Brain

Article	Citations
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings	809
Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study	398
Microglial exosomes facilitate α-synuclein transmission in Parkinson’s disease	252
COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital	243
Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19	237
Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model	224
Development and validation of an interpretable deep learning framework for Alzheimer’s disease classification	216
Cerebrovascular disease in patients with COVID-19: neuroimaging, histological and clinical description	210
Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barré syndrome	203
Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease	193
MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide	184
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state	169
Phosphorylated tau interactome in the human Alzheimer’s disease brain	168
Post-stroke deficit prediction from lesion and indirect structural and functional disconnection	165
Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study	165
Medial temporal lobe connectivity and its associations with cognition in early Alzheimer’s disease	161
Neurofilaments: neurobiological foundations for biomarker applications	161
Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease	148
Sleep deprivation impairs molecular clearance from the human brain	145
Definitions and classification of malformations of cortical development: practical guidelines	144
18F-MK-6240 PET for early and late detection of neurofibrillary tangles	143
Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in non-human primates	135
Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons	130
Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions	129
How patients with multiple sclerosis acquire disability	128

CD4 T cells mediate brain inflammation and neurodegeneration in a mouse model of Parkinson's disease	126
Time course of phosphorylated-tau181 in blood across the Alzheimer’s disease spectrum	125
Long-term evolution of multiple sclerosis iron rim lesions in 7 T MRI	123
Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer’s disease	120
The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options	120
CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson’s disease	118
Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures	116
White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study	113
Neurovascular injury with complement activation and inflammation in COVID-19	113
Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis	109
Diabetes medications and risk of Parkinson’s disease: a cohort study of patients with diabetes	109
Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease	107
Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease	106
Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism	104
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer’s disease	100
Relationship between cortical iron and tau aggregation in Alzheimer’s disease	100
Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease	99
18F-flortaucipir PET to autopsy comparisons in Alzheimer’s disease and other neurodegenerative diseases	98
The role of genetics in Parkinson’s disease: a large cohort study in Chinese mainland population	97
The potential of serum neurofilament as biomarker for multiple sclerosis	97
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis	96
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex	95
Acute and non-resolving inflammation associate with oxidative injury after human spinal cord injury	95
Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes	92
Genetic variants and functional pathways associated with resilience to Alzheimer’s disease	91
Hearing and dementia: from ears to brain	90
Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder	90
To what degree is late life cognitive decline driven by age-related neuropathologies?	90
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients	89
Pathophysiological subtypes of Alzheimer’s disease based on cerebrospinal fluid proteomics	87
Natural history of motor symptoms in Parkinson’s disease and the long-duration response to levodopa	87
Detection of neuron-derived pathological α-synuclein in blood	85
Functional cognitive disorder: dementia’s blind spot	85
CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer’s disease	84
Depression, dementia and immune dysregulation	81
Developmental and epileptic encephalopathies: what we do and do not know	81
Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis	81
The GGC repeat expansion inNOTCH2NLCis associated with oculopharyngodistal myopathy type 3	80
An MRI radiomics approach to predict survival and tumour-infiltrating macrophages in gliomas	79
Early stages of tau pathology and its associations with functional connectivity, atrophy and memory	79
Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management	78
Studying human nociceptors: from fundamentals to clinic	78
The synapse in traumatic brain injury	78
The role of noradrenaline in cognition and cognitive disorders	77
A clinical-radiological framework of the right temporal variant of frontotemporal dementia	77
Predicting future rates of tau accumulation on PET	76
The development and convergence of co-pathologies in Alzheimer’s disease	76
Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy	75
COVID-19 vaccine and Guillain-Barré syndrome: let’s not leap to associations	75
Glymphatic system impairment in multiple sclerosis: relation with brain damage and disability	75

Corticospinal-motor neuronal plasticity promotes exercise-mediated recovery in humans with spinal cord injury	74
Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats	73
Gut metagenomics-derived genes as potential biomarkers of Parkinson’s disease	73
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms	72
The microglial component of amyotrophic lateral sclerosis	71
The extracellular matrix as modifier of neuroinflammation and remyelination in multiple sclerosis	71
Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis	70
Acute ischaemic stroke alters the brain’s preference for distinct dynamic connectivity states	69
The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity	69
Consciousness among delta waves: a paradox?	68
Models of psychedelic drug action: modulation of cortical-subcortical circuits	68
Diffuse axonal injury predicts neurodegeneration after moderate–severe traumatic brain injury	68
Plasma markers predict changes in amyloid, tau, atrophy and cognition in non-demented subjects	67
