Brain

Article	Citations
Correction to: Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders	410
Reply: Is postural tachycardia syndrome a psychogenic disorder?; Notes on establishing fear conditioning as causal in the postural orthostatic tachycardia syndrome; Patients with POTS fear that data o	385
Methodological drawbacks in the alleged association between foetal sonographic anomalies and autism	376
‘Seeding’ the idea of early diagnostics in synucleinopathies	228
Trigeminal nerve microstructure is linked with neuroinflammation and brainstem activity in migraine	203
PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models	201
Apathy, effort-based decisions and brain integrity in Alzheimer’s and Parkinson’s diseases	196
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1	194
ActivatingRAC1variants in the switch II region cause a developmental syndrome and alter neuronal morphology	189
Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults	189
In vivo self-assembled siRNAs ameliorate neurological pathology in TDP-43-associated neurodegenerative disease	185
Genetically identical twin-pair difference models support the amyloid cascade hypothesis	185
We’re all in this together: a rejoinder to Masud Husain’s (rant) editorial	178
Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder	171
Deep brain stimulation: a tale of two targets … and closing the loop	166
Peripherin is a biomarker of axonal damage in Guillain-Barré syndrome: a pathophysiological annotation	166
The axon initial segment as a source of neuropathic pain	149
Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures	149
Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism	148
Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy	143
Lesion correlates of impaired acoustic-phonetic perception after unilateral left hemisphere stroke	141
De novo variants in ATXN7L3 lead to developmental delay, hypotonia and distinctive facial features	141
Mapping the peripheral immune landscape of Parkinson’s disease patients with single-cell sequencing	140
Dysfunction of the magnocellular subdivision of the visual thalamus in developmental dyslexia	137
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations	136

The vascular contribution of apolipoprotein E to Alzheimer’s disease	136
Clinical and genetic spectrum of 355 Chinese children with epilepsy: a trio-sequencing-based study	125
Global network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages	124
Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum	124
The use of optical coherence tomography in neurology: a review	117
The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy	115
Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline	114
Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery	112
Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease	109
Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease	108
Source-sink connectivity: a novel interictal EEG marker for seizure localization	107
Speech and language markers of neurodegeneration: a call for global equity	105
3T MRI of rapid brain activity changes driven by subcallosal cingulate deep brain stimulation	103
A data-driven study of Alzheimer's disease related amyloid and tau pathology progression	101
Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes	100
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development	99
Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins	99
‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy	98
Brain repair mechanisms after cell therapy for stroke	96
From bugs to brain: unravelling the GABA signalling networks in the brain–gut–microbiome axis	93
Correction to: New genotype-phenotype correlations in a large European cohort of patients with sarcoglycanopathy	92
Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorder	91
Molecular and clinical spectrum of epilepsy-dyskinesia syndromes: a cross-sectional study of 609 patients	90
Demystifying interictal discharges and seizure initiation in focal epilepsy	90
Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders	89
The spectrum of disease and tau pathology of nodding syndrome in Uganda	89
Reply: Unblinding in the lecanemab trial in Alzheimer’s disease	89
Cortical cerebral microinfarcts spark cognitive decline	89
Evolutionary perspectives on mRNA signatures of neurodegeneration-related brain remodelling	88
Normalization of network activity in an epilepsy model with a constitutively active GABBR2 variant	88
Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy	87
That which we call cortisol awakening response, by any other word would smell as sweet	86
The three deceits of bureaucracy	84
Extra-cranial cholinergic lesions in dementia with Lewy bodies	84
New mechanistic insights into hereditary spastic paraplegias	83
Disruption of DNA methylation underpins the neuroinflammation induced by targeted CNS radiotherapy	81
Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1–ADAM22/23 pathway	81
