Canadian Journal of Physiology and Pharmacology

Article	Citations
Correction: Cardiac physiology and pathophysiology in pregnancy	28
Note of appreciation	25
Existence and importance of Na+K+-ATPase in the plasma membrane of boar spermatozoa	25
Sex-specific considerations in cardiovascular drug therapy	19
Different responses to homocysteine in primary endothelial cells and an immortalized endothelial cell line	16
Cytochrome P450 1B1 is critical in the development of TNF-α, IL-6, and LPS-induced cellular hypertrophy	15
Ameliorative effect of roxithromycin against prostate inflammation-induced chronic pelvic pain in a preclinical model	14
Detection of joining points for genomic DNA circularization in cell culture	14
Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals	14
Naringin prevents the impairment of hepatic mitochondrial function in diabetic rats	13
The impact of ionizing radiation compared to drug-induced immunological changes	12
Cardiogenic shock—sex-specific risk factors and outcome differences	12
Porphyromonas gingivalis infection upregulates the endothelin (ET) system in brain microvascular endothelial cells	12
RAD54B inhibits vascular endothelial senescence via suppression of CHK1/p53/p21 pathway	12
Role of phospholipase C in catecholamine-induced increase in myocardial protein synthesis	11
Canadian Society of Pharmacology and Therapeutics	11
Beneficial effects of the remifentanil/thiopental combination on cardiac function and redox status in diabetic rats	11
Vascular effects of midazolam, flumazenil, and a novel imidazobenzodiazepine MP-III-058 on isolated rat aorta	11
Histamine H3 receptor activation increases the firing of striatal medium spiny neurons in slices from infantile rats	10
Endoplasmic reticulum stress, calcium homeostasis and the aging heart	10
Correction: Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	10
Restoration of cardiac metabolic flexibility by acetate in high-fat diet-induced obesity is independent of ANP/BNP modulation	10
The effect of dapagliflozin on myocardial ischemia–reperfusion injury in diabetic rats	10
Sex-specific vascular effects of menthol: TRPM8- and TRPA1-dependent relaxation in female mouse aorta and pudendal arteries	10
Assessment of human placental microbial signatures in pre-eclampsia using shotgun metagenomics	9

Clozapine and pharmacogenomics testing: opportunities and challenges for personalized treatment in schizophrenia	8
Right ventricular dysfunction in preclinical models of type I and type II diabetes	8
Fishing antioxidant 4-hydroxycoumarin derivatives: synthesis, characterization, and in vitro assessments	8
Exogenous and endogenous antioxidants (ROS) in physiology and pathology of the cardiovascular system	8
Correction: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1channels	8
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma	8
Echocardiographic assessment of epicardial adipose tissue thickness as independent predictor in coronary artery disease	7
Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and (or) creatine in HIIT-trained rats	7
Focus on aging, heart failure, regeneration, and cardiovascular medicine	7
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury	7
Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation	7
Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress	7
Abstracts for The 2025 Scientific Meeting of the Canadian Society of Pharmacology and Therapeutics	7
Engaging women in decision-making about their heart health: a literature review with patients’ perspective	7
Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells	7
Mechanism and effects of artesunate on the liver function of rats with type 1 diabetic periodontitis	7
Causality assessment of adverse events by healthcare professionals in an academic hospital setting: a descriptive retrospective study	7
Endothelin A receptor antagonist attenuated renal iron accumulation in iron overload heme oxygenase-1 knockout mice	7
5 weeks of online resistance training with blood flow restriction increases sit-to-stand oxygen consumption in healthy older adults	7
Effects of acute aerobic exercise on skeletal muscle and liver glucose metabolism in male rodents with type 1 diabetes	7
Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction	7
Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats	7
Cardioprotective effects of liraglutide pretreatment on isoprenaline-induced myocardial injury in rats	6
Protective role of nebivolol via AKT1/Hif-1α/eNOS signaling pathway: nephrotoxicity caused by methotrexate in a rat model	6
Endothelin A receptors contribute to senescence of brain microvascular endothelial cells	6
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells via mTOR activation and augmented mitochondrial strength	6
Potassium depolarized rat uterus in response to oxytocin and its structural analogues: Kinetic analysis	6
Sarcopenia: recent advances for detection, progression, and metabolic alterations along with therapeutic targets	6
Myotubularin related protein 7, a novel STIM1 binding protein	6
Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells	6
Introduction—Unveiling gender disparity in heart disease	6
Effect of ostarine on glucose level, lipid profile, and osteoporosis in streptozotocin induced diabetic male rats	6
Canadian Society of Pharmacology and Therapeutics	6
Effects of sclerostin injection on soleus and extensor digitorum longus muscle tissue in male mice	6
