Canadian Journal of Physiology and Pharmacology

Article	Citations
Gut microbiota dysbiosis in polycystic ovary syndrome: association with obesity — a preliminary report	52
Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro	38
Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease	36
Butyrate improves cardiac function and sympathetic neural remodeling following myocardial infarction in rats	30
After the storm: an objective appraisal of the efficacy of c-kit+ cardiac progenitor cells in preclinical models of heart disease	24
Rhein attenuates lipopolysaccharide-primed inflammation through NF-κB inhibition in RAW264.7 cells: targeting the PPAR-γ signal pathway	22
Effect of casein kinase 1α inhibition on autophagy flux and the AKT/phospho-β-catenin (S552) axis in HCT116, a RAS-mutated colorectal cancer cell line	19
Vascular smooth muscle remodeling in health and disease	19
Cpt1a promoted ROS-induced oxidative stress and inflammation in liver injury via the Nrf2/HO-1 and NLRP3 inflammasome signaling pathway	17
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment	17
Sovateltide (IRL-1620) affects neuronal progenitors and prevents cerebral tissue damage after ischemic stroke	17
Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro	16
Silencing of lncRNA PVT1 ameliorates streptozotocin-induced pancreatic β cell injury and enhances insulin secretory capacity by regulating miR-181a-5p	15
Effect of high-intensity interval training and high-intensity resistance training on irisin and fibroblast growth factor 21 in men with overweight and obesity	15
Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage	15
Metformin regulates TRPM6, a potential explanation for magnesium imbalance in type 2 diabetes patients	15
p75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway	14
Metabolically healthy obesity: is there a link with polyunsaturated fatty acid intake and status?	14
The possible protective effect of colchicine against liver damage induced by renal ischemia–reperfusion injury: role of Nrf2 and NLRP3 inflammasome	14
Inhibition of autophagy improves resistance and enhances sensitivity of gastric cancer cells to cisplatin	13
Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway	13
Inhibition of YAP activation attenuates renal injury and fibrosis in angiotensin II hypertensive mice	13
Cyanidin-3-O-glucoside attenuates high glucose–induced podocyte dysfunction by inhibiting apoptosis and promoting autophagy via activation of SIRT1/AMPK pathway	12
Astragaloside IV relieves gestational diabetes mellitus in genetic mice through reducing hepatic gluconeogenesis	12
Quercetin modulates NRF2 and NF-κB/TLR-4 pathways to protect against isoniazid- and rifampicin-induced hepatotoxicity in vivo	12

Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways	12
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	12
Blockade of IL-6 alleviates bone loss induced by modeled microgravity in mice	12
Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1	12
A novel regulatory network of linc00174/miR-150-5p/VEGFA modulates pathological angiogenesis in diabetic retinopathy	12
Galectin-3 inhibition attenuates doxorubicin-induced cardiac dysfunction by upregulating the expression of peroxiredoxin-4	11
Serum prokineticin-2 in prepubertal and adult Klinefelter individuals	11
Mechanisms of action of SGLT2 inhibitors and their beneficial effects on the cardiorenal axis	11
Aprocitentan and the endothelin system in resistant hypertension	11
Hyperhomocysteinemia: an instigating factor for periodontal disease	11
High-methionine diet in skeletal muscle remodeling: epigenetic mechanism of homocysteine-mediated growth retardation	11
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	11
Effect of parthenolide, an NLRP3 inflammasome inhibitor, on insulin resistance in high-fat diet-obese mice	10
Long non-coding RNA SNHG16 regulates E2F1 expression by sponging miR-20a-5p and aggravating proliferative diabetic retinopathy	10
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury	10
Antifibrotic effects of bezafibrate and pioglitazone against thioacetamide-induced liver fibrosis in albino rats	10
Fluoxetine-induced hepatic lipid accumulation is linked to elevated serotonin production	9
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	9
α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts	9
Combined treatment of menadione and calcitriol increases the antiproliferative effect by promoting oxidative/nitrosative stress, mitochondrial dysfunction, and autophagy in breast cancer MCF-7 cells	9
Gut microbiota and the periodontal disease: role of hyperhomocysteinemia	9
Dual mechanism of modulation of NaV1.8 sodium channels by ouabain	9
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	8
Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural evidence	8
Long non-coding RNA H19 acts as a microRNA-194 sponge to inhibit the apoptosis and promote the proliferation of hypertrophic scar fibroblasts	8
Evaluation of antioxidant activity and toxicity of sulfur- or selenium-containing 4-(arylchalcogenyl)-1H-pyrazoles	8
