British Journal of Pharmacology

Papers
(The TQCC of British Journal of Pharmacology is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)
ArticleCitations
425
Issue Information347
324
Issue Information248
213
Palbociclib blocks neutrophilic phosphatidylinositol 3‐kinase activity to alleviate psoriasiform dermatitis181
155
The potential for biased signalling in the P2Y receptor family of GPCRs151
Correction to ‘Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy’150
Correction to “Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by silent information regulator 1”134
EXPRESSION OF CONCERN: Nitropravastatin Stimulates Reparative Neovascularisation and Improves Recovery from Limb Ischaemia in Type‐1 Diabetic Mice123
Dual action of macrophage miR‐204 confines cyclosporine A‐induced atherosclerosis122
Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model102
Issue Information91
Matsupexole: A novel nonergot dopamine receptor agonist with sustained efficacy in a rat model of Parkinson's disease and limited off‐target activity89
Justifying and reporting the use of severe stress in experiments that use animals86
Clinical‐data‐driven pharmacological framework in liver disease: From liver cirrhosis to hepatocellular carcinoma73
Opportunities of patient‐derived organoids in drug development71
Integrating novel immunotherapeutic approaches in organ‐preserving therapies for bladder cancer69
Identification of active ingredients from Lamiophlomis rotata that increase wound repair in mouse skin68
Cardiotoxicity of BRAF/MEK inhibitors66
Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases66
The β 2 ‐adrenoceptor agonist formoterol attenuates hallmarks of adrenal Cushing's syndrome66
Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs62
Down‐regulation of M 6 A demethylase ALKBH5 facilitates morphine tolerance via SGK1 in mice57
Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors56
Pharmacokinetics and cardioprotective efficacy of intravenous miR‐125b* microRNA mimic in a mouse model of acute myocardial infarction55
Gβγ subunit signalling underlies neuropeptide Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries55
GPR84 in physiology—Many functions in many tissues55
The fast‐dissociating D 2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment53
Chronic stress induces behavioural changes through increased kynurenic acid by downregulation of kynurenine‐3‐monooxygenase with microglial decline51
6‴‐Feruloylspinosin ameliorates pressure overload‐induced heart failure with comorbid insomnia through the activation of RORα50
Novel therapeutic approaches to target neurodegeneration48
Decoding fatal toxic effects in checkpoint inhibitor therapy using real‐world pharmacovigilance data and machine learning48
Allosterism in the adenosine A2A and cannabinoid CB2 heteromer47
Activation of peripheral cannabinoid receptors by CB13 attenuates burn injury–induced chronic pain through TRP channel modulation45
Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury43
Mas‐related G protein‐coupled receptors in gastrointestinal dysfunction and inflammatory bowel disease: A review42
Publication fraud in the era of generative artificial intelligence42
Biphasic effect of nicotine on glutamatergic activity in male mouse brain42
Exploring pharmacological inhibition of Gq/11 as an analgesic strategy42
The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors42
Supersulfide biology and translational medicine for disease control41
Combined therapy with pirfenidone and nintedanib counteracts fibrotic silicosis in mice41
Evidence generation throughout paediatric medicines life cycle: findings from collaborative work between European Medicines Agency (EMA) and EUnetHTA on use of extrapolation40
In vitro and in vivo study of butyrylfentanyl and 4‐fluorobutyrylfentanyl in female and male mice: Role of the CRF1 receptor in cardiorespiratory impairment40
40
Potential medicinal value of N6‐methyladenosine in autoimmune diseases and tumours38
TREM2 activation suppresses central sensitisation by promoting autophagy in a chronic migraine model with recurrent nitroglycerin stimulation in mice38
A comprehensive review of cancer‐induced cardiac wasting38
Development of new Kir2.1 channel openers from propafenone analogues38
Exosomes from macrophages intervened by Jiedu Yangxin decoction mediated endothelial‐to‐mesenchymal transition to improve myocardial fibrosis after myocardial infarction38
Efficacy in diet‐induced obese mice of the hepatotropic, peripheral cannabinoid 1 receptor inverse agonist TM3883738
Bioactivity‐based molecular networking‐guided identification of guttiferone J from Garcinia cambogia as an anti‐obesity candidate37
Elucidating the beneficial impact of exercise on chronic obstructive pulmonary disease and its comorbidities: Integrating proteomic and immunological insights37
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats37
Intravenous recombinant cerebellin 1 treatment restores signalling by spinal glutamate delta 1 receptors and mitigates chronic pain36
Niclosamide prodrug enhances oral bioavailability and efficacy against hepatocellular carcinoma by targeting vasorin‐TGFβ signalling36
RGS6 negatively regulates inhibitory G protein signaling in dopamine neurons and positively regulates binge‐like alcohol consumption in mice35
Site‐specific m6A‐miR‐494‐3p, not unmethylated miR‐494‐3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis35
Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential35
β‐Arrestin‐biased proteinase‐activated receptor‐2 antagonist C781 limits allergen‐induced airway hyperresponsiveness and inflammation35
Network‐based precision medicine and systems pharmacology34
From mundane to classic: Sinomenine as a multi‐therapeutic agent34
Insight in article retractions inBritish Journal of Pharmacologybetween the years 2000–2023. Implications for reducing fraud‐containing articles34
Host genetic variants in the lactose metabolism pathway associated with bifidobacterium abundance have prognostic value for immunotherapy efficacy33
Identification of a human blood biomarker of pharmacological 11β‐hydroxysteroid dehydrogenase 1 inhibition33
Macrocyclic diterpenoids from Stellera chamaejasme roots alleviate imiquimod‐induced psoriasiform inflammation via STAT1/S100A9 signalling pathway33
Fifty years with aspirin and platelets32
Combination therapy enhances efficacy and overcomes toxicity of metal‐based anti‐diabetic agent32
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities32
Sevoflurane acts as an antidepressant by suppression of GluN2D‐containing NMDA receptors on interneurons32
Correction to “Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets”32
Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice31
Subregion‐specific perineuronal net remodelling in the dorsal hippocampus drives vulnerability and resilience to chronic stress: The role of venlafaxine treatment31
Silibinin, a commonly used therapeutic agent for non‐alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/1930
Decoding functional specialization in G protein‐coupled receptors (GPCRs) through evolution‐guided residue profiling30
tiRNA‐Gly‐GCC‐002 promotes epithelial‐mesenchymal transition and fibrosis in lupus nephritis via FKBP5‐mediated activation of Smad29
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors28
Targeting cluster of differentiation 26 / dipeptidyl peptidase 4 (CD26/DPP4) in organ fibrosis28
Exploring effects of chronic d ‐cycloserine administration on expression of GluN2 subunits and tripartite synaptic transmission in thalamocortical pa28
The role of venous capacity in fluid retention with endothelin A antagonism: Mathematical modelling of the RADAR trial28
Defining and unpacking the core concepts of pharmacology: A global initiative28
NRF2 signalling in cytoprotection and metabolism28
Discovery of alantolactone as a naturally occurring NLRP3 inhibitor to alleviate NLRP3‐driven inflammatory diseases in mice28
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Carfentanil is a β‐arrestin‐biased agonist at the μ opioid receptor27
Differential regulation of Cav3.2 and Cav2.2 calcium channels by CB1 receptors and cannabidiol27
27
Issue Information26
Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy26
Therapeutic effect of human ApoA‐I‐Milano variant in aged transgenic mouse model of Alzheimer's disease26
Bioavailability of flumequine and diclofenac in mice exposed to a metal‐drug chemical cocktail. Evaluation of the protective role of selenium.26
25
AMP‐activated protein kinase in the amygdala and hippocampus contributes to enhanced fear memory in diabetic mice25
25
Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells25
Cav1.3‐selective inhibitors of voltage‐gated L‐type Ca2+ channels: Fact or (still) fiction?25
QM107, a novel CD148 (RTP Type J) activating peptide therapy for treating neovascular age‐related macular degeneration25
25
Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells25
R2R01: A long‐acting single‐chain peptide agonist of RXFP1 for renal and cardiovascular diseases24
FM‐dye inhibition of Piezo2 relieves mechanically evoked pain in mouse models of acute inflammatory and osteoarthritic knee pain24
Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice24
Resolution pharmacology and the treatment of infectious diseases24
BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus24
A proposal for rational drug class terminology: A gastrointestinal perspective24
A p75 neurotrophin receptor‐sparing nerve growth factor protects retinal ganglion cells from neurodegeneration by targeting microglia24
Cathepsins and SARS‐CoV‐2 infection: From pathogenic factors to potential therapeutic targets24
Natural products and cancer: From drug discovery to prevention and therapy23
Ticagrelor increases its own potency at the P2Y12 receptor by directly changing the plasma membrane lipid order in platelets23
Dual effects of mefenamic acid on the IKs molecular complex23
Preclinical models for evaluating psychedelics in the treatment of major depressive disorder23
A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain23
Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two‐sided nature of antagonistic ligands resulting from partial dissociation of Gq23
Issue Information22
Methanobactin rapidly facilitates biliary copper excretion in a Wilson disease rat model visualised by 64 Cu PET/MRI22
Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function22
Expression of Concern: Effects of Tyrphostins and Genistein on the Virculatory Gailure and Organ Dysfunction Caused by Endotoxin in the Rat: A Possible Role for Protein Tyrosine Kinase22
Issue Information22
The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients22
q signalling from endosomes: A new conundrum22