Preclinical type 2 diabetes mellitus subtypes: new insights into diabetes, depression and dementia	81
Treatment-resistant recurrent unipolar and bipolar depression: associative learning abnormalities	81
Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?	80
How COVID-19 affects microvessels in the brain	80
Activation and sensitization of meningeal nociceptors by PACAP-38: implications for migraine headache	79
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability	79
Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy	78
The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy	78
Biallelic null variants in PNPLA8 cause microcephaly by reducing the number of basal radial glia	78
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit	77
Multiple sclerosis in Denmark (1950–2023): mean age, sex distribution, incidence and prevalence	77
Cross-seeding by prion protein inactivates TDP-43	76
Loss-of-function variants inMYCBP2cause neurobehavioural phenotypes and corpus callosum defects	76

Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury	75
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration	74
GGC repeat expansions in NOTCH2NLC cause uN2CpolyG cerebral amyloid angiopathy	74
Routes of precursors’ migration in remyelination	72
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis	72
The low dimensionality of post-stroke cognitive deficits: it’s the lesion anatomy!	72
Genome-wide association study of neuropathological features in Lewy body disease	71
Clinical and MRI measures to identify non-acute MOG-antibody disease in adults	70
Clinical features and prognostic factors in adults with brain abscess	68
A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings	68
Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases	68
Deciphering the impact of coding and non-coding SCN1A gene variants on RNA splicing	68
Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations	67
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy	67
Multimodal mapping of regional brain vulnerability to focal cortical dysplasia	66
Stuttering associated with a pathogenic variant in the chaperone protein cyclophilin 40	66
Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline?	65
Extracellular vesicle biomarkers for complement dysfunction in schizophrenia	65
Cytotoxic T cells and plasma cells dominate early in temporal lobe epilepsy with GAD antibodies	64
Defective lipid signalling caused by mutations inPIK3C2Bunderlies focal epilepsy	64
A sensory neuron-specific long non-coding RNA reduces neuropathic pain by rescuing KCNN1 expression	64
How modular are modules in visual cortex?	63
Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain	63
From shadows to spotlight: the evolution of migraine stigma since the 17th century	63
Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances	63
Correction to: Sex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in females	62
Correction to: Remyelination of chronic demyelinated lesions with directly induced neural stem cells	61
Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease	61
Correction to: Blood–brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound	61
Wheelchair use in genetically confirmed FSHD1 from a large cohort study in Chinese population	60
Decoding inflammatory pathways in spinal muscular atrophy: implications for next-generation therapies	60
Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum	60
White matter connections within the central sulcus subserving the somato-cognitive action network	60
A novel eye-movement impairment in multiple sclerosis indicating widespread cortical damage	60
Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis	60
Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation	59
Sorting out Parkinson’s disease: one cell at a time	58
Correction to: Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders	58
Untangling white matter fibre changes in Alzheimer's disease and small vessel disease	58
A journey towards the pot of gold	57
Reply: The correlation of behavioural deficits post-stroke: a trivial issue?	57
Neuromelanin as a nidus for neurodegeneration	57
Delineation of functionally essential protein regions for 242 neurodevelopmental genes	57
Reply: Do we need new MRI criteria for the diagnosis of radiologically isolated syndrome?	57
Reply: Lecanemab: turning point, or status quo? An ethics perspective	56
Repeat conformation heterogeneity in cerebellar ataxia, neuropathy, vestibular areflexia syndrome	56
UNC13B and focal epilepsy	56
Estimating the time course of biomarker changes in Alzheimer’s disease	56
In silico versus functional characterization of genetic variants: lessons from muscle channelopathies	56
Endosomal 2Cl−/H+ exchangers regulate neuronal excitability by tuning Kv7/KCNQ channel density	55
Distinct cerebellar networks underpin clinical improvement in adolescent Tourette disorder	55
Impaired value-based decision-making in Parkinson’s disease apathy	55
