OOIR: Observatory of International Research

Papers

(The median citation count of British Journal of Pharmacology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-11-01 to 2024-11-01.)

Article	Citations
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors	323
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes	317
Planning experiments: Updated guidance on experimental design and analysis and their reporting III	292
Update of P2X receptor properties and their pharmacology: IUPHAR Review 30	198
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets	187
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels	171
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors	149
Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species‐dependent ferroptosis	132
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes	131
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters	115
Community guidelines for GPCR ligand bias: IUPHAR review 32	114
Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice	99
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors	97
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors	94
Nuciferine protects against folic acid‐induced acute kidney injury by inhibiting ferroptosis	92
Leonurine alleviates ferroptosis in cisplatin‐induced acute kidney injury by activating the Nrf2 signalling pathway	91
Butyrate ameliorates skeletal muscle atrophy in diabetic nephropathy by enhancing gut barrier function and FFA2‐mediated PI3K/Akt/mTOR signals	86
Novel non‐steroidal mineralocorticoid receptor antagonists in cardiorenal disease	81
Osteosarcoma mechanobiology and therapeutic targets	80
Zebrafish as a tractable model of human cardiovascular disease	77
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations	73
Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro	71
Protective properties of GLP‐1 and associated peptide hormones in neurodegenerative disorders	71
Clinical applications for exosomes: Are we there yet?	70
Review of delta‐8‐tetrahydrocannabinol (Δ⁸‐THC): Comparative pharmacology with Δ⁹‐THC	64

Triptolide prevents LPS‐induced skeletal muscle atrophy via inhibiting NF‐κB/TNF‐α and regulating protein synthesis/degradation pathway	62
The role of glucagon‐like peptide 1 (GLP‐1) in addictive disorders	61
Eating microRNAs: pharmacological opportunities for cross‐kingdom regulation and implications in host gene and gut microbiota modulation	60
Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis	60
Mechanisms of enzalutamide resistance in castration‐resistant prostate cancer and therapeutic strategies to overcome it	60
The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets	59
Activation of thyroid hormone receptor‐β improved disease activity and metabolism independent of body weight in a mouse model of non‐alcoholic steatohepatitis and fibrosis	59
Transcriptome‐level discovery of survival‐associated biomarkers and therapy targets in non‐small‐cell lung cancer	56
Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment	55
Omega‐3 polyunsaturated fatty acids and hypertension: a review of vasodilatory mechanisms of docosahexaenoic acid and eicosapentaenoic acid	54
Macrophage extracellular traps aggravate iron overload‐related liver ischaemia/reperfusion injury	54
The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors	54
Short‐chain fatty acids regulate B cells differentiation via the FFA2 receptor to alleviate rheumatoid arthritis	53
Novel drug developmental strategies for treatment‐resistant depression	51
Sex‐dependent effects of endocannabinoid modulation of conditioned fear extinction in rats	51
Sphingolipid metabolism during Toll‐like receptor 4 (TLR4)‐mediated macrophage activation	48
The Concise Guide to PHARMACOLOGY 2023/24: Transporters	47
Soluble GC stimulators and activators: Past, present and future	47
STAT3/NF‐κB signalling disruption in M2 tumour‐associated macrophages is a major target of PLGA nanocarriers/PD‐L1 antibody immunomodulatory therapy in breast cancer	46
The anomalous pharmacology of fentanyl	46
Complement, inflammation and thrombosis	46
The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation	46
Honokiol ameliorates cisplatin‐induced acute kidney injury via inhibition of mitochondrial fission	46
Pharmacological treatment of migraine: Drug classes, mechanisms of action, clinical trials and new treatments	46
Small interfering RNA: Discovery, pharmacology and clinical development—An introductory review	45
Fifteen years of Na_V1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?	43
Understanding and countering opioid‐induced respiratory depression	42
Rhein regulates redox‐mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage‐activated crosstalk	41
Targeted inhibition of Rev‐erb‐α/β limits ferroptosis to ameliorate folic acid‐induced acute kidney injury	41
Perspectives for therapy of treatment‐resistant depression	41
Animal models of pulmonary hypertension: Getting to the heart of the problem	40
