Biophysical Journal

Article	Citations
Empagliflozin and ROS-CaMKII-late sodium current signaling in heart failure with preserved ejection fraction	84
Diversity and molecular mechanisms of channelrhodopsins	82
Lipids and microparticles, physical characterization as a lung-contamination model	67
Measurements of cholesterol chemical potential constrain models of cholesterol-phosphatidylcholine interactions	62
Critical regulation of the voltage-gated sodium channel, Nav1.4, by PIP2	60
Dissecting metabotropic glutamate receptor activation by single molecule FRET using minimally invasive labeling strategies	58
Disease mutations of human α3 Na+/K+-ATPase define extracellular Na+ binding/occlusion kinetics at ion binding site III	58
“Helicase” activity promoted through dynamic interactions between a ssDNA translocase and a diffusing SSB protein	56
Single molecule evidence for linker histone H1 DNA sliding and nucleosomal bypassing regulated by the C-terminal disordered domain	52
Differential nuclear translocation of STAT6 regulates the mechanosensitive immune cell activation	51
Investigation of nonselective cation permeation through CNGA1 channels by MD simulations	50
Myosin-I facilitates symmetry breaking and promotes the growth of actin ‘comet tails’	47
How lipids modulate association of proteins in lipid membranes	46
Modulation of potassium channels preserves temporal fidelity in auditory network models	44
Examining HIV-1 envelope conformational transitions at high temporal resolution	44
Novel biomolecular fingerprint using graph convolutional networks	41
Intrinsic stiffening and dynamic softening by cholesterol	40
Unraveling the molecular basis of protein search on ssDNA track and binding specificity of the ssDNA sequences	40
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family	39
Inter-domain coordination essential for dengue virus non-structural (5) NS5 interaction with stem loop a (SLA)	39
A multi-view reflector microscope visualizes six-dimensional single-molecule translational and rotational dynamics with isotropic nanoscale resolution	37
Long-range regulation of cytochrome c binding to bc1 complex	37
Origins of protein concentration noise in mitochondria	37
Myosin binding protein-C: Everything, everywhere, all at once	36
Dynamic association of an assembly platform subcomplex of the bacterial type two secretion system	36

Method for direct measuring antibody affinity in biological sample	36
Treatment of osteoarthritis by salvianolic acid derivatives	36
Sarcomere dynamics simulations to uncover mechanisms in hypertrophic cardiomyopathy	35
cryo-EM structure of tarantula myosin filament: Implications for analysis of myopathy mutations	35
Visualizing both nucleosome disassembly and reassembly during FACT chaperone activity	33
Expansion microscopy through mechanical force	33
Fluctuating diffusivity of intrinsically disordered proteins	33
FkpA enhances outer membrane protein folding using an extensive interaction surface	32
The rigidization of water dynamics around proteins: A molecular dynamics study	32
Novel approaches to understand function and explore inhibition within protein-membrane interfaces	31
NFATC1 modulation of atrial excitability in zebrafish	31
Investigating Dnase1L3's role in inflammation and redesigning the enzyme to be used as a therapeutic	31
Bacterial brains: How bacteria use electrochemical potentials to solve complex problems	31
Using HDX-MS to probe the dynamics and denatured state of GlpG, a helical membrane protein	30
Experimental methods and mathematical modeling quantify and predict DUSP1 RNA expression dynamics in response to dexamethasone	30
Solution NMR studies reveal novel CLIC4 chaperone activity with respect to profilin-1	30
Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels	29
Storm imaging provides nanodomain-lengthscale observation of coordination between Arabidopsis root hair membrane proteins	29
Drug discovery for heart failure: Targeting the myosin-binding protein C interactions with actin	29
