Biophysical Journal

Article	Citations
Empagliflozin and ROS-CaMKII-late sodium current signaling in heart failure with preserved ejection fraction	78
Diversity and molecular mechanisms of channelrhodopsins	75
Lipids and microparticles, physical characterization as a lung-contamination model	63
Measurements of cholesterol chemical potential constrain models of cholesterol-phosphatidylcholine interactions	60
Critical regulation of the voltage-gated sodium channel, Nav1.4, by PIP2	57
Disease mutations of human α3 Na+/K+-ATPase define extracellular Na+ binding/occlusion kinetics at ion binding site III	57
Dissecting metabotropic glutamate receptor activation by single molecule FRET using minimally invasive labeling strategies	56
“Helicase” activity promoted through dynamic interactions between a ssDNA translocase and a diffusing SSB protein	53
Investigation of nonselective cation permeation through CNGA1 channels by MD simulations	52
Differential nuclear translocation of STAT6 regulates the mechanosensitive immune cell activation	52
Single molecule evidence for linker histone H1 DNA sliding and nucleosomal bypassing regulated by the C-terminal disordered domain	52
Myosin-I facilitates symmetry breaking and promotes the growth of actin ‘comet tails’	50
Modulation of potassium channels preserves temporal fidelity in auditory network models	49
How lipids modulate association of proteins in lipid membranes	49
Examining HIV-1 envelope conformational transitions at high temporal resolution	46
Novel biomolecular fingerprint using graph convolutional networks	43
Intrinsic stiffening and dynamic softening by cholesterol	42
Unraveling the molecular basis of protein search on ssDNA track and binding specificity of the ssDNA sequences	39
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family	38
Inter-domain coordination essential for dengue virus non-structural (5) NS5 interaction with stem loop a (SLA)	38
Origins of protein concentration noise in mitochondria	37
Long-range regulation of cytochrome c binding to bc1 complex	36
A multi-view reflector microscope visualizes six-dimensional single-molecule translational and rotational dynamics with isotropic nanoscale resolution	35
Method for direct measuring antibody affinity in biological sample	35
Myosin binding protein-C: Everything, everywhere, all at once	34

Dynamic association of an assembly platform subcomplex of the bacterial type two secretion system	34
Treatment of osteoarthritis by salvianolic acid derivatives	34
Fluctuating diffusivity of intrinsically disordered proteins	33
cryo-EM structure of tarantula myosin filament: Implications for analysis of myopathy mutations	33
Sarcomere dynamics simulations to uncover mechanisms in hypertrophic cardiomyopathy	33
Expansion microscopy through mechanical force	32
Visualizing both nucleosome disassembly and reassembly during FACT chaperone activity	32
FkpA enhances outer membrane protein folding using an extensive interaction surface	31
The rigidization of water dynamics around proteins: A molecular dynamics study	31
Novel approaches to understand function and explore inhibition within protein-membrane interfaces	30
Experimental methods and mathematical modeling quantify and predict DUSP1 RNA expression dynamics in response to dexamethasone	30
NFATC1 modulation of atrial excitability in zebrafish	30
Investigating Dnase1L3's role in inflammation and redesigning the enzyme to be used as a therapeutic	30
Bacterial brains: How bacteria use electrochemical potentials to solve complex problems	30
Regioselective metabolism of cannabinoids by cytochrome P450 2J2	29
A Bayesian framework for systems model refinement and selection of calcium signaling	29
Using HDX-MS to probe the dynamics and denatured state of GlpG, a helical membrane protein	29
Extreme-value analysis of intracellular cargo transport by motor proteins	29
Solution NMR studies reveal novel CLIC4 chaperone activity with respect to profilin-1	29
Transmembrane determinants of voltage-gating differences between BK (Slo1) and Slo3 channels	29
Sensing membrane voltage by reorientation of dipolar transmembrane peptides	28
Quantitative views of protein dynamics through the computational microscope	28
Drug discovery for heart failure: Targeting the myosin-binding protein C interactions with actin	28
Quantitative fret studies of EphA2-Lyn interactions	27
Storm imaging provides nanodomain-lengthscale observation of coordination between Arabidopsis root hair membrane proteins	27
Optimal efficacy in mosquito-host interaction inhibition by 35-60 kHz animal sounds for malaria control	27
Action at a distance along the microtubule couples kinesin motors	27
High throughput mechanotyping via flow cytometry and DNA sequencing	27
