British Journal of Pharmacology

Article	Citations
Pharmacogenomics	323
The pathogenesis and development of targeted drugs in acute T lymphoblastic leukaemia	317
Issue Information	292
Identification and pre‐clinical investigation of 3‐O‐cyclohexanecarbonyl‐11‐keto‐β‐boswellic acid as a drug for external use to treat psoriasis	187
Alpha 7‐nicotinic cholinoceptor regulation of pericyte‐containing retinal capillaries	173
Scientific integrity in the era of predatory journals: Insights from an editors in chief symposium	153
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The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine	125
A vitamin D‐based strategy overcomes chemoresistance in prostate cancer	122
Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis	115
The importance of binding kinetics and drug–target residence time in pharmacology	104
Ticagrelor inverse agonist activity at the P2Y12 receptor is non‐reversible versus its endogenous agonist adenosine 5´‐diphosphate	97
Astrocyte‐derived lactoferrin reduces β‐amyloid burden by promoting the interaction between p38 kinase and PP2A phosphatase in male APP/PS1 transgenic mice	92
Heterogeneity in response to repeated intranasal oxytocin in schizophrenia and autism spectrum disorders: A meta‐analysis of variance	92
Early erythroferrone levels can predict the long‐term haemoglobin responses to erythropoiesis‐stimulating agents	86
IDH2‐NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis	86
Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy	84
Endothelium‐derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large‐conductance Ca2+‐activated K+ channels	81
Mitragynine (Kratom)—Withdrawal behaviour and cognitive impairments can be ameliorated by an epigenetic mechanism	75
Asthma: role of the angiotensin‐(1‐7)/Mas (MAS1) pathway in pathophysiology and therapy	72
The role of the mineralocorticoid receptor in immune cells in cardiovascular disease	71
The anti‐parasitic drug miltefosine suppresses activation of human eosinophils and ameliorates allergic inflammation in mice	70
β2‐Adrenoceptor agonist profiling reveals biased signalling phenotypes for the β2‐adrenoceptor with possible implications for the treatment of asthma	65
No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies	64

Issue Information	62
Low molecular weight fucoidan restores diabetic endothelial glycocalyx by targeting neuraminidase2: A new therapy target in glycocalyx shedding	62
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Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance	59
Commentary on: Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain	56
PACAP‐38 related modulation of the cranial parasympathetic projection: A novel mechanism and therapeutic target in severe primary headache	54
In vitro sepsis up‐regulates Nociceptin/Orphanin FQ receptor expression and function on human T‐ but not B‐cells	54
Issue Information	54
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Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene‐related peptide responsive receptors	53
Anti‐chitinase‐3‐like 1 antibody attenuated atopic dermatitis‐like skin inflammation through inhibition of STAT3‐dependent CXCL8 expression	50
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Issue Information	48
Insight into the regulatory mechanism of β‐arrestin2 and its emerging role in diseases	47
Glucagon‐like peptide‐1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?	47
Issue Information	46
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis	46
The ratio of ursodeoxycholyltaurine to 7‐oxolithocholyltaurine serves as a biomarker of decreased 11β‐hydroxysteroid dehydrogenase 1 activity in mouse	46
Issue Information	46
Issue Information	46
Discovery of a novel, potent and selective small‐molecule inhibitor of PD‐1/PD‐L1 interaction with robust in vivo anti‐tumour efficacy	44
Inhibition of p38MAPK signalling pathway alleviates radiation‐induced testicular damage through improving spermatogenesis	42
Regulation of the ATP‐binding cassette transporters ABCB1, ABCG2 and ABCC5 by nuclear receptors in porcine blood–brain barrier endothelial cells	41
Riboflavin protects against heart failure via SCAD‐dependent DJ‐1–Keap1–Nrf2 signalling pathway	40
Biased GLP‐2 agonist with strong G protein‐coupling but impaired arrestin recruitment and receptor desensitization enhances intestinal growth in mice	40
Synergism between remdesivir and ribavirin leads to SARS‐CoV‐2 extinction in cell culture	39
Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT2A and 5‐HT1A receptors	38
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR	38
Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome	37
SerpinB1 is required for Rev‐erbα‐mediated protection against acute lung injury induced by lipopolysaccharide‐in mice	36
Network medicine and systems pharmacology approaches to predicting adverse drug effects	36
Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer	35
Measuring mania‐like elevated mood through amphetamine‐induced 50‐kHz ultrasonic vocalizations in rats	35
GPR84 in physiology—Many functions in many tissues	35
Coronavirus disease 2019 and the revival of passive immunization: Antibody therapy for inhibiting severe acute respiratory syndrome coronavirus 2 and preventing host cell infection: IUPHAR review 31	34
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Issue Information	34
Modulation of interleukin‐36 based inflammatory feedback loop through the hepatocyte‐derived IL‐36R‐P2X7R axis improves steatosis in alcoholic steatohepatitis	34
