Cardiovascular Research

Papers
(The TQCC of Cardiovascular Research is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)
ArticleCitations
Global burden of heart failure: a comprehensive and updated review of epidemiology924
Cardiac fibrosis540
Vascular smooth muscle cells in atherosclerosis: time for a re-assessment214
Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome133
Neutrophil extracellular traps: from physiology to pathology131
Senescence mechanisms and targets in the heart124
Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets110
Environmental risk factors and cardiovascular diseases: a comprehensive expert review109
NLRP3 inflammasome as a key driver of vascular disease104
Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute Card102
mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification101
Obesity, kidney dysfunction, and inflammation: interactions in hypertension97
The role of CD36 in cardiovascular disease95
Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart92
NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias85
Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working 82
Optimizing indices of atrial fibrillation susceptibility and burden to evaluate atrial fibrillation severity, risk and outcomes74
Side effects of statins: from pathophysiology and epidemiology to diagnostic and therapeutic implications73
Inflammation during the life cycle of the atherosclerotic plaque73
Loss of Yap/Taz in cardiac fibroblasts attenuates adverse remodelling and improves cardiac function70
The key contribution of platelet and vascular arachidonic acid metabolism to the pathophysiology of atherothrombosis69
Physiological and pathological roles of protein kinase A in the heart66
Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis66
Soil and water pollution and human health: what should cardiologists worry about?65
Risk factors profile of young and older patients with myocardial infarction64
Emerging views of statin pleiotropy and cholesterol lowering64
Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases63
Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications63
Interleukin-1β suppression dampens inflammatory leucocyte production and uptake in atherosclerosis62
Transthyretin cardiac amyloidosis61
Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension60
Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles60
From RESCUE to ZEUS: will interleukin-6 inhibition with ziltivekimab prove effective for cardiovascular event reduction?59
Dietary recommendations for prevention of atherosclerosis59
Titin (TTN): from molecule to modifications, mechanics, and medical significance55
Association of COVID-19 with short- and long-term risk of cardiovascular disease and mortality: a prospective cohort in UK Biobank55
Relationship between lipoproteins, thrombosis, and atrial fibrillation54
Dynamics of monocyte-derived macrophage diversity in experimental myocardial infarction53
Cell therapy in patients with heart failure: a comprehensive review and emerging concepts53
Association of cardiometabolic microRNAs with COVID-19 severity and mortality52
Computational models of atrial fibrillation: achievements, challenges, and perspectives for improving clinical care50
Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer49
Fibrin clot properties in cardiovascular disease: from basic mechanisms to clinical practice48
Myocardin-related transcription factor A regulates integrin beta 2 transcription to promote macrophage infiltration and cardiac hypertrophy in mice47
Vascular endothelial tissue factor contributes to trimethylamine N-oxide-enhanced arterial thrombosis47
Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart47
The role of autophagy in cardiovascular pathology46
How machine learning is impacting research in atrial fibrillation: implications for risk prediction and future management46
Efficacy and limitations of senolysis in atherosclerosis45
Sodium-glucose co-transporter 2 inhibitor empagliflozin inhibits the cardiac Na+/H+ exchanger 1: persistent inhibition under various experimental conditions45
Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart44
Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension44
Cardiovascular complications in chronic kidney disease: a review from the European Renal and Cardiovascular Medicine Working Group of the European Renal Association43
Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working 43
Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions43
Sex differences in cardiorespiratory fitness are explained by blood volume and oxygen carrying capacity42
Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells42
Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq40
Concurrent diabetes and heart failure: interplay and novel therapeutic approaches40
Endothelial cell metabolic memory causes cardiovascular dysfunction in diabetes40
Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP1040
EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization40
Role of oxidative stress in calcific aortic valve disease and its therapeutic implications39
Neuroscientific therapies for atrial fibrillation39
Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission38
Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it38
Mapping the developing human cardiac endothelium at single-cell resolution identifies MECOM as a regulator of arteriovenous gene expression37
