British Journal of Pharmacology

Article	Citations
	498
Issue Information	412
	330
Issue Information	317
	203
Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis	196
	173
The potential for biased signalling in the P2Y receptor family of GPCRs	151
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy	146
Decoding fatal toxic effects in checkpoint inhibitor therapy using real‐world pharmacovigilance data and machine learning	133
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer	123
Correction to ‘Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy’	117
Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”	112
EXPRESSION OF CONCERN: Nitropravastatin Stimulates Reparative Neovascularisation and Improves Recovery from Limb Ischaemia in Type‐1 Diabetic Mice	104
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis	90
Opportunities of patient‐derived organoids in drug development	81
Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer	64
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin	63
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review	63
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury	63
Novel therapeutic approaches to target neurodegeneration	60
6‴‐Feruloylspinosin ameliorates pressure overload‐induced heart failure with comorbid insomnia through the activation of RORα	59
Activation of peripheral cannabinoid receptors by CB13 attenuates burn injury–induced chronic pain through TRP channel modulation	59
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice	58
Cardiotoxicity of BRAF/MEK inhibitors	55

The β 2 ‐adrenoceptor agonist formoterol attenuates hallmarks of adrenal Cushing's syndrome	51
Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases	51
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs	51
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline	50
Down‐regulation of M 6 A demethylase ALKBH5 facilitates morphine tolerance via SGK1 in mice	50
Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors	49
Issue Information	47
Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model	47
Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity	45
Justifying and reporting the use of severe stress in experiments that use animals	44
Clinical‐data‐driven pharmacological framework in liver disease: From liver cirrhosis to hepatocellular carcinoma	43
Biphasic effect of nicotine on glutamatergic activity in male mouse brain	42
GPR84 in physiology—Many functions in many tissues	41
Gβγ subunit signalling underlies neuropeptide Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries	40
Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction	39
Supersulfide biology and translational medicine for disease control	39
The fast‐dissociating D 2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment	39
In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment	38
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The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors	38
Identification of a human blood biomarker of pharmacological 11β‐hydroxysteroid dehydrogenase 1 inhibition	37
Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation	37
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice	36
A comprehensive review of cancer‐induced cardiac wasting	36
β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation	36
Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain	36
The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial	35
From mundane to classic: Sinomenine as a multi‐therapeutic agent	35
TREM2 activation suppresses central sensitisation by promoting autophagy in a chronic migraine model with recurrent nitroglycerin stimulation in mice	35
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities	35
Host genetic variants in the lactose metabolism pathway associated with bifidobacterium abundance have prognostic value for immunotherapy efficacy	35
Exploring effects of chronic d ‐cycloserine administration on expression of GluN2 subunits and tripartite synaptic transmission in thalamocortical pa	34
Defining and unpacking the core concepts of pharmacology: A global initiative	34
Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice	34
Potential medicinal value of N6‐methyladenosine in autoimmune diseases and tumours	33
Insight in article retractions inBritish Journal of Pharmacologybetween the years 2000–2023. Implications for reducing fraud‐containing articles	32
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice	32
Exosomes from macrophages intervened by Jiedu Yangxin decoction mediated endothelial‐to‐mesenchymal transition to improve myocardial fibrosis after myocardial infarction	31
Sevoflurane acts as an antidepressant by suppression of GluN2D‐containing NMDA receptors on interneurons	31
Efficacy in diet‐induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM38837	31
Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis	30
Development of new Kir2.1 channel openers from propafenone analogues	30
Silibinin, a commonly used therapeutic agent for non‐alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19	30
Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent	30
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors	30
Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis	30
Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential	30
Elucidating the beneficial impact of exercise on chronic obstructive pulmonary disease and its comorbidities: Integrating proteomic and immunological insights	29
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats	29
tiRNA‐Gly‐GCC‐002 promotes epithelial‐mesenchymal transition and fibrosis in lupus nephritis via FKBP5‐mediated activation of Smad	29

RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice	28
Bioactivity‐based molecular networking‐guided identification of guttiferone J from Garcinia cambogia as an anti‐obesity candidate	28
Fifty years with aspirin and platelets	28
Network‐based precision medicine and systems pharmacology	27
NRF2 signalling in cytoprotection and metabolism	27
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod‐induced psoriasiform inflammation via STAT1/S100A9 signalling pathway	27
Issue Information	26
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Bioavailability of flumequine and diclofenac in mice exposed to a metal‐drug chemical cocktail. Evaluation of the protective role of selenium.	26