Quantitative views of protein dynamics through the computational microscope	29
Extreme-value analysis of intracellular cargo transport by motor proteins	29
Regioselective metabolism of cannabinoids by cytochrome P450 2J2	29
RTK-integrin interactions universally modulate αVβ3 integrin-mediated cell adhesion	28
Optimal efficacy in mosquito-host interaction inhibition by 35-60 kHz animal sounds for malaria control	28
Action at a distance along the microtubule couples kinesin motors	28
High throughput mechanotyping via flow cytometry and DNA sequencing	28
Quantitative fret studies of EphA2-Lyn interactions	28
Cataracts and copper: A spectroscopic perspective of copper-induced aggregation of betaB2-crystallin	27
Single-molecule dynamics of ribonuclease H enzymes in Bacillus subtilis	27
RNA structure controls composition and network dynamics of condensates	27
Nascent-chain interaction networks and their effect on the bacterial ribosome	27
Investigation of G-protein specificity and biased agonism at the beta-2 adrenergic receptor (β2AR)	27
Probing synaptic distribution and arrangement of native surface AMPAR in mouse brain slices with 3D super-resolution microscopy	27
Analysis and comparison of amorphous & amyloid aggregates of the tumor suppressor p53	27
Characterizing the APOBEC3B closed to open pathway with weighted ensemble	27
Sequence adaptation in various environments across organisms; similar yet different superoxide dismutase	27
Functional impact of the interaction between S1 segment and KCNE subunit in the modulation of KCNQ1 channels	26
Solution structure of poly(UG) RNA reveals a new fold that drives gene silencing	26
Compounds specifically enhance IKs by modulating VSD-pore coupling	26
Insights on plasma membrane asymmetry from studies of asymmetric model membranes	25
The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM	25
From loops to stacks: Early steps in the DNA folding pathway by protamine	25
Investigating how the anionic lipid, BMP, plays a crucial role in the initation of SARS-CoV-2 fusion	25
Thank You to Our Reviewers	25
Amplification-free rapid detection of viral genomes at single molecule level	25
Reversing aberrant phase transitions of ALS-linked disease protein FUS with RNA	25
Dissecting ER stress signaling with live-cell single-molecule imaging and optogenetics	25
Discovering inhibitors against human norovirus protein target 3CLpro using ligand-protein docking	25
2-d liquid-liquid phase separation of GM130 Golgin protein bound to supported bilayer	25
De novo design of a DNA-binding protein capable of multi-site recognition	25

Temperature dependence of α-crystallin membrane binding	25
Multi-GPU-powered UNRES package for physics-based coarse-grained simulations of structure, dynamics, and thermodynamics of protein systems at biological size- and timescales	24
The Piezo1 channel interacts with the transmembrane channel Tmc1 to exert mechanoelectrical transducer (MET) functions	24
Enhancing sarcomere function and length-dependent activation in engineered human myocardium via triiodothyronine and dexamethasone treatment	24
Elucidation of a dynamic interplay between beta-adrenergic receptors, its agonists, and stimulatory G protein	24
Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation	24
A structural model of TCR-pMHC catch bonding	24
Machine learning for prediction of protein function and elucidation of enzyme function and control	24
The N-terminus is not the Ca2+-regulated gate in CALHM1 channels	24
ERK activation waves are key drivers in the mechanical cell competition that leads to collective onslaught of bacterially infected cells	24
Structural basis for the intracellular regulation of ferritin degradation	23
Quantifying water rigidization near protein surfaces	23
Stress-induced BAG3 cleavage and its effects on sarcomere contractile functions	23
Cardiac dysfunction in a mouse model of colon cancer cachexia is due to sarcomeric changes	23
Understanding transport processes with simulation	22