Early onset hereditary neuronopathies: an update on non-5qmotor neuron diseases	55
Cdc42GAP deficiency contributes to the Alzheimer’s disease phenotype	55
Sleep and seizure risk in epilepsy: bed and wake times are more important than sleep duration	55
JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation	55
Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders	55
Large-scale rare variant burden testing in Parkinson's disease	55
Human lesions and animal studies link the claustrum to perception, salience, sleep and pain	54
Startle responses in Duchenne muscular dystrophy: a novel biomarker of brain dystrophin deficiency	54
Age-related and amyloid-beta-independent tau deposition and its downstream effects	53
Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson’s disease	53
Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration	53
Failure of C9orf72 sense repeat-targeting antisense oligonucleotides: lessons learned and the path forward	53
The lysosomal β-glucocerebrosidase strikes mitochondria: implications for Parkinson’s therapeutics	52
Anatomo-functional basis of emotional and motor resonance elicited by facial expressions	52
Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms	52
Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease	52
Imaging chronic active lesions in multiple sclerosis: a consensus statement	52
Recovery from aphasia in the first year after stroke	52
Effort avoidance as a core mechanism of apathy in frontotemporal dementia	52
The human subthalamic nucleus transiently inhibits active attentional processes	52
Occludin modulates HIV and ischaemic stroke response via mitochondrial antiviral signalling pathway	52
Multicompartmental models and diffusion abnormalities in paediatric mild traumatic brain injury	52
Interferon-γ controls aquaporin 4-specific Th17 and B cells in neuromyelitis optica spectrum disorder	52
Bridging the gaps between JCV infection models and human disease	51
Amyloid-β predominant Alzheimer’s disease neuropathologic change	51
Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer’s disease	51
Is it time to rename hereditary cases of cerebral palsy?	51
How patients with multiple sclerosis acquire disability	51

Motor compensation in Parkinson’s disease: an empirical challenge with clinical implications	51
Genetic variability in sporadic amyotrophic lateral sclerosis	51
Tiam1 is part of a novel mechanism for morphine tolerance and hyperalgesia	50
Correction to: Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates	50
Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase	50
Shedding light on a novel circuit within primary motor cortex as a target for neuromodulation	50
The visual cortex in the blind but not the auditory cortex in the deaf becomes multiple-demand regions	50
Amyloid-β-activated microglia can induce compound proteinopathies	49
Understanding brain calcification via N-terminal acetylation at the Golgi apparatus	49
CGRP signalling in migraine: time to look downstream?	49
Localizing epileptogenic tissues in epilepsy: are we losing (the) focus?	49
Surgical white matter disruption leads to downstream atrophy in the non-resected human brain	49
Thalamic stereo-EEG in epilepsy surgery: where do we stand?	48
Biomarker evidence of neurodegeneration in mid-life former rugby players	47
Four dimensions of naturalistic language production in aphasia after stroke	47
Smarter adaptive platform clinical trials in neurology	47
ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations	47
Ageing and remyelination failure in people with multiple sclerosis	47
USP25 in genetic generalized epilepsy: a gene under scrutiny	47
The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease	47
Characterizing proteomic and transcriptomic features of missense variants in amyotrophic lateral sclerosis genes	46
Motor network gamma oscillations in chronic home recordings predict dyskinesia in Parkinson’s disease	46
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes	46
Brain accumulation of lactosylceramide characterizes GALC deficiency in a zebrafish model of Krabbe disease	46
A foothold in detection of limbic-predominant age-related TDP-43 encephalopathy	46
Anterior optic pathway pathology in CNS demyelinating diseases	46
Cul-4 inhibition rescues spastin levels and reduces defects in hereditary spastic paraplegia models	46
Interleukin-17B is a new biomarker of human muscle regeneration in dystrophinopathies	46
Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy	46
PTPA variants and the risk for Parkinson’s disease in diverse ancestry populations	45
Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis	45
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments	45
Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation	45
Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia	45
Diffusely abnormal white matter converts to T2 lesion volume in the absence of MRI-detectable acute inflammation	45
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study	45