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Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling	26
Therapeutic effect of human ApoA‐I‐Milano variant in aged transgenic mouse model of Alzheimer's disease	26
Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy	26
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Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells	25
Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64 Cu PET/MRI	25
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Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs	25
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes	24
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age‐related macular degeneration	24
Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two‐sided nature of antagonistic ligands resulting from partial dissociation of Gq	24
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Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol	24
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Cav1.3‐selective inhibitors of voltage‐gated L‐type Ca2+ channels: Fact or (still) fiction?	23
R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases	23
Dual effects of mefenamic acid on the IKs molecular complex	23
AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice	23
Sex‐related susceptibility to pulmonary fibrosis development in mice	23
BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus	23
The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients	23
Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells	23
Gαq signalling from endosomes: A new conundrum	22
Resolution pharmacology and the treatment of infectious diseases	22
A proposal for rational drug class terminology: A gastrointestinal perspective	22
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice	22
A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia	22
FM‐dye inhibition of Piezo2 relieves mechanically evoked pain in mouse models of acute inflammatory and osteoarthritic knee pain	22
Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor	22
Perspective article: A proposal for rational drug class terminology	22
Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets	22
Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function	22
A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain	22
Issue Information	21
Natural products and cancer: From drug discovery to prevention and therapy	21
Expression of Concern: Effects of Tyrphostins and Genistein on the Virculatory Gailure and Organ Dysfunction Caused by Endotoxin in the Rat: A Possible Role for Protein Tyrosine Kinase	21
Substitution of the SERCA2 Cys674 reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation	21
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain	21
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets	21
Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea	21
Activation of the pentose phosphate pathway flux by hydrogen peroxide is not regulated by NADPH‐mediated feedback inhibition	21
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder	21
Issue Information	21
EXPRESSION OF CONCERN: H 2 S‐Donating Sildenafil (ACS6) Inhibits Superoxide Formation and gp91 phox	21
Sex‐specific impact of repeated adolescent vapour exposure to JWH‐018 on dopamine response, behaviour and pharmacokinetics across adolescence and adulthood	20
Silencing the fibronectin gene (FN1 ) improves NaCl‐induced cardiac fibrosis via ferritinophagy‐mediated ferroptosis in a nuclear receptor coactivator 4	20
A peptide rich in glycine–serine–alanine repeats ameliorates Alzheimer‐type neurodegeneration	20
Activating transcription factor‐3 orchestrates the modulation of vascular anti‐contractile activity and relaxation by governing the secretion of HDL‐bound sphingosine‐1‐phosphate in perivascular adipo	20
Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review	20
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment	20
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein	19
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial–mesenchymal trophic unit activation in asthma	19
Targeting noncoding RNAs to treat atherosclerosis	19
Photochemical control of cold‐sensitive TRPA1 ion channel gating for modulation of pain sensation	19
Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair	19
The flavonoid GL‐V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells	19
The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration	19
Stimulation of platelet P2Y 1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling	19
Advancing antihypertensive drug development	19
Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice	19
Noncanonical function of sphingosine kinase 2 (SPHK2) sustains hepatic triglyceride homeostasis	18
Safety Toxicology	18
Issue Information	18
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The Concise Guide to PHARMACOLOGY 2025/26: Ion channels	18
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia	18
Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish	18
Issue Information	18
Baclofen modulates the immune response after spinal cord injury with locomotor benefits	18
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A	18

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Neutrophil β1 adrenoceptor blockade blunts stroke‐associated neuroinflammation	17
Soluble epoxide hydrolase inhibition enhances production of specialized pro‐resolving lipid mediator and promotes macrophage plasticity	17
Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery	17
CircPTK2 enhances non‐small cell lung cancer proliferation by inhibiting cellular senescence through stabilizing NFYA and elevating FOXM1	17
Opioid receptors in cardiovascular function	17
Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration	17
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The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons	17
Cannabigerol reverses mechanical allodynia through α 2A ‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy	17
Enterolactone promotes efficacy of gemcitabine on epithelial ovarian cancer and ameliorates gut dysbacteriosis	17
The role of free‐fatty acid receptors FFA1 and FFA4 in organ fibrosis	17
Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive	17
