Brain

Article	Citations
Correction to: Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders	441
Source-sink connectivity: a novel interictal EEG marker for seizure localization	302
PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models	261
The RAB3A hot spot variant R83W causes spasticity as part of the ataxia-spasticity spectrum	230
Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline	222
Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1	219
Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures	211
Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder	210
Deep brain stimulation: a tale of two targets … and closing the loop	207
Dysregulated cortical excitability and tau phosphorylation in a β3 integrin mouse model of autism	196
We’re all in this together: a rejoinder to Masud Husain’s (rant) editorial	190
Genetically identical twin-pair difference models support the amyloid cascade hypothesis	186
Thalamic stereo EEG: a clinically justified extension of hypothesis-driven intracranial exploration	177
Reply: Is postural tachycardia syndrome a psychogenic disorder?; Notes on establishing fear conditioning as causal in the postural orthostatic tachycardia syndrome; Patients with POTS fear that data o	172
The axon initial segment as a source of neuropathic pain	162
Methodological drawbacks in the alleged association between foetal sonographic anomalies and autism	157
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations	156
Peripherin is a biomarker of axonal damage in Guillain-Barré syndrome: a pathophysiological annotation	152
Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum	151
Dysfunction of the magnocellular subdivision of the visual thalamus in developmental dyslexia	150
In vivo self-assembled siRNAs ameliorate neurological pathology in TDP-43-associated neurodegenerative disease	147
Lesion correlates of impaired acoustic-phonetic perception after unilateral left hemisphere stroke	139
Maternal microbiome-derived propionate regulates offspring myelination via histone lactylation	136
Global network and local vulnerabilities underlie brain atrophy across Parkinson’s disease stages	134
De novo variants in ATXN7L3 lead to developmental delay, hypotonia and distinctive facial features	134

Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins	133
Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery	132
The vascular contribution of apolipoprotein E to Alzheimer’s disease	129
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development	124
Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping	122
Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer’s disease	120
‘Hippocampal innate inflammatory gliosis only’ in pharmacoresistant temporal lobe epilepsy	120
Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases	114
The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy	113
Trigeminal nerve microstructure is linked with neuroinflammation and brainstem activity in migraine	112
Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults	110
From bugs to brain: unravelling the GABA signalling networks in the brain–gut–microbiome axis	108
Mapping the peripheral immune landscape of Parkinson’s disease patients with single-cell sequencing	107
The use of optical coherence tomography in neurology: a review	106
Brain repair mechanisms after cell therapy for stroke	104
Speech and language markers of neurodegeneration: a call for global equity	104
A data-driven study of Alzheimer's disease related amyloid and tau pathology progression	99
Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes	99
Correction to: New genotype-phenotype correlations in a large European cohort of patients with sarcoglycanopathy	98
Stuttering associated with a pathogenic variant in the chaperone protein cyclophilin 40	97
Normalization of network activity in an epilepsy model with a constitutively active GABBR2 variant	96
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability	94
Distinct contribution of spinal neuropeptide Y and NPY1R neurons to morphine analgesia	94
Loss of DOT1L disrupts neuronal transcription and leads to a neurodevelopmental disorder	94
Demystifying interictal discharges and seizure initiation in focal epilepsy	93
The low dimensionality of post-stroke cognitive deficits: it’s the lesion anatomy!	93
Reply: Unblinding in the lecanemab trial in Alzheimer’s disease	92
Loss-of-function variants inMYCBP2cause neurobehavioural phenotypes and corpus callosum defects	91
How COVID-19 affects microvessels in the brain	86
Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances	85
Clinical features and prognostic factors in adults with brain abscess	85
Extra-cranial cholinergic lesions in dementia with Lewy bodies	84
New mechanistic insights into hereditary spastic paraplegias	84
Preclinical type 2 diabetes mellitus subtypes: new insights into diabetes, depression and dementia	82
Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1–ADAM22/23 pathway	81
Disruption of DNA methylation underpins the neuroinflammation induced by targeted CNS radiotherapy	81
Evolutionary perspectives on mRNA signatures of neurodegeneration-related brain remodelling	80