Single-molecule dynamics of ribonuclease H enzymes in Bacillus subtilis	26
Sequence adaptation in various environments across organisms; similar yet different superoxide dismutase	26
Characterizing the APOBEC3B closed to open pathway with weighted ensemble	26
Quantum-enabled ghost imaging for non-invasive imaging of plants	26
RTK-integrin interactions universally modulate αVβ3 integrin-mediated cell adhesion	26
Solution structure of poly(UG) RNA reveals a new fold that drives gene silencing	25
Cataracts and copper: A spectroscopic perspective of copper-induced aggregation of betaB2-crystallin	25
RNA structure controls composition and network dynamics of condensates	25
Probing synaptic distribution and arrangement of native surface AMPAR in mouse brain slices with 3D super-resolution microscopy	25
Analysis and comparison of amorphous & amyloid aggregates of the tumor suppressor p53	25
Investigation of G-protein specificity and biased agonism at the beta-2 adrenergic receptor (β2AR)	25
Functional impact of the interaction between S1 segment and KCNE subunit in the modulation of KCNQ1 channels	25
Nascent-chain interaction networks and their effect on the bacterial ribosome	25
Physical determinants of multiphase organisation in multi-component protein/RNA condensates	25
Insights on plasma membrane asymmetry from studies of asymmetric model membranes	24
A dynamic biomimetic model of the membrane-bound CD4-CD3-TCR complex during pMHC disengagement	24
2-d liquid-liquid phase separation of GM130 Golgin protein bound to supported bilayer	24
Compounds specifically enhance IKs by modulating VSD-pore coupling	24
FRETsael: Nanometer localization of biomolecular interactions using fluorescence lifetime imaging	24
Amplification-free rapid detection of viral genomes at single molecule level	24
Biophysical insights into OR2T7: Investigation of a potential prognostic marker for glioblastoma	24
Flexibility of flanking DNA is a key determinant of transcription factor affinity for the core motif	23

BPS2025 - Functional assessment of recombinant human alpha-cardiac myosin and the effect of atrial arrhythmia mutations	23
Discovering inhibitors against human norovirus protein target 3CLpro using ligand-protein docking	23
Thank You to Our Reviewers	23
The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM	23
Active-learning-guided and high-throughput synthesis of membrane proteins	23
Vinculin transmits high-level integrin tensions that are dispensable for focal adhesion formation	23
De novo design of a DNA-binding protein capable of multi-site recognition	23
From loops to stacks: Early steps in the DNA folding pathway by protamine	23
Conformational free energy landscape of sorting signal peptides in complex with bacterial sortases	23
Structural studies of human serum albumin using cryo-EM up to 0.38 nm resolution	23
Dissecting ER stress signaling with live-cell single-molecule imaging and optogenetics	23
Reversing aberrant phase transitions of ALS-linked disease protein FUS with RNA	23
A structural model of TCR-pMHC catch bonding	22
The Piezo1 channel interacts with the transmembrane channel Tmc1 to exert mechanoelectrical transducer (MET) functions	22
Temperature dependence of α-crystallin membrane binding	22
Machine learning for prediction of protein function and elucidation of enzyme function and control	22
Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation	22
ERK activation waves are key drivers in the mechanical cell competition that leads to collective onslaught of bacterially infected cells	22
Investigating how the anionic lipid, BMP, plays a crucial role in the initation of SARS-CoV-2 fusion	22
Enhancing sarcomere function and length-dependent activation in engineered human myocardium via triiodothyronine and dexamethasone treatment	22
The N-terminus is not the Ca2+-regulated gate in CALHM1 channels	22
Stress-induced BAG3 cleavage and its effects on sarcomere contractile functions	21
Structural basis for the intracellular regulation of ferritin degradation	21
Biochemical signaling encoded in emergent properties	21
Elucidation of a dynamic interplay between beta-adrenergic receptors, its agonists, and stimulatory G protein	21
Cardiac dysfunction in a mouse model of colon cancer cachexia is due to sarcomeric changes	21
Extracting conformational heterogeneity from 2D and 3D cryo-EM data	21
Multi-GPU-powered UNRES package for physics-based coarse-grained simulations of structure, dynamics, and thermodynamics of protein systems at biological size- and timescales	21
Quantifying water rigidization near protein surfaces	21
Understanding transport processes with simulation	21
