OOIR: Observatory of International Research

Papers

(The TQCC of Canadian Journal of Physiology and Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Correction: Cardiac physiology and pathophysiology in pregnancy	28
Note of appreciation	26
Existence and importance of Na⁺K⁺-ATPase in the plasma membrane of boar spermatozoa	25
Different responses to homocysteine in primary endothelial cells and an immortalized endothelial cell line	20
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	17
Detection of joining points for genomic DNA circularization in cell culture	16
Ameliorative effect of roxithromycin against prostate inflammation-induced chronic pelvic pain in a preclinical model	15
Sex-specific considerations in cardiovascular drug therapy	15
The impact of ionizing radiation compared to drug-induced immunological changes	14
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	14
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	14
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	13
Cardiogenic shock—sex-specific risk factors and outcome differences	12
Canadian Society of Pharmacology and Therapeutics	12
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	12
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	11
Histamine H₃ receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	11
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	11
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	11
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	10
Sex-specific vascular effects of menthol: TRPM8- and TRPA1-dependent relaxation in female mouse aorta and pudendal arteries	10
Endoplasmic reticulum stress, calcium homeostasis and the aging heart	10
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	10
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	10
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	10

Clozapine and pharmacogenomics testing: opportunities and challenges for personalized treatment in schizophrenia	8
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	8
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	8
Assessment of human placental microbial signatures in pre-eclampsia using shotgun metagenomics	8
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	8
5 weeks of online resistance training with blood flow restriction increases sit-to-stand oxygen consumption in healthy older adults	8
Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system	8
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	8
Focus on aging, heart failure, regeneration, and cardiovascular medicine	8
Right ventricular dysfunction in preclinical models of type I and type II diabetes	8
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	7
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	7
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	7
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	7
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	7
Abstracts for The 2025 Scientific Meeting of the Canadian Society of Pharmacology and Therapeutics	7
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	7
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	7
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	7
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	7
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	7
Myotubularin related protein 7, a novel STIM1 binding protein	6
Introduction—Unveiling gender disparity in heart disease	6
Correction: Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose	6
Canadian Society of Pharmacology and Therapeutics	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	6
Deferoxamine alleviates brain ischemia/reperfusion injury through decreasing LAG-3 and α-Syn expression	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
Effect of ostarine on glucose level, lipid profile, and osteoporosis in streptozotocin induced diabetic male rats	6
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	6
The addictive process of opioids: current and novel interventions in opioid use disorder	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	5
New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: in vivo and in silico studies	5
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	5
Potassium depolarized rat uterus in response to oxytocin and its structural analogues: kinetic analysis	5
Glucagon-like peptide 1 receptor agonists: anti-inflammatory effects in cardiovascular diseases	5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
Note of appreciation	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	4
KCNQ3 activation by the naturally occurring phenol, eugenol	4
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	4

High fructose consumption induces cardiac dysfunction and vascular abnormalities	4
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca²⁺ influx	4
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
Editorial Expression of Concern: Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1	4
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	4
Coenzyme Q10 ameliorates hepatoprotective effect of metformin in experimentally-induced type 2 diabetes mellitus in rats: a functional and histological study	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	4
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	4
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	4
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	4
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
High-sensitivity troponin I-guided cardiovascular risk assessment in a general asymptomatic population: a cost-effectiveness analysis in 4000 adults	4
Formation of a border ischemic zone depends on plasma potassium concentration	4
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	4
Maternal high-fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	4
Untangling the heart–brain connection in Parkinson’s disease: emerging mechanisms and models	4
Impact of biological sex on valvular heart disease, interventions, and outcomes	4
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	4
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4
Time to treat the climate and nature crisis as one indivisible global health emergency	4
In memoriam: Morley D. Hollenberg (1944–2025), scientist, artist, mentor, and friend	4
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line	4
Opioid agonist treatment dispensing trends between 2018 and 2022 across six Canadian provinces	4
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	4
Epigenetic regulation of sex dimorphism in cardiovascular health	4