The cancer mucin barrier plays a multifunctional role in providing sustained physical resistance to natural killer cell attack	22
Measuring the effects of infection on disordered viral proteins	22
Distinct spatiotemporal dynamics of calmodulin genes in cardiac myocytes under beta-adrenergic stimulation	22
Extracting conformational heterogeneity from 2D and 3D cryo-EM data	22
Graded cleavage of elastic titin in living mouse hearts reveals the role of titin stiffness for cardiac contractility	22
Phase separation of myosin-15 and centrin-2 contributes to stereocilia tip density formation	22
Biochemical signaling encoded in emergent properties	22
Spatial distribution of adhesion force generation in human cardiomyocytes	22
Does it stick? Long-term outcomes for biology majors from introductory physics for the life sciences	22
Student usage and perceptions of ChatGPT: The good, the bad, and the ugly	21
Druggable and allosteric pocket prints of G-protein coupled receptors	21
Spelunking with potassium: Functional analysis of the water tunnel in the potassium pump KdpFABC	21
Comparing photosynthetic metabolite free energy and permeability across bacterial microcompartment shell proteins	21
Alchemical free-energy simulations support the formation of the sarco-endoplasmic reticulum calcium pump (SERCA) inhibitory complex from the phospholamban pentamer	21
Targeting anti-aggregation and anti-oxidation of amyloid deposits for therapeutic intervention of Alzheimer’s using machine learning-enhanced molecular docking	20
Allosteric mechanisms of transcriptional control in FXR	20
Chloride intracellular channels regulate spermatogenesis	20
Engineering inducible dipoles to develop better fluorescent biosensors	20
Configuring extracellular matrix architectures with dynamic forces	20
Membrane composition affects binding and insertion of the influenza virus fusion peptide	20
Computational analyses of SERCA, phospholamban, and sarcolipin complexes	20
Structural studies of connexin 32 gap junction channels by cryo-EM	20
Towards revealing functionally relevant conformational dynamics of the C-terminal tail of β-arrestin	20
Cryo-EM structures of nanodisc reconstituted ligand-gated ion channel GLIC in various conformations reveal state-dependent protein-lipid interactions and gating mechanism	20
Structural basis of closed groove scrambling by a TMEM16 protein	20
Co-VET: Correlative-voltage imaging and cryo-electron tomography	19
Characterizing salt and humidity induced 3D electrospun matrices	19
Mapping the tension-gated transition of the bacterial MscS with MD simulations	19
Molecular kinetics of polycomb body formation during development	19
Structural basis of distinct signaling kinetics of calcitonin-like receptor peptide ligands	19
Investigating the presence of carbon quantum dots in the inhalable aerosol from electronic cigarettes	19
Cryo-electron microscopy structure of human Kir2.1 potassium channel bound to the activator PIP2 reveals its gating mechanism	19
Bind-and-bend model for DNA looping	19
X-ray single molecule observations using SR and laboratory source	19
Molecular insights into the role of SNX1-SNX5 heterodimer in endosomal trafficking	19
Self-organization of ovarian cancer organoids revealed by 3D image segmentation and phase-field model	19
Structural insights into a new class of noncovalent, potent, and highly selective G protein-coupled receptor kinase 5 inhibitors	19
Centromere and telomere dynamics reveal heterogeneity of the human cell nucleus	18
Unraveling the dance of phosphoproteins at adhesion planes: Modeling YAP phosphorylation by a particle-based stochastic model	18
The plasma membrane as an emulsion: A rational basis for “rafts,” and a different look at them	18
BAG3 differentially responds to acute and chronic stress via a post-transcriptional mechanism	18
Structural studies of human serum albumin using cryo-EM up to 0.38 nm resolution	18
DNA and mRNA as molecular speed bumps in Escherichia coli’s cytoplasm	18
Extent of raft composition in a model plasma membrane	18
Quantification of NINJ1-mediated membrane rupture	18