The cancer mucin barrier plays a multifunctional role in providing sustained physical resistance to natural killer cell attack	20
Graded cleavage of elastic titin in living mouse hearts reveals the role of titin stiffness for cardiac contractility	20
Distinct spatiotemporal dynamics of calmodulin genes in cardiac myocytes under beta-adrenergic stimulation	20
Spatial distribution of adhesion force generation in human cardiomyocytes	20
Druggable and allosteric pocket prints of G-protein coupled receptors	20
Does it stick? Long-term outcomes for biology majors from introductory physics for the life sciences	20
Comparing photosynthetic metabolite free energy and permeability across bacterial microcompartment shell proteins	20
Fluorescent drug analogs to study drug-target interactions in intact cells	20
Measuring the effects of infection on disordered viral proteins	20
Phase separation of myosin-15 and centrin-2 contributes to stereocilia tip density formation	20
Spelunking with potassium: Functional analysis of the water tunnel in the potassium pump KdpFABC	19
Configuring extracellular matrix architectures with dynamic forces	19
Cryo-EM structures of nanodisc reconstituted ligand-gated ion channel GLIC in various conformations reveal state-dependent protein-lipid interactions and gating mechanism	19
Student usage and perceptions of ChatGPT: The good, the bad, and the ugly	19
Structural studies of connexin 32 gap junction channels by cryo-EM	19
Allosteric mechanisms of transcriptional control in FXR	19
Towards revealing functionally relevant conformational dynamics of the C-terminal tail of β-arrestin	19
Alchemical free-energy simulations support the formation of the sarco-endoplasmic reticulum calcium pump (SERCA) inhibitory complex from the phospholamban pentamer	19
Targeting anti-aggregation and anti-oxidation of amyloid deposits for therapeutic intervention of Alzheimer’s using machine learning-enhanced molecular docking	19
Membrane composition affects binding and insertion of the influenza virus fusion peptide	19
Engineering inducible dipoles to develop better fluorescent biosensors	18
Structural insights into a new class of noncovalent, potent, and highly selective G protein-coupled receptor kinase 5 inhibitors	18
Cryo-electron microscopy structure of human Kir2.1 potassium channel bound to the activator PIP2 reveals its gating mechanism	18
Characterizing salt and humidity induced 3D electrospun matrices	18
Molecular insights into the role of SNX1-SNX5 heterodimer in endosomal trafficking	18
Computational analyses of SERCA, phospholamban, and sarcolipin complexes	18
Chloride intracellular channels regulate spermatogenesis	18
Molecular kinetics of polycomb body formation during development	18
Bind-and-bend model for DNA looping	18
Investigating the presence of carbon quantum dots in the inhalable aerosol from electronic cigarettes	18
Structural basis of closed groove scrambling by a TMEM16 protein	18
Co-VET: Correlative-voltage imaging and cryo-electron tomography	18
X-ray single molecule observations using SR and laboratory source	18
Structural basis of distinct signaling kinetics of calcitonin-like receptor peptide ligands	18
Self-organization of ovarian cancer organoids revealed by 3D image segmentation and phase-field model	18
Quantification of NINJ1-mediated membrane rupture	17
Centromere and telomere dynamics reveal heterogeneity of the human cell nucleus	17
β-Barrel formation examined through β-hairpin interactions with lipid vesicles	17
Elucidating the spatial distribution of genomic and epigenetic lamina-associated domains implicated in adipocyte differentiation and hypertrophy	17
Active and inactive pathways in the kinetic mechanism of the G51V retinitis pigmentosa mutant photoreaction	17
Unraveling the dance of phosphoproteins at adhesion planes: Modeling YAP phosphorylation by a particle-based stochastic model	17
Regulatory mechanisms of kinesin function at varying pH	17
Modeling toxin effects on sodium channels in neurons using real-time dynamic clamp	17
The plasma membrane as an emulsion: A rational basis for “rafts,” and a different look at them	17
BAG3 differentially responds to acute and chronic stress via a post-transcriptional mechanism	17
Small-angle x-ray scattering investigation of the integration of free fatty acids in polysorbate 20 micelles	17
Mapping the tension-gated transition of the bacterial MscS with MD simulations	17
Metabolic regulation by enzyme polymerization	17
NMR studies of the complex between the small GTPase Arf1 and segmentally labeled ARFGAP ASAP1 at the membrane surface of nanodiscs	17
Open software for analyzing lipid-resolved mechanics of complex bilayers	17

Predicting side chain conformations in folded proteins by AlphaFold: Perspective and challenges	17
