Brain

Article	Citations
Reply: Is postural tachycardia syndrome a psychogenic disorder?; Notes on establishing fear conditioning as causal in the postural orthostatic tachycardia syndrome; Patients with POTS fear that data o	329
The axon initial segment as a source of neuropathic pain	318
De novo variants in ATXN7L3 lead to developmental delay, hypotonia and distinctive facial features	280
Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease	265
Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum	169
Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins	160
Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery	159
Correction to: Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders	156
Methodological drawbacks in the alleged association between foetal sonographic anomalies and autism	156
The efficacy and deficiency of contemporary treatment for spinal cord arteriovenous shunts	150
Proust and his neurologists: the challenge of functional disorders	144
‘Seeding’ the idea of early diagnostics in synucleinopathies	142
Genetically identical twin-pair difference models support the amyloid cascade hypothesis	140
Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease	140
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations	135
From bugs to brain: unravelling the GABA signalling networks in the brain–gut–microbiome axis	132
3T MRI of rapid brain activity changes driven by subcallosal cingulate deep brain stimulation	132
Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism	131
The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy	125
Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures	122
Lesion correlates of impaired acoustic-phonetic perception after unilateral left hemisphere stroke	121
Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder	120
Peripherin is a biomarker of axonal damage in Guillain-Barré syndrome: a pathophysiological annotation	119
Speech and language markers of neurodegeneration: a call for global equity	118
Dysfunction of the magnocellular subdivision of the visual thalamus in developmental dyslexia	118

Clinical and genetic spectrum of 355 Chinese children with epilepsy: a trio-sequencing-based study	117
Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease	115
Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes	111
Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline	110
Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups	109
Deep brain stimulation: a tale of two targets … and closing the loop	108
18F-MK-6240 tau-PET in genetic frontotemporal dementia	108
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1	108
Brain repair mechanisms after cell therapy for stroke	104
Biallelic FRA10AC1 variants cause a neurodevelopmental disorder with growth retardation	101
Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults	101
Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy	100
Source-sink connectivity: a novel interictal EEG marker for seizure localization	100
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development	98
A data-driven study of Alzheimer's disease related amyloid and tau pathology progression	98
Trigeminal nerve microstructure is linked with neuroinflammation and brainstem activity in migraine	97
ActivatingRAC1variants in the switch II region cause a developmental syndrome and alter neuronal morphology	96
The use of optical coherence tomography in neurology: a review	95
‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy	89
Correction to: New genotype-phenotype correlations in a large European cohort of patients with sarcoglycanopathy	86
The vascular contribution of apolipoprotein E to Alzheimer’s disease	86
Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations	85
Genome-wide association study of neuropathological features in Lewy body disease	84
Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy	83
The neuroethics of disorders of consciousness: a brief history of evolving ideas	83
Hitching a ride on exosomes: a new approach for the delivery of siRNA-mediated therapies	82
Multiple sclerosis in Denmark (1950–2023): mean age, sex distribution, incidence and prevalence	80
A sensory neuron-specific long non-coding RNA reduces neuropathic pain by rescuing KCNN1 expression	79
Loss-of-function variants inMYCBP2cause neurobehavioural phenotypes and corpus callosum defects	79
How COVID-19 affects microvessels in the brain	78
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy	78
Reply: Unblinding in the lecanemab trial in Alzheimer’s disease	77
Defective lipid signalling caused by mutations inPIK3C2Bunderlies focal epilepsy	76
Clinical and MRI measures to identify non-acute MOG-antibody disease in adults	74
Clinical features and prognostic factors in adults with brain abscess	74
Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline?	74
Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain	74
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration	73
The cost to see the Wizard: buy-ins and trade-offs in neurological rehabilitation	72