Dopaminergic imaging and clinical predictors for phenoconversion of REM sleep behaviour disorder	66
Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies	66
The spatiotemporal changes in dopamine, neuromelanin and iron characterizing Parkinson’s disease	66
Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease	65
Local sleep-like cortical reactivity in the awake brain after focal injury	65
Damage to Broca’s area does not contribute to long-term speech production outcome after stroke	64
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene	63
Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction	63
Increased perception-action binding in Tourette syndrome	63
The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects	63
Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants	63
Psychosis in neurodegenerative disease: differential patterns of hallucination and delusion symptoms	62
Detecting axonal injury in individual patients after traumatic brain injury	62
Microglial activation and blood–brain barrier permeability in cerebral small vessel disease	62
RFC1 expansions are a common cause of idiopathic sensory neuropathy	62
Recent progress in translational engineeredin vitromodels of the central nervous system	62
Spatiotemporal changes in substantia nigra neuromelanin content in Parkinson’s disease	61
Modulation of beta bursts in subthalamic sensorimotor circuits predicts improvement in bradykinesia	60
Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications	60
Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration	60
Repetitive transcranial magnetic stimulation for neuropathic pain: a randomized multicentre sham-controlled trial	60
Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer’s disease	60
Macrophage phagocytosis after spinal cord injury: when friends become foes	59
Precuneus magnetic stimulation for Alzheimer’s disease: a randomized, sham-controlled trial	59
Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer’s disease	59
COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis	58
Myelin and axon pathology in multiple sclerosis assessed by myelin water and multi-shell diffusion imaging	58
Molecular signature of slowly expanding lesions in progressive multiple sclerosis	57
Evolution of neuroinflammation across the lifespan of individuals with Down syndrome	57
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease	57
Reactive microglia enhance the transmission of exosomal α-synuclein via toll-like receptor 2	56
Precision medicine in stroke: towards personalized outcome predictions using artificial intelligence	56
The apparently milder course of multiple sclerosis: changes in the diagnostic criteria, therapy and natural history	55
GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition	54
KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation	53
A novel RFC1 repeat motif (ACAGG) in two Asia-Pacific CANVAS families	53
Blunted medial prefrontal cortico-limbic reward-related effective connectivity and depression	53
Driving motor cortex oscillations modulates bradykinesia in Parkinson’s disease	53
SomaticMAP3K3andPIK3CAmutations in sporadic cerebral and spinal cord cavernous malformations	53
COVID-19 vaccination and Guillain-Barré syndrome: analyses using the National Immunoglobulin Database	53
Multimodal neuroimaging in post-COVID syndrome and correlation with cognition	53
Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma	53
O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease	52
Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice	52
Towards network-guided neuromodulation for epilepsy	52
Sex effects on brain structure in de novo Parkinson’s disease: a multimodal neuroimaging study	52
Disease-modifying drugs can reduce disability progression in relapsing multiple sclerosis	52
Stop that! It’s not Tourette’s but a new type of mass sociogenic illness	52
Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes	51
A new science of emotion: implications for functional neurological disorder	51
Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3	51
Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brain	50
A unified model of post-stroke language deficits including discourse production and their neural correlates	50
Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease	50
Sequence of clinical and neurodegeneration events in Parkinson’s disease progression	50
Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease	50
A daily temperature rhythm in the human brain predicts survival after brain injury	49
Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer’s disease	49
APOE4 derived from astrocytes leads to blood–brain barrier impairment	49
Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome	49
Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders	49
Anti-amyloid antibody therapies in Alzheimer’s disease	49
Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit	49
The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson’s disease	48
rs34331204 regulates TSPAN13 expression and contributes to Alzheimer’s disease with sex differences	48
Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons	48
Reimagining cholinergic therapy for Alzheimer’s disease	48

Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages	48
Opening of ATP sensitive potassium channels causes migraine attacks with aura	48
Persistent white matter changes in recovered COVID-19 patients at the 1-year follow-up	48
Epilepsy subtype-specific copy number burden observed in a genome-wide study of 17 458 subjects	47
Beyond the average patient: how neuroimaging models can address heterogeneity in dementia	47
Brain responsivity provides an individual readout for motor recovery after stroke	47
From biomechanics to pathology: predicting axonal injury from patterns of strain after traumatic brain injury	47
Riluzole, a glutamate modulator, slows cerebral glucose metabolism decline in patients with Alzheimer’s disease	47
Protein contributions to brain atrophy acceleration in Alzheimer’s disease and primary age-related tauopathy	46
Sex-dependent autosomal effects on clinical progression of Alzheimer’s disease	46
Towards realizing the vision of precision medicine: AI based prediction of clinical drug response	46
Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function	46
Dopamine and reward hypersensitivity in Parkinson’s disease with impulse control disorder	46
Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy	46
Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation	45
New genotype-phenotype correlations in a large European cohort of patients with sarcoglycanopathy	45