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From the vulnerable plaque to the vulnerable patient: Current concepts in atherosclerosis	32
Glycyrrhetinic acid blocks SARS‐CoV‐2 infection by activating the cGAS‐STING signalling pathway	31
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Issue Information	31
Extent of foetal exposure to maternal elexacaftor/tezacaftor/ivacaftor during pregnancy	30

Pharmacology of PACAP and VIP receptors in the spinal cord highlights the importance of the PAC1 receptor	30
In vitro and in vivo anti‐epileptic efficacy of eslicarbazepine acetate in a mouse model of KCNQ2‐related self‐limited epilepsy	29
P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism	29
Approaches towards tissue‐selective pharmacology of the mineralocorticoid receptor	29
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pH‐dependent modulation of TRPV1 by modality‐selective antagonists	29
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In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity	28
Are insulin sensitizers the new strategy to treat Type 1 diabetes? A long‐acting dual amylin and calcitonin receptor agonist improves insulin‐mediated glycaemic control and controls body weight	28
Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia‐induced pulmonary hypertension	28
The role of nucleus of the solitary tract glucagon‐like peptide‐1 and prolactin‐releasing peptide neurons in stress: anatomy, physiology and cellular interactions	28
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Hypothesis: Efficacy of early treatments with some NSAIDs in COVID‐19: Might it also depend on their direct and/or indirect zinc chelating ability?	27
Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP)	26
Compulsive alcohol seeking and relapse: Central role of conditioning factors associated with alleviation of withdrawal states by alcohol	26
G protein‐coupled estrogen receptor 1: a novel target to treat cardiovascular disease in a sex‐specific manner?	26
Anti‐arrhythmic investigations in large animal models of atrial fibrillation	26
Sex‐ and age‐specific respiratory alterations induced by prenatal exposure to the cannabinoid receptor agonist WIN 55,212‐2 in rats	26
Issue Information	26
Paradoxical changes in brain reward status during oxycodone self‐administration in a novel test of the negative reinforcement hypothesis	26
Bias translation: The final frontier?	25
The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases	25
Animal models of diabetes‐associated vascular diseases: an update on available models and experimental analysis	25
Regulation of depressive‐like behaviours by palmitoylation: Role of AKAP150 in the basolateral amygdala	25
Amlodipine, an anti‐hypertensive drug, alleviates non‐alcoholic fatty liver disease by modulating gut microbiota	25
Topical application of a P2X2/P2X3 purine receptor inhibitor suppresses the bitter taste of medicines and other taste qualities	25
The search for anti‐oxytotic/ferroptotic compounds in the plant world	25
Tumour brain: Pretreatment cognitive and affective disorders caused by peripheral cancers	25
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Characterization of cytochrome P450 (CYP) 2D6 drugs as substrates of human organic cation transporters and multidrug and toxin extrusion proteins	24
Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis	24
Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice	24
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity	24
The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors	24
Issue Information	24
How far are we from predicting multi‐drug interactions during treatment for COVID‐19 infection?	24
Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature	23
Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide‐induced migration of primary macrophages	23
Vitamin D regulation of energy metabolism in cancer	23
Novel luciferase‐based glucagon‐like peptide 1 reporter assay reveals naturally occurring secretagogues	23
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl− concentration	23
Structural and molecular determinants of mineralocorticoid receptor signalling	23
Insights into the mechanisms underlying opioid use disorder and potential treatment strategies	22
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition	22
Issue Information	22
Inhibition of HSP90 S‐nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway	22
Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity	22
Gβγ subunit signalling underlies neuropeptide Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries	22
Targeting Na+/K+‐ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma	22
Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction	22
Resveratrol attenuates behavioural impairment associated with learning and memory in rats with diabetes induced by a high‐fat diet and streptozotocin	22
Schwann cell TRPA1 elicits reserpine‐induced fibromyalgia pain in mice	22
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Epithelial deletion of the glucocorticoid receptor (Nr3c1) protects the mouse intestine against experimental inflammation	22
Single nucleotide variations encoding missense mutations in G protein‐coupled receptors may contribute to autism	21
A new class of 5‐HT2A/5‐HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins	21
