OOIR: Observatory of International Research

Papers

(The TQCC of Canadian Journal of Physiology and Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	25
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	24
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria	21
Sex-specific considerations in cardiovascular drug therapy	20
Detection of joining points for genomic DNA circularization in cell culture	19
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	18
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	18
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats	18
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K⁺ channel pathway	16
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	16
Existence and importance of Na⁺K⁺-ATPase in the plasma membrane of boar spermatozoa	15
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	15
Note of appreciation	15
Correction: Cardiac physiology and pathophysiology in pregnancy	15
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	14
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	14
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats	14
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	13
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	13
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	13
The impact of ionizing radiation compared to drug-induced immunological changes	13
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	12
Canadian Society of Pharmacology and Therapeutics	12
Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart	11
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	11

Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	11
Histamine H₃ receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	11
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	10
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	10
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	10
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	10
Cardiogenic shock—sex-specific risk factors and outcome differences	10
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	10
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	10
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	10
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	10
Gender-specific side effects of chemotherapy in pancreatic cancer patients	9
Right ventricular dysfunction in preclinical models of type I and type II diabetes	9
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	9
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	9
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	9
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	9
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia	9
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	9
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	8
Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative	8
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	8
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	8
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	8
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	8
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	8
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	8
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	8
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	7
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	7
Canadian Society of Pharmacology and Therapeutics	7
Association of blood pressure and BMI to corrected QT interval in young adults	7
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	7
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	7
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
The active fragments of ghrelin cross the blood–brain barrier and enter the brain to produce antinociceptive effects after systemic administration	6
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	6
Myotubularin related protein 7, a novel STIM1 binding protein	6
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	6
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	6
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study	6
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	6
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	6
Introduction—Unveiling gender disparity in heart disease	6
The S1PR1 agonist SEW2871 promotes the survival of skin flap	6
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat	6
Role of the NO-cGMP-K⁺ channels pathway in the peripheral antinociception induced by α-bisabolol	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6

Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	6
The addictive process of opioids: current and novel interventions in opioid use disorder	6
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	6
KCNQ3 activation by the naturally occurring phenol, eugenol	5
The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II–induced dopaminergic neuron injury mouse model and by biochanin A	5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
Note of appreciation	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
Epigenetic regulation of sex dimorphism in cardiovascular health	5
Time to treat the climate and nature crisis as one indivisible global health emergency	5
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering	5
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	5
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	5
Effects of physical exercise on baroreflex sensitivity and renal sympathetic nerve activity in chronic nicotine-treated rats	5
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa	5
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	5
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats	5
New insight on the role of liraglutide in alleviating dexamethasone-induced pancreatic cytotoxicity via improving redox status, autophagy flux, and PI3K/Akt/Nrf2 signaling	5
Formation of a border ischemic zone depends on plasma potassium concentration	5
Correction: Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	5
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	5
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	5
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	5
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	5