Regulatory mechanisms of kinesin function at varying pH	18
Modeling toxin effects on sodium channels in neurons using real-time dynamic clamp	18
Elucidating the spatial distribution of genomic and epigenetic lamina-associated domains implicated in adipocyte differentiation and hypertrophy	18
β-Barrel formation examined through β-hairpin interactions with lipid vesicles	18
Mechanically induced conformational transition of spectrin in the mammalian cell cortex	18
Collective functionalities emerging in microbial active matter	18
Vinculin transmits high-level integrin tensions that are dispensable for focal adhesion formation	18
Metabolic regulation by enzyme polymerization	18
NMR studies of the complex between the small GTPase Arf1 and segmentally labeled ARFGAP ASAP1 at the membrane surface of nanodiscs	18
Open software for analyzing lipid-resolved mechanics of complex bilayers	18
Tyrosine fluorescence as an intrinsic probe for protein aggregation	18
Conformational preferences of disordered proteins in biomolecular condensates	18
Organization and dynamics of cross-linked actin filaments in confined environments	18
Probing the mechanisms of low-voltage activation in T-type CaV3.1 calcium channels	18
Active-learning-guided and high-throughput synthesis of membrane proteins	17
BPS2025 - Functional assessment of recombinant human alpha-cardiac myosin and the effect of atrial arrhythmia mutations	17
Small-angle x-ray scattering investigation of the integration of free fatty acids in polysorbate 20 micelles	17
Conformational free energy landscape of sorting signal peptides in complex with bacterial sortases	17
BPS2025 - Phylogenetic corrections and higher-order sequence statistics in protein families: The Potts model and MSA transformer showdown	17
2D-dwell-time analysis with simulations of ion-channel gating using high-performance computing	17

Engineering of the high-affinity chemokine CXCL13 to screen CXCR5 antagonists to treat cancer and autoimmune diseases	17
BPS2025 - Enhancing the AMBER ff19SB-BSC1-OPC force field for improved molecular dynamics simulations of proteins, nucleic acids, and their complexes	17
Role of glycine and its methyl derivatives on conformational stability and dynamics of cytochrome c	17
In silico modeling of patient-specific blood rheology in type 2 diabetes mellitus	17
The protocadherin-15-LHFPL5 tip link complex is a heterotetrameric assembly in hair cell stereocilia	17
Calculation of solvation force in molecular dynamics simulation by deep-learning method	17
BPS2025 - Ultrafast fluorescence lifetimes of NADH via FLIM	17
BPS2025 - Cell-free protein synthesis as a platform for studying liquid-liquid phase separation	16
BPS2025 - Quantifying IgG oligomerization on the cell membrane using fluorescence nanoscopy	16
BPS2025 - Cryo-EM reveals binding and activation of the ryanodine receptor by multiple statin molecules	16
BPS2025 - PPM1D phosphatase: Crystal structure, mechanistic studies, and structure-based virtual screening	16
BPS2025 - Effective charge of RNA in a fully packaged viral particle	16
BPS2025 - Recovering true FRET efficiencies from smFRET investigations requires triplet state mitigation	16
BPS2025 - Replication organelles of arboviruses through the lens of a cryo-electron microscope	16
BPS2025 - Reconstitution and analysis of membrane proteins in a micro-patterned model membrane	16
BPS2025 - Physiological and pathological role of tau’s proline rich region in microtubule assembly	16
BPS2025 - Measuring ER-mitochondrial contacts in live cells	16
BPS2025 - A de novo designed miniprotein prevents Ca2+-feedback of CaV1 channels	16
BPS2025 - Antibody-induced changes in host cell membrane dynamics during assembly trigger tuning of influenza A virion shape	16
BPS2025 - Molecular pharmacology of human P2X7 receptor ligands visualized by cryo-EM	16
BPS2025 - Real-time tracking of the structural dynamics of adenylate kinase	15
BPS2025 - Regulated confinement patterns elicit the organized collective migration of rear cells	15