Reply: From early limbic inflammation to long COVID sequelae	72
The three deceits of bureaucracy	71
Evolutionary perspectives on mRNA signatures of neurodegeneration-related brain remodelling	71
Extra-cranial cholinergic lesions in dementia with Lewy bodies	71
Biallelic null variants in PNPLA8 cause microcephaly by reducing the number of basal radial glia	70
Cytotoxic T cells and plasma cells dominate early in temporal lobe epilepsy with GAD antibodies	70
Demystifying interictal discharges and seizure initiation in focal epilepsy	70
New mechanistic insights into hereditary spastic paraplegias	69
GGC repeat expansions in NOTCH2NLC cause uN2CpolyG cerebral amyloid angiopathy	69
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis	69
Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?	68

Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy	68
Extracellular vesicle biomarkers for complement dysfunction in schizophrenia	68
The low dimensionality of post-stroke cognitive deficits: it’s the lesion anatomy!	67
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability	67
BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis	67
Stuttering associated with a pathogenic variant in the chaperone protein cyclophilin 40	66
Human platelet lysate biotherapy for traumatic brain injury: preclinical assessment	66
Preclinical type 2 diabetes mellitus subtypes: new insights into diabetes, depression and dementia	66
Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury	66
Intravenous delivery of adeno-associated viral gene therapy in feline GM1 gangliosidosis	65
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit	65
Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases	64
Cross-seeding by prion protein inactivates TDP-43	64
A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings	64
Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances	63
Disruption of DNA methylation underpins the neuroinflammation induced by targeted CNS radiotherapy	63
Deciphering the impact of coding and non-coding SCN1A gene variants on RNA splicing	63
The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy	63
The spectrum of disease and tau pathology of nodding syndrome in Uganda	63
Multimodal mapping of regional brain vulnerability to focal cortical dysplasia	60
Survival of brain tumour patients with epilepsy	60
Correction to: Blood–brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound	60
The potential of serum neurofilament as biomarker for multiple sclerosis	60
How modular are modules in visual cortex?	59
Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum	59
The lysosomal β-glucocerebrosidase strikes mitochondria: implications for Parkinson’s therapeutics	59
Repeat conformation heterogeneity in cerebellar ataxia, neuropathy, vestibular areflexia syndrome	59
Failure of C9orf72 sense repeat-targeting antisense oligonucleotides: lessons learned and the path forward	58
Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms	58
From shadows to spotlight: the evolution of migraine stigma since the 17th century	58
Amyloid-β predominant Alzheimer’s disease neuropathologic change	58
Age-related and amyloid-beta-independent tau deposition and its downstream effects	56
Genetic variability in sporadic amyotrophic lateral sclerosis	56
Human lesions and animal studies link the claustrum to perception, salience, sleep and pain	56
A passive and objective measure of recognition memory in Alzheimer’s disease using Fastball memory assessment	55
Imaging chronic active lesions in multiple sclerosis: a consensus statement	55
Anatomo-functional basis of emotional and motor resonance elicited by facial expressions	55
Startle responses in Duchenne muscular dystrophy: a novel biomarker of brain dystrophin deficiency	55
Interferon-γ controls aquaporin 4-specific Th17 and B cells in neuromyelitis optica spectrum disorder	55
JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation	53
Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer’s disease	53
Intracranial pressure spikes trigger spreading depolarizations	53
Impaired value-based decision-making in Parkinson’s disease apathy	53
Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration	52
Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders	52
Sleep and seizure risk in epilepsy: bed and wake times are more important than sleep duration	52
Recovery from aphasia in the first year after stroke	52
White matter connections within the central sulcus subserving the somato-cognitive action network	52
The human subthalamic nucleus transiently inhibits active attentional processes	52
A novel eye-movement impairment in multiple sclerosis indicating widespread cortical damage	51
Correction to: Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders	51
Corrigendum to: Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease	51
UNC13B and focal epilepsy	50
Multicompartmental models and diffusion abnormalities in paediatric mild traumatic brain injury	50
