OOIR: Observatory of International Research

Papers

(The TQCC of Chemical & Pharmaceutical Bulletin is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Advances in Preparation of Peptide and Protein Thioesters Aiming to Use in Medicinal Sciences	47
Development of Ethylcellulose Microparticles for Taste Masking of Fexofenadine	30
Errata for Chemical and Pharmaceutical Bulletin	24
Foreword	24
Concise and Highly Stereoselective Synthesis of <i>β</i>,<i>β</i>-Disubstituted <i>α</i>,<i>β</i>-Unsaturated Esters	21
Rapid Determination of Dapagliflozin in Rat Plasma by UHPLC-Q-Orbitrap MS and Its Application to a Pharmacokinetic Study	19
Teleocidin Analogs Isolated from <i>Streptomyces eurocidicus</i> as Membrane-Vesicle-Regulated Natural Products	15
Synthesis and Evaluation of Novel Triaryl Derivatives with Readthrough-Inducing Activity	15
Design, Synthesis and Radioprotective Activity Evaluation of Novel <i>N</i>-Phenyl-2<i>H</i>-chromene-3-carboxamides Derived from Ex-RAD	14
2-Azanorbornane-Based Amino Amide Organocatalysts for Asymmetric Michael Addition of <i>β</i>-Keto Esters with Nitroolefins	14
Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction	13
Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA	13
Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups	13
Syntheses of Aryl Thioethers <i>via</i> Aromatic Substitution of Aryl Halides at 0 to 25 °C	13
Protective Effect of Apple Polyphenols on H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress Damage in Human Colon Adenocarcinoma Caco-2 Cells	13
Clinical Pipelines for Alzheimer’s Disease Psychosis and Agitation	13
Unusual Enzymatic C–C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis	11
Design, Synthesis, and Characterization of 1-(Anthracen-9-ylmethyl)-1,5,9-triazacyclododecane (Ant-[12]aneN3) and Its DNA Photocleavage Activity	11
Anti-hepatitis C Virus Activity of Juglorubin Derivatives	11
Substituent Effects at the <i>N</i>-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser	11
<i>In Vitro</i> Study on Combined Effect of Drugs for Hyperphosphatemia on Phosphorus Adsorption Capacity	11
Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation <i>via</i> Attachment of <i>N</i>-Methylpyrrole at the 2-Position	11
Near-Infrared Metabolic Profiling for Discrimination of Apricot and Peach Kernels	11
Elucidation of Degradation Behavior of Barbiturates in Artificial Gastric Juice: Study on Degradability of Drugs in Stomach (V)	11
Natural Compounds with BMI1 Promoter Inhibitory Activity from <i>Mammea siamensis</i> and <i>Andrographis paniculata</i>	10

Development of a Potential-Modulated Electrochemiluminescence Measurement System for Selective and Sensitive Determination of the Controlled Drug Codeine	10
Optimization and Advantages of Molded Tablets Using Trehalose as a Binder	10
Effectively Determining Dopamine Based on Dopamine Self-polymerization through Fluorescent Method Using Silicon Quantum Dots as Probe	10
Synthesis of Coumarin-Conjugated Oligonucleotides <i>via</i> Knoevenagel Condensation to Prepare an Oligonucleotide Library	10
Aminoalkylation of Alkenes for Modular Pyrrolidine Synthesis <i>via</i> Electron Donor–Acceptor Complexes Generated from Alkenes and Amine-Tethered <i>N</i>-Hydroxyphthalimide	9
Functions, Structures, and Engineering of the Teleocidin Biosynthetic Enzymes	9
Solid Fat Content and Relaxation Time Measurement of Petrolatum Using Time-Domain NMR, and the Correlation with Viscosity and Crystallinity	9
Terminalagin, a New Ellagitannin from Kakadu Plum (<i>Terminalia ferdinandiana</i>)	9
Molecular Modeling, Synthesis, and Preliminary Cytotoxicity Evaluation of New Indole-Based Molecules as Possible Sirtuin Inhibitors	9
<i>p</i>-Methoxy- and 2,4-Dimethoxybenzyl <i>N</i>-Acetylcarbamate Potassium Salts: Versatile Reagents for <i>N</i>-Alkylacetamide and <i>p</i>-Methoxy-	9
Synthesis of 2-Substituted Indoles <i>via</i> Migration Reaction of 3-Substituted Indoles with Triflic Acid	9
Oxygen-Fueled Iterative Hydride Transfer Driven by a Rigid Planar Architecture	9
Development of Efficient Synthetic Reactions Using Enamines and Enamides Carrying Oxygen Atom Substituent on Nitrogen Atom	9