DNA-RNA hybrid G-quadruplex tends to form near the 3′ end of telomere overhang	16
Calculation of solvation force in molecular dynamics simulation by deep-learning method	16
Properties of a tardigrade desiccation-tolerance protein aerogel	16
BPS2025 - Reconstitution and analysis of membrane proteins in a micro-patterned model membrane	16
BPS2025 - A de novo designed miniprotein prevents Ca2+-feedback of CaV1 channels	16
Engineering of the high-affinity chemokine CXCL13 to screen CXCR5 antagonists to treat cancer and autoimmune diseases	16
DNA and mRNA as molecular speed bumps in Escherichia coli’s cytoplasm	16
BPS2025 - Physiological and pathological role of tau’s proline rich region in microtubule assembly	16
BPS2025 - Antibody-induced changes in host cell membrane dynamics during assembly trigger tuning of influenza A virion shape	16
BPS2025 - Real-time tracking of the structural dynamics of adenylate kinase	16
Probing the mechanisms of low-voltage activation in T-type CaV3.1 calcium channels	16
Characteristic frequencies of localized stress relaxation in scaling-law rheology of living cells	16
Collective functionalities emerging in microbial active matter	16
BPS2025 - Cryo-EM reveals binding and activation of the ryanodine receptor by multiple statin molecules	16
BPS2025 - PPM1D phosphatase: Crystal structure, mechanistic studies, and structure-based virtual screening	16
BPS2025 - GIRK2 drug repurposing screen identifies treatment options for patients suffering from extremely rare diseases	15
BPS2025 - The effects of pH on condensate and cortex formation	15
BPS2025 - Dynamics of IDPs in biomolecular condensates from massive all-atom explicit-solvent simulations	15
BPS2025 - How α-parvalbumin mutations impact calcium-binding affinity in the presence and absence of its AB-domain	15
BPS2025 - High-spatial-resolved heat manipulating membrane heterogeneity alters cellular migration and signaling	15
BPS2025 - Toxic competitors of phospholamban may contribute to dysregulation of SERCA in heart failure	15
BPS2025 - Monitoring conformational dynamics and interactions of p53-TAD via an MspA nanopore	15
BPS2025 - On the cooperativity of fold-switching sequences	15
BPS2025 - Mesoscale properties of protein clusters determine the size and nature of liquid-liquid phase separation	15
BPS2025 - Drug block near lipid-binding fenestrae in LRRC8/volume-regulated anion channels	15
BPS2025 - A tool for determining the release rate and number of mRNA molecules released from lipid nanoparticles in cells based on fluorescence readout and simulation	15
BPS2025 - Differential modulation of beta-cardiac myosin conformations by cardiomyopathy-associated mutations in the converter domain	15
BPS2025 - Minimal protein components for chromatin replication-coupled symmetric histone recycling	15
BPS2025 - Direct quantification of human αβ-tubulin binding kinetics at microtubule ends reveals nucleotide regulation of end-binding affinity	15
BPS2025 - Knowledge-based coarse-grained model for multi-protein assembly: Effects of electrostatic contributions to protein-protein interfaces	15
BPS2025 - Single-molecule measurements of p44-enhanced XPD helicase activity	15
BPS2025 - Electromagnetic dynamics and characterization of cancer cell-magnetic bead interactions	15
BPS2025 - Cardiac voltage-gated sodium channels are a common pathological pathway in COVID-19-induced arrhythmia	15
BPS2025 - COBY: An advanced tool for accurate creation of coarse-grained simulation systems	15
BPS2025 - Optimization of therapeutic T cells through biophysical modeling	15
BPS2025 - Mechanisms underlying distinct cardiac arrhythmia phenotypes caused by calmodulin mutation D132E in Calm2 and Calm3 genes	15
BPS2025 - DNA nanotechnology for large-scale hybrid nanopore integration	15
BPS2025 - Complex DNA effects on polyphosphate condensate growth and architecture	15
BPS2025 - Calcium-mediated structural dynamics and zinc sequestration in S100A12: Insights from NMR and molecular dynamics studies	15
BPS2025 - Deciphering the phase behavior of model membranes composed of branched-chain bacterial lipids	14
BPS2025 - Stepping dynamics of dynein characterized by MINFLUX	14
BPS2025 - Molecular mechanisms of keratin-based polymer materials for bioengineering applications	14
BPS2025 - A computational model of angiotensin II receptor type 1 dynamics: Insights into vascular regulation	14
BPS2025 - Developing a model to study iPSC-CM integration with human heart tissue	14
BPS2025 - Cardiotoxic effects of synthetic cannabinoid receptor agonists: Inhibition of hERG and Kv7.1/KCNE1 channels with proposed hERG binding site	14