The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy	80
Cytotoxic T cells and plasma cells dominate early in temporal lobe epilepsy with GAD antibodies	80
That which we call cortisol awakening response, by any other word would smell as sweet	79
Integrative miRNA–mRNA profiling of human epidermis: unique signature of SCN9A painful neuropathy	76
Cross-seeding by prion protein inactivates TDP-43	76
Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy	75
Defective lipid signalling caused by mutations inPIK3C2Bunderlies focal epilepsy	75
Multiple sclerosis in Denmark (1950–2023): mean age, sex distribution, incidence and prevalence	75
Is glymphatic clearance the secret to restorative sleep?	74
Clinical and MRI measures to identify non-acute MOG-antibody disease in adults	74
Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit	74
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis	73
Plasma pTau 217/β-amyloid 1–42 ratio for enhanced accuracy and reduced uncertainty in detecting amyloid pathology	73

Biallelic null variants in PNPLA8 cause microcephaly by reducing the number of basal radial glia	72
The three deceits of bureaucracy	72
Routes of precursors’ migration in remyelination	72
Rigidity in Parkinson’s disease	72
Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases	71
Natural experiment on neuroinflammatory disease incidence and infection links pre- and post-COVID-19	70
Molecular and clinical spectrum of epilepsy-dyskinesia syndromes: a cross-sectional study of 609 patients	69
Extracellular vesicle biomarkers for complement dysfunction in schizophrenia	69
Cortical cerebral microinfarcts spark cognitive decline	68
Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?	68
Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations	68
GGC repeat expansions in NOTCH2NLC cause uN2CpolyG cerebral amyloid angiopathy	68
Multimodal mapping of regional brain vulnerability to focal cortical dysplasia	67
A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings	67
Genome-wide association study of neuropathological features in Lewy body disease	67
Midbrain cytotoxic T cells as a distinct neuropathological feature of progressive supranuclear palsy	66
Treatment-resistant recurrent unipolar and bipolar depression: associative learning abnormalities	66
Activation and sensitization of meningeal nociceptors by PACAP-38: implications for migraine headache	66
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration	65
Novel insight into TRPV1-induced mitochondrial dysfunction in neuropathic pain	65
From phenomena to phrasing: rethinking seizure classification through history	65
A sensory neuron-specific long non-coding RNA reduces neuropathic pain by rescuing KCNN1 expression	65
Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders	65
Deciphering the impact of coding and non-coding SCN1A gene variants on RNA splicing	65
Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline?	64
From shadows to spotlight: the evolution of migraine stigma since the 17th century	64
How modular are modules in visual cortex?	64
Correction to: Blood–brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound	62
Correction to: Sex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in females	62
Correction to: Remyelination of chronic demyelinated lesions with directly induced neural stem cells	62
Distinct cerebellar networks underpin clinical improvement in adolescent Tourette disorder	61
Endosomal 2Cl−/H+ exchangers regulate neuronal excitability by tuning Kv7/KCNQ channel density	61
Reply: Lecanemab: turning point, or status quo? An ethics perspective	61
Delineation of functionally essential protein regions for 242 neurodevelopmental genes	60
Correction to: Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders	60
Sleep and seizure risk in epilepsy: bed and wake times are more important than sleep duration	60
Decoding inflammatory pathways in spinal muscular atrophy: implications for next-generation therapies	60
Untangling white matter fibre changes in Alzheimer's disease and small vessel disease	59
A journey towards the pot of gold	59
Neuromelanin as a nidus for neurodegeneration	58
Age-related and amyloid-beta-independent tau deposition and its downstream effects	57
Reply: Do we need new MRI criteria for the diagnosis of radiologically isolated syndrome?	57
Reply: The correlation of behavioural deficits post-stroke: a trivial issue?	57
Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis	57
JC virus spread is potentiated by glial replication and demyelination-linked glial proliferation	57
Occludin modulates HIV and ischaemic stroke response via the mitochondrial antiviral signalling pathway	56
Early onset hereditary neuronopathies: an update on non-5qmotor neuron diseases	56
Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum	56
Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease	56
Impaired value-based decision-making in Parkinson’s disease apathy	56
Estimating the time course of biomarker changes in Alzheimer’s disease	55
The use of animals in neuroscience research	55