Endothelin antagonism reduces hemoglobin A1c in patients with pulmonary hypertension	6
Deferoxamine alleviates brain ischemia/reperfusion injury through decreasing LAG-3 and α-Syn expression	6
Sex hormone dose escalation for treating abnormal sleep in ovariectomized rats: in vitro GABA synthesis in sleep-related brain areas	5
Structure–activity relationship of three new piperazine derivates with anxiolytic-like and antidepressant-like effects	5
Chronic cannabis use is associated with altered monocyte phenotype, immune response, and depression in physically active individuals	5
Endurance training-induced cardiac remodeling in a guinea pig athlete's heart model	5
New hypoglycemic effects of indorenate mediated by the 5-HT1a and 5-HT2a receptors: in vivo and in silico studies	5
High fructose consumption induces cardiac dysfunction and vascular abnormalities	5
The impacts of vorinostat on NADPH oxidase and mitochondrial biogenesis gene expression in the heart of mice model of depression	5
Age-dependent effect of insulin in the regulation of intracellular calcium in ventricular cardiomyocytes	5
Long-term potentiation and its neurotrophin-dependent modulation in the superior cervical ganglion of the rat are influenced by KCNQ channel function	5
Time to treat the climate and nature crisis as one indivisible global health emergency	5
Note of appreciation	5
Correction: Pharmacological safety of dimethoxy curcumin-human serum albumin conjugate for potential therapeutic purpose	5
The addictive process of opioids: current and novel interventions in opioid use disorder	5
Formation of a border ischemic zone depends on plasma potassium concentration	4

Direct cellular reprogramming techniques for cardiovascular regenerative therapeutics	4
Coenzyme Q10 ameliorates hepatoprotective effect of metformin in experimentally-induced type 2 diabetes mellitus in rats: a functional and histological study	4
Alleviation of adipose–hepatic glycolipid dysregulation by acetate in experimental PCOS model is associated with NF-κB/NLRP3 repression	4
Cardio-rheumatology: the cardiovascular, pharmacological, and surgical risks associated with rheumatological diseases in women	4
In memoriam: Morley D. Hollenberg (1944–2025), scientist, artist, mentor, and friend	4
Maternal high-fat diet promotes enhanced airway hyperresponsiveness and impaired bronchodilation response in adult male offspring	4
Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice	4
The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line	4
Opioid agonist treatment dispensing trends between 2018 and 2022 across six Canadian provinces	4
Endothelial characteristics of cardiac stem cell antigen-1 expressing cells and their relevance to right ventricular adaptation	4
Editorial Expression of Concern: Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1	4
The antioxidant and anti-inflammatory activities of caffeine effectively attenuate nonalcoholic steatohepatitis and thioacetamide-induced hepatic injury in male rats	4
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery	4
Hemostasis and oxidative stress in chronic kidney disease in children and adolescents	4
Untangling the heart–brain connection in Parkinson’s disease: emerging mechanisms and models	4
Pharmacological evidence that GABA-induced relaxation of rat proximal duodenum longitudinal muscle depends on NKCC cotransporter activity and Ca2+ influx	4
Impact of biological sex on valvular heart disease, interventions, and outcomes	4
Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice	4
Evaluation of liver stiffness using ultrasonic shear wave elastography in patients with COVID-19 induced pneumonia	4
The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors	4
Nebivolol prevents redox imbalance and attenuates bladder dysfunction induced by cyclophosphamide in mice	4
The effect of the long-term inhibition of hydrogen sulfide production on the reactivity of the cardiovascular system in Wistar rats	4
Analysis of literature-derived duplicate records in the FDA Adverse Event Reporting System (FAERS) database	4
KCNQ3 activation by the naturally occurring phenol, eugenol	4
High-sensitivity troponin I-guided cardiovascular risk assessment in a general asymptomatic population: a cost-effectiveness analysis in 4000 adults	4
Epigenetic regulation of sex dimorphism in cardiovascular health	4
Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line	4
Wnt/β-catenin inhibitor pyrivinium attenuates cisplatin-induced acute kidney injury by possibly reducing platinum uptake and accumulation mediated by reduced organic cation transporter-2 expressions	4
The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction	4
Cardiovascular and physiological risk factors in women at mid-life and beyond	3
Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension	3
Metabolic therapy for cardiovascular diseases with propionyl L-carnitine	3
Microemboli model of vascular cognitive impairment/dementia (VCID) presents with long-term brain tissue hypoxia: relevance to the endothelin (ET) system	3
Potential benefits of therapeutic drug monitoring for beta-lactam antibiotics in augmented renal clearance patients: a case report	3
Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy	3
Cardioprotective effects of losartan and diminazene against the ischemia/reperfusion injury in hyperthyroidism rats	3
Buprenorphine administration during gestation induces hepatotoxicity in the rat fetus	3