Issue Information	17
Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib	17
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Bioactive ligands targeting ectopic olfactory receptors: Implications for therapeutic strategies	17
A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages	17
Naringenin relieves paclitaxel‐induced pain by suppressing calcitonin gene‐related peptide signalling and enhances the anti‐tumour action of paclitaxel	16
In silico , in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants l	16
Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis	16
Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors	16
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats	16
EXPRESSION OF CONCERN: Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells	16
Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis	16
Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer	16
Mechanopharmacology	16
Corticosteroid insensitivity in asthma associated with obstructive sleep apnoea: Role of oxidative stress and histone acetylation	16
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential	16
Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth	16
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?	16
Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence	16
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Natural Products	15
The polypharmacological profiles of xanomeline and N‐desmethylxanomeline	15
Chemistry/structural biology of psychedelic drugs and their receptor(s)	15
Issue Information	15
RETRACTION: L6H21 protects against cognitive impairment and brain pathologies via toll‐like receptor 4–myeloid differentiation factor 2 Signalling in Prediabetic rats	15
An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis	15
Correction to “Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adioponectin release”	15
Issue Information	15
The Concise Guide to PHARMACOLOGY 2023/24: Transporters	15
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China	15
Commentary on ‘Identification and characterization of select oxysterols as ligands for GPR17’	15
Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity	15
ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis	15
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders	15
Issue Information	15
V‐domain immunoglobulin suppressor of T‐cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma	15
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Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity	15
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum	15
Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21	15
Cell‐based therapy for diabetic cardiovascular complications: Prospects and challenges	15
No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies	14
To CB2 or not CB2: Revisiting renoprotection in acute and chronic kidney injury	14
Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state	14
Berberine alleviates pre‐eclampsia by modulating M1/M2 macrophage polarization and T helper (Th1/Th2) cells cytokine balance	14
Galangin alleviates vitiligo by targeting ANXA2 degradation in macrophages	14
Pulmonary arterial hypertension: Sex matters	14
Issue Information	14
Non‐canonical PKG1 regulation in cardiovascular health and disease	14
Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights	14
Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1‐mediated autophagy	14
A pH‐sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation	14
The paraventricular thalamus is required for homeostatic sleep regulation by adenosine	14
Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis	14
The Australia story: Current status and future challenges for the clinical applications of psychedelics	14
Issue Information	14
Explainable AI and debiased networks: The ‘last mile’ for precision medicine delivery	14
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Disruption of survivin protein expression by treatment with YM155 accelerates the resolution of neutrophilic inflammation	14
EDITORIAL for BJP themed issue “noncoding RNA therapeutics”	14
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease	14
AMG487 alleviates influenza A (H1N1) virus‐induced pulmonary inflammation through decreasing IFN‐γ‐producing lymphocytes and IFN‐γ concentrations	14
Issue Information	14
Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction	13
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials	13
SerpinB1 is required for Rev‐erbα‐mediated protection against acute lung injury induced by lipopolysaccharide‐in mice	13
Statin activation of skeletal ryanodine receptors (RyR1) is a class effect but separable from HMG‐CoA reductase inhibition	13
The TREK‐1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension	13
Asthma and inflammation transcriptionally up‐regulate the aryl hydrocarbon receptor in airway smooth muscle via p38/JNK‐AP1 signalling	13
Correction to “Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota”	13
Expression of Concern: Toll‐like receptor 4 knockout protects against anthrax lethal toxin‐induced cardiac contractile dysfunction: role of autophagy	13
Genetic polymorphisms influencing antihypertensive drug responses	13
Bortezomib promotes neutrophil‐mediated bacterial clearance in sepsis by inhibiting plasmablast activation	13
P2X7 receptor‐dependent increase in endocannabinoid 2‐arachidonoyl glycerol production by neuronal cells in culture: Dynamics and mechanism	13
D‐amino acid oxidase as a chemogenetic tool for spatiotemporally controlled hydrogen peroxide production: The oxygen connection	13
Dopaminergic signalling and behavioural alterations by Comt–Dtnbp1 genetic interaction and their clinical relevance	13
Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice	13
Reporting innovations in pharmacology and drug development, upholding excellence and improving author experience at the British Journal of Pharmacology in 2024	13
Advancing Alzheimer's disease pharmacotherapy: efficacy of glucocorticoid modulation with dazucorilant (CORT113176) in preclinical mouse models	13
Improving K v 7 targeting anticonvulsants ‐ will repurposing save the day?	13
The opioid partial agonist PPL‐138 reduces alcohol self‐administration in rats susceptible to post‐traumatic stress disorder	13