British Journal of Pharmacology

Article	Citations
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Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs	163
Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”	157
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice	156
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Role of NaV1.7 in action potential conduction along human bronchial vagal afferent C‐fibres	146
Gβγ subunit signalling underlies neuropeptide Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries	139
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Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice	123
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy	120
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review	93
The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine	93
Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases	91
Decoding fatal toxic effects in checkpoint inhibitor therapy using real‐world pharmacovigilance data and machine learning	89
EXPRESSION OF CONCERN: Nitropravastatin Stimulates Reparative Neovascularisation and Improves Recovery from Limb Ischaemia in Type‐1 Diabetic Mice	83
Structural and molecular determinants of mineralocorticoid receptor signalling	81
GPR84 in physiology—Many functions in many tissues	71
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis	68
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity	67
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin	66
The potential for biased signalling in the P2Y receptor family of GPCRs	65

Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis	64
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR	60
Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors	59
Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction	57
Opportunities of patient‐derived organoids in drug development	55
The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment	54
Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer	54
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury	51
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer	50
Supersulfide biology and translational medicine for disease control	50
A new class of 5‐HT2A/5‐HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins	49
Novel therapeutic approaches to target neurodegeneration	48
Issue Information	48
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline	48
Development of new Kir2.1 channel openers from propafenone analogues	46
Insight in article retractions inBritish Journal of Pharmacologybetween the years 2000–2023. Implications for reducing fraud‐containing articles	45
The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial	43
Silibinin, a commonly used therapeutic agent for non‐alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19	43
Efficacy in diet‐induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM38837	41
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Mineralocorticoid receptors in non‐alcoholic fatty liver disease	40
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice	40
Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis	40
Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation	39
Identification of a human blood biomarker of pharmacological 11β‐hydroxysteroid dehydrogenase 1 inhibition	39
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities	38
Network‐based precision medicine and systems pharmacology	38
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod‐induced psoriasiform inflammation via STAT1/S100A9 signalling pathway	38
Fifty years with aspirin and platelets	37
β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation	36
tiRNA‐Gly‐GCC‐002 promotes epithelial‐mesenchymal transition and fibrosis in lupus nephritis via FKBP5‐mediated activation of Smad	36
Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent	36
Targeting mitochondrial proteases for therapy of acute myeloid leukaemia	36
Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling	35
Pharmacological characterization of novel heteromeric GluCl subtypes from Caenorhabditis elegans and parasitic nematodes	34
Potential medicinal value of N6‐methyladenosine in autoimmune diseases and tumours	34
Elucidating the beneficial impact of exercise on chronic obstructive pulmonary disease and its comorbidities: Integrating proteomic and immunological insights	34
Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain	34
Sevoflurane acts as an antidepressant by suppression of GluN2D‐containing NMDA receptors on interneurons	33
In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment	33
Bioactivity‐based molecular networking‐guided identification of guttiferone J from Garcinia cambogia as an anti‐obesity candidate	33
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice	32
Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis	32
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice	32
Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential	32
From mundane to classic: Sinomenine as a multi‐therapeutic agent	31
NRF2 signalling in cytoprotection and metabolism	31
Defining and unpacking the core concepts of pharmacology: A global initiative	31
Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice	30
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats	30

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Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64Cu PET/MRI	29
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A proposal for rational drug class terminology: A gastrointestinal perspective	28
Proteinase‐activated receptor‐2 antagonist C391 inhibits Alternaria‐induced airway epithelial signalling and asthma indicators in acute exposure mouse models	28
Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells	27
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Therapeutic effect of human ApoA‐I‐Milano variant in aged transgenic mouse model of Alzheimer's disease	27
Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy	27
Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two‐sided nature of antagonistic ligands resulting from partial dissociation of Gq	27
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder	27
