British Journal of Pharmacology

Article	Citations
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Issue Information	407
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Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases	170
Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis	169
Gβγ subunit signalling underlies neuropeptide Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries	149
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The potential for biased signalling in the P2Y receptor family of GPCRs	122
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy	121
Decoding fatal toxic effects in checkpoint inhibitor therapy using real‐world pharmacovigilance data and machine learning	117
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer	109
Correction to ‘Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy’	103
Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”	101
EXPRESSION OF CONCERN: Nitropravastatin Stimulates Reparative Neovascularisation and Improves Recovery from Limb Ischaemia in Type‐1 Diabetic Mice	90
Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction	76
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis	63
Opportunities of patient‐derived organoids in drug development	63
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice	58
Down‐regulation of M 6 A demethylase ALKBH5 facilitates morphine tolerance via SGK1 in mice	58
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs	57
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review	54
Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer	54
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin	51

The β 2 ‐adrenoceptor agonist formoterol attenuates hallmarks of adrenal Cushing's syndrome	50
6‴‐Feruloylspinosin ameliorates pressure overload‐induced heart failure with comorbid insomnia through the activation of RORα	50
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury	50
Novel therapeutic approaches to target neurodegeneration	50
Activation of peripheral cannabinoid receptors by CB13 attenuates burn injury–induced chronic pain through TRP channel modulation	48
Supersulfide biology and translational medicine for disease control	47
Justifying and reporting the use of severe stress in experiments that use animals	46
Clinical‐data‐driven pharmacological framework in liver disease: From liver cirrhosis to hepatocellular carcinoma	43
Biphasic effect of nicotine on glutamatergic activity in male mouse brain	43
Issue Information	42
Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model	42
The fast‐dissociating D 2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment	39
Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors	39
Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity	39
The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors	38
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline	38
GPR84 in physiology—Many functions in many tissues	38
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In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment	37
From mundane to classic: Sinomenine as a multi‐therapeutic agent	36
Network‐based precision medicine and systems pharmacology	36
Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling	35
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod‐induced psoriasiform inflammation via STAT1/S100A9 signalling pathway	35
Identification of a human blood biomarker of pharmacological 11β‐hydroxysteroid dehydrogenase 1 inhibition	35
A comprehensive review of cancer‐induced cardiac wasting	35
Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation	35
Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain	34
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats	34
Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice	34
tiRNA‐Gly‐GCC‐002 promotes epithelial‐mesenchymal transition and fibrosis in lupus nephritis via FKBP5‐mediated activation of Smad	33
Bioactivity‐based molecular networking‐guided identification of guttiferone J from Garcinia cambogia as an anti‐obesity candidate	33
Elucidating the beneficial impact of exercise on chronic obstructive pulmonary disease and its comorbidities: Integrating proteomic and immunological insights	33
Insight in article retractions inBritish Journal of Pharmacologybetween the years 2000–2023. Implications for reducing fraud‐containing articles	33
Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis	32
Sevoflurane acts as an antidepressant by suppression of GluN2D‐containing NMDA receptors on interneurons	31
Exosomes from macrophages intervened by Jiedu Yangxin decoction mediated endothelial‐to‐mesenchymal transition to improve myocardial fibrosis after myocardial infarction	31
Potential medicinal value of N6‐methyladenosine in autoimmune diseases and tumours	31
Silibinin, a commonly used therapeutic agent for non‐alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19	31
Development of new Kir2.1 channel openers from propafenone analogues	30
β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation	30
Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential	30
Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent	30
Defining and unpacking the core concepts of pharmacology: A global initiative	29
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice	29
Exploring effects of chronic d ‐cycloserine administration on expression of GluN2 subunits and tripartite synaptic transmission in thalamocortical pa	29
Fifty years with aspirin and platelets	29
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities	29
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors	28
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice	28
Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis	27

Efficacy in diet‐induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM38837	27
TREM2 activation suppresses central sensitisation by promoting autophagy in a chronic migraine model with recurrent nitroglycerin stimulation in mice	27
The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial	27
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice	27
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NRF2 signalling in cytoprotection and metabolism	26