A novel eye-movement impairment in multiple sclerosis indicating widespread cortical damage	55
Multicompartmental models and diffusion abnormalities in paediatric mild traumatic brain injury	55
Failure of C9orf72 sense repeat-targeting antisense oligonucleotides: lessons learned and the path forward	55
Cdc42GAP deficiency contributes to the Alzheimer’s disease phenotype	54
Nigrostriatal tau pathology in parkinsonism and Parkinson’s disease	54
Basal forebrain integrity, cholinergic innervation and cognition in idiopathic Parkinson’s disease	54
Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer’s disease	54
The human subthalamic nucleus transiently inhibits active attentional processes	54
Effort avoidance as a core mechanism of apathy in frontotemporal dementia	54
In silico versus functional characterization of genetic variants: lessons from muscle channelopathies	54
White matter connections within the central sulcus subserving the somato-cognitive action network	53
Anatomo-functional basis of emotional and motor resonance elicited by facial expressions	53
Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders	53
Interferon-γ controls aquaporin 4-specific Th17 and B cells in neuromyelitis optica spectrum disorder	53
The lysosomal β-glucocerebrosidase strikes mitochondria: implications for Parkinson’s therapeutics	53
Genetic variability in sporadic amyotrophic lateral sclerosis	52
Large-scale rare variant burden testing in Parkinson's disease	52
Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation	52
Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms	52
Amyloid-β predominant Alzheimer’s disease neuropathologic change	52
Localizing epileptogenic tissues in epilepsy: are we losing (the) focus?	51
Is it time to rename hereditary cases of cerebral palsy?	51
Imaging chronic active lesions in multiple sclerosis: a consensus statement	51
Interleukin-17B is a new biomarker of human muscle regeneration in dystrophinopathies	51
Tiam1 is part of a novel mechanism for morphine tolerance and hyperalgesia	51
A foothold in detection of limbic-predominant age-related TDP-43 encephalopathy	51
Shedding light on a novel circuit within primary motor cortex as a target for neuromodulation	50
The visual cortex in the blind but not the auditory cortex in the deaf becomes multiple-demand regions	50

Bridging the gaps between JCV infection models and human disease	50
The ageing central nervous system in multiple sclerosis: the imaging perspective	50
Surgical white matter disruption leads to downstream atrophy in the non-resected human brain	50
Correction to: Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates	50
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes	50
Understanding brain calcification via N-terminal acetylation at the Golgi apparatus	50
Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease	49
Four dimensions of naturalistic language production in aphasia after stroke	49
Biomarker evidence of neurodegeneration in mid-life former rugby players	49
USP25 in genetic generalized epilepsy: a gene under scrutiny	49
The ‘secret connections’ of the brain: a connectomic reserve for neuroplasticity?	49
Synaptic and cognitive impairment associated with L444P heterozygous glucocerebrosidase mutation	48
Motor compensation in Parkinson’s disease: an empirical challenge with clinical implications	48
Sleep circuit modulation: from animal models to human translation	48
CGRP signalling in migraine: time to look downstream?	47
Thalamic stereo-EEG in epilepsy surgery: where do we stand?	47
HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer’s disease	47
Precision dynamics of predictive coding in functional neurological disorder	47
Brain accumulation of lactosylceramide characterizes GALC deficiency in a zebrafish model of Krabbe disease	47
Amyloid-β-activated microglia can induce compound proteinopathies	47
Cul-4 inhibition rescues spastin levels and reduces defects in hereditary spastic paraplegia models	47
Clinical and biochemical characterization of amyotrophic lateral sclerosis in a CHCHD10 R15L family	47
Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter	46
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments	46
PTPA variants and the risk for Parkinson’s disease in diverse ancestry populations	46
Ageing and remyelination failure in people with multiple sclerosis	46
Satellite glial GLRX3 drives ageing-biased neuropathic pain via HMGB1	45
The basal forebrain cholinergic system as target for cell replacement therapy in Parkinson’s disease	45
Machine learning model based on plasma proteomics for the identification of Parkinson’s disease	45
Characterizing proteomic and transcriptomic features of missense variants in amyotrophic lateral sclerosis genes	45
Emotional bias modification weakens game-related compulsivity and reshapes frontostriatal pathways	45
Multimodal multicentre investigation of diagnostic and prognostic markers in disorders of consciousness	45
Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase	44
Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study	44
The functional role of the precuneus	44