Rosuvastatin corrects oxidative stress and inflammation induced by LPS to attenuate cardiac injury by inhibiting the NLRP3/TLR4 pathway	8
Circulating endothelial cell derived microvesicles are elevated with hypertension and associated with endothelial dysfunction	8
Hepatoprotective effect of linagliptin against liver fibrosis induced by carbon tetrachloride in mice	8
S-ketamine alleviates carbon tetrachloride-induced hepatic injury and oxidative stress by targeting the Nrf2/HO-1 signaling pathway	8
The impact of sex and gender on heart–brain axis dysfunction: current concepts and novel perspectives	8
The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes	8
Impact of ellagic acid application on doxorubicin-induced cardiovascular toxicity model	8
Nicorandil prevents the nephrotoxic effect of cyclosporine-A in albino rats through modulation of HIF-1α/VEGF/eNOS signaling	8
Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and upregulation of inflammatory cytokines in the kidney	8
Long noncoding RNA GAS5 ameliorates chronic constriction injury induced neuropathic pain in rats by modulation of the miR-452-5p/CELF2 axis	8
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	8
Hypoxia-driven secretion of extracellular matrix proteins in the exosomes reflects the asymptomatic pathology of rotator cuff tendinopathies	8
Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults	8
Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	7
New approaches to the design of analgesic medicinal substances	7
Fibroblast growth factor 21 improves lipopolysaccharide-induced pulmonary microvascular endothelial cell dysfunction and inflammatory response through SIRT1-mediated NF-κB deacetylation	7
FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells	7
Exercise ameliorates insulin resistance and improves SIRT6-mediated insulin signaling transduction in liver of obese rats	7
Folic acid affects cardiometabolic, oxidative stress, and immunohistochemical parameters in monocrotaline-induced rat heart failure	7
Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1	7
Anisomycin inhibits angiogenesis, growth, and survival of triple-negative breast cancer through mitochondrial dysfunction, AMPK activation, and mTOR inhibition	7
Involvement of Rho-kinase/IκB-α/NF-κB activation in IL-1β-induced inflammatory response and oxidative stress in human chondrocytes	7
Anti-cancer potential of cannabis terpenes in a Taxol-resistant model of breast cancer	7
Pharmacokinetic profile of the selective 5-HT3 receptor antagonist ondansetron in the rat: an original study and a minireview of the behavioural pharmacological literature in the rat	7

Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line	7
Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway	7
Suppression of high-mobility group box 1 ameliorates xerostomia in a Sjögren syndrome-triggered mouse model	7
Participation of the opioid receptor – nitric oxide – cGMP – K+channel pathway in the peripheral antinociceptive effect of nalbuphine and buprenorphine in rats	7
Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells	7
Comparative protective effects of N-acetylcysteine and melatonin against obesity-induced testicular dysfunction in rats	7
Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response	7
Loss of endothelin type B receptor function improves insulin sensitivity in rats	7
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	6
Redox and apoptotic potential of novel ruthenium complexes in rat blood and heart	6
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	6
Two-month administration of methylphenidate improves olfactory sensitivity and suppresses appetite in individuals with obesity	6
Protective effects of selenium in tacrolimus-induced lung toxicity: potential role of heme oxygenase 1	6
Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	6
Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis	6
Meclizine ameliorates memory deficits in streptozotocin-induced experimental dementia in mice: role of nuclear pregnane X receptors	6
Current therapies under investigation for COVID-19: potential COVID-19 treatments	6
Endothelin-1 (ET-1) promotes a proinflammatory microglia phenotype in diabetic conditions	6
Chondroitin sulfate mediates liver responses to injury induced by dual endothelin receptor inhibition	6
Effects of oleuropein on rat’s atria and thoracic aorta: a study of antihypertensive mechanisms	6
Regulatory role of cardiomyocyte metabolism via AMPK activation in modulating atrial structural, contractile, and electrical properties following atrial fibrillation	6
Tetrahydroxystilbene glucoside alleviates angiotensin II induced HUVEC senescence via SIRT1	6
The effect of gender and ABCB1 gene polymorphism on the pharmacokinetics of azithromycin in healthy male and female Pakistani subjects	6
Possible protective effect of TNF-α inhibition and triad NO/cGMP/VEGF activation on gastric ulcer in rats	6
In vivo protective effects of upper zone of growth plate and cartilage matrix associated protein against cartilage degeneration in a monosodium iodoacetate induced osteoarthritis model	6