From organic and inorganic phosphates to valvular and vascular calcifications37
Treatment and prevention of lipoprotein(a)-mediated cardiovascular disease: the emerging potential of RNA interference therapeutics37
Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury37
Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study36
Role of the vascular endothelial sodium channel activation in the genesis of pathologically increased cardiovascular stiffness36
Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis36
Human-induced pluripotent stem cells in cardiovascular research: current approaches in cardiac differentiation, maturation strategies, and scalable production35
Exercise effects on cardiovascular disease: from basic aspects to clinical evidence35
Coronary microcirculation damage in anthracycline cardiotoxicity35
Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes34
Cholesteryl ester transfer protein inhibitors: from high-density lipoprotein cholesterol to low-density lipoprotein cholesterol lowering agents?34
Metabolic alterations in a rat model of takotsubo syndrome34
Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes33
Flow-mediated dilation reference values for evaluation of endothelial function and cardiovascular health33
Plasma high-density lipoprotein cholesterol and risk of dementia: observational and genetic studies33
Heart–gut microbiota communication determines the severity of cardiac injury after myocardial ischaemia/reperfusion33
The vasculature: a therapeutic target in heart failure?32
Central role of c-Src in NOX5- mediated redox signalling in vascular smooth muscle cells in human hypertension32
Circulating microRNAs predispose to takotsubo syndrome following high-dose adrenaline exposure32
Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact32
Empagliflozin inhibits excessive autophagy through the AMPK/GSK3β signalling pathway in diabetic cardiomyopathy32
Interleukin-5-induced eosinophil population improves cardiac function after myocardial infarction31
Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications31
Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options31
Reciprocal organ interactions during heart failure: a position paper from the ESC Working Group on Myocardial Function30
Remodelling of adult cardiac tissue subjected to physiological and pathological mechanical load in vitro30
MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling30
HDAC1: an environmental sensor regulating endothelial function30
Phenomapping in heart failure with preserved ejection fraction: insights, limitations, and future directions30
Cardiac metabolism in HFpEF: from fuel to signalling30
European Society of Cardiology guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1—epidemiology, pathophysiology, and diagnosis30
Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart30
SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy30
G protein-coupled receptor kinase 5 (GRK5) contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure29
COVID-19-related cardiac complications from clinical evidences to basic mechanisms: opinion paper of the ESC Working Group on Cellular Biology of the Heart29
Anxa1 in smooth muscle cells protects against acute aortic dissection29
Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcircul29
The complex network of mTOR signalling in the heart28
Ketone therapy for heart failure: current evidence for clinical use28
Sequence meets function—microbiota and cardiovascular disease28
ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 2—care pathways, treatment, and follow-up28
Management of cardiac fibrosis is the largest unmet medical need in heart failure28
Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart28
Natriuretic peptide pathways in heart failure: further therapeutic possibilities27
Asymmetric Hapln1a drives regionalized cardiac ECM expansion and promotes heart morphogenesis in zebrafish development27
New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation27
The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism27
The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation27
Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart27
Rapid neutrophil mobilization by VCAM-1+ endothelial cell-derived extracellular vesicles27
Prevalence of microvascular angina among patients with stable symptoms in the absence of obstructive coronary artery disease: a systematic review26
Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion26
Non-invasive transcutaneous vagal nerve stimulation improves myocardial performance in doxorubicin-induced cardiotoxicity26
Coronary artery disease patients without standard modifiable risk factors (SMuRFs)- a forgotten group calling out for new discoveries26
Innate and adaptive immunity: the understudied driving force of heart valve disease26
Network medicine in Cardiovascular Research26
Determining a minimum set of variables for machine learning cardiovascular event prediction: results from REFINE SPECT registry26
Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy26
New therapies for obesity26
Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology26
Two-faced Janus: the dual role of macrophages in atherosclerotic calcification26
Functional and structural adaptations of the coronary macro- and microvasculature to regular aerobic exercise by activation of physiological, cellular, and molecular mechanisms: ESC Working Group on C25