Closed-loop stimulation of the medial septum terminates epileptic seizures	45
Improved relapse recovery in paediatric compared to adult multiple sclerosis	45
Post-stroke outcomes predicted from multivariate lesion-behaviour and lesion network mapping	45
Regional brain iron and gene expression provide insights into neurodegeneration in Parkinson’s disease	45
A Māori specific RFC1 pathogenic repeat configuration in CANVAS, likely due to a founder allele	44
Cortical disinhibition in Parkinson’s disease	44
Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies	44
Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition	44
Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer’s disease	44
Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease	44
5′ UTR CGG repeat expansion inGIPC1is associated with oculopharyngodistal myopathy	44
The neuroethics of disorders of consciousness: a brief history of evolving ideas	44
Severe COVID-19-related encephalitis can respond to immunotherapy	44
The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications	44
Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration	43
Antibodies to the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy	43
Transcranial alternating current stimulation for treating depression: a randomized controlled trial	43
Imaging meningeal inflammation in CNS autoimmunity identifies a therapeutic role for BTK inhibition	43
Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators	42
Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice	42
Astrocyte–neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade	42
Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players	42
Functional maps of direct electrical stimulation-induced speech arrest and anomia: a multicentre retrospective study	42
Activation of Wnt/β-catenin pathway mitigates blood–brain barrier dysfunction in Alzheimer’s disease	42
Gene variant effects across sodium channelopathies predict function and guide precision therapy	42
Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma	42
The structural connectome and motor recovery after stroke: predicting natural recovery	42
Assessing the landscape of STXBP1-related disorders in 534 individuals	42
Molecular and cellular correlates of human nerve regeneration: ADCYAP1/PACAP enhance nerve outgrowth	41
Spreading depolarizations in ischaemia after subarachnoid haemorrhage, a diagnostic phase III study	41
Distinct patterns of structural damage underlie working memory and reasoning deficits after traumatic brain injury	41
Cardiovascular brain impulses in Alzheimer’s disease	40
Structural white matter connectometry of word production in aphasia: an observational study	40
In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse model	40
UNC13B variants associated with partial epilepsy with favourable outcome	40
Progression is independent of relapse activity in early multiple sclerosis: a real-life cohort study	40
Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders	40
Quantitative spinal cord MRI in MOG-antibody disease, neuromyelitis optica and multiple sclerosis	40
RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain	40
Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma	40
Autoimmune encephalitis mediated by B-cell response against N-methyl-d-aspartate receptor	39
BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer’s disease brain	39
Natural history of Charcot-Marie-Tooth disease type 2A: a large international multicentre study	39
Cognitive load amplifies Parkinson’s tremor through excitatory network influences onto the thalamus	39
Guillain-Barré syndrome after SARS-CoV-2 infection in an international prospective cohort study	39
Unravelling the enigma of cortical tremor and other forms of cortical myoclonus	38
Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer’s disease	38
Spatiotemporal features of β-γ phase-amplitude coupling in Parkinson’s disease derived from scalp EEG	38
Motor and cognitive outcomes of cerebello-spinal stimulation in neurodegenerative ataxia	38
The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?	38
Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia	38
Clinical, serological and genetic predictors of response to immunotherapy in anti-IgLON5 disease	38
Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases	38
Intrinsic blood–brain barrier dysfunction contributes to multiple sclerosis pathogenesis	37
Post-acute blood biomarkers and disease progression in traumatic brain injury	37
Tau accelerates α-synuclein aggregation and spreading in Parkinson’s disease	37
Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe	37
Differential medication overuse risk of novel anti-migraine therapeutics	37
ATP1A2- and ATP1A3-associated early profound epileptic encephalopathy and polymicrogyria	37
Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism with polyneuropathy	37
Vestibular agnosia in traumatic brain injury and its link to imbalance	36
VEGF signalling causes stalls in brain capillaries and reduces cerebral blood flow in Alzheimer’s mice	36
Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis	36
A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment	36
Therapeutic reversal of Huntington’s disease by in vivo self-assembled siRNAs	36
A brain network for deep brain stimulation induced cognitive decline in Parkinson’s disease	36
Nogo receptor decoy promotes recovery and corticospinal growth in non-human primate spinal cord injury	35
GPR151 in nociceptors modulates neuropathic pain via regulating P2X3 function and microglial activation	35
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses	35
Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia	35
Functional preservation and enhanced capacity for visual restoration in subacute occipital stroke	35
Dissecting autism and schizophrenia through neuroimaging genomics	35
Cervical lymph nodes and ovarian teratomas as germinal centres in NMDA receptor-antibody encephalitis	34
Deep brain stimulation modulates directional limbic connectivity in obsessive-compulsive disorder	34
KCNT1-related epilepsies and epileptic encephalopathies: phenotypic and mutational spectrum	34
SLC12A2 variants cause a neurodevelopmental disorder or cochleovestibular defect	34
Multiple sclerosis lesions in motor tracts from brain to cervical cord: spatial distribution and correlation with disability	34
Paclitaxel increases axonal localization and vesicular trafficking of Nav1.7	34
Bringing proportional recovery into proportion: Bayesian modelling of post-stroke motor impairment	34