Oxytocin and vasopressin: Signalling, behavioural modulation and potential therapeutic effects	40
TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury	39
Icariside II preconditioning evokes robust neuroprotection against ischaemic stroke, by targeting Nrf2 and the OXPHOS/NF‐κB/ferroptosis pathway	39
Targeting α‐synuclein aggregation and its role in mitochondrial dysfunction in Parkinson's disease	38
Niclosamide—A promising treatment for COVID‐19	38
The Concise Guide to PHARMACOLOGY 2023/24: Ion channels	38
The role of glia in the physiology and pharmacology of glucagon‐like peptide‐1: implications for obesity, diabetes, neurodegeneration and glaucoma	37
RNA‐binding motif protein 39 (RBM39): An emerging cancer target	37
N‐acetylcysteine as a new prominent approach for treating psychiatric disorders	36
The development of inhibitors of leucine‐rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease: the current state of play	35
Cannabigerolic acid, a major biosynthetic precursor molecule in cannabis, exhibits divergent effects on seizures in mouse models of epilepsy	35
Glucagon‐like peptide‐1 (GLP‐1) receptor agonists and their cardiovascular benefits—The role of the GLP‐1 receptor	35
Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats	34
Beyond CGRP: The calcitonin peptide family as targets for migraine and pain	34
Strategies towards safer opioid analgesics—A review of old and upcoming targets	34
How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders	33
A plant‐derived TRPV3 inhibitor suppresses pain and itch	33
1‐Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway	33
Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity	32

KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis	32
Role of intracellular complement activation in kidney fibrosis	32
In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity	32
The therapeutic potential of GLP‐1 receptor biased agonism	32
Rodent models of hypertension	31
Structural and molecular determinants of mineralocorticoid receptor signalling	31
Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B	31
TRV130 partial agonism and capacity to induce anti‐nociceptive tolerance revealed through reducing available μ‐opioid receptor number	30
Jumonji domain‐containing protein‐3 (JMJD3) promotes myeloid fibroblast activation and macrophage polarization in kidney fibrosis	30
CGRP receptor antagonists for migraine. Are they also AMY₁ receptor antagonists?	29
Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia‐induced pulmonary hypertension	29
The importance of Ras in drug resistance in cancer	29
Glucagon‐like peptide‐1 (GLP‐1) signalling in the brain: From neural circuits and metabolism to therapeutics	29
Perivascular fat imaging by computed tomography (CT): a virtual guide	28
Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment	28
Cerebroprotection by dioscin after experimental subarachnoid haemorrhage via inhibiting NLRP3 inflammasome through SIRT1‐dependent pathway	28
Mechanisms of endocannabinoid transport in the brain	28
Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2‐mediated mechanism	28
Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing	27
Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor	27
The T‐type calcium channel antagonist, Z944, reduces spinal excitability and pain hypersensitivity	27
Emerging therapies and their delivery for treating age‐related macular degeneration	26
FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1‐dependent autophagy	26
Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel	26
Gut microbiota contributes to the development of hypertension in a genetic mouse model of systemic lupus erythematosus	26
Heterogeneity in response to repeated intranasal oxytocin in schizophrenia and autism spectrum disorders: A meta‐analysis of variance	26
Reappraising the role of the vagus nerve in GLP‐1‐mediated regulation of eating	26
Mitophagy: A promising therapeutic target for neuroprotection during ageing and age‐related diseases	26
Mineralocorticoid receptor in cardiovascular diseases—Clinical trials and mechanistic insights	25
Formylpeptide receptor 2: Nomenclature, structure, signalling and translational perspectives: IUPHAR review 35	25
Emerging benefits and drawbacks of α₂‐adrenoceptor agonists in the management of sepsis and critical illness	25
Actions of glucagon‐like peptide‐1 receptor ligands in the gut	25
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker	25
Inhibition of DNA methylation de‐represses peroxisome proliferator‐activated receptor‐γ and attenuates pulmonary fibrosis	25
Macrophage migration inhibitory factor exerts pro‐proliferative and anti‐apoptotic effects via CD74 in murine hepatocellular carcinoma	25
Amlodipine, an anti‐hypertensive drug, alleviates non‐alcoholic fatty liver disease by modulating gut microbiota	25
TLR4 deficiency upregulates TLR9 expression and enhances irinotecan‐related intestinal mucositis and late‐onset diarrhoea	24