Central and peripheral sympathetic activation in heart failure25
Chronically elevated branched chain amino acid levels are pro-arrhythmic25
Impairment of mitophagy and autophagy accompanies calcific aortic valve stenosis favouring cell death and the severity of disease25
Obesity increases heart failure incidence and mortality: observational and Mendelian randomization studies totalling over 1 million individuals25
Chitinase 3 like 1 is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability25
The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells25
SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX25
Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus25
Mitochondrial calcium and reactive oxygen species in cardiovascular disease25
Two-hit mechanism of cardiac arrhythmias in diabetic hyperglycaemia: reduced repolarization reserve, neurohormonal stimulation, and heart failure exacerbate susceptibility25
No sex-related differences in infarct size, no-reflow, and protection by ischaemic pre-conditioning in Göttingen minipigs25
Sex differences in acute cardiovascular care: a review and needs assessment25
Evolution of drug-eluting coronary stents: a back-and-forth journey from the bench to bedside24
Association between BNT162b2 or CoronaVac COVID-19 vaccines and major adverse cardiovascular events among individuals with cardiovascular disease24
Patient-specific iPSC-derived cardiomyocytes reveal abnormal regulation of FGF16 in a familial atrial septal defect24
Cardiovascular effects of non-insulin glucose-lowering agents: a comprehensive review of trial evidence and potential cardioprotective mechanisms24
Kcnk3 dysfunction exaggerates the development of pulmonary hypertension induced by left ventricular pressure overload24
Cardiovascular comorbidities, inflammation, and cerebral small vessel disease24
Extracellular histones are a target in myocardial ischaemia–reperfusion injury24
Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance24
Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications24
Neutrophils in cardiovascular disease: warmongers, peacemakers, or both?24
Dissecting the transcriptome in cardiovascular disease24
Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes23
Hooked on heart regeneration: the zebrafish guide to recovery23
Emerging epigenetic therapies of cardiac fibrosis and remodelling in heart failure: from basic mechanisms to early clinical development23
Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation23
Deciphering endothelial heterogeneity in health and disease at single-cell resolution: progress and perspectives23
Rosuvastatin for the prevention of venous thromboembolism: a pooled analysis of the HOPE-3 and JUPITER randomized controlled trials23
Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice23
Remdesivir induces persistent mitochondrial and structural damage in human induced pluripotent stem cell-derived cardiomyocytes23
Endothelial mechanobiology in atherosclerosis23
Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling23
Therapeutic targeting of inflammation in hypertension: from novel mechanisms to translational perspective23
Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis23
Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension22
Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage22
Cardiac xenotransplantation: from concept to clinic22
The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure22
Acute coronary syndrome is associated with a substantial change in the platelet lipidome22
Interferon-stimulated gene 15 pathway is a novel mediator of endothelial dysfunction and aneurysms development in angiotensin II infused mice through increased oxidative stress22
Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis22
Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage22
Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: a position paper from the EU-CardioRNA COST action CA1712921
The effects of cardiac stretch on atrial fibroblasts: analysis of the evidence and potential role in atrial fibrillation21
Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation21
MicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease21
Trimethylamine N-oxide induces osteogenic responses in human aortic valve interstitial cells in vitro and aggravates aortic valve lesions in mice21
Cardiac lipid metabolism, mitochondrial function, and heart failure21
Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels21
Heterogeneous subpopulations of adventitial progenitor cells regulate vascular homeostasis and pathological vascular remodelling21
The role of immunoglobulin E and mast cells in hypertension21
Targeting the Hippo pathway in heart repair21
Human cardiosphere-derived stromal cells exposed to SARS-CoV-2 evolve into hyper-inflammatory/pro-fibrotic phenotype and produce infective viral particles depending on the levels of ACE2 recept20
Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy20
The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single-cell resolution20
Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload20
Current progress in clinical, molecular, and genetic aspects of adult fibromuscular dysplasia20
Novel approaches to mechanism-based atrial fibrillation ablation20
AIM2-driven inflammasome activation in heart failure20
Cardiac troponin and defining myocardial infarction20