Sorting out Parkinson’s disease: one cell at a time	50
Untangling white matter fibre changes in Alzheimer's disease and small vessel disease	49
A journey towards the pot of gold	49
Reply: Do we need new MRI criteria for the diagnosis of radiologically isolated syndrome?	49
In silico versus functional characterization of genetic variants: lessons from muscle channelopathies	49
Neuromelanin as a nidus for neurodegeneration	49
Reply: The correlation of behavioural deficits post-stroke: a trivial issue?	49
Delineation of functionally essential protein regions for 242 neurodevelopmental genes	49
Wheelchair use in genetically confirmed FSHD1 from a large cohort study in Chinese population	48
Reply: Lecanemab: turning point, or status quo? An ethics perspective	48
Pallido-putaminal connectivity predicts outcomes of deep brain stimulation for cervical dystonia	47
Early onset hereditary neuronopathies: an update on non-5qmotor neuron diseases	47
Random forest: random results or meaningful insights for patients with facioscapulohumeral muscular dystrophy?	47
Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson’s disease	46
Cdc42GAP deficiency contributes to the Alzheimer’s disease phenotype	46
Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease	46
How patients with multiple sclerosis acquire disability	46
Tiam1 is part of a novel mechanism for morphine tolerance and hyperalgesia	46
Microglial activation and blood–brain barrier permeability in cerebral small vessel disease	46
Stimulation of frontal pathways disrupts hand muscle control during object manipulation	46
Effort avoidance as a core mechanism of apathy in frontotemporal dementia	46
Large-scale rare variant burden testing in Parkinson's disease	46
CGRP signalling in migraine: time to look downstream?	46
Characterizing proteomic and transcriptomic features of missense variants in amyotrophic lateral sclerosis genes	46
Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase	45
Diffusely abnormal white matter converts to T2 lesion volume in the absence of MRI-detectable acute inflammation	45

Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation	45
Decomposing MRI phenotypic heterogeneity in epilepsy: a step towards personalized classification	45
Smarter adaptive platform clinical trials in neurology	45
Localizing epileptogenic tissues in epilepsy: are we losing (the) focus?	45
ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations	44
PTPA variants and the risk for Parkinson’s disease in diverse ancestry populations	44
Interleukin-17B is a new biomarker of human muscle regeneration in dystrophinopathies	44
Correction to: Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates	44
The visual cortex in the blind but not the auditory cortex in the deaf becomes multiple-demand regions	44
Erratum to: Reply: Broca’s area: why was neurosurgery neglected for so long when seeking to re-establish the scientific truth? and Where is the speech production area? Evidence from direct cort	44
Is it time to rename hereditary cases of cerebral palsy?	44
Corrigendum to: Formation and immunomodulatory function of meningeal B cell aggregates in progressive CNS autoimmunity	44
Motor compensation in Parkinson’s disease: an empirical challenge with clinical implications	44
Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms	43
Four dimensions of naturalistic language production in aphasia after stroke	43
Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy	43
The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease	43
Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease	42
Thalamic stereo-EEG in epilepsy surgery: where do we stand?	42
The ageing central nervous system in multiple sclerosis: the imaging perspective	42
Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis	42
Imbalanced basal ganglia connectivity is associated with motor deficits and apathy in Huntington’s disease	42
Shedding light on a novel circuit within primary motor cortex as a target for neuromodulation	42
Motor network gamma oscillations in chronic home recordings predict dyskinesia in Parkinson’s disease	41
Emotional bias modification weakens game-related compulsivity and reshapes frontostriatal pathways	41
Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe	41
Cul-4 inhibition rescues spastin levels and reduces defects in hereditary spastic paraplegia models	41
Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis	40
Anterior optic pathway pathology in CNS demyelinating diseases	40
Amyloid-β-activated microglia can induce compound proteinopathies	40
The functional role of the precuneus	40
In vitro ictogenesis is stochastic at the single neuron level	40
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments	40
Brain accumulation of lactosylceramide characterizes GALC deficiency in a zebrafish model of Krabbe disease	40
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study	40
Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia	40
Bridging the gaps between JCV infection models and human disease	40