The Effect of Iontophoresis with and without Electroporation on the Penetration of High Molecular Compounds into the Stratum Corneum	9
Dynamic Dialysis Method for Characterizing Ammonia-Driven Drug Release from Liposomal Doxorubicin: Applicability and Kinetic Modeling	8
Enteric Microcapsules Encapsulation of Roxithromycin-PVP Composite Core Particles to Inhibit Drug Crystallization upon Fluidized Bed Method for Oral Administration	8
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine	8
Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction	8
Liquid Chromatographic Determination of <i>o</i>-Phosphoethanolamine in Human Plasma Using Fluorescent Derivatization	8
Evaluation of the Mechanism of Phosphate Removal Using Oyster Shell Powder in Aqueous Environments	8
Palatability of Aripiprazole Gummies Prepared from Commercially Available Products: Pharmaceutical Formulation for Improving Patient Adherence	8
Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite	8
Flip-Flop Promotion Mechanisms by Model Transmembrane Peptides	8
Estimation for Raw Material Plants of a Henna Product Using LC-High Resolution MS and Multivariate Analysis	7
8-Iodoisoquinolinone, a Conformationally Rigid Highly Reactive 2-Iodobenzamide Catalyst for the Oxidation of Alcohols by Hypervalent Iodine	7
C21 Steroidal Glycosides from the Roots of <i>Oxypetalum caeruleum</i>	7
Development of a Novel TLC Identification Test for “Rosemary Oil” and “Rosemary Water” Listed in the Japanese Standards of Quasi-Drug Ingredients	7
Self-assembly of Urea Derivatives into Supramolecular Gels	7
Transport Characteristics of Placenta-Derived Extracellular Vesicles and Their Relevance to Placenta-to-Maternal Tissue Communication	7
Toward the Synthesis of Strychnos Alkaloids: Effective Construction of Fused Cyclohexane and Pyrrolidine Portion of the Strychnos Skeleton <i>via</i> Domino Intermolecular and Intramolecul	7
Identification of a Functionally Efficient and Thermally Stable Outward Sodium-Pumping Rhodopsin (<i>Be</i>NaR) from a Thermophilic Bacterium	7
Preparation of Model Intercellular Membrane Using Low-Toxic Solvent Ethanol	7
Chlorocyclization of Alkenoic Thioester	7
Isolation and Structure Elucidation of JBIR-157, a Skeletally Novel Aromatic Polyketide Produced by the Heterologous Expression of a Cryptic Gene Cluster	7
Organocatalyzed Amine-Free <i>O</i>-Phosphorylation of Alcohols with 4-Methylpyridine <i>N</i>-Oxide	7
Theoretical Study of the Substituent Effect on the Diradical Character of <i>α</i>-Substituted <i>α</i>,3-Didehydrotoluenes	7
Optimization of the Hydrothermal Activation Treatment with Sodium Hydroxide Solution for the Conversion of Coal Fly Ash to Zeolite and Its Adsorption Capability of Lead (II) Ions from the Liquid Phase	7
Two New Halimanes with a <i>γ</i>-Lactone from <i>Croton argyratus</i>	7
Total Synthesis of (+)-Silybin A	7
Simultaneous Overcoming Approach for Poor Wettability and Low Stability in Stomach by Simple Methods; Formulation Design and Development of Monoacylglycerol Acyltransferase 2 Inhibitor, S-309309	6
Effects of Physicochemical Properties of Constituent Ions of Ionic Liquid on Its Permeation through a Silicone Membrane	6
Tantalum-Catalyzed Peptide Elongation of Unprotected Amino Acids Using <i>N</i>-Trimethylsilylimidazole	6
Physical Properties for Novel Cilostazol Co-amorphous; Effect of Preparation Method and Molar Ratio on the Co-amorphous	6
First Total Syntheses of Natural Phenanthrene Alkaloids, Uvariopsamine, Noruvariopsamine, 8-Hydroxystephenanthrine, 8-Methoxyuvariopsine, Thalihazine, and Secophoebine, and Their Potential as Antimala	6
Isosteric Replacement of Ester Linkage of Lysophospholipids with Heteroaromatic Rings Retains Potency and Subtype Selectivity	6
Novel Pharmaceutical Cocrystals and Solvate Crystals of Nobiletin, a Citrus Flavonoid with Potent Pharmacological Activity	6
PEO-Reinforced Hydrogel-Forming PVA Nanofibrous Mats Prepared by Coaxial Electrospinning: A Physicochemical Basis for Biomedical Evaluation	6
Comparison of Phosphate and Bicarbonate Buffer Solutions as Dissolution Test Media for Predicting Bioequivalence of Febuxostat Formulation	6
Sulfonate Derivatives Containing a Kakuol Moiety as Potential Fungicidal Candidates: Design, Synthesis and Antifungal Activity Evaluation	6
