OOIR: Observatory of International Research

Papers

(The TQCC of Canadian Journal of Physiology and Pharmacology is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Note of appreciation	44
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K⁺ channel pathway	29
Sex-specific considerations in cardiovascular drug therapy	23
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	22
Detection of joining points for genomic DNA circularization in cell culture	20
Existence and importance of Na⁺K⁺-ATPase in the plasma membrane of boar spermatozoa	18
Correction: Cardiac physiology and pathophysiology in pregnancy	17
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	16
The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes	16
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	15
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria	15
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	15
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats	14
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats	14
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	14
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	13
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	13
The impact of ionizing radiation compared to drug-induced immunological changes	13
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	13
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	13
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	13
FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells	12
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	12
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	11
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	11

Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart	11
Cardiogenic shock—sex-specific risk factors and outcome differences	10
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	10
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	10
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	10
Histamine H₃ receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	10
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	9
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	9
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	9
Canadian Society of Pharmacology and Therapeutics	9
Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro	9
The intervention oftert-butylhydroquinone protects ethanol-induced gastric ulcer in type II diabetic rats: the role of Nrf2 pathway	9
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	9
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	9
Gender-specific side effects of chemotherapy in pancreatic cancer patients	9
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	9
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	9
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	8
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	8
Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative	8
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia	8
Right ventricular dysfunction in preclinical models of type I and type II diabetes	8
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	7
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	7
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	7
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	7
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	7
Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	6
Association of blood pressure and BMI to corrected QT interval in young adults	6
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	6
Lipopolysaccharide induces BV2 microglial cell migration via a decrease in SET8 expression	6
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	6
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study	6
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	6
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
The active fragments of ghrelin cross the blood–brain barrier and enter the brain to produce antinociceptive effects after systemic administration	6
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	6
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	6
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat	6
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	6
Canadian Society of Pharmacology and Therapeutics	6
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	6
Role of the NO-cGMP-K⁺ channels pathway in the peripheral antinociception induced by α-bisabolol	6
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	6
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	5

The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
Time to treat the climate and nature crisis as one indivisible global health emergency	5
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	5
The S1PR1 agonist SEW2871 promotes the survival of skin flap	5
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II–induced dopaminergic neuron injury mouse model and by biochanin A	5
Note of appreciation	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
Introduction—Unveiling gender disparity in heart disease	5
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	5
Effects of physical exercise on baroreflex sensitivity and renal sympathetic nerve activity in chronic nicotine-treated rats	5
Correction: Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	5
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	5
Renal expression and urinary excretion of aquaporin-2 in postobstructive uropathy in rats	5
The addictive process of opioids: current and novel interventions in opioid use disorder	5
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	5
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	4
Formation of a border ischemic zone depends on plasma potassium concentration	4
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	4
Epigenetic regulation of sex dimorphism in cardiovascular health	4
New insight on the role of liraglutide in alleviating dexamethasone-induced pancreatic cytotoxicity via improving redox status, autophagy flux, and PI3K/Akt/Nrf2 signaling	4
Maternal high fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa	4
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	4
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	4
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	4
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	4
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats	4
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering	4
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	4
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	4
Paradoxical effects of acidosis on the noradrenaline-induced and neurogenic constriction of the rat tail artery at low temperatures	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
Modified cancer TNM classification for localized renal cell carcinoma based on the prognostic analysis of 3748 cases from a single center	4