Brain

Article	Citations
Correction to: Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders	478
Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder	361
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1	306
Peripherin is a biomarker of axonal damage in Guillain-Barré syndrome: a pathophysiological annotation	251
We’re all in this together: a rejoinder to Masud Husain’s (rant) editorial	248
Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures	240
The RAB3A hot spot variant R83W causes spasticity as part of the ataxia-spasticity spectrum	225
Deep brain stimulation: a tale of two targets … and closing the loop	218
Reply: Is postural tachycardia syndrome a psychogenic disorder?; Notes on establishing fear conditioning as causal in the postural orthostatic tachycardia syndrome; Patients with POTS fear that data o	197
Thalamic stereo EEG: a clinically justified extension of hypothesis-driven intracranial exploration	192
Genetically identical twin-pair difference models support the amyloid cascade hypothesis	176
Maternal microbiome-derived propionate regulates offspring myelination via histone lactylation	175
In vivo self-assembled siRNAs ameliorate neurological pathology in TDP-43-associated neurodegenerative disease	175
Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism	167
Lesion correlates of impaired acoustic-phonetic perception after unilateral left hemisphere stroke	155
Mapping the peripheral immune landscape of Parkinson’s disease patients with single-cell sequencing	147
PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models	145
Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases	144
Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery	142
Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults	142
Source-sink connectivity: a novel interictal EEG marker for seizure localization	134
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations	129
Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum	124
Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes	124
A data-driven study of Alzheimer's disease related amyloid and tau pathology progression	121

Trigeminal nerve microstructure is linked with neuroinflammation and brainstem activity in migraine	117
De novo variants in ATXN7L3 lead to developmental delay, hypotonia and distinctive facial features	116
The use of optical coherence tomography in neurology: a review	116
Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins	116
Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping	115
Global network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages	112
The significance of electrophysiological recordings from the bed nucleus of the stria terminalis in humans	108
Brain repair mechanisms after cell therapy for stroke	108
Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease	104
The vascular contribution of apolipoprotein E to Alzheimer’s disease	102
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development	99
Speech and language markers of neurodegeneration: a call for global equity	99
From bugs to brain: unravelling the GABA signalling networks in the brain–gut–microbiome axis	98
Subthalamic spatio-spectral-connectivity of psychiatric symptoms in Parkinson’s disease	97
Dysfunction of the magnocellular subdivision of the visual thalamus in developmental dyslexia	95
‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy	94
The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy	92
Correction to: New genotype-phenotype correlations in a large European cohort of patients with sarcoglycanopathy	91
Reply: Unblinding in the lecanemab trial in Alzheimer’s disease	85
Demystifying interictal discharges and seizure initiation in focal epilepsy	85
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability	85
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy	84
Routes of precursors’ migration in remyelination	84
Natural experiment on neuroinflammatory disease incidence and infection links pre- and post-COVID-19	84
Extra-cranial cholinergic lesions in dementia with Lewy bodies	82
New mechanistic insights into hereditary spastic paraplegias	82
That which we call cortisol awakening response, by any other word would smell as sweet	81
Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?	81
Deciphering the impact of coding and non-coding SCN1A gene variants on RNA splicing	81
Preclinical type 2 diabetes mellitus subtypes: new insights into diabetes, depression and dementia	81
Evolutionary perspectives on mRNA signatures of neurodegeneration-related brain remodelling	81
Cross-seeding by prion protein inactivates TDP-43	78
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration	77
From phenomena to phrasing: rethinking seizure classification through history	76
Normalization of network activity in an epilepsy model with a constitutively active GABBR2 variant	76
Distinct contribution of spinal neuropeptide Y and NPY1R neurons to morphine analgesia	75
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis	75
The low dimensionality of post-stroke cognitive deficits: it’s the lesion anatomy!	75
Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1–ADAM22/23 pathway	75
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit	75
Clinical and MRI measures to identify non-acute MOG-antibody disease in adults	75
Cortical cerebral microinfarcts spark cognitive decline	73
Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders	72
Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy	72
Biallelic null variants in PNPLA8 cause microcephaly by reducing the number of basal radial glia	69
Multiple sclerosis in Denmark (1950–2023): mean age, sex distribution, incidence and prevalence	69
GGC repeat expansions in NOTCH2NLC cause uN2CpolyG cerebral amyloid angiopathy	69
Loss-of-function variants inMYCBP2cause neurobehavioural phenotypes and corpus callosum defects	69
Multimodal mapping of regional brain vulnerability to focal cortical dysplasia	69
Beyond distal arthrogryposis: refining the phenotypic landscape of PIEZO2 -related disorders	67

A sensory neuron-specific long non-coding RNA reduces neuropathic pain by rescuing KCNN1 expression	67
Rigidity in Parkinson’s disease	67
Treatment-resistant recurrent unipolar and bipolar depression: associative learning abnormalities	67
Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorder	67
Plasma pTau 217/β-amyloid 1–42 ratio for enhanced accuracy and reduced uncertainty in detecting amyloid pathology	66
Extracellular vesicle biomarkers for complement dysfunction in schizophrenia	66
Do non-language regions become language regions? The case of deprived sensory cortices	65
A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings	65
Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline?	64
Stuttering associated with a pathogenic variant in the chaperone protein cyclophilin 40	64
Cytotoxic T cells and plasma cells dominate early in temporal lobe epilepsy with GAD antibodies	64
Activation and sensitization of meningeal nociceptors by PACAP-38: implications for migraine headache	64
Genome-wide association study of neuropathological features in Lewy body disease	64
Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases	63
Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations	62
Molecular and clinical spectrum of epilepsy-dyskinesia syndromes: a cross-sectional study of 609 patients	62
Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain	62
Interpreting early default mode network dysfunction across the Alzheimer’s disease spectrum	61
Is glymphatic clearance the secret to restorative sleep?	61
Clinical features and prognostic factors in adults with brain abscess	61
Disruption of DNA methylation underpins the neuroinflammation induced by targeted CNS radiotherapy	59
The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy	59
Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances	59
Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy	59
From shadows to spotlight: the evolution of migraine stigma since the 17th century	58
How modular are modules in visual cortex?	58
A novel eye-movement impairment in multiple sclerosis indicating widespread cortical damage	58
Correction to: Sex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in females	58
Decoding inflammatory pathways in spinal muscular atrophy: implications for next-generation therapies	57
Failure of C9orf72 sense repeat-targeting antisense oligonucleotides: lessons learned and the path forward	57
Correction to: Blood–brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound	57
Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis	57
Sleep and seizure risk in epilepsy: bed and wake times are more important than sleep duration	57
The use of animals in neuroscience research	57
Correction to: Remyelination of chronic demyelinated lesions with directly induced neural stem cells	56
The lysosomal β-glucocerebrosidase strikes mitochondria: implications for Parkinson’s therapeutics	56
White matter connections within the central sulcus subserving the somato-cognitive action network	56
Correction to: Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders	56
Cdc42GAP deficiency contributes to the Alzheimer’s disease phenotype	56
A journey towards the pot of gold	55
Untangling white matter fibre changes in Alzheimer's disease and small vessel disease	55
Reply: Do we need new MRI criteria for the diagnosis of radiologically isolated syndrome?	55
Neuromelanin as a nidus for neurodegeneration	55
Reply: The correlation of behavioural deficits post-stroke: a trivial issue?	54
Occludin modulates HIV and ischaemic stroke response via the mitochondrial antiviral signalling pathway	54
Reply: Lecanemab: turning point, or status quo? An ethics perspective	54
Effort avoidance as a core mechanism of apathy in frontotemporal dementia	53
In silico versus functional characterization of genetic variants: lessons from muscle channelopathies	53
Impaired value-based decision-making in Parkinson’s disease apathy	52
Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum	52
Delineation of functionally essential protein regions for 242 neurodevelopmental genes	51
JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation	51