COVID-19 and the cardiovascular system: insights into effects and treatments	6
Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro	6
Mechanism and effects of fructose diphosphate on anti-hypoxia fatigue and learning memory ability	6
Upregulation of exonuclease 1 caused by homology-dependent repair confers cisplatin resistance to gastric cancer cells	5
7-Chloro-4-(phenylselanyl) quinoline reduces renal oxidative stress induced by oxaliplatin in mice	5
Exercise training suppresses Mst1 activation and attenuates myocardial dysfunction in mice with type 1 diabetes	5
Galectin-3 mediates high-glucose-induced cardiomyocyte injury by the NADPH oxidase/reactive oxygen species pathway	5
Expression of cholinesterases and their anchoring proteins in rat heart	5
Possible cardioprotective role of NaHS on ECG and oxidative stress markers in an unpredictable chronic mild stress model in rats	5
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	5
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	5
Long-term survival outcome for pre-capillary pulmonary hypertension at a Japanese single center	5
Protecting the aging eye with hydrogen sulfide	5
Gender-specific side effects of chemotherapy in pancreatic cancer patients	5
Role of 7-chloro-4-(phenylselanyl) quinoline in the treatment of oxaliplatin-induced hepatic toxicity in mice	5
Melatonin modulates acute cardiac muscle damage induced by carbon tetrachloride — involvement of oxidative damage, glutathione, and arginine and nitric oxide metabolism	5
Taurine alleviates kidney injury in a thioacetamide rat model by mediating Nrf2/HO-1, NQO-1, and MAPK/NF-κB signaling pathways	5
Reorienting of pramipexole as a promising therapy for acute pancreatitis in a rat model by suppressing TLR4\NF-κB p65\NLRP3 inflammasome signaling	5
Endothelin receptor heteromerization inhibits β-arrestin function in HEK293 cells	5
Clinical study of pulmonary CT lesions and associated bronchiectasis in 115 convalescent patients with novel coronavirus pneumonia (COVID-19) in China	5
Vascular and renal telomere shortening in mice exposed to chronic intermittent hypoxia	5
The intervention oftert-butylhydroquinone protects ethanol-induced gastric ulcer in type II diabetic rats: the role of Nrf2 pathway	5
MicroRNA regulation of vascular smooth muscle cells and its significance in cardiovascular diseases	5
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1	5
Gestational postprandial insulin sensitivity in the Sprague Dawley rat: the putative role of hepatic insulin sensitizing substance in glucose partitioning in pregnancy	5
Effects of phytocannabinoids on heart rate variability and blood pressure variability in female post-concussion syndrome patients: case series	4
Knockdown of bone morphogenetic protein type II receptor leads to decreased aquaporin 1 expression and function in human pulmonary microvascular endothelial cells	4
Early predictive blood markers of hemorrhagic stroke — influence of cytoflavin therapy	4
The role of aldosterone inhibitors in cardiac ischemia–reperfusion injury	4
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	4
A high dose of estrogen can improve renal ischemia-reperfusion-induced pulmonary injury in ovariectomized female rats	4
Effect of ivabradine in heart failure: a meta-analysis of heart failure patients with reduced versus preserved ejection fraction	4
Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy	4
Metformin alleviates hydrogen peroxide–induced inflammation and oxidative stress via inhibiting P2X7R signaling in spinal cord tissue cells neurons	4
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	4
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation	4
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K+ channel pathway	4
The ratio of circulating endothelin-1 to endothelin-3 associated with TIMI risk and dynamic TIMI risk score in ST elevation acute myocardial infarction	4
Endothelin-1 induces lysyl oxidase expression in pulmonary artery smooth muscle cells	4
Lack of renoprotective effects of targeting the endothelin A receptor and (or) sodium glucose transporter 2 in a mouse model of Type 2 diabetic kidney disease	4
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa	4
4,4′-Dichloro-diphenyl diselenide modulated oxidative stress that differently affected peripheral tissues in streptozotocin-exposed mice	4
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	4
Vitamin D3 potentiates the nephroprotective effects of metformin in a rat model of metabolic syndrome: role of AMPK/SIRT1 activation and DPP-4 inhibition	4
Nanoparticle-eluting stents for coronary intervention: formulation, characterization, and in vitro evaluation	4
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	4
The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF-κB pathway	4
Association of blood pressure and BMI to corrected QT interval in young adults	4
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia	4
New insight on the role of liraglutide in alleviating dexamethasone-induced pancreatic cytotoxicity via improving redox status, autophagy flux, and PI3K/Akt/Nrf2 signaling	4
Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats	4
Transgenerational impact of topical steroid application on superoxide dismutase activities of hypothalamus-pituitary-adrenal axis in rats	4
Opioid receptor μ, not δ and κ, modulate food intake induced by ghrelin in laying chickens	4
Biased signaling in platelet G-protein coupled receptors	4
Modulation of hydrogen sulfide synthesis improves heart function and endothelium-dependent vasorelaxation in diabetes	4

Effects of physical exercise on baroreflex sensitivity and renal sympathetic nerve activity in chronic nicotine-treated rats	3
miR-138-5p targets sirtuin1 to regulate acute lung injury by regulation of the NF-κB signaling pathway	3
Scleraxis as a prognostic marker of myocardial fibrosis in hypertrophic cardiomyopathy (SPARC) study	3
Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review	3
Inhibitory effect of resveratrol on the pharmacokinetics of ticagrelor in vivo and in vitro	3
Neonatal fluoxetine exposure delays reflex ontogeny, somatic development, and food intake similarly in male and female rats	3
Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure	3
An animal model of gestational obesity and prediabetes: HISS-dependent insulin resistance induced by a high-sucrose diet in Sprague Dawley rats	3
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats	3
Effect of high-fat diet on mechanosensitive transient receptor potential channel activation in vagal afferent neurons	3
Combined treatments with metformin and phosphodiesterase inhibitors alleviate nonalcoholic fatty liver disease in high-fat diet fed rats: a comparative study	3
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	3
Overexpression of miR-365a-3p relieves sepsis-induced acute myocardial injury by targeting MyD88/NF-κB pathway	3
Lipopolysaccharide induces BV2 microglial cell migration via a decrease in SET8 expression	3
Irisin relaxes rat thoracic aorta: MEK1/2 signaling pathway, KV channels, SKCa channels, and BKCa channels are involved in irisin-induced vasodilation	3
Differential regulation of TGFβ type-I receptor expressions in TGFβ1-induced myofibroblast differentiation	3
BW373U86 upregulates autophagy by inhibiting the PI3K/Akt pathway and regulating the mTOR pathway to protect cardiomyocytes from hypoxia–reoxygenation injury	3
Toxicity of silver nanoparticles on endometrial receptivity in female mice	3
Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	3
LINC01857 promotes the proliferation, migration, and invasion of gastric cancer cells via regulating miR-4731-5p/HOXC6	3
Circadian regulation of genetic and hormonal risk factors of cardiovascular disease in women	3
Effect of intracutaneous pyonex on analgesia and sedation in critically ill patients with mechanical ventilation	3
The influences of chokeberry extract supplementation on redox status and body composition in handball players during competition phase	3
Activation of the Akt/FoxO3 signaling pathway enhances oxidative stress-induced autophagy and alleviates brain damage in a rat model of ischemic stroke	3
The role of visfatin and resistin in an in vitro model of obesity-induced invasive liver cancer	3
The screening of albumin as a key serum component in preventing release of neutrophil extracellular traps by selectively inhibiting mitochondrial ROS generation	3
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	3
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	3
The S1PR1 agonist SEW2871 promotes the survival of skin flap	3
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering	3
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria	3
Potential role of d-chiro-inositol in reducing oxidative stress in the blood of nonobese women with polycystic ovary syndrome	3
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	3
Anti-hyperglycaemic effects of dioxidovanadium complexcis-[VO2(obz)py] avert kidney dysfunction in streptozotocin-induced diabetic male Sprague–Dawley rats	3
Upregulation of PACE4 in prostate cancer is not dependent on E2F transcription factors	3
Role of the NO-cGMP-K+ channels pathway in the peripheral antinociception induced by α-bisabolol	3
Involvement of G proteins and Rho kinase in α1-adrenoceptor mediated contractions of the rat portal vein	3
Intricacies of the endothelin system in human obesity: role in the development of complications and potential as a therapeutic target	3
Cardiopulmonary values and organ blood flows before and during heat stress: data in nine subjects at rest in the upright position	3
Intracellular pH regulation and the acid delusion	3
C-type natriuretic peptide (CNP)/guanylate cyclase B (GC-B) system and endothelin-1(ET-1)/ET receptor A and B system in human vasculature	3
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	3
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats	3
Inhibition of angiotensin II–induced hypertrophy and cardiac dysfunction by North American ginseng (Panax quinquefolius)	3
Endothelin-1, endothelin receptor antagonists, and vein graft occlusion in coronary artery bypass surgery: 20 years on and still no journey from bench to bedside	3