Cyclic helix B peptide promotes random‐pattern skin flap survival via TFE3‐mediated enhancement of autophagy and reduction of ROS levels	24
Oxoglaucine mediates Ca²⁺ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK‐II pathway	24
Glucagon‐like peptide‐1 in diabetes care: Can glycaemic control be achieved without nausea and vomiting?	24
PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR	24
Uncovering the signalling, structure and function of the 20‐HETE‐GPR75 pairing: Identifying the chemokine CCL5 as a negative regulator of GPR75	24
Therapeutic effect of kaempferol on atopic dermatitis by attenuation of T cell activity via interaction with multidrug resistance‐associated protein 1	24
Rho kinase inhibitor fasudil reduces l‐DOPA‐induced dyskinesia in a rat model of Parkinson's disease	24
Therapeutic strategies to fight COVID‐19: Which is the status artis?	24
Ruthenium 360 and mitoxantrone inhibit mitochondrial calcium uniporter channel to prevent liver steatosis induced by high‐fat diet	24
Identification and characterization of a novel adiponectin receptor agonist adipo anti‐inflammation agonist and its anti‐inflammatory effects in vitro and in vivo	23
Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID‐19	23
Non‐peptide agonists and positive allosteric modulators of glucagon‐like peptide‐1 receptors: Alternative approaches for treatment of Type 2 diabetes	23
Sphingosine‐1‐phosphate/TGF‐β axis drives epithelial mesenchymal transition in asthma‐like disease	23
Preclinical models of myocardial infarction: from mechanism to translation	23
Pathophysiological roles of cell surface and extracellular protein disulfide isomerase and their molecular mechanisms	23
Metabolic phenotyping of opioid and psychostimulant addiction: A novel approach for biomarker discovery and biochemical understanding of the disorder	23
Screening for liver X receptor modulators: Where are we and for what use?	23
The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors	23
The oxysterol receptor GPR183 in inflammatory bowel diseases	22
Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1^G93Amice	22
Amitriptyline blocks innate immune responses mediated by toll‐like receptor 4 and IL‐1 receptor: Preclinical and clinical evidence in osteoarthritis and gout	22
Can rodent models elucidate the pathomechanisms of genetic epilepsy?	22
RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice	22
5‐hydroxytryptamine in migraine: The puzzling role of ionotropic 5‐HT₃ receptor in the context of established therapeutic effect of metabotropic 5‐HT₁ subtypes	22
Altered blood–brain barrier and blood–spinal cord barrier dynamics in amyotrophic lateral sclerosis: Impact on medication efficacy and safety	22
Bisphosphonates for delivering drugs to bone	22
Brain mineralocorticoid receptor in health and disease: From molecular signalling to cognitive and emotional function	22
SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB₁ receptors	22
Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia	21
Squalene epoxidase promotes hepatocellular carcinoma development by activating STRAP transcription and TGF‐β/SMAD signalling	21
Inhibition of the sodium–glucose co‐transporter SGLT2 by canagliflozin ameliorates diet‐induced obesity by increasing intra‐adipose sympathetic innervation	21
Endothelium‐derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large‐conductance Ca²⁺‐activated K⁺ channels	21
Regulation of hepatic stellate cell contraction and cirrhotic portal hypertension by Wnt/β‐catenin signalling via interaction with Gli1	21
Stimulation of soluble guanylyl cyclase (sGC) by riociguat attenuates heart failure and pathological cardiac remodelling	21
Detrimental effects of adolescent escalating low‐dose Δ⁹‐tetrahydrocannabinol leads to a specific bio‐behavioural profile in adult male rats	21
Sodium rutin extends lifespan and health span in mice including positive impacts on liver health	21
Towards a druggable epitranscriptome: Compounds that target RNA modifications in cancer	21
Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ	21
Increased expression of the ATP‐gated P2X7 receptor reduces responsiveness to anti‐convulsants during status epilepticus in mice	21
Halofuginone, a promising drug for treatment of pulmonary hypertension	21
Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents	20
The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer	20
Maresin 1 intervention reverses experimental pulmonary arterial hypertension in mice	20

Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene‐deleted mice	20
Metabolomics analysis of human plasma reveals decreased production of trimethylamine N‐oxide retards the progression of chronic kidney disease	20
Gut microbiota‐derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling	20
Targeted delivery of triptolide by dendritic cell‐derived exosomes for colitis and rheumatoid arthritis therapy in murine models	20
