Canadian Journal of Physiology and Pharmacology

Article	Citations
Role of the NO-cGMP-K+ channels pathway in the peripheral antinociception induced by α-bisabolol	41
Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway	27
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study	25
Reply to “Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study”	25
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	21
Ascorbic acid reduces insulin resistance and pancreatic steatosis by regulating adipocyte hypertrophy in obese ovariectomized mice	17
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat	17
Detection of joining points for genomic DNA circularization in cell culture	17
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	16
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	16
Canadian Society of Pharmacology and Therapeutics	15
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K+ channel pathway	15
Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation	14
Protective effects of sildenafil administration on chemotherapeutic-induced ovarian damage in rats	14
Unexpected challenges for the translation of research on food interventions to applications in the food industry: using flaxseed research as an example	14
Lipopolysaccharide induces BV2 microglial cell migration via a decrease in SET8 expression	14
Note of appreciation	13
Muscarinic agonists inhibit the ATP-dependent potassium current and suppress the ventricle–Purkinje action potential dispersion	13
Angiogenesis effects of 4-methoxy benzyl alcohol on cerebral ischemia-reperfusion injury via regulation of VEGF-Ang/Tie2 balance	13
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	13
Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	13
Existence and importance of Na+K+-ATPase in the plasma membrane of boar spermatozoa	12
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	12
URB597 attenuates stress-induced ventricular structural remodeling by modulating cytokines, NF-κB, and JAK2/STAT3 pathways in female and male rats	11
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	11

Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review	10
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	10
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	10
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	10
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca2+ influx	10
COVID-19 pathophysiology and pharmacology: what do we know and how did Canadians respond? A review of Health Canada authorized clinical vaccine and drug trials	10
COVID-19 and the cardiovascular system: insights into effects and treatments	9
Sex-specific considerations in cardiovascular drug therapy	9
Antifibrotic effects of bezafibrate and pioglitazone against thioacetamide-induced liver fibrosis in albino rats	9
Anti-hyperglycaemic effects of dioxidovanadium complexcis-[VO2(obz)py] avert kidney dysfunction in streptozotocin-induced diabetic male Sprague–Dawley rats	9
Krešimir Krnjević (1927–2021) and GABAergic inhibition: a lifetime dedication	9
Preventing broken hearts in women with breast cancer: a concise review on chemotherapy-mediated cardiotoxicity	9
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	9
Sleep deprivation disturbs uterine contractility and structure in pregnant rats: role of matrix metalloproteinase 9 and transforming growth factor-β	9
Hypoxia-driven secretion of extracellular matrix proteins in the exosomes reflects the asymptomatic pathology of rotator cuff tendinopathies	9
NLG-919 combined with cisplatin to enhance inhibitory effect on cell migration and invasion via IDO1–Kyn–AhR pathway in human nasopharyngeal carcinoma cell	9
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	9
Protective effects of selenium in tacrolimus-induced lung toxicity: potential role of heme oxygenase 1	8
Long non-coding RNA SNHG16 regulates E2F1 expression by sponging miR-20a-5p and aggravating proliferative diabetic retinopathy	8
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	8
Neonatal fluoxetine exposure delays reflex ontogeny, somatic development, and food intake similarly in male and female rats	8
Circadian regulation of genetic and hormonal risk factors of cardiovascular disease in women	8
Serum prokineticin-2 in prepubertal and adult Klinefelter individuals	8
Oxygen sensor of the heart	8
TLR/mTOR inflammatory signaling pathway: novel insight for the treatment of schizophrenia	7
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	7
Effect of intracutaneous pyonex on analgesia and sedation in critically ill patients with mechanical ventilation	7
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	7
Simultaneous intervention against oxidative stress and inflammation by targeting Nrf2/ARE and NLRP3 inflammasome pathway mitigates thioacetamide-induced liver fibrosis in rat	7
Erythropoietin alters the pharmacokinetics of organic anions mainly eliminated by the kidney in rats	7
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats	7
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria	7
Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	7
The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF-κB pathway	6
Expression of concern: Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53	6
Cpt1a promoted ROS-induced oxidative stress and inflammation in liver injury via the Nrf2/HO-1 and NLRP3 inflammasome signaling pathway	6
Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line	6
Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro	6
The active fragments of ghrelin cross the blood–brain barrier and enter the brain to produce antinociceptive effects after systemic administration	6
Evaluation of the effects of pioglitazone on perivascular adipose tissue function, properties, and structure in a rat model of type-2 diabetes	6
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	6
Correction: Cardiac physiology and pathophysiology in pregnancy	6
Effect of 4-hydroxychalcone as preventive and curative treatment in Wistar rats with liver injury	6
Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response	6
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways	6
The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes	6
Sex-specific effects of frailty on cardiac structure and function: insights from preclinical models	6
Reorienting of pramipexole as a promising therapy for acute pancreatitis in a rat model by suppressing TLR4\NF-κB p65\NLRP3 inflammasome signaling	6
Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model	6
Impact of biological sex on valvular heart disease, interventions, and outcomes	6

Anti-cancer potential of cannabis terpenes in a Taxol-resistant model of breast cancer	6
Differences between exhausted CD8+ T cells in hepatocellular carcinoma patients with and without uremia	5
Correction: Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	5
Effect of high-intensity interval training and high-intensity resistance training on irisin and fibroblast growth factor 21 in men with overweight and obesity	5
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension	5
The impact of sex and gender on heart–brain axis dysfunction: current concepts and novel perspectives	5
Inhaled argon dilates pulmonary vasculature in rat isolated lungs	5
Preventative effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives (N-functional group loading) on MPTP-induced parkinsonism in mice	5
Calcitriol attenuates vascular remodeling in association with alteration of ppET-1/ETBR/eNOS and ETAR expression in acute and chronic phases of kidney ischemia–reperfusion injury	5
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	5
Mental health in COVID-19 Delta variant survivors and healthcare workers during the 2021 outbreak in Nanjing, China: a cross-sectional study	5
Possible cardioprotective role of NaHS on ECG and oxidative stress markers in an unpredictable chronic mild stress model in rats	5
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats	5
The impact of ionizing radiation compared to drug-induced immunological changes	5
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1	5
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	5
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity	5
Role of prostaglandin E2 in allogeneic mesenchymal stem cell therapy for cardiac repair	5
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	5
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	5
Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus	5
Inhibition of inducible nitric oxide synthase protects against the deleterious effects of sub-lethal sepsis and ethanol in the cardiorenal system	5
Effects of a high-fat low-carbohydrate diet under different energy conditions on glucose homeostasis and fatty liver development in rats and on gluconeogenesis in the isolated perfused liver	5
Decreased Na+/K+ pump activity in the erythrocyte membrane due to malondialdehyde in rheumatoid arthritis: an in vivo and in silico study	5
Preventive effects of antenatal CDP-choline in a rat model of neonatal hyperoxia-induced lung injury	5
Azilsartan prevents muscle loss and fast- to slow-twitch muscle fiber shift in natural ageing sarcopenic rats	5
PPARα/γ, adiponectin, and GLUT4 overexpression induced by moronic acid methyl ester influenced glucose and triglyceride levels of experimental diabetic mice	5
Astaxanthin prevents nephrotoxicity through Nrf2/HO-1 pathway	5
FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells	4
Effect of nitric oxide–cyclic GMP–K+ channel pathway blockers, naloxone and metformin, on the antinociception induced by the diuretic pamabrom	4
Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1	4
Cardiovascular and physiological risk factors in women at mid-life and beyond	4
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	4
Taurine alleviates kidney injury in a thioacetamide rat model by mediating Nrf2/HO-1, NQO-1, and MAPK/NF-κB signaling pathways	4
Cardioprotective effects of losartan and diminazene against the ischemia/reperfusion injury in hyperthyroidism rats	4
S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway	4
Long non-coding RNA H19 acts as a microRNA-194 sponge to inhibit the apoptosis and promote the proliferation of hypertrophic scar fibroblasts	4
Introduction—Unveiling gender disparity in heart disease	4
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury	4
mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats	4
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats	4
Short-term effects induced by nicotinamide in ovariectomized females	4
Modification of ischemia/reperfusion induced infarct size by ischemic preconditioning in hypertrophied hearts	4
Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission	4
Cyanidin-3-O-glucoside attenuates high glucose–induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK pathway	4
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	4
Stimulation of mitochondrial hydrogen sulfide and glutathione production improves the Frank–Starling response of the rat heart via a nitric oxide–dependent pathway	3
Involvement of G proteins and Rho kinase in α1-adrenoceptor mediated contractions of the rat portal vein	3
Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner	3
Note of appreciation	3
Tribute—Dr. Pawan K. Singal	3
The anti-anginal ranolazine does not confer beneficial actions against hepatic steatosis in male mice subjected to high-fat diet and streptozotocin-induced type 2 diabetes	3
The role of visfatin and resistin in an in vitro model of obesity-induced invasive liver cancer	3
Effect of high-fat diet on mechanosensitive transient receptor potential channel activation in vagal afferent neurons	3
Retraction: Endothelin axis induces metalloproteinase activation and invasiveness in human lymphatic endothelial cells	3
Synergistic effect of aminoguanidine andl-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural evidence	3
Psychological interventions targeting mental health and stress among females with cardiac disease: a scoping review	3
Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand–foot syndrome induced by capecitabine in rats	3
Luminal Ca2+ regulation of RyR1 Ca2+ channel leak activation and inactivation in sarcoplasmic reticulum membrane vesicles	3
NOTE OF APPRECIATION	3
Renal expression and urinary excretion of aquaporin-2 in postobstructive uropathy in rats	3
Protective effects of diclofenac on liver graft preservation	3
Influence of permeability enhancers on the paracellular permeability of metformin hydrochloride and furosemide across Caco-2 cells	3
Protective effect of sitagliptin and whole-body γ-irradiation in diabetes-induced cardiac injury	3
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation	3
β-elemene relieves neuropathic pain in mice through the regulation on C-X-C motif chemokine receptor 3 and GABAA receptor	3
Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart	3
Cardiovascular adverse events associated with triptans for treatment of migraine: a pharmacovigilance study of the FDA adverse event reporting system (FAERS)	3
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	3
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	3
Endothelial colony forming cells’ tetrahydrobiopterin level in coronary artery disease patients and its association with circulating endothelial progenitor cells	3
Hepatalin: the missing link in prediabetes, obesity, and type 2 diabetes	3
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	3
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	3
Inhibitory effect of resveratrol on the pharmacokinetics of ticagrelor in vivo and in vitro	3
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	3
2021 Scientific Abstracts: Canadian Society of Pharmacology and Therapeutics annual conference	3
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	3
The interactive effect of vitamin D3 supplementation and vitamin D receptor polymorphisms on weight and body composition in overweight women with hypovitaminosis D: a randomized, double-blind, placebo	3
Thyroid hormones regulate reelin expression in neuropsychiatric disorders	3

Nanoparticle-eluting stents for coronary intervention: formulation, characterization, and in vitro evaluation	3
Effects of phytocannabinoids on heart rate variability and blood pressure variability in female post-concussion syndrome patients: case series	3
The S1PR1 agonist SEW2871 promotes the survival of skin flap	3
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats	3
Involvement of Rho-kinase/IκB-α/NF-κB activation in IL-1β-induced inflammatory response and oxidative stress in human chondrocytes	2
Canadian Society of Pharmacology and Therapeutics	2
Unraveling the molecular landscape of kAE1: a narrative review	2
Sirtuin 3 overexpression preserves maximal sarco(endo)plasmic reticulum calcium ATPase activity in the skeletal muscle of mice subjected to high fat – high sucrose feeding	2
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	2
After the storm: an objective appraisal of the efficacy of c-kit+ cardiac progenitor cells in preclinical models of heart disease	2
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	2
Metformin alleviates hydrogen peroxide–induced inflammation and oxidative stress via inhibiting P2X7R signaling in spinal cord tissue cells neurons	2
Upregulation of circFOXP1 attenuates inflammation and apoptosis induced by ox-LDL in human umbilical vein endothelial cells by regulating the miR-185-5p/BCL-2 axis	2
p-Chloro-diphenyl diselenide modulates Nrf2/Keap1 signaling and counteracts renal oxidative stress in mice exposed to repeated dexamethasone administrations	2
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	2
TMEM98, a novel secretory protein, promotes endothelial cell adhesion as well as vascular smooth muscle cell proliferation and migration	2
Acute and chronic metabolic effects of carvedilol in high-fructose, high-fat diet–fed mice: implication of β-arrestin2 pathway	2
SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression	2
Colorectal and bladder prokinetic activity of [Lys5, MeLeu9, Nle10]-NKA(4–10) after intranasal or sublingual delivery in dogs	2
Effect of ivabradine in heart failure: a meta-analysis of heart failure patients with reduced versus preserved ejection fraction	2
Effect of parthenolide, an NLRP3 inflammasome inhibitor, on insulin resistance in high-fat diet-obese mice	2
Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production	2
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	2
Melatonin modulates acute cardiac muscle damage induced by carbon tetrachloride — involvement of oxidative damage, glutathione, and arginine and nitric oxide metabolism	2
Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells	2
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients	2
Biased signaling in platelet G-protein coupled receptors	2
Nicorandil prevents the nephrotoxic effect of cyclosporine-A in albino rats through modulation of HIF-1α/VEGF/eNOS signaling	2
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	2
Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: role of AMPK/SIRT1 activation and DPP-4 inhibition	2
Lysophosphatidic acid metabolism and signaling in heart disease	2
Aprocitentan and the endothelin system in resistant hypertension	2
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	2
Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy	2
Modulation of hydrogen sulfide synthesis improves heart function and endothelium-dependent vasorelaxation in diabetes	2
MicroRNA regulation of vascular smooth muscle cells and its significance in cardiovascular diseases	2
Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba	2
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	2
Efficacy and safety of fenofibrate in combination with phototherapy for the treatment of neonatal hyperbilirubinemia: A systematic review and meta-analyses.	2
Endothelin system expression in the kidney following cisplatin-induced acute kidney injury in male and female mice	2
Opioid receptor μ, not δ and κ, modulate food intake induced by ghrelin in laying chickens	2
Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p	2
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	2
Cardiodiabetology: newer pharmacologic strategies for reducing cardiovascular disease risks	2
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	2
4,4′-Dichloro-diphenyl diselenide modulated oxidative stress that differently affected peripheral tissues in streptozotocin-exposed mice	2
Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and upregulation of inflammatory cytokines in the kidney	2
Clinical efficacy and safety of two concentrations of intravenous nicardipine hydrochloride for nicardipine-related phlebitis in patients with preeclampsia	2
Modulatory effect of simvastatin on redox status, caspase-3 expression, p-protein kinase B (p-Akt), and brain-derived neurotrophic factor (BDNF) in an ethanol-induced neurodegeneration model	2
Stem cell therapy for cardiac regeneration: past, present, and future	2
Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report	2
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	2
Cardiac physiology and pathophysiology in pregnancy	2
Cardiogenic shock—sex-specific risk factors and outcome differences	2