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Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells	25
Therapeutic effect of human ApoA‐I‐Milano variant in aged transgenic mouse model of Alzheimer's disease	25
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age‐related macular degeneration	25
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Dual effects of mefenamic acid on the IKs molecular complex	24
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets	24
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes	24
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Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice	24
Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells	23
Bioavailability of flumequine and diclofenac in mice exposed to a metal‐drug chemical cocktail. Evaluation of the protective role of selenium.	23
Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function	23
Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64 Cu PET/MRI	23
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain	23
Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol	23
AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice	23
R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases	23
Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two‐sided nature of antagonistic ligands resulting from partial dissociation of Gq	23
A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia	22
A proposal for rational drug class terminology: A gastrointestinal perspective	22
BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus	22
Gαq signalling from endosomes: A new conundrum	22
Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy	22
The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients	22
Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets	22
Perspective article: A proposal for rational drug class terminology	22
Sex‐related susceptibility to pulmonary fibrosis development in mice	22
Issue Information	21
FM‐dye inhibition of Piezo2 relieves mechanically evoked pain in mouse models of acute inflammatory and osteoarthritic knee pain	21
Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor	21
Issue Information	21
Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs	21
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder	21
Resolution pharmacology and the treatment of infectious diseases	21
Natural products and cancer: From drug discovery to prevention and therapy	21
Cav1.3‐selective inhibitors of voltage‐gated L‐type Ca2+ channels: Fact or (still) fiction?	21
A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain	21
Sex‐specific impact of repeated adolescent vapour exposure to JWH‐018 on dopamine response, behaviour and pharmacokinetics across adolescence and adulthood	20
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial–mesenchymal trophic unit activation in asthma	20
EXPRESSION OF CONCERN: H 2 S‐Donating Sildenafil (ACS6) Inhibits Superoxide Formation and gp91 phox	20
A peptide rich in glycine–serine–alanine repeats ameliorates Alzheimer‐type neurodegeneration	20
Baclofen modulates the immune response after spinal cord injury with locomotor benefits	20
Photochemical control of cold‐sensitive TRPA1 ion channel gating for modulation of pain sensation	20
Expression of Concern: Effects of Tyrphostins and Genistein on the Virculatory Gailure and Organ Dysfunction Caused by Endotoxin in the Rat: A Possible Role for Protein Tyrosine Kinase	20
Activation of the pentose phosphate pathway flux by hydrogen peroxide is not regulated by NADPH‐mediated feedback inhibition	20
The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration	20
Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review	20
Noncanonical function of sphingosine kinase 2 (SPHK2) sustains hepatic triglyceride homeostasis	20
Activating transcription factor‐3 orchestrates the modulation of vascular anti‐contractile activity and relaxation by governing the secretion of HDL‐bound sphingosine‐1‐phosphate in perivascular adipo	20
Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea	20
Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish	20
Stimulation of platelet P2Y 1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling	19
Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation	19
Silencing the fibronectin gene (FN1 ) improves NaCl‐induced cardiac fibrosis via ferritinophagy‐mediated ferroptosis in a nuclear receptor coactivator 4	19
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment	19
Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair	19
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Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China	18
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels	18
Targeting noncoding RNAs to treat atherosclerosis	18
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia	18
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A GLP‐1/glucagon (GCG)/CCK2 receptors tri‐agonist provides new therapy for obesity and diabetes	18
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein	18
The flavonoid GL‐V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells	18
Issue Information	18
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons	18

Advancing antihypertensive drug development	18
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A	18
Safety Toxicology	18
The role of free‐fatty acid receptors FFA1 and FFA4 in organ fibrosis	17
Soluble epoxide hydrolase inhibition enhances production of specialized pro‐resolving lipid mediator and promotes macrophage plasticity	17
Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive	17
Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib	17
EXPRESSION OF CONCERN: Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells	17
A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages	17
Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis	17
Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration	17
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential	17
In silico , in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants l	16
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Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity	16