Effects of pH and 5-Substitution of Templated Thymine on Metal-Mediated Primer Extension Reaction by DNA Polymerases: Insights into Base Selectivity of Metal Ions	6

Optimized Molecular Weight of Hydroxypropyl Cellulose in Inhaled Spray-Freeze-Dried Powders for High Deagglomeration and Pulmonary Retention Abilities	6
Antiproliferative Activities of Diterpenes from Leaves of <i>Isodon trichocarpus</i> against Cancer Stem Cells	6
Synthesis and Evaluation of DHMEQ Derivatives with Tertiary Hydroxyl Group Instead of Secondary Hydroxyl Group	6
A Tricyclic Aromatic Polyketide Isolated from the Marine-Derived Fungus <i>Curvularia aeria</i>	6
Inhaled Biologics: Overcoming Challenges and Recent Advances	6
Lewis Acid-Conjugated Pyrene Photoredox Catalyst Promoting the Addition Reaction of α-Silyl Amines with Benzalmalononitriles	5
Structure-Guided Engineering of 2-Oxoglutarate-Dependent Oxygenases: Principles, Case Studies, and Emerging Opportunities	5
Electrochemical Characterization of a Novel Organoelectrocatalyst, 7-Azabicyclo[2.2.1]heptan-7-ol (ABHOL), and Its Application to Electrochemical Sensors	5
Side-Chain Fluorine Engineering of Vitamin D<sub>3</sub> Derivatives for VDR-Silent SREBP Inhibitors	5
C–H▪▪▪S Hydrogen Bonds in Ampicillin and Amoxicillin Crystals Investigated by Sulfur K-Edge X-Ray Absorption Near-Edge Structure Spectroscopy and Single-Crystal X-Ray Structure Analysis	5
Comparison of Growth in <i>Hydrangea macrophylla</i> var. <i>thunbergii</i> Grown in Different Soil pH and Quantitative Analysis of Its Sweetness-Related Constituents	5
Remarkable Solvent Effect of Fluorinated Alcohols on Azo–Ene Reactions	5
Exosome-Hijacking Drug Delivery System with Branched Arginine Linker Effectively Deliver Antisense Oligonucleotides into Lung Adenocarcinoma Cells	5
Development of Highly Sensitive Method for Sugar Determination in Herbal Medicine; Application of Monosaccharides and Oligosaccharides in Japanese Angelica Root and Rehmannia Root	5
Effects of Membrane Cholesterol on Stability of Transmembrane Helix Associations	5
Synthesis and Characterization of Novel Radioiodinated Triazole-Pyrolidine Derivative to Detect Orexin 2 Receptor in the Brain	5
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities	5
Synthesis, Duplex-Forming Ability, and Nuclease Resistance of Oligonucleotides Containing a Thymidine Derivative with a 1-Oxaspiro[4.5]decane Skeleton	5
New Candidate Preservative in Ophthalmic Solution Instead of Benzalkonium Chloride: 1,3-Didecyl-2-methyl Imidazolium Chloride	5
Guided Isolation of Isopentenyl Flavonoids from <i>Daphne giraldii</i> Based on the Combination of GNPS and SMART	5
Errata for Chemical and Pharmaceutical Bulletin	5
Methylene Blue Removal from the Aqueous Phase Using a Magnetic-Calcined Bamboo Composite Adsorbent	5
Structural Characterization of Zinc(II)/Cobalt(II) Complexes of Chiral <i>N</i>-(Anthracen-9-yl)methyl-<i>N</i>,<i>N</i>-bis(2-picolyl)amine and Evaluation of DNA P	5
Design, Synthesis and Cytotoxicity Evalufation of Substituted Benzimidazole Conjugated 1,3,4-Oxadiazoles	5
Structure–Activity Relationship Study of Affinity Peptides for the Fc Site of Human Immunoglobulin G	5
Effect of Solubility Improvement <i>via</i> Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability	5
Foreword	5
Compounds Designs of CK2α Inhibitors Derived from Virtual Screening Hit Compounds by Computational Chemistry with Crystallography	4
Cyclosporin A Inhibits the Activation of Membrane-Bound Guanylate Cyclase GC-A of Atrial Natriuretic Factor <i>via</i> NAD(P)H Oxidase	4
Total Synthesis and Antibacterial Activity of 5-Geranyloxy-7-hydroxycoumarin and Murrayacoumarin A	4
Elucidating the Factors Affecting the Patient-Centric Usability of Blister Packs for Spherical Capsules	4
The New Delivery Strategy of Albumin Carrier Utilizing the Interaction with Albumin Receptors	4
Influence of Surfactants on the Stability of Cannabidiol, Formulated as a Water-Soluble Product, in Simulated Gastric Fluid	4
Three-Step Synthesis of 1-Azabicyclo[1.1.0]butanes from Azetidinone and Theoretical Study of Their Stability	4
Dissolution Profiles of Oral Disintegrating Tablet with Taste Masking Granule Polymer Coating in Biorelevant Bicarbonate Buffer	4
