OOIR: Observatory of International Research

Papers

(The TQCC of Canadian Journal of Physiology and Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K⁺ channel pathway	27
Correction: Cardiac physiology and pathophysiology in pregnancy	25
Detection of joining points for genomic DNA circularization in cell culture	17
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	16
Note of appreciation	16
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	15
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats	15
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	15
Existence and importance of Na⁺K⁺-ATPase in the plasma membrane of boar spermatozoa	15
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	14
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	14
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	14
Sex-specific considerations in cardiovascular drug therapy	14
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	13
The impact of ionizing radiation compared to drug-induced immunological changes	13
Cardiogenic shock—sex-specific risk factors and outcome differences	12
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	12
Canadian Society of Pharmacology and Therapeutics	12
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	12
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	12
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	11
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	11
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	11
Histamine H₃ receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	11
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	11

Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	10
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	10
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	9
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	9
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	9
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	9
Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart	9
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	8
Endoplasmic reticulum stress, calcium homeostasis and the aging heart	8
Clozapine and pharmacogenomics testing: opportunities and challenges for personalized treatment in schizophrenia	8
Gender-specific side effects of chemotherapy in pancreatic cancer patients	8
Exogenous and endogenous antioxidants (ROS) in Physiology and Pathology of the Cardiovascular System	8
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	8
Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative	7
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	7
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	7
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	7
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	7
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	7
Right ventricular dysfunction in preclinical models of type I and type II diabetes	7
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	7
Focus on aging, heart failure, regeneration, and cardiovascular medicine	7
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	6
Canadian Society of Pharmacology and Therapeutics	6
Myotubularin related protein 7, a novel STIM1 binding protein	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	6
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	6
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	6
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	6
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	6
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	6
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	6
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	6
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering	5
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa	5
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	5
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
The addictive process of opioids: current and novel interventions in opioid use disorder	5
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	5
Note of appreciation	5
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	5
Time to treat the climate and nature crisis as one indivisible global health emergency	5

Introduction—Unveiling gender disparity in heart disease	5
Deferoxamine alleviates brain ischemia/reperfusion injury through decreasing LAG-3 and α-Syn expression	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
Correction: Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	5
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	5
Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review	4
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	4
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	4
Untangling the Heart–Brain Connection in Parkinson’s Disease: Emerging Mechanisms and Models	4
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	4
Formation of a border ischemic zone depends on plasma potassium concentration	4
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
Modified cancer TNM classification for localized renal cell carcinoma based on the prognostic analysis of 3748 cases from a single center	4
Effect of intracutaneous pyonex on analgesia and sedation in critically ill patients with mechanical ventilation	4
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	4
New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: In vivo and In silico studies	4
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	4
Maternal high-fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	4
Epigenetic regulation of sex dimorphism in cardiovascular health	4
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	4
High-sensitivity troponin I-guided cardiovascular risk assessment in a general asymptomatic population: a cost-effectiveness analysis in 4000 adults	4
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	4
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca²⁺ influx	4
High fructose consumption induces cardiac dysfunction and vascular abnormalities	4
KCNQ3 activation by the naturally occurring phenol, eugenol	4
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	4
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats	4
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line	4
Impact of biological sex on valvular heart disease, interventions, and outcomes	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	4