Chemistry/structural biology of psychedelic drugs and their receptor(s)	16
Issue Information	16
V‐domain immunoglobulin suppressor of T‐cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma	16
CircPTK2 enhances non‐small cell lung cancer proliferation by inhibiting cellular senescence through stabilizing NFYA and elevating FOXM1	16
Neutrophil β1 adrenoceptor blockade blunts stroke‐associated neuroinflammation	16
Cannabigerol reverses mechanical allodynia through α 2A ‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy	16
Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery	16
Bioactive ligands targeting ectopic olfactory receptors: Implications for therapeutic strategies	16
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Enterolactone promotes efficacy of gemcitabine on epithelial ovarian cancer and ameliorates gut dysbacteriosis	16
An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis	15
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Opioid receptors in cardiovascular function	15
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats	15
Mechanopharmacology	15
Naringenin relieves paclitaxel‐induced pain by suppressing calcitonin gene‐related peptide signalling and enhances the anti‐tumour action of paclitaxel	15
Natural Products	15
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders	15
Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity	15
Issue Information	15
The polypharmacological profiles of xanomeline and N‐desmethylxanomeline	15
Corticosteroid insensitivity in asthma associated with obstructive sleep apnoea: Role of oxidative stress and histone acetylation	15
Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors	15
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?	15
The Concise Guide to PHARMACOLOGY 2023/24: Transporters	15
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Cell‐based therapy for diabetic cardiovascular complications: Prospects and challenges	15
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Commentary on ‘Identification and characterization of select oxysterols as ligands for GPR17’	15
Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis	15
Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer	15
Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence	15
Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth	15
Issue Information	15
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum	14
Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21	14
Berberine alleviates pre‐eclampsia by modulating M1/M2 macrophage polarization and T helper (Th1/Th2) cells cytokine balance	14
Pulmonary arterial hypertension: Sex matters	14
Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis	14
Explainable AI and debiased networks: The ‘last mile’ for precision medicine delivery	14
ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis	14
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Galangin alleviates vitiligo by targeting ANXA2 degradation in macrophages	14
Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1‐mediated autophagy	14
The Australia story: Current status and future challenges for the clinical applications of psychedelics	14
A pH‐sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation	14
Correction to “Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adioponectin release”	14
RETRACTION: L6H21 protects against cognitive impairment and brain pathologies via toll‐like receptor 4–myeloid differentiation factor 2 Signalling in Prediabetic rats	14
To CB2 or not CB2: Revisiting renoprotection in acute and chronic kidney injury	14
Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights	14
Disruption of survivin protein expression by treatment with YM155 accelerates the resolution of neutrophilic inflammation	14
Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state	14
EDITORIAL for BJP themed issue “noncoding RNA therapeutics”	14
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease	14
Correction to “Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota”	13
AMG487 alleviates influenza A (H1N1) virus‐induced pulmonary inflammation through decreasing IFN‐γ‐producing lymphocytes and IFN‐γ concentrations	13
Issue Information	13
A comment on the interpretation of ligand binding experiments for agonists	13
Molecular and structural insights into the 5‐HT2C receptor as a therapeutic target for substance use disorders	13
P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism	13
Beyond TGFβ inhibition: Chitosan oligosaccharide targets PGC‐1α‐mediated mitochondrial repair to combat pulmonary fibrosis	13
SerpinB1 is required for Rev‐erbα‐mediated protection against acute lung injury induced by lipopolysaccharide‐in mice	13
The plant extract PNS mitigates atherosclerosis via promoting Nrf2‐mediated inhibition of ferroptosis through reducing USP2‐mediated Keap1 deubiquitination	13
Withdrawn	13
Non‐canonical PKG1 regulation in cardiovascular health and disease	13
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SEW2871 attenuates myocyte necroptosis in heart failure through inhibition of oxidative stress and inflammatory cytokines	13
Asthma and inflammation transcriptionally up‐regulate the aryl hydrocarbon receptor in airway smooth muscle via p38/JNK‐AP1 signalling	13
Pharmacology of PACAP and VIP receptors in the spinal cord highlights the importance of the PAC1 receptor	13
Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance	13
Novel luciferase‐based glucagon‐like peptide 1 reporter assay reveals naturally occurring secretagogues	13
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No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies	13
Issue Information	13
Selected Abstracts from Pharmacology 2025	13
Genetic polymorphisms influencing antihypertensive drug responses	13
Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction	13
Advancing Alzheimer's disease pharmacotherapy: efficacy of glucocorticoid modulation with dazucorilant (CORT113176) in preclinical mouse models	13
JAK–STAT inhibitory effect of IN‐115314, a novel small molecule inhibitor, and pharmacokinetic/pharmacodynamic study in canine	13