Early onset hereditary neuronopathies: an update on non-5qmotor neuron diseases	51
Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders	51
Genetic variability in sporadic amyotrophic lateral sclerosis	51
Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease	51
Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation	51
Large-scale rare variant burden testing in Parkinson's disease	51
Age-related and amyloid-beta-independent tau deposition and its downstream effects	50
Distinct cerebellar networks underpin clinical improvement in adolescent Tourette disorder	50
The human subthalamic nucleus transiently inhibits active attentional processes	50
Endosomal 2Cl−/H+ exchangers regulate neuronal excitability by tuning Kv7/KCNQ channel density	50
Interferon-γ controls aquaporin 4-specific Th17 and B cells in neuromyelitis optica spectrum disorder	50
Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer’s disease	50
Estimating the time course of biomarker changes in Alzheimer’s disease	50
Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson’s disease	49
Anatomo-functional basis of emotional and motor resonance elicited by facial expressions	49
Imaging chronic active lesions in multiple sclerosis: a consensus statement	49
Amyloid-β predominant Alzheimer’s disease neuropathologic change	48
Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease	48
Bridging the gaps between JCV infection models and human disease	48
Tiam1 is part of a novel mechanism for morphine tolerance and hyperalgesia	48
Correction to: Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates	48
The visual cortex in the blind but not the auditory cortex in the deaf becomes multiple-demand regions	48
Localizing epileptogenic tissues in epilepsy: are we losing (the) focus?	48
Understanding brain calcification via N-terminal acetylation at the Golgi apparatus	48
Shedding light on a novel circuit within primary motor cortex as a target for neuromodulation	48
HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer’s disease	47
Motor compensation in Parkinson’s disease: an empirical challenge with clinical implications	47
Is SORL1 a common genetic target across neurodegenerative diseases? A multi-ancestry biobank study	47

Cul-4 inhibition rescues spastin levels and reduces defects in hereditary spastic paraplegia models	47
Interleukin-17B is a new biomarker of human muscle regeneration in dystrophinopathies	47
PTPA variants and the risk for Parkinson’s disease in diverse ancestry populations	47
Precision dynamics of predictive coding in functional neurological disorder	47
Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter	46
Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase	46
CGRP signalling in migraine: time to look downstream?	46
Comparative transcriptomics reveal molecular convergence and divergence in parkinsonian disorders	46
A foothold in detection of limbic-predominant age-related TDP-43 encephalopathy	45
Machine learning model based on plasma proteomics for the identification of Parkinson’s disease	45
Targeting glutamatergic pathways: genetic insights into comorbid neurodevelopmental disorders	45
The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease	45
USP25 in genetic generalized epilepsy: a gene under scrutiny	45
Satellite glial GLRX3 drives ageing-biased neuropathic pain via HMGB1	45
Brain accumulation of lactosylceramide characterizes GALC deficiency in a zebrafish model of Krabbe disease	44
Emotional bias modification weakens game-related compulsivity and reshapes frontostriatal pathways	44
Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation	44
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments	44
ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations	44
The secret connections of the brain: a connectomic reserve for neuroplasticity?	43
Surgical white matter disruption leads to downstream atrophy in the non-resected human brain	43
Characterizing proteomic and transcriptomic features of missense variants in amyotrophic lateral sclerosis genes	43
Ageing and remyelination failure in people with multiple sclerosis	43
Motor network gamma oscillations in chronic home recordings predict dyskinesia in Parkinson’s disease	43
The ageing central nervous system in multiple sclerosis: the imaging perspective	43
Clinical and biochemical characterization of amyotrophic lateral sclerosis in a CHCHD10 R15L family	43
Thalamic stereo-EEG in epilepsy surgery: where do we stand?	42
‘Only in England’: the origins of the British Migraine Association and Migraine Trust, 1954–66	42
Amyloid-β-activated microglia can induce compound proteinopathies	42
Sleep circuit modulation: from animal models to human translation	42
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study	42
The functional role of the precuneus	42
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes	42
Multimodal multicentre investigation of diagnostic and prognostic markers in disorders of consciousness	42
One transgene, two myopathies: an MTM1 ‘cross gene therapy’ for BIN1 deficiency?	41