Synergistic effects of two naturally occurring iridoids in eliciting a rapid antidepressant action by up‐regulating hippocampal PACAP signalling	20
What skeletal muscle has to say in amyotrophic lateral sclerosis: Implications for therapy	20
Postoperative ileus: A pharmacological perspective	20
Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels	20
Pharmacological characterisation of mouse calcitonin and calcitonin receptor‐like receptors reveals differences compared with human receptors	20
Doxycycline and its derivative, COL‐3, decrease dyskinesia induced by l‐DOPA in hemiparkinsonian rats	20
The role of nucleus of the solitary tract glucagon‐like peptide‐1 and prolactin‐releasing peptide neurons in stress: anatomy, physiology and cellular interactions	20
Deletion of the E3 ubiquitin ligase, Parkin, exacerbates chronic alcohol intake‐induced cardiomyopathy through an Ambra1‐dependent mechanism	19
Aberrant branched‐chain amino acid accumulation along the microbiota–gut–brain axis: Crucial targets affecting the occurrence and treatment of ischaemic stroke	19
Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: Sex differences in rats	19
Amelioration of endothelial dysfunction by sodium glucose co‐transporter 2 inhibitors: pieces of the puzzle explaining their cardiovascular protection	19
Phytocannabinoid‐dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity	19
Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3‐mediated muscle wasting in cancer cachexia mice	19
Carbenoxolone and 18β‐glycyrrhetinic acid inhibit inositol 1,4,5‐trisphosphate‐mediated endothelial cell calcium signalling and depolarise mitochondria	19
Neutrophil elastase promotes neointimal hyperplasia by targeting toll‐like receptor 4 (TLR4)–NF‐κB signalling	19
Sirtuins as pharmacological targets in neurodegenerative and neuropsychiatric disorders	19
Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation	19
The selective 5‐HT_1F receptor agonist lasmiditan inhibits trigeminal nociceptive processing: Implications for migraine and cluster headache	19
The importance of binding kinetics and drug–target residence time in pharmacology	19
Inhibition of sodium conductance by cannabigerol contributes to a reduction of dorsal root ganglion neuron excitability	18
The mineralocorticoid receptor in chronic kidney disease	18
The canine chronic atrioventricular block model in cardiovascular preclinical drug research	18
Presynaptic release‐regulating NMDA receptors in isolated nerve terminals: A narrative review	18
Dual inhibition of CB₁ receptors and iNOS, as a potential novel approach to the pharmacological management of acute and long COVID‐19	18
Beneficial effects of a combination of natural product activators of autophagy on endothelial cells and platelets	18
Artificial intelligence for solid tumour diagnosis in digital pathology	18
Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity	18
Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms	18
Chronic itch: emerging treatments following new research concepts	18
Chronic fluoxetine treatment impairs motivation and reward learning by affecting neuronal plasticity in the central amygdala	18
Physalin B attenuates liver fibrosis via suppressing LAP2α–HDAC1‐mediated deacetylation of the transcription factor GLI1 and hepatic stellate cell activation	18
Approved drugs ezetimibe and disulfiram enhance mitochondrial Ca²⁺ uptake and suppress cardiac arrhythmogenesis	18
Mitomycin C induces pulmonary vascular endothelial‐to‐mesenchymal transition and pulmonary veno‐occlusive disease via Smad3‐dependent pathway in rats	18
An in silico–in vitro pipeline for drug cardiotoxicity screening identifies ionic pro‐arrhythmia mechanisms	18
BBIT20 inhibits homologous DNA repair with disruption of the BRCA1–BARD1 interaction in breast and ovarian cancer	18
Characterisation of agonist signalling profiles and agonist‐dependent antagonism at PACAP‐responsive receptors: Implications for drug discovery	18
Differential regulation of Ca_v3.2 and Ca_v2.2 calcium channels by CB₁ receptors and cannabidiol	18
Remote local photoactivation of morphine produces analgesia without opioid‐related adverse effects	17
Established pulmonary hypertension in rats was reversed by a combination of a HIF‐2α antagonist and a p53 agonist	17
Visualising and understanding cGMP signals in the cardiovascular system	17
Phosphoproteomic identification of vasopressin‐regulated protein kinases in collecting duct cells	17
Behavioural and pharmacological effects of cannabidiol (CBD) and the cannabidiol analogue KLS‐13019 in mouse models of pain and reinforcement	17
Factor H‐related protein 1: a complement regulatory protein and guardian of necrotic‐type surfaces	17
Approaches towards tissue‐selective pharmacology of the mineralocorticoid receptor	17
Disease‐modifying treatment with I₂ imidazoline receptor ligand LSL60101 in an Alzheimer's disease mouse model: a comparative study with donepezil	17