Of networked lesions and lesioned networks	44
Reply: Methodological drawbacks in the alleged association between foetal sonographic anomalies and autism	44
Reply: Putative benefits of vitamin D supplements in multiple sclerosis out of reach due to sample size	44
Emotional bias modification weakens game-related compulsivity and reshapes frontostriatal pathways	44
The ageing central nervous system in multiple sclerosis: the imaging perspective	44
Poor statistical reporting in a spinal cord injury clinical trial	44
Reply: The challenge of assessing invasive biomarkers for epilepsy surgery and To plan efficacious epilepsy surgery	44
TGFβ4 alleviates the phenotype of Charcot–Marie–Tooth disease type 1A	44
Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease	44
Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide	44
Chasing MOG antibodies down … assays and lumbar punctures	44
Ockham’s razor, not a barber’s weapon but a writer’s tool	44
Plasma biomarkers in chronic single moderate/severe traumatic brain injury	44
The functional role of the precuneus	44
Multimodal layer modelling reveals in vivo pathology in amyotrophic lateral sclerosis	43
Increase of HCN current in SOD1-associated amyotrophic lateral sclerosis	43
One transgene, two myopathies: an MTM1 ‘cross gene therapy’ for BIN1 deficiency?	43
Defining repetitive behaviours in frontotemporal dementia	43
Great science does not communicate itself: but who should and how?	42
Mitochondrial dynamics and bioenergetics in Alzheimer’s induced pluripotent stem cell-derived neurons	42
An extended amygdala circuit at the core of long-term post-sepsis psychiatric disorders	42
Limitation of life sustaining therapy in disorders of consciousness: ethics and practice	42
Reply: Neural substrates of the link between dual-task gait and dementia: an intermediary step in which direction?	42
Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort	42
Ligand-free mitochondria-localized mutant AR-induced cytotoxicity in spinal bulbar muscular atrophy	42
Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine	41
Dynamic reorganization of task-related network interactions in post-stroke aphasia recovery	41
Reply: An epigenetic basis for genetic anticipation in facioscapulohumeral muscular dystrophy type 1	41
Nifuroxazide rescues the deleterious effects due to CHCHD10-associated MICOS defects in disease models	41
Uncovering the distinct macro-scale anatomy of dysexecutive and behavioural degenerative diseases	41
The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis	40
Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities	40
Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophy	40
Direct electrical brain stimulation of human memory: lessons learnt and future perspectives	40
Genome-wide epistasis analysis reveals significant epistatic signals associated with Parkinson’s disease risk	40
Brainstem cavernous malformations: observation, microsurgical resection or stereotactic radiosurgery	40
Myelination potential and injury susceptibility of grey versus white matter human oligodendrocytes	40
Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?	40
Mitochondrial damage is associated with an early immune response in inclusion body myositis	39
Cation leak through the ATP1A3 pump causes spasticity and intellectual disability	39
Heterozygous PRKN mutations are common but do not increase the risk of Parkinson’s disease	39
Motivational and cognitive predictors of apathy after subthalamic nucleus stimulation in Parkinson’s disease	39
Clinicopathological correlates in the frontotemporal lobar degeneration–motor neuron disease spectrum	39
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease	39
The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom mapping	39
Intra-putaminal muscarinic receptor agonist infusion induces a dystonic phenotype in non-human primates	39
Noradrenergic alterations in Parkinson’s disease: a combined 11C-yohimbine PET/neuromelanin MRI study	38
Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation	38
Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson’s disease	38
Phenotypic individual clusters and metabolic tuber subtypes refine surgical strategy in tuberous sclerosis complex	38
Neurophysiological consequences of synapse loss in progressive supranuclear palsy	38
Genome-wide contribution of common short-tandem repeats to Parkinson’s disease genetic risk	38
Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study	38
Role of pattern recognition receptors in chemotherapy-induced neuropathic pain	38
Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes	38
Clinical features and prognostic factors in adults with viral meningitis	38
Reply: Wheelchair use in genetically confirmed FSHD1 from a large cohort study in Chinese population	37
Different factors underlie mild and severe forms of spinal muscular atrophy	37
On the complex localization and phenomenology of pathological laughter and crying	37