British Journal of Pharmacology

Article	Citations
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review	423
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis	341
Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61‐8048 after chronic intermittent ethanol in mice	324
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Animal models of diabetes‐associated vascular diseases: an update on available models and experimental analysis	203
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Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer	157
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The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine	147
P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity	128
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A new class of 5‐HT2A/5‐HT2C receptor inverse agonists: Synthesis, molecular modeling, in vitro and in vivo pharmacology of novel 2‐aminotetralins	118
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer	115
Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”	110
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs	107
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice	105
Novel therapeutic approaches to target neurodegeneration	100
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin	96
Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases	94
Opportunities of patient‐derived organoids in drug development	92
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Structural and molecular determinants of mineralocorticoid receptor signalling	90
Epithelial deletion of the glucocorticoid receptor (Nr3c1) protects the mouse intestine against experimental inflammation	85
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury	83

Inhibition of HSP90 S‐nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway	77
A small molecule CFTR potentiator restores ATP‐dependent channel gating to the cystic fibrosis mutant G551D‐CFTR	76
Gβγ subunit signalling underlies neuropeptide Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries	70
Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice	69
Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction	69
Role of NaV1.7 in action potential conduction along human bronchial vagal afferent C‐fibres	69
GPR84 in physiology—Many functions in many tissues	68
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline	68
Scorpion venom heat‐resistant synthesized peptide ameliorates 6‐OHDA‐induced neurotoxicity and neuroinflammation: likely role of Nav1.6 inhibition in microglia	67
Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis	66
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy	65
Quantitative prediction of P‐glycoprotein‐mediated drug–drug interactions and intestinal absorption using humanized mice	65
Supersulfide biology and translational medicine for disease control	62
Exploring group size for statistical analysis of real‐time signalling experiments	59
Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity	59
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β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation	55
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats	55
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Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain	53
Translational PK/PD and model‐informed development of JNJ‐67842125, a Fab reversal agent for JNJ‐64179375, a long‐acting thrombin inhibitor	53
Identification of a human blood biomarker of pharmacological 11β‐hydroxysteroid dehydrogenase 1 inhibition	51
Targeting mitochondrial proteases for therapy of acute myeloid leukaemia	50
Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis	49
From mundane to classic: Sinomenine as a multi‐therapeutic agent	48
Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice	47
Bioactivity‐based molecular networking‐guided identification of guttiferone J from Garcinia cambogia as an anti‐obesity candidate	47
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice	47
Silibinin, a commonly used therapeutic agent for non‐alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19	46
The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial	46
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities	45
Defining and unpacking the core concepts of pharmacology: A global initiative	45
Normalisation of glucose metabolism by exendin‐4 in the chronic phase after stroke promotes functional recovery in male diabetic mice	44
Fifty years with aspirin and platelets	44
Animal models of pulmonary hypertension: Getting to the heart of the problem	43
Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis	42
In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment	41
Understanding the role of host metabolites in the induction of immune senescence: Future strategies for keeping the ageing population healthy	41
Sevoflurane acts as an antidepressant by suppression of GluN2D‐containing NMDA receptors on interneurons	41
tiRNA‐Gly‐GCC‐002 promotes epithelial‐mesenchymal transition and fibrosis in lupus nephritis via FKBP5‐mediated activation of Smad	40
Development of new Kir2.1 channel openers from propafenone analogues	40
Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential	40
Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation	39
Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent	38
Insight in article retractions inBritish Journal of Pharmacologybetween the years 2000–2023. Implications for reducing fraud‐containing articles	38
Elucidating the beneficial impact of exercise on chronic obstructive pulmonary disease and its comorbidities: Integrating proteomic and immunological insights	38
Mineralocorticoid receptors in non‐alcoholic fatty liver disease	37
Efficacy in diet‐induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM38837	36
Pharmacological characterization of novel heteromeric GluCl subtypes from Caenorhabditis elegans and parasitic nematodes	36
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice	35

Potential medicinal value of N6‐methyladenosine in autoimmune diseases and tumours	35
Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs	34
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod‐induced psoriasiform inflammation via STAT1/S100A9 signalling pathway	34
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NRF2 signalling in cytoprotection and metabolism	34
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Biological and small molecule strategies in migraine therapy with relation to the calcitonin gene‐related peptide family of peptides	33
Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets	33
AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice	33
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder	33
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes	32
A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia	32
Transient Receptor Potential channels, TRPV1 and TRPA1 in melanocytes synergize UV‐dependent and UV‐independent melanogenesis	31
Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor	31
Cav1.3‐selective inhibitors of voltage‐gated L‐type Ca2+ channels: Fact or (still) fiction?	31
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets	31
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R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases	30
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice	30
Central metabolism as a potential origin of sex differences in morphine antinociception but not induction of antinociceptive tolerance in mice	30
Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice	30
Natural products and cancer: From drug discovery to prevention and therapy	30
Resolution pharmacology and the treatment of infectious diseases	29
Preclinical rodent models of cardiac fibrosis	29
Proteinase‐activated receptor‐2 antagonist C391 inhibits Alternaria‐induced airway epithelial signalling and asthma indicators in acute exposure mouse models	29
Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells	29
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain	29
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A proposal for rational drug class terminology: A gastrointestinal perspective	29
Gαq signalling from endosomes: A new conundrum	29
Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells	29
Bioavailability of flumequine and diclofenac in mice exposed to a metal‐drug chemical cocktail. Evaluation of the protective role of selenium.	29
Effects of microsomal prostaglandin E synthase‐1 inhibition on resistance artery tone in patients with end stage kidney disease	28
Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two‐sided nature of antagonistic ligands resulting from partial dissociation of Gq	28
Dual effects of mefenamic acid on the IKs molecular complex	28
Therapeutic effect of human ApoA‐I‐Milano variant in aged transgenic mouse model of Alzheimer's disease	28
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Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol	28
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Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function	27
Perspective article: A proposal for rational drug class terminology	27
Nicotinic‐acid derivative BGP‐15 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy	27
Cyclic helix B peptide promotes random‐pattern skin flap survival via TFE3‐mediated enhancement of autophagy and reduction of ROS levels	27
A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain	27
The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation	27
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors	27
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age‐related macular degeneration	27
BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus	27
Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34	26
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Novel agonist and antagonist radioligands for the GLP‐2 receptor. Useful tools for studies of basic GLP‐2 receptor pharmacology	26
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Hypothesis: Possible influence of antivector immunity and SARS‐CoV‐2 variants on efficacy of ChAdOx1 nCoV‐19 vaccine	25
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Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation	25
Linking drug and food addiction via compulsive appetite	25
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment	25
A peptide rich in glycine–serine–alanine repeats ameliorates Alzheimer‐type neurodegeneration	24
Activating transcription factor‐3 orchestrates the modulation of vascular anti‐contractile activity and relaxation by governing the secretion of HDL‐bound sphingosine‐1‐phosphate in perivascular adipo	24
Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea	24
Baclofen modulates the immune response after spinal cord injury with locomotor benefits	24
Molecular basis for ligand modulation of the cannabinoid CB1 receptor	24
Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish	24
Expression of Concern: Effects of Tyrphostins and Genistein on the Virculatory Gailure and Organ Dysfunction Caused by Endotoxin in the Rat: A Possible Role for Protein Tyrosine Kinase	23
Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling	23
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia	23
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein	23
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial–mesenchymal trophic unit activation in asthma	23
Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID‐19	23
Targeting noncoding RNAs to treat atherosclerosis	22
Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: Sex differences in rats	22
The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration	22
Amitriptyline blocks innate immune responses mediated by toll‐like receptor 4 and IL‐1 receptor: Preclinical and clinical evidence in osteoarthritis and gout	22
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels	22
The flavonoid GL‐V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells	22
A GLP‐1/glucagon (GCG)/CCK2 receptors tri‐agonist provides new therapy for obesity and diabetes	22
Photochemical control of cold‐sensitive TRPA1 ion channel gating for modulation of pain sensation	22
EXPRESSION OF CONCERN: H2S‐Donating Sildenafil (ACS6) Inhibits Superoxide Formation and gp91phox Expression in Arterial Endothelial Cells: Role of Protein Kinases A and G	22

Pharmacological characterisation of mouse calcitonin and calcitonin receptor‐like receptors reveals differences compared with human receptors	21
Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis	21
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Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors	21
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons	21
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A	21
Characterisation of agonist signalling profiles and agonist‐dependent antagonism at PACAP‐responsive receptors: Implications for drug discovery	21