Chasing MOG antibodies down … assays and lumbar punctures	41
Biomarker evidence of neurodegeneration in mid-life former rugby players	41
TGFβ4 alleviates the phenotype of Charcot–Marie–Tooth disease type 1A	41
Plasma biomarkers in chronic single moderate/severe traumatic brain injury	41
Elucidating the nociceptive role of CGRP in migraine headache	41
Reply: Putative benefits of vitamin D supplements in multiple sclerosis out of reach due to sample size	41
Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide	41
Four dimensions of naturalistic language production in aphasia after stroke	41
Clinicopathological correlates in the frontotemporal lobar degeneration–motor neuron disease spectrum	40
Sex-specific genetic drivers of memory, executive functioning and language in older adults	40
Parkinson’s disease beyond the brain: erythrocyte α-synuclein transfer across the blood–brain barrier	40
Nifuroxazide rescues the deleterious effects due to CHCHD10-associated MICOS defects in disease models	40
Reply: Neural substrates of the link between dual-task gait and dementia: an intermediary step in which direction?	40
Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes	39
Increase of HCN current in SOD1-associated amyotrophic lateral sclerosis	39
Brainstem cavernous malformations: observation, microsurgical resection or stereotactic radiosurgery	39
The complexity of interpreting TSPO PET neuroimaging in first-episode psychosis	39
Phenotypic individual clusters and metabolic tuber subtypes refine surgical strategy in tuberous sclerosis complex	39
Pure autonomic failure as an essential window into progression of synucleinopathies	39
Intra-putaminal muscarinic receptor agonist infusion induces a dystonic phenotype in non-human primates	38
The entropic brain today	38
Reply: The challenge of assessing invasive biomarkers for epilepsy surgery and To plan efficacious epilepsy surgery	38
Neurophysiological consequences of synapse loss in progressive supranuclear palsy	38
Great science does not communicate itself: but who should and how?	38
Genome-wide contribution of common short-tandem repeats to Parkinson’s disease genetic risk	38
Brain essay competition winner on artificial general intelligence	38
Direct electrical brain stimulation of human memory: lessons learnt and future perspectives	37
Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities	37
Uncovering the distinct macro-scale anatomy of dysexecutive and behavioural degenerative diseases	37
Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophy	37
Oxytocin receptor neurons in the paraventricular thalamus as a nexus for social behaviour and fear	37
Cation leak through the ATP1A3 pump causes spasticity and intellectual disability	37
Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine	37
Genome-wide epistasis analysis reveals significant epistatic signals associated with Parkinson’s disease risk	37
Reply: An epigenetic basis for genetic anticipation in facioscapulohumeral muscular dystrophy type 1	37
Multimodal layer modelling reveals in vivo pathology in amyotrophic lateral sclerosis	37
Motivational and cognitive predictors of apathy after subthalamic nucleus stimulation in Parkinson’s disease	37
Clinical features and prognostic factors in adults with viral meningitis	36
Mitochondrial dynamics and bioenergetics in Alzheimer’s induced pluripotent stem cell-derived neurons	36
Noradrenergic alterations in Parkinson’s disease: a combined 11C-yohimbine PET/neuromelanin MRI study	36
Mitochondrial damage is associated with an early immune response in inclusion body myositis	36
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease	36
Defining repetitive behaviours in frontotemporal dementia	36
Limitation of life sustaining therapy in disorders of consciousness: ethics and practice	36
Dynamic reorganization of task-related network interactions in post-stroke aphasia recovery	36
Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson’s disease	36
Role of pattern recognition receptors in chemotherapy-induced neuropathic pain	35
Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study	35
Snatches of time. Fragments	35
Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease	35
Correction to: TMEM63C mutations cause mitochondrial morphology defects and underlie hereditary spastic paraplegia	35
Reply: Lack of statistical significance is not evidence against modularity in visual feature processing	35
Myelination potential and injury susceptibility of grey versus white matter human oligodendrocytes	35
Who am I?	35
An alternative therapeutic approach to haematopoetic stem cell transplantation in early cerebral adrenoleukodystrophy	35
The risk of secondary progressive multiple sclerosis is geographically determined but modifiable	34
Transdiagnostic inflexible learning dynamics explain deficits in depression and schizophrenia	34
Mapping human glymphatic compartments and putative meningeal border pathways in diseased models	34
Missense variants in TUBA4A cause myo-tubulinopathies	34
Different factors underlie mild and severe forms of spinal muscular atrophy	34