One transgene, two myopathies: an MTM1 ‘cross gene therapy’ for BIN1 deficiency?	39
Neurophysiological consequences of synapse loss in progressive supranuclear palsy	39
Cation leak through the ATP1A3 pump causes spasticity and intellectual disability	39
Corrigendum to: Myopathic mitochondrial DNA depletion syndrome associated with biallelic variants in LIG3	39
TGFβ4 alleviates the phenotype of Charcot–Marie–Tooth disease type 1A	39
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes	39
Chasing MOG antibodies down … assays and lumbar punctures	38
Uncovering the distinct macro-scale anatomy of dysexecutive and behavioural degenerative diseases	38
Reply: Looking beyond indirect lesion network mapping of prosopagnosia: direct measures required	38
The BS variant of C4 protects against age-related loss of white matter microstructural integrity	38
Reply: Methodological drawbacks in the alleged association between foetal sonographic anomalies and autism	38
Of networked lesions and lesioned networks	38
Great science does not communicate itself: but who should and how?	38
Poor statistical reporting in a spinal cord injury clinical trial	38
Reply: The challenge of assessing invasive biomarkers for epilepsy surgery and To plan efficacious epilepsy surgery	38
Ockham’s razor, not a barber’s weapon but a writer’s tool	38
Plasma biomarkers in chronic single moderate/severe traumatic brain injury	38
Reply: Putative benefits of vitamin D supplements in multiple sclerosis out of reach due to sample size	38
Reply: An epigenetic basis for genetic anticipation in facioscapulohumeral muscular dystrophy type 1	38
Increase of HCN current in SOD1-associated amyotrophic lateral sclerosis	37
Myelination potential and injury susceptibility of grey versus white matter human oligodendrocytes	37
Nifuroxazide rescues the deleterious effects due to CHCHD10-associated MICOS defects in disease models	37
An extended amygdala circuit at the core of long-term post-sepsis psychiatric disorders	37
Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine	37
Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson’s disease	37
Mitochondrial dynamics and bioenergetics in Alzheimer’s induced pluripotent stem cell-derived neurons	37
The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom mapping	36
Role of pattern recognition receptors in chemotherapy-induced neuropathic pain	36
Heterozygous PRKN mutations are common but do not increase the risk of Parkinson’s disease	36
Limitation of life sustaining therapy in disorders of consciousness: ethics and practice	36
Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study	36
Genome-wide contribution of common short-tandem repeats to Parkinson’s disease genetic risk	36
Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study	36
Genome-wide epistasis analysis reveals significant epistatic signals associated with Parkinson’s disease risk	36
The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis	36
Predictors of functional outcomes in patients with facioscapulohumeral muscular dystrophy	36
Ligand-free mitochondria-localized mutant AR-induced cytotoxicity in spinal bulbar muscular atrophy	36
Dopamine and deep brain stimulation accelerate the neural dynamics of volitional action in Parkinson's disease	36
Motivational and cognitive predictors of apathy after subthalamic nucleus stimulation in Parkinson’s disease	35
Dynamic reorganization of task-related network interactions in post-stroke aphasia recovery	35
Defining repetitive behaviours in frontotemporal dementia	35
Biallelic mutations in RNF220 cause laminopathies featuring leukodystrophy, ataxia and deafness	35
Neurovascular injury with complement activation and inflammation in COVID-19	35
Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort	35
Clinical features and prognostic factors in adults with viral meningitis	35
Clinicopathological correlates in the frontotemporal lobar degeneration–motor neuron disease spectrum	35
Multimodal layer modelling reveals in vivo pathology in amyotrophic lateral sclerosis	35
Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes	35
Common molecular mechanisms ofSLC6A1variant-mediated neurodevelopmental disorders in astrocytes and neurons	35
Noradrenergic alterations in Parkinson’s disease: a combined 11C-yohimbine PET/neuromelanin MRI study	35
Mitochondrial damage is associated with an early immune response in inclusion body myositis	35
Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?	34
Distal symmetric polyneuropathy in diabetes: a progressive disorder?	34
Bobby Fischer and the delusions of a king of logic	34
Reply: Poor statistical reporting in a spinal cord injury clinical trial	34
An alternative therapeutic approach to haematopoetic stem cell transplantation in early cerebral adrenoleukodystrophy	34
Correction to: TMEM63C mutations cause mitochondrial morphology defects and underlie hereditary spastic paraplegia	34
Blood–CSF barrier integrity in amyotrophic lateral sclerosis	34