OOIR: Observatory of International Research

Papers

(The TQCC of Canadian Journal of Physiology and Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Correction: Cardiac physiology and pathophysiology in pregnancy	28
Note of appreciation	25
Existence and importance of Na⁺K⁺-ATPase in the plasma membrane of boar spermatozoa	25
Sex-specific considerations in cardiovascular drug therapy	19
Different responses to homocysteine in primary endothelial cells and an immortalized endothelial cell line	16
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	15
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	14
Ameliorative effect of roxithromycin against prostate inflammation-induced chronic pelvic pain in a preclinical model	14
Detection of joining points for genomic DNA circularization in cell culture	14
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	13
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	12
The impact of ionizing radiation compared to drug-induced immunological changes	12
Cardiogenic shock—sex-specific risk factors and outcome differences	12
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	12
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	11
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	11
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	11
Canadian Society of Pharmacology and Therapeutics	11
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	10
Sex-specific vascular effects of menthol: TRPM8- and TRPA1-dependent relaxation in female mouse aorta and pudendal arteries	10
Histamine H₃ receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	10
Endoplasmic reticulum stress, calcium homeostasis and the aging heart	10
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	10
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	10
Assessment of human placental microbial signatures in pre-eclampsia using shotgun metagenomics	9

Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	8
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	8
Clozapine and pharmacogenomics testing: opportunities and challenges for personalized treatment in schizophrenia	8
Right ventricular dysfunction in preclinical models of type I and type II diabetes	8
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	8
Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system	8
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	7
5 weeks of online resistance training with blood flow restriction increases sit-to-stand oxygen consumption in healthy older adults	7
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	7
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	7
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	7
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	7
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	7
Focus on aging, heart failure, regeneration, and cardiovascular medicine	7
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	7
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	7
Abstracts for The 2025 Scientific Meeting of the Canadian Society of Pharmacology and Therapeutics	7
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	7
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	7
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	7
Canadian Society of Pharmacology and Therapeutics	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	6
Deferoxamine alleviates brain ischemia/reperfusion injury through decreasing LAG-3 and α-Syn expression	6
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	6
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	6
Potassium depolarized rat uterus in response to oxytocin and its structural analogues: Kinetic analysis	6
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	6
Myotubularin related protein 7, a novel STIM1 binding protein	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
Introduction—Unveiling gender disparity in heart disease	6
Effect of ostarine on glucose level, lipid profile, and osteoporosis in streptozotocin induced diabetic male rats	6
Time to treat the climate and nature crisis as one indivisible global health emergency	5
Note of appreciation	5
Correction: Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose	5
The addictive process of opioids: current and novel interventions in opioid use disorder	5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: in vivo and in silico studies	5
High fructose consumption induces cardiac dysfunction and vascular abnormalities	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4

Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	4
High-sensitivity troponin I-guided cardiovascular risk assessment in a general asymptomatic population: a cost-effectiveness analysis in 4000 adults	4
Editorial Expression of Concern: Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1	4
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	4
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	4
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
Untangling the heart–brain connection in Parkinson’s disease: emerging mechanisms and models	4
Impact of biological sex on valvular heart disease, interventions, and outcomes	4
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	4
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	4
In memoriam: Morley D. Hollenberg (1944–2025), scientist, artist, mentor, and friend	4
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	4
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	4
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats	4
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line	4
KCNQ3 activation by the naturally occurring phenol, eugenol	4
Opioid agonist treatment dispensing trends between 2018 and 2022 across six Canadian provinces	4
Epigenetic regulation of sex dimorphism in cardiovascular health	4
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	4
Formation of a border ischemic zone depends on plasma potassium concentration	4
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca²⁺ influx	4
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	4
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
Coenzyme Q10 ameliorates hepatoprotective effect of metformin in experimentally-induced type 2 diabetes mellitus in rats: a functional and histological study	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	4
Maternal high-fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	4