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Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis	21
Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth	21
Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing	21
Safety Toxicology	21
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Neutrophil β1 adrenoceptor blockade blunts stroke‐associated neuroinflammation	21
Chemistry/structural biology of psychedelic drugs and their receptor(s)	21
V‐domain immunoglobulin suppressor of T‐cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma	20
Quercetin relieves D‐amphetamine‐induced manic‐like behaviour through activating TREK‐1 potassium channels in mice	20
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Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity	20
Statin‐boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential	20
Correction	20
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?	20
Naringenin relieves paclitaxel‐induced pain by suppressing calcitonin gene‐related peptide signalling and enhances the anti‐tumour action of paclitaxel	20
Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive	19
Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence	19
Soluble epoxide hydrolase inhibition enhances production of specialized pro‐resolving lipid mediator and promotes macrophage plasticity	19
Molecular imaging of arterial and venous thrombosis	19
Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release	19
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats	19
Mucin‐fused myeloid‐derived growth factor (MYDGF164) exhibits a prolonged serum half‐life and alleviates fibrosis in chronic kidney disease	19
A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages	19
Mechanisms of endocannabinoid transport in the brain	19
Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity	19
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China	19
The Concise Guide to PHARMACOLOGY 2023/24: Transporters	18
Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis	18
Bacterial growth dynamics and pharmacokinetic–pharmacodynamic relationships of rifampicin and bedaquiline in BALB/c mice	18
CORRECTION	18
Natural Products	18
Perivascular fat imaging by computed tomography (CT): a virtual guide	18
Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity	18
EDITORIAL for BJP themed issue “noncoding RNA therapeutics”	18
Correction	18
Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1‐mediated autophagy	18
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Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21	18
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease	17
Cell‐based therapy for diabetic cardiovascular complications: Prospects and challenges	17
The diverse effects of brain glucagon‐like peptide 1 receptors on ingestive behaviour	17
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Disease‐modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil	17
Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia	17
Building Bridges In Neuropharmacology: New therapeutic approaches for psychiatric and neurodegenerative disorders	17
ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis	17
Genetic deletion or pharmacological blockade of nociceptin/orphanin FQ receptors in the ventral tegmental area attenuates nicotine‐motivated behaviour	17
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Apocynin prevents cigarette smoking‐induced loss of skeletal muscle mass and function in mice by preserving proteostatic signalling	17
A pH‐sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation	17
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum	17
Evidence for 5‐HT1A receptor‐mediated antiallodynic and antihyperalgesic effects of apigenin in mice suffering from mononeuropathy	17
Commentary on ‘Identification and characterization of select oxysterols as ligands for GPR17’	17
Disruption of survivin protein expression by treatment with YM155 accelerates the resolution of neutrophilic inflammation	17
An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis	17
The Australia story: Current status and future challenges for the clinical applications of psychedelics	16
AMG487 alleviates influenza A (H1N1) virus‐induced pulmonary inflammation through decreasing IFN‐γ‐producing lymphocytes and IFN‐γ concentrations	16
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition	16
Molecular and structural insights into the 5‐HT2C receptor as a therapeutic target for substance use disorders	16
Sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA2b) mediates oxidation‐induced endoplasmic reticulum stress to regulate neuropathic pain	16
Blocking glutamate mGlu5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1G93A mouse model of amyotrophic lateral sclerosis	16
Transgenic rabbit models for cardiac disease research	16
The search for anti‐oxytotic/ferroptotic compounds in the plant world	16
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Taspine is a natural product that suppresses P2X4 receptor activity via phosphoinositide 3‐kinase inhibition	16
Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights	16
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl− concentration	16
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Pulmonary arterial hypertension: Sex matters	16
SEW2871 attenuates myocyte necroptosis in heart failure through inhibition of oxidative stress and inflammatory cytokines	15
SerpinB1 is required for Rev‐erbα‐mediated protection against acute lung injury induced by lipopolysaccharide‐in mice	15
No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies	15
Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance	15
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A comment on the interpretation of ligand binding experiments for agonists	15
β‐Arrestin1 and GPCR kinase2 play permissive roles in Src‐mediated endocytosis of α4β2 nicotinic ACh receptors	15
P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism	15
Molecular dynamic and pharmacological studies on protein‐engineered hirudin variants of Hirudinaria manillensis and Hirudo medicinalis	15
Scientific integrity in the era of predatory journals: Insights from an editors in chief symposium	15
The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases	15
Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms	15
Bias translation: The final frontier?	14
D‐amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection	14
Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice	14
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