A novel oncotherapy strategy: Direct thrombin inhibitors suppress progression, dissemination and spontaneous metastasis in non‐small cell lung cancer	17
Suppression of myeloid PFKFB3‐driven glycolysis protects mice from choroidal neovascularization	17
Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1	17
Metabolic responses and benefits of glucagon‐like peptide‐1 (GLP‐1) receptor ligands	17
Fifty years with aspirin and platelets	17
Measuring mania‐like elevated mood through amphetamine‐induced 50‐kHz ultrasonic vocalizations in rats	17
Analysis of inhibitors of the anoctamin‐1 chloride channel (transmembrane member 16A, TMEM16A) reveals indirect mechanisms involving alterations in calcium signalling	17
IL‐17‐induced inflammation modulates the mPGES‐1/PPAR‐γ pathway in monocytes/macrophages	17
Targeting macrophage liver X receptors by hydrogel‐encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis	17
Inhibition of Na⁺/H⁺ exchanger isoform 3 improves gut fluidity and alkalinity in cystic fibrosis transmembrane conductance regulator‐deficient and F508del mutant mice	17
Oxysterols and retinal degeneration	17
The role of the mineralocorticoid receptor in immune cells in cardiovascular disease	17
Inhibition of HSP90 S‐nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway	17
Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice	16
Glucosylsphingosine evokes pruritus via activation of 5‐HT_2A receptor and TRPV4 in sensory neurons	16
Protective effect of suppressor of cytokine signalling 1‐based therapy in experimental abdominal aortic aneurysm	16
Preclinical rodent models of cardiac fibrosis	16
Advancements in G protein‐coupled receptor biosensors to study GPCR‐G protein coupling	16
Advocacy of targeting protease‐activated receptors in severe coronavirus disease 2019	16
Targeting lipid metabolism in multiple myeloma cells: Rational development of a synergistic strategy with proteasome inhibitors	16
The P2X7 receptor contributes to seizures and inflammation‐driven long‐lasting brain hyperexcitability following hypoxia in neonatal mice	16
Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney	16
Sex differences in the effect of chronic delivery of the buprenorphine analogue BU08028 on heroin relapse and choice in a rat model of opioid maintenance	16
The VRAC blocker DCPIB directly gates the BK channels and increases intracellular Ca²⁺ in melanoma and pancreatic duct adenocarcinoma cell lines	16
Anti‐inflammatory effects of α7‐nicotinic ACh receptors are exerted through interactions with adenylyl cyclase‐6	16
Endothelial TRPV4–eNOS coupling as a vital therapy target for treatment of hypertension	16
A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice	16
G‐CSFR antagonism reduces mucosal injury and airways fibrosis in a virus‐dependent model of severe asthma	16
Lactobacillus species ameliorate membranous nephropathy through inhibiting the aryl hydrocarbon receptor pathway via tryptophan‐produced indole metabolites	16
Discovery of a novel, potent and selective small‐molecule inhibitor of PD‐1/PD‐L1 interaction with robust in vivo anti‐tumour efficacy	16
Sordarin— An anti‐fungal antibiotic with a unique modus operandi	15
Insights into the mechanism by which atropine inhibits myopia: evidence against cholinergic hyperactivity and modulation of dopamine release	15
Large‐conductance calcium‐activated K⁺ channels, rather than K_ATP channels, mediate the inhibitory effects of nitric oxide on mouse lymphatic pumping	15
Lung pharmacokinetics of inhaled and systemic drugs: A clinical evaluation	15
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX‐5461 on pulmonary arterial hypertension and associated vascular remodelling	15
Transgenic rabbit models for cardiac disease research	15
Activation of trace amine‐associated receptor 1 selectively attenuates the reinforcing effects of morphine	15
Dysregulation of mitophagy and mitochondrial homeostasis in cancer stem cells: Novel mechanism for anti‐cancer stem cell‐targeted cancer therapy	15
Protein arginine methyltransferase 2 (PRMT2) promotes dextran sulfate sodium‐induced colitis by inhibiting the SOCS3 promoter via histone H3R8 asymmetric dimethylation	15
The tandem stenosis mouse model: Towards understanding, imaging, and preventing atherosclerotic plaque instability and rupture	15
cGMP and mitochondrial K⁺ channels—Compartmentalized but closely connected in cardioprotection	15
The role of the adenosine system in epilepsy and its comorbidities	15
Tumour brain: Pretreatment cognitive and affective disorders caused by peripheral cancers	15
Use of NanoBiT and NanoBRET to monitor fluorescent VEGF‐A binding kinetics to VEGFR2/NRP1 heteromeric complexes in living cells	14
Vitamin D regulation of energy metabolism in cancer	14
Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso‐occlusion and nephropathy in mouse models of sickle cell disease	14