OOIR: Observatory of International Research

Papers

(The TQCC of Canadian Journal of Physiology and Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity — a preliminary report	55
Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro	41
After the storm: an objective appraisal of the efficacy of c-kit+ cardiac progenitor cells in preclinical models of heart disease	25
Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line	21
Vascular smooth muscle remodeling in health and disease	21
Cpt1a promoted ROS-induced oxidative stress and inflammation in liver injury via the Nrf2/HO-1 and NLRP3 inflammasome signaling pathway	20
Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro	17
Effect of high-intensity interval training and high-intensity resistance training on irisin and fibroblast growth factor 21 in men with overweight and obesity	17
Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage	17
Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?	17
Quercetin modulates NRF2 and NF-κB/TLR-4 pathways to protect against isoniazid- and rifampicin-induced hepatotoxicity in vivo	16
p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway	16
The possible protective effect of colchicine against liver damage induced by renal ischemia–reperfusion injury: role of Nrf2 and NLRP3 inflammasome	16
Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p	15
Mechanisms of action of SGLT2 inhibitors and their beneficial effects on the cardiorenal axis	14
Cyanidin-3-O-glucoside attenuates high glucose–induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK pathway	14
Inhibition of YAP activation attenuates renal injury and fibrosis in angiotensin II hypertensive mice	14
Aprocitentan and the endothelin system in resistant hypertension	14
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways	13
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	13
Rosuvastatin corrects oxidative stress and inflammation induced by LPS to attenuate cardiac injury by inhibiting the NLRP3/TLR4 pathway	13
Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway	13
High-methionine diet in skeletal muscle remodeling: epigenetic mechanism of homocysteine-mediated growth retardation	12
Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1	12
A novel regulatory network of linc00174/miR-150-5p/VEGFA modulates pathological angiogenesis in diabetic retinopathy	12

Hyperhomocysteinemia: an instigating factor for periodontal disease	12
Effect of parthenolide, an NLRP3 inflammasome inhibitor, on insulin resistance in high-fat diet-obese mice	12
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	11
Long non-coding RNA SNHG16 regulates E2F1 expression by sponging miR-20a-5p and aggravating proliferative diabetic retinopathy	11
Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults	10
Dual mechanism of modulation of Na_V1.8 sodium channels by ouabain	10
Long noncoding RNA GAS5 ameliorates chronic constriction injury induced neuropathic pain in rats by modulation of the miR-452-5p/CELF2 axis	10
Serum prokineticin-2 in prepubertal and adult Klinefelter individuals	10
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury	10
Antifibrotic effects of bezafibrate and pioglitazone against thioacetamide-induced liver fibrosis in albino rats	10
Nicorandil prevents the nephrotoxic effect of cyclosporine-A in albino rats through modulation of HIF-1α/VEGF/eNOS signaling	9
Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production	9
Anti-cancer potential of cannabis terpenes in a Taxol-resistant model of breast cancer	9
Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response	9
Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway	9
α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts	9
Gut microbiota and the periodontal disease: role of hyperhomocysteinemia	9
Synergistic effect of aminoguanidine andl-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural evidence	9
The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes	9
Impact of ellagic acid application on doxorubicin-induced cardiovascular toxicity model	9
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	9
Comparative protective effects of N-acetylcysteine and melatonin against obesity-induced testicular dysfunction in rats	9
Long non-coding RNA H19 acts as a microRNA-194 sponge to inhibit the apoptosis and promote the proliferation of hypertrophic scar fibroblasts	9
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	9
Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1	8
Hepatoprotective effect of linagliptin against liver fibrosis induced by carbon tetrachloride in mice	8
FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells	8
Hypoxia-driven secretion of extracellular matrix proteins in the exosomes reflects the asymptomatic pathology of rotator cuff tendinopathies	8
Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and upregulation of inflammatory cytokines in the kidney	8
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats	8
The impact of sex and gender on heart–brain axis dysfunction: current concepts and novel perspectives	8
Involvement of Rho-kinase/IκB-α/NF-κB activation in IL-1β-induced inflammatory response and oxidative stress in human chondrocytes	8
S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway	8
Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line	8
Upregulation of exonuclease 1 caused by homology-dependent repair confers cisplatin resistance to gastric cancer cells	7
Anisomycin inhibits angiogenesis, growth, and survival of triple-negative breast cancer through mitochondrial dysfunction, AMPK activation, and mTOR inhibition	7
Fibroblast growth factor 21 improves lipopolysaccharide-induced pulmonary microvascular endothelial cell dysfunction and inflammatory response through SIRT1-mediated NF-κB deacetylation	7
Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells	7
Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	7
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia	7
Two-month administration of methylphenidate improves olfactory sensitivity and suppresses appetite in individuals with obesity	7
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	7
Participation of the opioid receptor – nitric oxide – cGMP – K⁺channel pathway in the peripheral antinociceptive effect of nalbuphine and buprenorphine in rats	7
New approaches to the design of analgesic medicinal substances	7
Regulatory role of cardiomyocyte metabolism via AMPK activation in modulating atrial structural, contractile, and electrical properties following atrial fibrillation	7
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	6
Tetrahydroxystilbene glucoside alleviates angiotensin II induced HUVEC senescence via SIRT1	6
Possible protective effect of TNF-α inhibition and triad NO/cGMP/VEGF activation on gastric ulcer in rats	6
Gender-specific side effects of chemotherapy in pancreatic cancer patients	6
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	6

Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	6
COVID-19 and the cardiovascular system: insights into effects and treatments	6
Protecting the aging eye with hydrogen sulfide	6
Role of 7-chloro-4-(phenylselanyl) quinoline in the treatment of oxaliplatin-induced hepatic toxicity in mice	6
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	6
Modulation of hydrogen sulfide synthesis improves heart function and endothelium-dependent vasorelaxation in diabetes	6
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	6
Reorienting of pramipexole as a promising therapy for acute pancreatitis in a rat model by suppressing TLR4\NF-κB p65\NLRP3 inflammasome signaling	6
Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis	6
Redox and apoptotic potential of novel ruthenium complexes in rat blood and heart	6
In vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model	6
Melatonin modulates acute cardiac muscle damage induced by carbon tetrachloride — involvement of oxidative damage, glutathione, and arginine and nitric oxide metabolism	6
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation	6
Protective effects of selenium in tacrolimus-induced lung toxicity: potential role of heme oxygenase 1	6
Effects of oleuropein on rat’s atria and thoracic aorta: a study of antihypertensive mechanisms	6
The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF-κB pathway	5
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	5
7-Chloro-4-(phenylselanyl) quinoline reduces renal oxidative stress induced by oxaliplatin in mice	5
Clinical study of pulmonary CT lesions and associated bronchiectasis in 115 convalescent patients with novel coronavirus pneumonia (COVID-19) in China	5
Galectin-3 mediates high-glucose-induced cardiomyocyte injury by the NADPH oxidase/reactive oxygen species pathway	5
The intervention oftert-butylhydroquinone protects ethanol-induced gastric ulcer in type II diabetic rats: the role of Nrf2 pathway	5
Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats	5
4,4′-Dichloro-diphenyl diselenide modulated oxidative stress that differently affected peripheral tissues in streptozotocin-exposed mice	5
Effects of phytocannabinoids on heart rate variability and blood pressure variability in female post-concussion syndrome patients: case series	5
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1	5
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	5
Knockdown of bone morphogenetic protein type II receptor leads to decreased aquaporin 1 expression and function in human pulmonary microvascular endothelial cells	5
The screening of albumin as a key serum component in preventing release of neutrophil extracellular traps by selectively inhibiting mitochondrial ROS generation	5
Toxicity of silver nanoparticles on endometrial receptivity in female mice	5
Lack of renoprotective effects of targeting the endothelin A receptor and (or) sodium glucose transporter 2 in a mouse model of Type 2 diabetic kidney disease	5
A high dose of estrogen can improve renal ischemia-reperfusion-induced pulmonary injury in ovariectomized female rats	5
Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: role of AMPK/SIRT1 activation and DPP-4 inhibition	5
Metformin alleviates hydrogen peroxide–induced inflammation and oxidative stress via inhibiting P2X7R signaling in spinal cord tissue cells neurons	5
Taurine alleviates kidney injury in a thioacetamide rat model by mediating Nrf2/HO-1, NQO-1, and MAPK/NF-κB signaling pathways	5
Possible cardioprotective role of NaHS on ECG and oxidative stress markers in an unpredictable chronic mild stress model in rats	5
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	5
Association of blood pressure and BMI to corrected QT interval in young adults	5
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	5
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa	5
Exercise training suppresses Mst1 activation and attenuates myocardial dysfunction in mice with type 1 diabetes	5
Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia	5
MicroRNA regulation of vascular smooth muscle cells and its significance in cardiovascular diseases	5
Nanoparticle-eluting stents for coronary intervention: formulation, characterization, and in vitro evaluation	5
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	5