6‐Shogaol (enexasogoal) treatment improves experimental knee osteoarthritis exerting a pleiotropic effect over immune innate signalling responses in chondrocytes	21
STAT1‐ and NFAT‐independent amplification of purinoceptor function integrates cellular senescence with interleukin‐6 production in preadipocytes	21
Issue Information	21
Unravelling G protein‐coupled receptor signalling networks using global phosphoproteomics	21
Extracellular ATP inhibits excitatory synaptic input on parvalbumin positive interneurons and attenuates gamma oscillations via P2X4 receptors	21
Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease	21
Role of NaV1.7 in action potential conduction along human bronchial vagal afferent C‐fibres	21
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review	21
The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid‐induced impaired wound healing	21
Recent changes in the British Journal of Pharmacology: widening scope and improving author and editor experience	21
β‐Arrestin1 and GPCR kinase2 play permissive roles in Src‐mediated endocytosis of α4β2 nicotinic ACh receptors	21
Resveratrol, a novel inhibitor of fatty acid binding protein 5, inhibits cervical cancer metastasis by suppressing fatty acid transport into nucleus and downstream pathways	21
Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of the Src‐YAP signalling axis	20
Molecular dynamic and pharmacological studies on protein‐engineered hirudin variants of Hirudinaria manillensis and Hirudo medicinalis	20
Flucloxacillin worsens while imipenem–cilastatin protects against vancomycin‐induced kidney injury in a translational rat model	20
The role of gut microbiota in cerebrovascular disease and related dementia	20
Clinical applications for exosomes: Are we there yet?	20
Intra‐articular injection of triamcinolone acetonide sustains macrophage levels and aggravates osteophytosis during degenerative joint disease in mice	20
Novel therapeutic approaches to target neurodegeneration	20
Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms	20
A new Kunitz‐type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor	20
Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT1 receptor–forkhead box subclass O transcription factor signalling axis	20

Non‐neuronal TRPA1 encodes mechanical allodynia associated with neurogenic inflammation and partial nerve injury in rats	20
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy	19
Pharmacological and behavioural effects of tryptamines present in psilocybin‐containing mushrooms	19
Harmine alleviates atherogenesis by inhibiting disturbed flow‐mediated endothelial activation via protein tyrosine phosphatase PTPN14 and YAP	19
Role of LRP5/6/GSK‐3β/β‐catenin in the differences in exenatide‐ and insulin‐promoted T2D osteogenesis and osteomodulation	19
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An agonist of the adenosine A2A receptor, CGS21680, promotes corneal epithelial wound healing via the YAP signalling pathway	19
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs	18
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels	18
Reinforcement‐based cognitive biases as vulnerability factors in alcohol addiction: From humans to animal models	18
The plant extract PNS mitigates atherosclerosis via promoting Nrf2‐mediated inhibition of ferroptosis through reducing USP2‐mediated Keap1 deubiquitination	18
Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2	18
Targeting sphingosine kinase‐1 with the low MW inhibitor SKI‐5C suppresses the development of endometriotic lesions in mice	18
Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle	18
Issue Information	18
The role of glucagon‐like peptide 1 (GLP‐1) in addictive disorders	18
PDE4B inhibition by nerandomilast: Effects on lung fibrosis and transcriptome in fibrotic rats and on biomarkers in human lung epithelial cells	18
Positive allosteric modulation of the cannabinoid CB1 receptor potentiates endocannabinoid signalling and changes ERK1/2 phosphorylation kinetics	18
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice	18
Bruton's tyrosine kinase inhibition suppresses pathological retinal angiogenesis	18
Molecular and structural insights into the 5‐HT2C receptor as a therapeutic target for substance use disorders	18
Soluble GC stimulators and activators: Past, present and future	18
Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins	18
The TREK‐1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension	18
Optimization of cancer immunotherapy on the basis of programmed death ligand‐1 distribution and function	17
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker	17
EXPRESSION OF CONCERN: Dose‐Dependent Biphasic Leptin‐Induced Proliferation is Caused by Non‐Specific IL‐6/NF‐κB Pathway Activation in Human Myometrial Cells	17
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX‐5461 on pulmonary arterial hypertension and associated vascular remodelling	17
The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors	17
Complement component C3 as a new target to lower albuminuria in hypertensive kidney disease	17
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice	17
Convallatoxin inhibits IL‐1β production by suppressing zinc finger protein 91 (ZFP91)‐mediated pro‐IL‐1β ubiquitination and caspase‐8 inflammasome activity	17
AhR–STAT3–HO‐1/COX‐2 signalling pathway may restrict ferroptosis and improve hMSC accumulation and efficacy in mouse liver	17
Residency time of agonists does not affect the stability of GPCR–arrestin complexes	17