Preferential uptake of SARS-CoV-2 by pericytes potentiates vascular damage and permeability in an organoid model of the microvasculature20
Cellular mechanisms of oligoclonal vascular smooth muscle cell expansion in cardiovascular disease20
Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes20
Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure20
Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells20
Culprit site extracellular DNA and microvascular obstruction in ST-elevation myocardial infarction20
Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy19
Temporal relationship between systemic endothelial dysfunction and alterations in erythrocyte function in a murine model of chronic heart failure19
Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia19
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion19
The size of apolipoprotein (a) is an independent determinant of the reduction in lipoprotein (a) induced by PCSK9 inhibitors19
The regulation of cardiac intermediary metabolism by NADPH oxidases19
Nicotine exacerbates endothelial dysfunction and drives atherosclerosis via extracellular vesicle-miRNA19
Long-term trends in the epidemiology of cardiovascular diseases in the UK: insights from the British Heart Foundation statistical compendium19
Impacts of a high-fat diet on the metabolic profile and the phenotype of atrial myocardium in mice19
Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the E19
Low-molecular-weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: a retrospective multicentre observational study19
Targeted delivery of protein arginine deiminase-4 inhibitors to limit arterial intimal NETosis and preserve endothelial integrity19
Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism19
SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens18
Cardiovascular disease related circulating biomarkers and cancer incidence and mortality: is there an association?18
Testosterone therapy and cardiovascular diseases18
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk18
Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state18
Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis18
Cardiac muscle patches containing four types of cardiac cells derived from human pluripotent stem cells improve recovery from cardiac injury in mice18
Aldosterone and cardiovascular diseases18
TNFα induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNFα antibodies18
Cell senescence: basic mechanisms and the need for computational networks in vascular ageing18
Monocyte heterogeneity in cardiovascular disease18
FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation18
Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1–directed novel therapeutics17
Natriuretic peptide receptor B maintains heart rate and sinoatrial node function via cyclic GMP-mediated signalling17
Humoral immunity in atherosclerosis and myocardial infarction: from B cells to antibodies17
Contributions of obesity to kidney health and disease: insights from Mendelian randomization and the human kidney transcriptomics17
Angiotensin II receptor 1 controls profibrotic Wnt/β-catenin signalling in experimental autoimmune myocarditis17
FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis17
Cardiovascular RNA markers and artificial intelligence may improve COVID-19 outcome: a position paper from the EU-CardioRNA COST Action CA1712917
Takotsubo syndrome: getting closer to its causes17
Genetics of atrial fibrillation—practical applications for clinical management: if not now, when and how?17
Myocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 117
Atherosclerosis is a major human killer and non-resolving inflammation is a prime suspect17
Single-cell profiling reveals age-associated immunity in atherosclerosis17
Epicardial origin of cardiac arrhythmias: clinical evidences and pathophysiology17
Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects17
Arrhythmogenesis in the aged heart following ischaemia–reperfusion: role of transient receptor potential vanilloid 416
Neuronal nitric oxide synthase regulates regional brain perfusion in healthy humans16
Resistin deletion protects against heart failure injury by targeting DNA damage response16
Inhibition of phosphoglycerate kinase 1 attenuates autoimmune myocarditis by reprogramming CD4+ T cell metabolism16
Adiponectin and cardiometabolic trait and mortality: where do we go?16
Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis16
NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis16
Down-regulation of AMPK/PPARδ signalling promotes endoplasmic reticulum stress-induced endothelial dysfunction in adult rat offspring exposed to maternal diabetes16
Neutralization of S100A4 induces stabilization of atherosclerotic plaques: role of smooth muscle cells16
Tbx5 variants disrupt Nav1.5 function differently in patients diagnosed with Brugada or Long QT Syndrome16
Influence of sex on intracellular calcium homoeostasis in patients with atrial fibrillation16
The effect of probiotic and synbiotic supplementation on lipid parameters among patients with cardiometabolic risk factors: a systematic review and meta-analysis of clinical trials16
Apolipoprotein B is an insufficient explanation for the risk of coronary disease associated with lipoprotein(a)16
New biomarkers from multiomics approaches: improving risk prediction of atrial fibrillation15
The role of the Hippo pathway in autophagy in the heart15
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