OOIR: Observatory of International Research

Papers

(The H4-Index of Biotechnology and Bioengineering is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review	88
Scale‐up economics for cultured meat	82
Metabolic engineering of Pichia pastoris for malic acid production from methanol	59
The role of extracellular DNA in the formation, architecture, stability, and treatment of bacterial biofilms	58
“High‐risk” host cell proteins (HCPs): A multi‐company collaborative view	58
Current technologies to endotoxin detection and removal for biopharmaceutical purification	58
Advances in encapsulin nanocompartment biology and engineering	53
Biogenesis and mechanisms of microRNA‐mediated gene regulation	49
Hybrid‐EKF: Hybrid model coupled with extended Kalman filter for real‐time monitoring and control of mammalian cell culture	49
Improving lysine production through construction of an Escherichia coli enzyme‐constrained model	45
Consolidated bioprocessing performance of a two‐species microbial consortium for butanol production from lignocellulosic biomass	44
A review of manufacturing capabilities of cell spheroid generation technologies and future development	43
Moving from the bench towards a large scale, industrial platform process for adeno‐associated viral vector purification	40
Microbial microdroplet culture system (MMC): An integrated platform for automated, high‐throughput microbial cultivation and adaptive evolution	40
Novel nucleic acid detection strategies based on CRISPR‐Cas systems: From construction to application	39
Overview on immobilization of enzymes on synthetic polymeric nanofibers fabricated by electrospinning	39
Optimizing the biosynthesis of oxygenated and acetylated Taxol precursors in Saccharomyces cerevisiae using advanced bioprocessing strategies	38
A genome‐scale metabolic network model and machine learning predict amino acid concentrations in Chinese Hamster Ovary cell cultures	38
Advances in mapping the epigenetic modifications of 5‐methylcytosine (5mC), N6‐methyladenine (6mA), and N4‐methylcytosine (4mC)	37
Ultrahigh‐cell‐density heterotrophic cultivation of the unicellular green alga Chlorella sorokiniana for biomass production	37
Metabolic engineering of E. coli for improving mevalonate production to promote NADPH regeneration and enhance acetyl‐CoA supply	36
Manufacturing a chimpanzee adenovirus‐vectored SARS‐CoV‐2 vaccine to meet global needs	36
A common framework for integrated and continuous biomanufacturing	36
A CRISPR‐Cas12a‐derived biosensor enabling portable personal glucose meter readout for quantitative detection of SARS‐CoV‐2	36
High‐level production of 3‐hydroxypropionic acid from glycerol as a sole carbon source using metabolically engineered Escherichia coli	35

Three‐dimensional culture models to study drug resistance in breast cancer	32
Rewiring central carbon metabolism for tyrosol and salidroside production in Saccharomyces cerevisiae	32
Extraction, isolation, purification, derivatization, bioactivity, structure–activity relationship, and application of polysaccharides from White jellyfungus	32
Modeling of photosynthesis and respiration rate for microalgae–bacteria consortia	32
Pilot‐scale demonstration of an end‐to‐end integrated and continuous biomanufacturing process	32
Production of β‐carotene in Saccharomyces cerevisiae through altering yeast lipid metabolism	31
Tailoring bacterial cellulose structure through CRISPR interference‐mediated downregulation of galU in Komagataeibacter xylinus CGMCC 2955	31