Pharmacokinetics and tissue distribution study of herpetotriol in rats by ultrahigh-performance liquid chromatography with tandem mass spectrometry	3
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	3
Ethanol and cyclophosphamide induce similar nephrotoxic effects: possible role for Nox4 and superoxide	3
Smoothelin-like 1 knockout mice display sex-dependent alterations in blood flow and cardiac function	2
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	2
PPARα/γ, adiponectin, and GLUT4 overexpression induced by moronic acid methyl ester influenced glucose and triglyceride levels of experimental diabetic mice	2
Future scope and challenges for congestive heart failure: moving toward development of pharmacotherapy	2
Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation	2
Female-biased association of NOS2-c.1823C>T (rs2297518) with co-susceptibility to metabolic syndrome and asthma	2
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study	2
Paraoxonase and oxidative stress changes in left and right ventricles of exhaustively exercised rats	2
Melatonin decreases circulating Trypanosoma cruzi load with no effect on tissue parasite replication	2
Vasorelaxant effect of monoterpene carvacrol on isolated human umbilical artery	2
Leptin induces a contracting effect on guinea pig tracheal smooth muscle via the Ob-R receptor mechanism: novel evidence	2
Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the baso	2
Sirtuin 3 overexpression preserves maximal sarco(endo)plasmic reticulum calcium ATPase activity in the skeletal muscle of mice subjected to high fat – high sucrose feeding	2
Inhibition of glutamatergic transmission and neuronal excitability by oxycodone in the rat hippocampal CA3 neurons	2
Porphyromonas gingivalis induces cardiovascular dysfunction	2
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	2
Exchange proteins directly activated by cAMP mediate cardiac repolarization and arrhythmogenesis during chronic heart failure	2
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	2
mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats	2
Protective effects of BiP inducer X (BIX) against diabetic cardiomyopathy in rats	2
COVID-19 pathophysiology and pharmacology: what do we know and how did Canadians respond? A review of Health Canada authorized clinical vaccine and drug trials	2
Single-center prognostic validation of the risk assessment of the 2015 ESC/ERS guidelines in patients with pulmonary arterial hypertension in Japan	2
Krešimir Krnjević (1927–2021) and GABAergic inhibition: a lifetime dedication	2
Unveiling the antibacterial and antioxidant potential of Hedera helix leaf extracts: recent findings	2
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	2
Thirty-day experimental diabetes impairs contractility and increases fatigue resistance in rat diaphragm muscle associated with increased anti-oxidative activity	2
Role of cyclic AMP response element binding protein (CREB) in angiotensin II-induced responses in vascular smooth muscle cells	2
Thyroid hormones regulate reelin expression in neuropsychiatric disorders	2
p-Chloro-diphenyl diselenide modulates Nrf2/Keap1 signaling and counteracts renal oxidative stress in mice exposed to repeated dexamethasone administrations	2
β-elemene relieves neuropathic pain in mice through the regulation on C-X-C motif chemokine receptor 3 and GABAA receptor	2
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	2
Short-term effects induced by nicotinamide in ovariectomized females	2
The effect of selected drugs on the mitigation of myocardial injury caused by gamma radiation	2
CF3-substituted diselenide modulatory effects on oxidative stress, induced by single and repeated morphine administrations, in susceptible tissues of mice	2
Simultaneous intervention against oxidative stress and inflammation by targeting Nrf2/ARE and NLRP3 inflammasome pathway mitigates thioacetamide-induced liver fibrosis in rat	2
Levetiracetam induction of theta frequency oscillations in rodent hippocampus in vitro	2
Oxygen sensor of the heart	2
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	2
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	2
Role of mitochondria in the differential action of sodium deoxycholate and ursodeoxycholic acid on rat duodenum	2
SET8 participates in lipopolysaccharide-mediated BV2 cell inflammation via modulation of TICAM-2 expression	2
Ethanol consumption increases renal dysfunction and mortality in a mice model of sub-lethal sepsis	2
Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner	2
TMEM98, a novel secretory protein, promotes endothelial cell adhesion as well as vascular smooth muscle cell proliferation and migration	2
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	2
Knockdown of lysyl oxidase like 1 inhibits the proliferation and pro-fibrotic effects of transforming growth factor-β1-induced hypertrophic scar fibroblasts	2
Predictive model of bosentan-induced liver toxicity in Japanese patients with pulmonary arterial hypertension	2