Canadian Journal of Physiology and Pharmacology

Article	Citations
Note of appreciation	44
Citral inhibits the nociception in the rat formalin test: effect of metformin and blockers of opioid receptor and the NO-cGMP-K+ channel pathway	29
Sex-specific considerations in cardiovascular drug therapy	23
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	22
Detection of joining points for genomic DNA circularization in cell culture	20
Existence and importance of Na+K+-ATPase in the plasma membrane of boar spermatozoa	18
Correction: Cardiac physiology and pathophysiology in pregnancy	17
Systemic study of selected histone deacetylase inhibitors in cardiac complications associated with cancer cachexia	16
The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetes	16
Cannabinoid 2 receptor agonist and L-arginine combination attenuates diabetic cardiomyopathy in rats via NF-ĸβ inhibition	15
L-ergothioneine and metformin alleviates liver injury in experimental type-2 diabetic rats via reduction of oxidative stress, inflammation, and hypertriglyceridemia	15
The protein tyrosine kinase inhibitor genistein suppresses hypoxia-induced atrial natriuretic peptide secretion mediated by the PI3K/Akt-HIF-1α pathway in isolated beating rat atria	15
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	14
Effect of fluoxetine treatment on neurotoxicity induced by lysolecithin in male rats	14
Hepatoprotective effect of trypsin/chymotrypsin against olanzapine-induced non-alcoholic steatohepatitis in rats	14
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	13
Inhibition of microRNA-297 alleviates THLE-2 cell injury induced by hypoxia/reoxygenation by inhibiting NLRP3 inflammasome activation via sirtuin 3	13
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	13
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	13
The impact of ionizing radiation compared to drug-induced immunological changes	13
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney	13
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	12
FoxO3 transcription factor promotes autophagy after oxidative stress injury in HT22 cells	12
Cardioprotective effect of fingolimod against calcium paradox–induced myocardial injury in the isolated rat heart	11
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	11

Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	11
Histamine H3 receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	10
Cardiogenic shock—sex-specific risk factors and outcome differences	10
SNHG8 promotes cell proliferation, migration, and invasion of nasopharyngeal carcinoma cells as an oncogene through miR-588/HMGA2 axis	10
Inhibition of endoplasmic reticulum stress combined with activation of angiotensin-converting enzyme 2: novel approach for the prevention of endothelial dysfunction in type 1 diabetic rats	10
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	10
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	9
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	9
Gender-specific side effects of chemotherapy in pancreatic cancer patients	9
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	9
Facile synthesis of bromelain copper nanoparticles to improve the primordial therapeutic potential of copper against acute myocardial infarction in diabetic rats	9
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	9
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	9
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	9
Canadian Society of Pharmacology and Therapeutics	9
Ribavirin shows antiviral activity against SARS-CoV-2 and downregulates the activity of TMPRSS2 and the expression of ACE2 in vitro	9
The intervention oftert-butylhydroquinone protects ethanol-induced gastric ulcer in type II diabetic rats: the role of Nrf2 pathway	9
MiR-145-5p modulates lipid metabolism and M2 macrophage polarization by targeting PAK7 and regulating β-catenin signaling in hyperlipidemia	8
Right ventricular dysfunction in preclinical models of type I and type II diabetes	8
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	8
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	8
Evaluation of the in vivo and in vitro anti-inflammatory activity of a new hybrid NSAID tetrahydropyran derivative	8
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	7
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	7
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	7
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	7
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	7
Nicaraven inhibits TNFα-induced endothelial activation and inflammation through suppression of NF-κB signaling pathway	6
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	6
Dexamethasone attenuates the modulatory effect of the insular cortex on the baroreflex in anesthetized rat	6
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	6
Canadian Society of Pharmacology and Therapeutics	6
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels	6
Role of the NO-cGMP-K+ channels pathway in the peripheral antinociception induced by α-bisabolol	6
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	6
Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	6
Association of blood pressure and BMI to corrected QT interval in young adults	6
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	6
Lipopolysaccharide induces BV2 microglial cell migration via a decrease in SET8 expression	6
miR-30a-5p inhibits the proliferation and collagen formation of cardiac fibroblasts in diabetic cardiomyopathy	6
Discussion: Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study	6
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	6