BPS2025 - Investigation of microtubule-CRMP2-isoforms interaction using high-speed atomic force microscopy	15
BPS2025 - Cryo-EM structures of mitochondrial RNA editing catalytic complexes from Trypanosoma brucei	15
BPS2025 - Toxic competitors of phospholamban may contribute to dysregulation of SERCA in heart failure	15
BPS2025 - Dynamics of IDPs in biomolecular condensates from massive all-atom explicit-solvent simulations	15
BPS2025 - Mavacamten and omecamtiv mecarbil modulate the structure of the interacting-heads motif by inducing distinct subfragment-2 conformations	15
BPS2025 - Networked interactions in biomolecular condensates formed by disordered proteins reveal structural and dynamic inhomogeneities	15
BPS2025 - DNA nanotechnology for large-scale hybrid nanopore integration	15
BPS2025 - Integrated data acquisition and real-time parameter-free reconstruction for cryo-ET	15
BPS2025 - A tool for determining the release rate and number of mRNA molecules released from lipid nanoparticles in cells based on fluorescence readout and simulation	15
BPS2025 - High-spatial-resolved heat manipulating membrane heterogeneity alters cellular migration and signaling	15
BPS2025 - Direct quantification of human αβ-tubulin binding kinetics at microtubule ends reveals nucleotide regulation of end-binding affinity	15
BPS2025 - Inferring single-cell dynamics of a molecular reporter from unlabeled live-cell light microscopy data analyzed with delay embedding	15
BPS2025 - The inaugural flatiron heterogeneity community challenge	15
BPS2025 - The effects of pH on condensate and cortex formation	15
BPS2025 - Native structure of mosquito salivary protein complexes unveils molecular mechanisms of malaria transmission	15
BPS2025 - Mechanisms underlying distinct cardiac arrhythmia phenotypes caused by calmodulin mutation D132E in Calm2 and Calm3 genes	15
BPS2025 - Structural dynamics study on mosaic spike heterotrimer provides insights into polyvalent vaccine immunogen display	14
BPS2025 - Deciphering the role of SNARE transmembrane domain palmitoylation in neurotransmitter release	14
BPS2025 - Developing an adaptable toolbox for measuring ion channel stoichiometry using stepwise photobleaching	14
BPS2025 - RSV fusion protein conformation transition pathway from prefusion to postfusion	14
BPS2025 - Studying the interaction of Kv1.3-specific inhibitors with Kv1.3-Kv1.x heterotetrameric ion channels	14
BPS2025 - Characterizing the potassium binding site in human excitatory amino acid transporter	14
BPS2025 - Drug block near lipid-binding fenestrae in LRRC8/volume-regulated anion channels	14
BPS2025 - Single-molecule measurements of p44-enhanced XPD helicase activity	14
BPS2025 - Comparison of multi-axes sample handler devices for multiview imaging of lung organoids	14
BPS2025 - Deciphering the phase behavior of model membranes composed of branched-chain bacterial lipids	14
BPS2025 - Time-resolved fluorometry reveals novel insights into small molecule drug interactions with the HCN channel voltage sensor	14
BPS2025 - Monitoring conformational dynamics and interactions of p53-TAD via an MspA nanopore	14
BPS2025 - How α-parvalbumin mutations impact calcium-binding affinity in the presence and absence of its AB-domain	14
BPS2025 - Beyond the core: investigating how accessory regions of PDZ-RhoGEF regulate its catalytic core in RhoA activation	14
BPS2025 - Generative computational modeling with CellPACK reveals interplay between rules of intracellular organization and geometry in hiPSCs	14
BPS2025 - Knowledge-based coarse-grained model for multi-protein assembly: Effects of electrostatic contributions to protein-protein interfaces	14
BPS2025 - Mesoscale properties of protein clusters determine the size and nature of liquid-liquid phase separation	14
BPS2025 - Complex DNA effects on polyphosphate condensate growth and architecture	14
BPS2025 - Electromagnetic dynamics and characterization of cancer cell-magnetic bead interactions	14