Thymidine phosphorylase as a molecular target for quercetin-incorporated collagen matrix in the prevention of hand–foot syndrome induced by capecitabine in rats	3
Salvianolic acid B attenuates diabetic nephropathy through alleviating ADORA2B, NALP3 in flammasome, and NFκB activity	3
Endothelial colony forming cells’ tetrahydrobiopterin level in coronary artery disease patients and its association with circulating endothelial progenitor cells	3
Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients	3
Correction: Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure	3
Crosstalk among apoptosis, inflammation, and autophagy in relation to melatonin protective effect against contrast-induced nephropathy in rats	3
Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission	3
β-elemene relieves neuropathic pain in mice through the regulation on C-X-C motif chemokine receptor 3 and GABAA receptor	3
The anti-anginal ranolazine does not confer beneficial actions against hepatic steatosis in male mice subjected to high-fat diet and streptozotocin-induced type 2 diabetes	3
Cost-Effectiveness of Incretin Therapies: A Canadian Lens on Diabetes, Obesity, and Emerging Indications	2
Cannabivarin and tetrahydrocannabivarin modulate nociception via vanilloid channels and cannabinoid-like receptors in Caenorhabditis elegans	2
Placental hypoxia and oxidative stress responses to smokeless tobacco use in Alaska Native participants in the MAW study	2
Delta-tocotrienol enhances the anti-tumor effects of interferon alpha through reactive oxygen species and Erk/MAPK signaling pathways in hepatocellular carcinoma cells	2
Butorphanol inhibits androgen biosynthesis and metabolism in rat immature Leydig cells in vitro	2
Upregulation of exonuclease 1 caused by homology-dependent repair confers cisplatin resistance to gastric cancer cells	2
Behavioral dynamics of medicinal signaling cells from porcine bone marrow in long-term culture	2
Potential role of d-chiro-inositol in reducing oxidative stress in the blood of nonobese women with polycystic ovary syndrome	2
Lipopolysaccharide-pretreated mesenchymal stem cell-conditioned medium optimized with 10 kDa filter attenuates the injury of H9c2 cardiomyocytes in a model of hypoxia/reoxygenation	2
Correction: Polygenic scores of obesity in childhood based on summary statistics from adults versus children	2
Lysophosphatidic acid metabolism and signaling in heart disease	2
White matter microglia morphological changes with aging in guinea pig offspring born growth restricted	2
A review of the common causes of acute coronary syndrome (ACS) in females, and the role of estrogen on its pathologies and risk factors—review article	2
Suppression of protein kinase RNA-like endoplasmic reticulum kinase by probiotics circumvents cardiovascular risk profile in experimentally induced PCOS model	2
Systematic review of Health Canada approved clinical therapeutic trials for the treatment or prevention of coronavirus disease 2019 (COVID-19)	2
Adaptive and maladaptive roles of different angiotensin receptors in the development of cardiac hypertrophy and heart failure	2
Role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in diabetic complications	2
Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice	2
Low-fat cheese ameliorates glucose intolerance and normalizes insulin secretion in a rat model of type 2 diabetes by promoting β-cell recovery	2
The Seventeenth International Conference on Endothelin (ET-17)	2
Role of endogenous incretin hormones, GLP-1 and GIP, in cardiovascular physiology	2
Discontinuing semaglutide after weight loss: strategy for weight maintenance and a possible new side effect	2
Transgenerational impact of topical steroid application on superoxide dismutase activities of hypothalamus-pituitary-adrenal axis in rats	2
Assessing feasibility and sex-related inequity in the cardiac rehabilitation quality indicators in Manitoba	2
Future scope and challenges for congestive heart failure: moving toward development of pharmacotherapy	2
Correction: Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model	2
Celebrating the life and legacy of Dr. Gary D. Lopaschuk (1955–2025)	2
Pilot study of jadomycin B pharmacokinetics and anti-tumoral effects in zebrafish larvae and mouse breast cancer xenograft models	2
Correction: Deciphering MMP9’s dual role in regulating SOD3 through protein–protein interactions	2
Influence of carvedilol and thyroid hormones on inflammatory proteins and cardioprotective factor HIF-1α in the infarcted heart	2
The non-nutritive sweetener sucralose increases β-arrestin signaling at the constitutively active orphan G protein-coupled receptor GPR52	2
Neonatal treatment with fluoxetine alters locomotor activity and the cortical glial/neuron index in rats with cerebral palsy	2
Neonatal administration of fenofibrate had no developmental programming effect on the lipid profile and relative leucocyte telomere lengths of adolescent rats fed a high-fructose diet postnatally	2

Nampt: a new therapeutic target for modulating NAD+ levels in metabolic, cardiovascular, and neurodegenerative diseases	2
Aprocitentan and the endothelin system in resistant hypertension	2
Protective effects of Melissa officinalis ethanolic extract on doxorubicin-induced cardiotoxicity in a rat model	2
SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression	2
Considerations for choosing an optimal animal model of cardiovascular disease	2
Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels	2