Motor network gamma oscillations in chronic home recordings predict dyskinesia in Parkinson’s disease	44
Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia	44
Elucidating the nociceptive role of CGRP in migraine headache	44
Reply: Methodological drawbacks in the alleged association between foetal sonographic anomalies and autism	43
Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide	43
Chasing MOG antibodies down … assays and lumbar punctures	43
ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial malformations	43
Reply: Putative benefits of vitamin D supplements in multiple sclerosis out of reach due to sample size	43
Plasma biomarkers in chronic single moderate/severe traumatic brain injury	43
Pure autonomic failure as an essential window into progression of synucleinopathies	42
Interaction of motor behaviour, cortical oscillations and deep brain stimulation in Parkinson’s disease	42
TGFβ4 alleviates the phenotype of Charcot–Marie–Tooth disease type 1A	42
One transgene, two myopathies: an MTM1 ‘cross gene therapy’ for BIN1 deficiency?	42
Reply: Neural substrates of the link between dual-task gait and dementia: an intermediary step in which direction?	42
The complexity of interpreting TSPO PET neuroimaging in first-episode psychosis	42
Ligand-free mitochondria-localized mutant AR-induced cytotoxicity in spinal bulbar muscular atrophy	42
Reply: An epigenetic basis for genetic anticipation in facioscapulohumeral muscular dystrophy type 1	41
Mitochondrial damage is associated with an early immune response in inclusion body myositis	41
Mitochondrial dynamics and bioenergetics in Alzheimer’s induced pluripotent stem cell-derived neurons	41
Great science does not communicate itself: but who should and how?	41
Brainstem cavernous malformations: observation, microsurgical resection or stereotactic radiosurgery	41
Increase of HCN current in SOD1-associated amyotrophic lateral sclerosis	41
Genome-wide epistasis analysis reveals significant epistatic signals associated with Parkinson’s disease risk	40
The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom mapping	40
Clinical features and prognostic factors in adults with viral meningitis	40
Neurophysiological consequences of synapse loss in progressive supranuclear palsy	40
Uncovering the distinct macro-scale anatomy of dysexecutive and behavioural degenerative diseases	40
Nifuroxazide rescues the deleterious effects due to CHCHD10-associated MICOS defects in disease models	40
Oxytocin receptor neurons in the paraventricular thalamus as a nexus for social behaviour and fear	39
Intra-putaminal muscarinic receptor agonist infusion induces a dystonic phenotype in non-human primates	39
Genome-wide contribution of common short-tandem repeats to Parkinson’s disease genetic risk	39
Cation leak through the ATP1A3 pump causes spasticity and intellectual disability	39
Myelination potential and injury susceptibility of grey versus white matter human oligodendrocytes	39
Reply: The challenge of assessing invasive biomarkers for epilepsy surgery and To plan efficacious epilepsy surgery	39
Brain essay competition winner on artificial general intelligence	39
Role of pattern recognition receptors in chemotherapy-induced neuropathic pain	39
Noradrenergic alterations in Parkinson’s disease: a combined 11C-yohimbine PET/neuromelanin MRI study	38
Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities	38
Expedited epilepsy surgery prior to drug resistance in children: a frontier worth crossing?	38
Motivational and cognitive predictors of apathy after subthalamic nucleus stimulation in Parkinson’s disease	38
Phenotypic individual clusters and metabolic tuber subtypes refine surgical strategy in tuberous sclerosis complex	38
Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes	37
Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophy	37
Neurovascular injury with complement activation and inflammation in COVID-19	37
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease	37
Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes	37
Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine	37
Heterozygous PRKN mutations are common but do not increase the risk of Parkinson’s disease	37
Limitation of life sustaining therapy in disorders of consciousness: ethics and practice	37
Clinicopathological correlates in the frontotemporal lobar degeneration–motor neuron disease spectrum	37
Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study	37
CSF amyloid-β40 levels are not associated with efficacy outcomes in Alzheimer’s disease trials	36
Astrocyte regeneration via FGF8-DBX1 signalling facilitates recovery in neuromyelitis optica rats	36
Mutations inTAF8cause a neurodegenerative disorder	36
Reply: Lack of statistical significance is not evidence against modularity in visual feature processing	36
Methodological considerations in neuronal extracellular vesicle isolation for α-synuclein biomarkers	36
Can immunological imprinting drive neurological dysfunction in long COVID?	36
Missense variants in TUBA4A cause myo-tubulinopathies	36
ILAE position on early surgery for drug sensitive lesional focal epilepsy	36
Snatches of time. Fragments	36