Sex‐related susceptibility to pulmonary fibrosis development in mice22
Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation22
Ligand bias and inverse agonism on 5‐HT2A receptor‐mediated modulation of G protein activity in post‐mortem human brain22
Blood pressure‐independent renoprotective effects of small interference RNA targeting liver angiotensinogen in experimental diabetes22
Synergistic augmentation of rhythmic myogenic contractions of human stomach by arginine vasopressin and adrenaline: Implications for the induction of nausea21
Baclofen modulates the immune response after spinal cord injury with locomotor benefits21
Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair21
Compound 4a induces paraptosis in liver cancer through endoplasmic reticulum stress mediated by the calreticulin protein21
Sex‐specific impact of repeated adolescent vapour exposure to JWH‐018 on dopamine response, behaviour and pharmacokinetics across adolescence and adulthood21
A peptide rich in glycine–serine–alanine repeats ameliorates Alzheimer‐type neurodegeneration21
EXPRESSION OF CONCERN: H 2 S‐Donating Sildenafil (ACS6) Inhibits Superoxide Formation and gp91 phox 21
Formation and clearance of TNF–TNF inhibitor complexes during TNF inhibitor treatment21
The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration21
Noncanonical function of sphingosine kinase 2 (SPHK2) sustains hepatic triglyceride homeostasis21
Activating transcription factor‐3 orchestrates the modulation of vascular anti‐contractile activity and relaxation by governing the secretion of HDL‐bound sphingosine‐1‐phosphate in perivascular adipo20
Advancing antihypertensive drug development20
The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling20
Activation of the pentose phosphate pathway flux by hydrogen peroxide is not regulated by NADPH‐mediated feedback inhibition20
Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice20
Artificial intelligence (AI) as a catalyst for mechanistic target discovery: Integrating systems pharmacology and multimodal data20
Hydroxyl chalcone derivative DK02 as a multi‐target‐directed ligand for Alzheimer's disease: A preclinical study in zebrafish20
Silencing the fibronectin gene (FN1 ) improves NaCl‐induced cardiac fibrosis via ferritinophagy‐mediated ferroptosis in a nuclear receptor coactivator 4 20
Photochemical control of cold‐sensitive TRPA1 ion channel gating for modulation of pain sensation20
Targeting noncoding RNAs to treat atherosclerosis20
Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial–mesenchymal trophic unit activation in asthma20
Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review20
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Stimulation of platelet P2Y 1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling19
Safety Toxicology19
Issue Information19
19
The flavonoid GL‐V9 alleviates liver fibrosis by triggering senescence by regulating the transcription factor GATA4 in activated hepatic stellate cells19
Smooth muscle cell Piezo1 is essential for phenotypic switch and neointimal hyperplasia19
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The Concise Guide to PHARMACOLOGY 2025/26: Ion channels19
Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A19
Issue Information19
Assessment of the molecular mechanisms of drug‐induced hidden cardiotoxicity by a multi‐omics approach: The example of rofecoxib18
18
Vesicular glutamate transporter VGLUT2 expression emerges in substantia nigra dopamine neurons in mouse models of parkinsonism in the absence of neurodegeneration18
Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer18
Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery18
CircPTK2 enhances non‐small cell lung cancer proliferation by inhibiting cellular senescence through stabilizing NFYA and elevating FOXM118
Issue Information18
Soluble epoxide hydrolase inhibition enhances production of specialized pro‐resolving lipid mediator and promotes macrophage plasticity18
Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China18
Cannabigerol reverses mechanical allodynia through α 2A ‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy18
18
Mechanopharmacology18
In silico , in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants l17
Opioid receptors in cardiovascular function17
The polypharmacological profiles of xanomeline and N‐desmethylxanomeline17
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin‐induced cardiotoxicity17
Corticosteroid insensitivity in asthma associated with obstructive sleep apnoea: Role of oxidative stress and histone acetylation17
Trilobatin attenuates cerebral ischaemia/reperfusion‐induced blood–brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive17
V‐domain immunoglobulin suppressor of T‐cell activation and programmed death receptor 1 dual checkpoint blockade enhances antitumour immunity and survival in glioblastoma17
The role of free‐fatty acid receptors FFA1 and FFA4 in organ fibrosis17
The ion channel TRPM8 is a direct target of the immunosuppressant rapamycin in primary sensory neurons17
Neutrophil β1 adrenoceptor blockade blunts stroke‐associated neuroinflammation17
Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats17
EXPRESSION OF CONCERN: Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells17
Enterolactone promotes efficacy of gemcitabine on epithelial ovarian cancer and ameliorates gut dysbacteriosis17