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
The active fragments of ghrelin cross the blood–brain barrier and enter the brain to produce antinociceptive effects after systemic administration	6
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5

Colchicine attenuates renal ischemia-reperfusion-induced liver damage: implication of TLR4/NF-κB, TGF-β, and BAX and Bcl-2 gene expression	5
Introduction—Unveiling gender disparity in heart disease	5
Effects of physical exercise on baroreflex sensitivity and renal sympathetic nerve activity in chronic nicotine-treated rats	5
Correction: Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid–induced liver injury	5
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	5
Renal expression and urinary excretion of aquaporin-2 in postobstructive uropathy in rats	5
The addictive process of opioids: current and novel interventions in opioid use disorder	5
Mild hyperhomocysteinemia induces blood–brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice	5
The protective effect of apelin-13 on cardiorenal toxicity induced by cyclophosphamide	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
Time to treat the climate and nature crisis as one indivisible global health emergency	5
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	5
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
The S1PR1 agonist SEW2871 promotes the survival of skin flap	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
The variations of endophilin A2-FoxO3a-autophagy signal in angiotensin II–induced dopaminergic neuron injury mouse model and by biochanin A	5
Note of appreciation	5
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	4
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	4
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	4
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats	4
Generation of prolactin-inducible protein (Pip) knockout mice by CRISPR/Cas9-mediated gene engineering	4
Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	4
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	4
Paradoxical effects of acidosis on the noradrenaline-induced and neurogenic constriction of the rat tail artery at low temperatures	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
Modified cancer TNM classification for localized renal cell carcinoma based on the prognostic analysis of 3748 cases from a single center	4
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	4
Formation of a border ischemic zone depends on plasma potassium concentration	4
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	4
Epigenetic regulation of sex dimorphism in cardiovascular health	4
New insight on the role of liraglutide in alleviating dexamethasone-induced pancreatic cytotoxicity via improving redox status, autophagy flux, and PI3K/Akt/Nrf2 signaling	4
Maternal high fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signa	4
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	4
Cardioprotective effects of losartan and diminazene against the ischemia/reperfusion injury in hyperthyroidism rats	3
Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus	3
White matter microglia morphological changes with aging in guinea pig offspring born growth restricted	3
TMEM98, a novel secretory protein, promotes endothelial cell adhesion as well as vascular smooth muscle cell proliferation and migration	3
SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression	3
Serum prokineticin-2 in prepubertal and adult Klinefelter individuals	3
Inducible nitric oxide synthase (iNOS) mediates ethanol-induced redox imbalance and upregulation of inflammatory cytokines in the kidney	3
Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission	3
Protective effect of sitagliptin and whole-body γ-irradiation in diabetes-induced cardiac injury	3
Long non-coding RNA SNHG16 regulates E2F1 expression by sponging miR-20a-5p and aggravating proliferative diabetic retinopathy	3
Taurine alleviates kidney injury in a thioacetamide rat model by mediating Nrf2/HO-1, NQO-1, and MAPK/NF-κB signaling pathways	3
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	3
Impact of biological sex on valvular heart disease, interventions, and outcomes	3
Post hoc assessment of the relationship among coronary stenosis, electrocardiography, and ventricular function in patients with heart disease	3
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	3
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation	3
Aprocitentan and the endothelin system in resistant hypertension	3
Modulatory effect of simvastatin on redox status, caspase-3 expression, p-protein kinase B (p-Akt), and brain-derived neurotrophic factor (BDNF) in an ethanol-induced neurodegeneration model	3
Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report	3
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity	3
β-elemene relieves neuropathic pain in mice through the regulation on C-X-C motif chemokine receptor 3 and GABAA receptor	3
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension	3
Sirtuin 3 overexpression preserves maximal sarco(endo)plasmic reticulum calcium ATPase activity in the skeletal muscle of mice subjected to high fat – high sucrose feeding	3
Nanoparticle-eluting stents for coronary intervention: formulation, characterization, and in vitro evaluation	3
Cardiovascular and physiological risk factors in women at mid-life and beyond	3
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca2+ influx	3
Effect of intracutaneous pyonex on analgesia and sedation in critically ill patients with mechanical ventilation	3
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line	3
Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand–foot syndrome induced by capecitabine in rats	3
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats	3
Lysophosphatidic acid metabolism and signaling in heart disease	3
Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy	3
The anti-anginal ranolazine does not confer beneficial actions against hepatic steatosis in male mice subjected to high-fat diet and streptozotocin-induced type 2 diabetes	3
Correction: Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	3
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients	3
Vitexin regulates Epac and NLRP3 and ameliorates chronic cerebral hypoperfusion injury	3
Theobromine ameliorates nonalcoholic fatty liver disease by regulating hepatic lipid metabolism via mTOR signaling pathway in vivo and in vitro	3
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	3

Endothelial colony forming cells’ tetrahydrobiopterin level in coronary artery disease patients and its association with circulating endothelial progenitor cells	3
Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review	3
Cardiopulmonary values and organ blood flows before and during heat stress: data in nine subjects at rest in the upright position	3
The Seventeenth International Conference on Endothelin (ET-17)	2
Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model	2
Discontinuing semaglutide after weight loss: strategy for weight maintenance and a possible new side effect	2
NLG-919 combined with cisplatin to enhance inhibitory effect on cell migration and invasion via IDO1–Kyn–AhR pathway in human nasopharyngeal carcinoma cell	2
Knockdown of lysyl oxidase like 1 inhibits the proliferation and pro-fibrotic effects of transforming growth factor-β1-induced hypertrophic scar fibroblasts	2
The correlation between the expression of ATF4 and procalcitonin combined with the detection of RET mutation and the pathological stage and clinical prognosis of medullary thyroid carcinoma	2
Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice	2
Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba	2
Upregulation of exonuclease 1 caused by homology-dependent repair confers cisplatin resistance to gastric cancer cells	2
The OPG/RANKL/RANK system modulates calcification of common carotid artery in simulated microgravity rats by regulating NF-κB pathway	2
Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	2
A review of the common causes of acute coronary syndrome (ACS) in females, and the role of estrogen on its pathologies and risk factors	2
Butorphanol inhibits androgen biosynthesis and metabolism in rat immature Leydig cells in vitro	2
Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response	2
Neonatal treatment with fluoxetine alters locomotor activity and the cortical glial/neuron index in rats with cerebral palsy	2
TLR/mTOR inflammatory signaling pathway: novel insight for the treatment of schizophrenia	2
Inhibition of dipeptidyl peptidase-4 averts free fatty acids deposition in the hearts of oral estrogen–progestin contraceptive-induced hyperinsulinemic female rats	2
Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure	2
Considerations for choosing an optimal animal model of cardiovascular disease	2
Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis	2
Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart	2
Effect of soya phosphatidylcholine and possible underlying mechanism on ischemia/reperfusion injury in isolated perfused rat heart: an experimental and computational study	2
Midazolam suppresses ischemia/reperfusion-induced cardiomyocyte apoptosis by inhibiting the JNK/p38 MAPK signaling pathway	2
Low-fat cheese ameliorates glucose intolerance and normalizes insulin secretion in a rat model of type 2 diabetes by promoting β-cell recovery	2
Behavioral dynamics of medicinal signaling cells from porcine bone marrow in long-term culture	2
A novel regulatory network of linc00174/miR-150-5p/VEGFA modulates pathological angiogenesis in diabetic retinopathy	2
Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diabetic complications	2
Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	2
Nampt as a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular and neurodegenerative diseases.	2
Effect of 4-hydroxychalcone as preventive and curative treatment in Wistar rats with liver injury	2
Potential role of d-chiro-inositol in reducing oxidative stress in the blood of nonobese women with polycystic ovary syndrome	2
Preventative effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives (N-functional group loading) on MPTP-induced parkinsonism in mice	2
Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
Transgenerational impact of topical steroid application on superoxide dismutase activities of hypothalamus-pituitary-adrenal axis in rats	2
Neonatal administration of fenofibrate had no developmental programming effect on the lipid profile and relative leucocyte telomere lengths of adolescent rats fed a high-fructose diet postnatally	2
Delta-tocotrienol enhances the anti-tumor effects of interferon alpha through reactive oxygen species and Erk/MAPK signaling pathways in hepatocellular carcinoma cells	2
The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52	2
Systematic review of Health Canada approved clinical therapeutic trials for the treatment or prevention of coronavirus disease 2019 (COVID-19)	2
Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels	2
New approaches to the design of analgesic medicinal substances	2
Future scope and challenges for congestive heart failure: moving toward development of pharmacotherapy	2
Alamandine via MrgD receptor attenuates pulmonary fibrosis via NOX4 and autophagy pathway	2