Scorpion venom heat‐resistant synthesized peptide ameliorates 6‐OHDA‐induced neurotoxicity and neuroinflammation: likely role of Nav1.6 inhibition in microglia	17
Natural products targeting tumour angiogenesis	17
The insulin‐like growth factor binding protein–microfibrillar associated protein–sterol regulatory element binding protein axis regulates fibroblast–myofibroblast transition and cardiac fibrosis	17
Up‐regulation of hepatic CD36 by increased corticosterone/cortisol levels via GR leads to lipid accumulation in liver and hypertriglyceridaemia during pregnancy	17
Genetic polymorphisms influencing antihypertensive drug responses	17
A plant‐derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy	17
Identifying the core concepts of pharmacology education: A global initiative	17
Basolateral amygdala astrocytes modulate diabetic neuropathic pain and may be a potential therapeutic target for koumine	17
Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice	17
Riociguat attenuates the changes in left ventricular proteome and microRNA profile after experimental aortic stenosis in mice	16
Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment	16
Cannabinoid CB2 receptor orthologues; in vitro function and perspectives for preclinical to clinical translation	16
Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post‐ischaemic blood flow recovery	16
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non‐alcoholic fatty liver disease	16
Ruthenium 360 and mitoxantrone inhibit mitochondrial calcium uniporter channel to prevent liver steatosis induced by high‐fat diet	16
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury	16
Nitric oxide (NO) synthase but not NO, HNO or H2O2 mediates endothelium‐dependent relaxation of resistance arteries from patients with cardiovascular disease	16
Chronic alcohol induced mechanical allodynia by promoting neuroinflammation: A mouse model of alcohol‐evoked neuropathic pain	16
Pentoxifylline as a therapeutic option for pre‐eclampsia: a study on its placental effects	16
Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2	16
Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B	16
The mineralocorticoid receptor in chronic kidney disease	16
Metabolomics analysis of human plasma reveals decreased production of trimethylamine N‐oxide retards the progression of chronic kidney disease	16
Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35	16
Bisphosphonates for delivering drugs to bone	15
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer	15
Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”	15
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline	15
Correction	15
Memantine‐induced functional rewiring of the glutamate synapse in the striatum of dopamine transporter knockout rats	15
KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis	15
Supersulfide biology and translational medicine for disease control	15
Withdrawn	15
Correction to “Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota”	15
Mechanopharmacology: in vitro techniques to advance drug discovery	15
Activation of thyroid hormone receptor‐β improved disease activity and metabolism independent of body weight in a mouse model of non‐alcoholic steatohepatitis and fibrosis	15
Correction	15
Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt‐induced hypertension	15
Correction	15
Cross‐pathway integration of cAMP signals through cGMP and calcium‐regulated phosphodiesterases in mouse striatal cholinergic interneurons	15
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S1P/S1PRs‐TRPV4 axis is a novel therapeutic target for persistent pain and itch in chronic dermatitis	14
NaHS alters synaptic plasticity proteins and enhances dendritic arborization to improve cognitive and motor deficits after traumatic brain injury in mice	14
Correction to “Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis”	14
Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy	14
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Osteosarcoma mechanobiology and therapeutic targets	14
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RETRACTION: Cloricromene, a Coumarine Derivative, Protects Against Collagen‐induced Arthritis in Lewis Rats	14
Erratum	14
A comment on the interpretation of ligand binding experiments for agonists	14
EXPRESSION OF CONCERN: Rosiglitazone and 15‐deoxy‐Δ12,14‐prostaglandin J2, ligands of the peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), reduce ischaemia/reperfusion inju	14
Tetrabenazine, a vesicular monoamine transporter 2 inhibitor, inhibits vesicular storage capacity and release of monoamine transmitters in mouse brain tissue	14
A partial agonist of PPARγ prevents paclitaxel‐induced peripheral neuropathy in mice, by inhibiting neuroinflammation	14
The endocannabinoid anandamide mediates anti‐inflammatory effects through activation of NR4A nuclear receptors	14
Expression of Concern: Toll‐like receptor 4 knockout protects against anthrax lethal toxin‐induced cardiac contractile dysfunction: role of autophagy	14
Recent advances in the pathogenesis and therapeutics of amyotrophic lateral sclerosis	14
Actions of dexmedetomidine in regulating NLRP3 in postoperative cognitive dysfunction in aged mice via the autophagy–lysosome pathway	14
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice	13
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Jumonji domain‐containing protein‐3 (JMJD3) promotes myeloid fibroblast activation and macrophage polarization in kidney fibrosis	13