A long‐acting FGF21 attenuates metabolic dysfunction‐associated steatohepatitis‐related fibrosis by modulating NR4A1‐mediated Ly6C phenotypic switch in macrophages17
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?17
Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors17
Chemistry/structural biology of psychedelic drugs and their receptor(s)17
Cannabinoid 1 (CB1) receptor arrestin subtype‐selectivity and phosphorylation dependence17
Bioactive ligands targeting ectopic olfactory receptors: Implications for therapeutic strategies17
Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis16
Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential16
Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth16
16
An antisense oligonucleotide targeting the heat‐shock protein HSPB5 as an innovative therapeutic approach in pulmonary fibrosis16
Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state16
Arbidol, an antiviral drug, identified as a sodium channel blocker with anticonvulsant activity16
Natural Products16
Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis16
Issue Information16
Issue Information16
EDITORIAL for BJP themed issue “noncoding RNA therapeutics”16
16
Cell‐based therapy for diabetic cardiovascular complications: Prospects and challenges16
Naringenin relieves paclitaxel‐induced pain by suppressing calcitonin gene‐related peptide signalling and enhances the anti‐tumour action of paclitaxel16
Difluorinated thromboxane A2 reveals crosstalk between platelet activatory and inhibitory pathways by targeting both the TP and IP receptors16
The Concise Guide to PHARMACOLOGY 2023/24: Transporters16
Commentary on ‘Identification and characterization of select oxysterols as ligands for GPR17’16
A pH‐sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation16
Issue Information16
The Australia story: Current status and future challenges for the clinical applications of psychedelics15
Safety, pharmacokinetics and pharmacodynamics of TQC3721, an innovative, dual PDE3 and PDE4 inhibitor, in healthy subjects and patients with chronic obstructive pulmonary disease: Randomised, double‐b15
AMG487 alleviates influenza A (H1N1) virus‐induced pulmonary inflammation through decreasing IFN‐γ‐producing lymphocytes and IFN‐γ concentrations15
Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights15
15
Disruption of survivin protein expression by treatment with YM155 accelerates the resolution of neutrophilic inflammation15
Butyrate acts as a positive allosteric modulator of the 5‐HT transporter to decrease availability of 5‐HT in the ileum15
ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis15
Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1‐mediated autophagy15
Explainable AI and debiased networks: The ‘last mile’ for precision medicine delivery15
Single cell G‐protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 2115
AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence15
Long‐acting relaxin for pulmonary hypertension: from systemic pharmacodynamics to disease‐site pharmacology15
Berberine alleviates pre‐eclampsia by modulating M1/M2 macrophage polarization and T helper (Th1/Th2) cells cytokine balance15
The paraventricular thalamus is required for homeostatic sleep regulation by adenosine15
Galangin alleviates vitiligo by targeting ANXA2 degradation in macrophages15
Correction to “Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adioponectin release”15
RETRACTION: L6H21 protects against cognitive impairment and brain pathologies via toll‐like receptor 4–myeloid differentiation factor 2 Signalling in Prediabetic rats15
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders15
Gut microbiota as a novel therapeutic target for eating disorders and obesity14
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease14
No new ‘mabs’ in medicine—New nomenclature for monoclonal antibodies14
Withdrawn14
JAK–STAT inhibitory effect of IN‐115314, a novel small molecule inhibitor, and pharmacokinetic/pharmacodynamic study in canine14
Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials14
14
Ginsenosides retard atherogenesis via remodelling host–microbiome metabolic homeostasis14
Pulmonary arterial hypertension: Sex matters14
Correction to “Potential type 2 diabetes mellitus drug HMPA promotes short‐chain fatty acid production by improving carbon catabolite repression effect of gut microbiota”14
Expression of Concern: Toll‐like receptor 4 knockout protects against anthrax lethal toxin‐induced cardiac contractile dysfunction: role of autophagy14
Dopaminergic signalling and behavioural alterations by ComtDtnbp1 genetic interaction and their clinical relevance14
Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice14
Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice14
To CB2 or not CB2: Revisiting renoprotection in acute and chronic kidney injury14
A novel quinoline and manganese‐based carbon monoxide‐releasing molecule for intravesical therapy of bladder cancer14
14
Molecular and structural insights into the 5‐HT2C receptor as a therapeutic target for substance use disorders14
Reporting innovations in pharmacology and drug development, upholding excellence and improving author experience at the British Journal of Pharmacology in 202414
Ibuprofen inhibits human sweet taste and glucose detection implicating an additional mechanism of metabolic disease risk reduction14
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