol on Stability of Transmembrane Helix Associations	5
Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain	5
GMP-Compliant Automated Radiolabeling and Quality Controls of [<sup>68</sup>Ga]Ga-FAPI-46 for Fibroblast Activation Protein-Targeted PET Imaging in Clinical Settings	5
Guided Isolation of Isopentenyl Flavonoids from <i>Daphne giraldii</i> Based on the Combination of GNPS and SMART	5
Effect of Solubility Improvement <i>via</i> Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	5
Structure–Activity Relationship Study of Affinity Peptides for the Fc Site of Human Immunoglobulin G	5
Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge <i>Psammocinia</i> sp.	5
Eurycomanoic Acids A–C: Three New Quassinoid Carboxylic Acids from <i>Eurycoma longifolia</i> (Simaroubaceae)	5
Methylene Blue Removal from the Aqueous Phase Using a Magnetic-Calcined Bamboo Composite Adsorbent	5
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities	5
Structure-Guided Engineering of 2-Oxoglutarate-Dependent Oxygenases: Principles, Case Studies, and Emerging Opportunities	5
Development of Highly Sensitive Method for Sugar Determination in Herbal Medicine; Application of Monosaccharides and Oligosaccharides in Japanese Angelica Root and Rehmannia Root	5
Compounds Designs of CK2α Inhibitors Derived from Virtual Screening Hit Compounds by Computational Chemistry with Crystallography	4
A Nonclassical <i>N</i>-Methyl Amidation Using <i>N</i>,<i>N</i>-Disubstituted Aminophosphonium Salts	4
Synthesis of Novel Pseudo-Enantiomeric Phase-Transfer Catalysts from <i>Cinchona</i> Alkaloids and Application to the Hydrolytic Dynamic Kinetic Resolution of Racemic 3-Phenyl-2-oxetanone	4
Total Synthesis and Antibacterial Activity of 5-Geranyloxy-7-hydroxycoumarin and Murrayacoumarin A	4
From 1,4- to 1,5-Disubstituted Triazoles: Enhanced Three-Dimensionality and Aqueous Solubility	4
Functional Characterization of Late-Stage Biosynthetic and Transporter Genes within the Biosynthetic Gene Cluster of the Organoarsenic Natural Product Bisenarsan	4
Cyclosporin A Inhibits the Activation of Membrane-Bound Guanylate Cyclase GC-A of Atrial Natriuretic Factor <i>via</i> NAD(P)H Oxidase	4
Crystalline Phase Transitions of 5′-<i>O</i>-Triethylsilyl-2′-deoxy-5-azacytidine under Varying Temperature and Humidity Conditions and Its Closed Storage Stability	4
Effect of Equipment Parameters on Amount and Dispersion of Wetting Liquid in Planetary Centrifugal Granulation	4
Improved Dissolution Properties of Co-amorphous Probucol with Atorvastatin Calcium Trihydrate Prepared by Spray-Drying	4
Photoaffinity Electrophoretic Mobility Shift Assay for Analyzing the Binding Specificity of DNA Aptamers to α-Thrombin	4
Dissolution Profiles of Oral Disintegrating Tablet with Taste Masking Granule Polymer Coating in Biorelevant Bicarbonate Buffer	4
Development of Fluorescent Estrogen Receptor Ligands with pH Sensor Functionality	4
Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication <i>via</i> Inflammation and Fibrosis Inhibition in Mice	4
Influence of Surfactants on the Stability of Cannabidiol, Formulated as a Water-Soluble Product, in Simulated Gastric Fluid	4
Effects of Substituting Disubstituted Amino Acids into the Amphipathic Cell Penetrating Peptide Pep-1	4
Synthesis of [1-<sup>13</sup>C]2-Oxoglutaric Acid and <sup>13</sup>C Breath Tests Designed to Assess TCA Cycle Flux	4
Foreword	4
Highly Precise Anomaly Detection Using Multivariate Statistical Process Control with Appropriate Scaling of Input Variables in Pharmaceutical Continuous Manufacturing	4
Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from <i>Streptomyces niveoruber</i>	4
Peptide Drug Discovery through Secondary Structure Control	4
An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery	4
Exploring the Effectiveness of Carboxymethylated and Crosslinked <i>Albizia procera</i> Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis	4
Elucidating the Factors Affecting the Patient-Centric Usability of Blister Packs for Spherical Capsules	4
Aqueous Dispersion Polymerization for the Development of Lamivudine-Polyacrylonitrile Nanoparticles through Quality by Design Approach	4
Three-Step Synthesis of 1-Azabicyclo[1.1.0]butanes from Azetidinone and Theoretical Study of Their Stability	4
Evaluation of Complex Formation between Aminated Polyrotaxane and Proteins Using FRET	4
Elucidating the Light-Emitting Species Generated from Aminoluciferin in Firefly/Beetle Bioluminescence	4
Comparison of Technetium-99m-Labeled Pentapeptides as Bone Imaging Agents: Influence of Different Types of Acidic Amino Acids	4
Novel Strategies for Enantio- and Site-Selective Molecular Transformations	4
Determination of the Absolute Configuration of 2′-Amino-3′-methylacetophenone Based on the Modified Mosher and Microcrystal Electron Diffraction Methods	4
Amide-Directed C–H Acetoxylation of Cubanes	4
Development of Drug Discovery Platforms Using Artificial Intelligence and Cheminformatics	4
Mild and Efficient Preparation of Arylphosphonium and Arylammonium Salts under Aqueous Conditions at Room Temperature Using Pseudocyclic Arylbenziodoxaboroles as Aryne Precursors	4
Effect of Cultivation Conditions on Components of <i>Ephedra</i> sp. Using Liquid Chromatography-Mass Spectrometry and Multivariate Analysis	4
Evaluation of Time-Dependent Deformation Behavior of Pharmaceutical Excipients in the Tableting Process	4
Insights on Molecular Interaction between Polymer and Poorly Water-Soluble Loratadine in Solid Dispersion from Molecular Dynamics and Experiments	4
Preparation of Carbonaceous Materials from Coffee Parchment and Their Potential Use for Removal of Gadolinium Ions from Aqueous Phases	4
Prediction of Intra-individual Variability in Bioequivalence Studies of 278 Formulations: Comprehensive Analysis Using Physicochemical and Pharmacokinetic Parameters	4
Quantification of Risperidone Contained in Precipitates Produced by Tea Catechins Using Nuclear Magnetic Resonance	4
Regioselectivity Inversion in the Cycloaddition Reaction between Stable Nitrile Oxides and Acylalkyne Derivatives	4
Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site	4
Two New 12-Membered Macrolides from Endophytic Fungi <i>Cladosporium tenuissimum</i> and Their Bioactivities	4
Synthesis of Formononetin Derivatives and Cardioprotective Effects	4