BPS2025 - Estimating antibody frequencies in humans using a structure-based approach	14
BPS2025 - Simulation of biopolymerization on surfaces—implications for biogenesis	14
BPS2025 - Optimization of therapeutic T cells through biophysical modeling	14
BPS2025 - COBY: An advanced tool for accurate creation of coarse-grained simulation systems	14
BPS2025 - Minimal protein components for chromatin replication-coupled symmetric histone recycling	14
BPS2025 - Protein intrinsically disordered regions have nonrandom, modular architectures that influence conformation and function	14
BPS2025 - On the cooperativity of fold-switching sequences	14
BPS2025 - GIRK2 drug repurposing screen identifies treatment options for patients suffering from extremely rare diseases	14
BPS2025 - Cardiac voltage-gated sodium channels are a common pathological pathway in COVID-19-induced arrhythmia	14
BPS2025 - A computational model of angiotensin II receptor type 1 dynamics: Insights into vascular regulation	14
Characteristic frequencies of localized stress relaxation in scaling-law rheology of living cells	13
Active learning model for extracting elastic modulus of cell on substrate	13
BPS2025 - Differential modulation of beta-cardiac myosin conformations by cardiomyopathy-associated mutations in the converter domain	13
BPS2025 - Anticooperative substrate binding in the yeast BC1 complex	13
BPS2025 - Characterization of seven new K+ channel blocker peptides of Centruroides bonito revealed that α-KTx 2.24 has a picomolar affinity for Kv1.2	13
BPS2025 - Inhibition of amyloid beta fibrillation by a heparin binding protein Midkine—a combined spectroscopy, microscopy, and proteomics study	13
BPS2025 - Molecular mechanisms of keratin-based polymer materials for bioengineering applications	13
BPS2025 - Deciphering the relationship between form and inherent electrochemical function during the phase transition of Aβ peptides	13
BPS2025 - Systematic embedding of biomechanics within dynamical graph grammars with application to actin networks in dendritic spine heads	13
An integrated multiscale computational framework deciphers SARS-CoV-2 resistance to sotrovimab	13
Unique molecular features in the activation of the AT1 receptor by chemical and mechanical stimuli	13
BPS2025 - Activation of TMEM16E scramblase induces ligand-independent growth factor receptor signaling and macropinocytosis for membrane repair	13
BPS2025 - Investigating the modulation of Kv1.3 channel inactivation by KCNE4	13
BPS2025 - TMEM175 chronicles: A journey from high throughput screening to lysosome	13
BPS2025 - Integrating accelerated molecular simulations and AI to elucidate Cas9 specificity factors	13
BPS2025 - A conserved “electrostatic cassette” and an alternatively spliced proline-rich motif enable compaction and isoform-specific autoinhibition by the intrinsically disordered variable domain of	13
BPS2025 - Calcium-mediated structural dynamics and zinc sequestration in S100A12: Insights from NMR and molecular dynamics studies	13
BPS2025 - Assessing the role of sodium channel fast inactivation in the mechanism of aryl/acyl-sulfonamide inhibition	13
BPS2025 - Phospholipase D-derived phosphatidic acid regulates multivesicular body fusion	13
BPS2025 - YAP charge patterning mediates signal integration through transcriptional co-condensates	13
Blocking uncertain mispriming errors of PCR	13
BPS2025 - Cryoprotectant-free lamella preparation of plant and animal tissue for cryo-electron tomography	13
BPS2025 - Synthetic intrinsically disordered proteins that exhibit phase separation	13
BPS2025 - Molecular mechanism of BMP signaling inhibition by twisted gastrulation	13
BPS2025 - Combination of cell penetrating peptides affects protein transportation efficiency	13
BPS2025 - Cardiotoxic effects of synthetic cannabinoid receptor agonists: Inhibition of hERG and Kv7.1/KCNE1 channels with proposed hERG binding site	13
BPS2025 - Developing a model to study iPSC-CM integration with human heart tissue	13
BPS2025 - Structure and dynamics of the p53-MDMX-CK1α complex	13