Cav1.3‐selective inhibitors of voltage‐gated L‐type Ca2+ channels: Fact or (still) fiction?	27
Resolution pharmacology and the treatment of infectious diseases	27
Gαq signalling from endosomes: A new conundrum	26
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Bioavailability of flumequine and diclofenac in mice exposed to a metal‐drug chemical cocktail. Evaluation of the protective role of selenium.	26
Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol	26
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A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia	26
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets	26
AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice	26
R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases	24
Natural products and cancer: From drug discovery to prevention and therapy	24
Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs	24
Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets	24
Perspective article: A proposal for rational drug class terminology	24
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice	24
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age‐related macular degeneration	24
BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus	23
Nicotinic‐acid derivative BGP‐15 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy	23
A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain	23
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes	23
Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells	23
Effects of microsomal prostaglandin E synthase‐1 inhibition on resistance artery tone in patients with end stage kidney disease	23
Dual effects of mefenamic acid on the IKs molecular complex	22
Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice	22
Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor	22
Central metabolism as a potential origin of sex differences in morphine antinociception but not induction of antinociceptive tolerance in mice	22
Cyclic helix B peptide promotes random‐pattern skin flap survival via TFE3‐mediated enhancement of autophagy and reduction of ROS levels	22
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain	22
Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function	22
Advancing antihypertensive drug development	21
Activating transcription factor‐3 orchestrates the modulation of vascular anti‐contractile activity and relaxation by governing the secretion of HDL‐bound sphingosine‐1‐phosphate in perivascular adipo	21
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Linking drug and food addiction via compulsive appetite	21
Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34	21
Expression of Concern: Effects of Tyrphostins and Genistein on the Virculatory Gailure and Organ Dysfunction Caused by Endotoxin in the Rat: A Possible Role for Protein Tyrosine Kinase	21
EXPRESSION OF CONCERN: H2S‐Donating Sildenafil (ACS6) Inhibits Superoxide Formation and gp91phox Expression in Arterial Endothelial Cells: Role of Protein Kinases A and G	21
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Baclofen modulates the immune response after spinal cord injury with locomotor benefits	20
Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation	20
Photochemical control of cold‐sensitive TRPA1 ion channel gating for modulation of pain sensation	20
A peptide rich in glycine–serine–alanine repeats ameliorates Alzheimer‐type neurodegeneration	20
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial–mesenchymal trophic unit activation in asthma	20
Safety Toxicology	19
Silencing the fibronectin gene (FN1) improves NaCl‐induced cardiac fibrosis via ferritinophagy‐mediated ferroptosis in a nuclear receptor coactivator 4 (NCOA4)‐dependent manner	19
Novel agonist and antagonist radioligands for the GLP‐2 receptor. Useful tools for studies of basic GLP‐2 receptor pharmacology	19
Targeting noncoding RNAs to treat atherosclerosis	19
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment	19
Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling	19
The flavonoid GL‐V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells	19
A GLP‐1/glucagon (GCG)/CCK2 receptors tri‐agonist provides new therapy for obesity and diabetes	19
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein	19
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia	19
Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: Sex differences in rats	19
Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish	19
Amitriptyline blocks innate immune responses mediated by toll‐like receptor 4 and IL‐1 receptor: Preclinical and clinical evidence in osteoarthritis and gout	19
Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review	19
Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea	19
The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration	19
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A	19
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Opioid receptors in cardiovascular function	18
Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery	18
Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer	18
V‐domain immunoglobulin suppressor of T‐cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma	18
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Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats	18
Neutrophil β1 adrenoceptor blockade blunts stroke‐associated neuroinflammation	18
Bioactive ligands targeting ectopic olfactory receptors: Implications for therapeutic strategies	18
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A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages	18
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential	18
Mucin‐fused myeloid‐derived growth factor (MYDGF164) exhibits a prolonged serum half‐life and alleviates fibrosis in chronic kidney disease	18
In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by	17
Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth	17
Naringenin relieves paclitaxel‐induced pain by suppressing calcitonin gene‐related peptide signalling and enhances the anti‐tumour action of paclitaxel	17
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Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence	17
Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive	17
Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib	17
Corticosteroid insensitivity in asthma associated with obstructive sleep apnoea: Role of oxidative stress and histone acetylation	17
Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors	17
Chemistry/structural biology of psychedelic drugs and their receptor(s)	17
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?	17
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Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis	17
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China	16
Soluble epoxide hydrolase inhibition enhances production of specialized pro‐resolving lipid mediator and promotes macrophage plasticity	16
Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis	16
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Disruption of survivin protein expression by treatment with YM155 accelerates the resolution of neutrophilic inflammation	16
The Concise Guide to PHARMACOLOGY 2023/24: Transporters	16
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Correction	16
RETRACTION: L6H21 protects against cognitive impairment and brain pathologies via toll‐like receptor 4–myeloid differentiation factor 2 Signalling in Prediabetic rats	16
CORRECTION	16
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons	16
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity	16
Natural Products	16
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AMG487 alleviates influenza A (H1N1) virus‐induced pulmonary inflammation through decreasing IFN‐γ‐producing lymphocytes and IFN‐γ concentrations	15
A pH‐sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation	15
Cell‐based therapy for diabetic cardiovascular complications: Prospects and challenges	15
Building Bridges In Neuropharmacology: New therapeutic approaches for psychiatric and neurodegenerative disorders	15
EDITORIAL for BJP themed issue “noncoding RNA therapeutics”	15
ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis	15
Sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA2b) mediates oxidation‐induced endoplasmic reticulum stress to regulate neuropathic pain	15
Commentary on ‘Identification and characterization of select oxysterols as ligands for GPR17’	15
Galangin alleviates vitiligo by targeting ANXA2 degradation in macrophages	15
Pulmonary arterial hypertension: Sex matters	15
An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis	15
Genetic deletion or pharmacological blockade of nociceptin/orphanin FQ receptors in the ventral tegmental area attenuates nicotine‐motivated behaviour	15
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Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity	15
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum	14
The Australia story: Current status and future challenges for the clinical applications of psychedelics	14
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease	14
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No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies	14
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Bacterial growth dynamics and pharmacokinetic–pharmacodynamic relationships of rifampicin and bedaquiline in BALB/c mice	14
Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1‐mediated autophagy	14
Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights	14
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Non‐canonical PKG1 regulation in cardiovascular health and disease	14
Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia	14
Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis	14
Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21	14
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Novel luciferase‐based glucagon‐like peptide 1 reporter assay reveals naturally occurring secretagogues	14
A comment on the interpretation of ligand binding experiments for agonists	14
Beyond TGFβ inhibition: Chitosan oligosaccharide targets PGC‐1α‐mediated mitochondrial repair to combat pulmonary fibrosis	13
Withdrawn	13
Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction	13
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The TREK‐1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension	13
Reporting innovations in pharmacology and drug development, upholding excellence and improving author experience at the British Journal of Pharmacology in 2024	13
Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance	13
Osteosarcoma mechanobiology and therapeutic targets	13
JAK–STAT inhibitory effect of IN‐115314, a novel small molecule inhibitor, and pharmacokinetic/pharmacodynamic study in canine	13
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Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice	13
Nitric oxide (NO) synthase but not NO, HNO or H2O2 mediates endothelium‐dependent relaxation of resistance arteries from patients with cardiovascular disease	13
D‐amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection	13
Correction to “Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota”	13
Sub‐chronic administration of AM6545 enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice	13
P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism	13
Biased GLP‐2 agonist with strong G protein‐coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice	13
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition	13
Expression of Concern: Toll‐like receptor 4 knockout protects against anthrax lethal toxin‐induced cardiac contractile dysfunction: role of autophagy	13
SerpinB1 is required for Rev‐erbα‐mediated protection against acute lung injury induced by lipopolysaccharide‐in mice	13
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A novel role for microtubule affinity‐regulating kinases in neuropathic pain	12
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Potential of natural flavonoids to target breast cancer angiogenesis (review)	12
Correction to “AQX‐1125, small molecule SHIP1 activator inhibits bleomycin‐induced pulmonary fibrosis”	12
RETRACTION: Pyrrolidine Dithiocarbamate Attenuates the Development of Acute and Chronic Inflammation	12