Development of Fluorescent Estrogen Receptor Ligands with pH Sensor Functionality	4
Development of an Artificial Nucleic Acid Skeleton Allowing for Unnatural-Type Triplex DNA Formation with Duplex DNA Having a TA Inversion Site	4
Determination of the Absolute Configuration of 2′-Amino-3′-methylacetophenone Based on the Modified Mosher and Microcrystal Electron Diffraction Methods	4
Novel Strategies for Enantio- and Site-Selective Molecular Transformations	4
Aqueous Dispersion Polymerization for the Development of Lamivudine-Polyacrylonitrile Nanoparticles through Quality by Design Approach	4
GMP-Compliant Automated Radiolabeling and Quality Controls of [<sup>68</sup>Ga]Ga-FAPI-46 for Fibroblast Activation Protein-Targeted PET Imaging in Clinical Settings	4
Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT)	4
Effect of Equipment Parameters on Amount and Dispersion of Wetting Liquid in Planetary Centrifugal Granulation	4
Five New Analogs of Streptogramin Antibiotic Viridogrisein Isolated from <i>Streptomyces niveoruber</i>	4
Development of an Antigen Delivery System for a B Cell-Targeted Vaccine as an Alternative to Dendritic Cell-Targeted Vaccines	4
Prediction of Intra-individual Variability in Bioequivalence Studies of 278 Formulations: Comprehensive Analysis Using Physicochemical and Pharmacokinetic Parameters	4
Development and Validation of an LC–MS/MS-Based Method for Quantifying Urinary Endogenous 6-Hydroxymelatonin	4
Synthesis of Formononetin Derivatives and Cardioprotective Effects	4
Regioselectivity Inversion in the Cycloaddition Reaction between Stable Nitrile Oxides and Acylalkyne Derivatives	4
An Amphipathic Structure of a Dipropylglycine-Containing Helical Peptide with Sufficient Length Enables Safe and Effective Intracellular siRNA Delivery	4
Synthesis of Novel Pseudo-Enantiomeric Phase-Transfer Catalysts from <i>Cinchona</i> Alkaloids and Application to the Hydrolytic Dynamic Kinetic Resolution of Racemic 3-Phenyl-2-oxetanone	4
Quantification of Risperidone Contained in Precipitates Produced by Tea Catechins Using Nuclear Magnetic Resonance	4
Amide-Directed C–H Acetoxylation of Cubanes	4
Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge <i>Psammocinia</i> sp.	4
Effects of Substituting Disubstituted Amino Acids into the Amphipathic Cell Penetrating Peptide Pep-1	4
An Update Mini-Review on the Progress of Azanucleoside Analogues	4
Exploring the Effectiveness of Carboxymethylated and Crosslinked <i>Albizia procera</i> Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis	4
Elucidating the Light-Emitting Species Generated from Aminoluciferin in Firefly/Beetle Bioluminescence	4
Effect of Cultivation Conditions on Components of <i>Ephedra</i> sp. Using Liquid Chromatography-Mass Spectrometry and Multivariate Analysis	4
Insights on Molecular Interaction between Polymer and Poorly Water-Soluble Loratadine in Solid Dispersion from Molecular Dynamics and Experiments	4
Highly Precise Anomaly Detection Using Multivariate Statistical Process Control with Appropriate Scaling of Input Variables in Pharmaceutical Continuous Manufacturing	4
Crystalline Phase Transitions of 5′-<i>O</i>-Triethylsilyl-2′-deoxy-5-azacytidine under Varying Temperature and Humidity Conditions and Its Closed Storage Stability	4
Improved Dissolution Properties of Co-amorphous Probucol with Atorvastatin Calcium Trihydrate Prepared by Spray-Drying	4
Mild and Efficient Preparation of Arylphosphonium and Arylammonium Salts under Aqueous Conditions at Room Temperature Using Pseudocyclic Arylbenziodoxaboroles as Aryne Precursors	4
Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication <i>via</i> Inflammation and Fibrosis Inhibition in Mice	4
Synthesis of [1-<sup>13</sup>C]2-Oxoglutaric Acid and <sup>13</sup>C Breath Tests Designed to Assess TCA Cycle Flux	4
Comparison of Technetium-99m-Labeled Pentapeptides as Bone Imaging Agents: Influence of Different Types of Acidic Amino Acids	4
A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity	4
Epigenetic Inhibitors as Alzheimer’s Disease Therapeutic Agents	4
Effect of Particle Size of Powdered Cellulose Nanofibers as an Additive in the Production of Orally Disintegrating Mini-Tablets by Direct Powder Compression	4