BPS2025 - Time-resolved fluorometry reveals novel insights into small molecule drug interactions with the HCN channel voltage sensor	14
BPS2025 - Beyond the core: investigating how accessory regions of PDZ-RhoGEF regulate its catalytic core in RhoA activation	14
BPS2025 - Molecular mechanism of BMP signaling inhibition by twisted gastrulation	14
BPS2025 - Studying the interaction of Kv1.3-specific inhibitors with Kv1.3-Kv1.x heterotetrameric ion channels	14
BPS2025 - Combination of cell penetrating peptides affects protein transportation efficiency	14
BPS2025 - Deciphering the role of SNARE transmembrane domain palmitoylation in neurotransmitter release	14
BPS2025 - Generative computational modeling with CellPACK reveals interplay between rules of intracellular organization and geometry in hiPSCs	14
BPS2025 - RSV fusion protein conformation transition pathway from prefusion to postfusion	14
BPS2025 - Simulation of biopolymerization on surfaces—implications for biogenesis	14
BPS2025 - Glycan-mediated regulation of IgG1 Fc-CD16a interactions: Insights from all-atom simulations	14
BPS2025 - Comparison of multi-axes sample handler devices for multiview imaging of lung organoids	14
BPS2025 - Inhibition of amyloid beta fibrillation by a heparin binding protein Midkine—a combined spectroscopy, microscopy, and proteomics study	14
BPS2025 - Developing an adaptable toolbox for measuring ion channel stoichiometry using stepwise photobleaching	14
BPS2025 - Estimating antibody frequencies in humans using a structure-based approach	14
BPS2025 - A conserved “electrostatic cassette” and an alternatively spliced proline-rich motif enable compaction and isoform-specific autoinhibition by the intrinsically disordered variable domain of	13
BPS2025 - Characterization of seven new K+ channel blocker peptides of Centruroides bonito revealed that α-KTx 2.24 has a picomolar affinity for Kv1.2	13
BPS2025 - Synthetic intrinsically disordered proteins that exhibit phase separation	13
BPS2025 - Effective charge of RNA in a fully packaged viral particle	13
BPS2025 - Replication organelles of arboviruses through the lens of a cryo-electron microscope	13
BPS2025 - Electromechanical coupling in diabetic human atria	13
BPS2025 - Investigating the modulation of Kv1.3 channel inactivation by KCNE4	13
BPS2025 - Structure and dynamics of the p53-MDMX-CK1α complex	13
BPS2025 - Characterizing the potassium binding site in human excitatory amino acid transporter	13
BPS2025 - TMEM175 chronicles: A journey from high throughput screening to lysosome	13
BPS2025 - Phospholipase D-derived phosphatidic acid regulates multivesicular body fusion	13
BPS2025 - Inferring single-cell dynamics of a molecular reporter from unlabeled live-cell light microscopy data analyzed with delay embedding	13
BPS2025 - Molecular pharmacology of human P2X7 receptor ligands visualized by cryo-EM	13
BPS2025 - Systematic embedding of biomechanics within dynamical graph grammars with application to actin networks in dendritic spine heads	13
BPS2025 - Molecular dynamics insights into lipid and nucleotide modulation of P-glycoprotein transport cycle	13
BPS2025 - Cryoprotectant-free lamella preparation of plant and animal tissue for cryo-electron tomography	13
BPS2025 - Structural dynamics study on mosaic spike heterotrimer provides insights into polyvalent vaccine immunogen display	13
BPS2025 - Protein intrinsically disordered regions have nonrandom, modular architectures that influence conformation and function	13
BPS2025 - Entropically generated SNARE linker forces maintain a maximally fusogenic, partially unzippered state and drive fusion	13
BPS2025 - Integrating accelerated molecular simulations and AI to elucidate Cas9 specificity factors	13
BPS2025 - Deciphering the relationship between form and inherent electrochemical function during the phase transition of Aβ peptides	13
BPS2025 - Mavacamten and omecamtiv mecarbil modulate the structure of the interacting-heads motif by inducing distinct subfragment-2 conformations	13
BPS2025 - Investigation of microtubule-CRMP2-isoforms interaction using high-speed atomic force microscopy	13
BPS2025 - Piezo and transciption factor auxiliary proteins regulate Piezo channels in sensory and non-sensory cell types	13
BPS2025 - The inaugural flatiron heterogeneity community challenge	13
BPS2025 - Anticooperative substrate binding in the yeast BC1 complex	13
BPS2025 - Activation of TMEM16E scramblase induces ligand-independent growth factor receptor signaling and macropinocytosis for membrane repair	13
BPS2025 - Assessing the role of sodium channel fast inactivation in the mechanism of aryl/acyl-sulfonamide inhibition	13
BPS2026 – High-speed multiplexed DNA-paint imaging of nuclear organization using an expanded sequence repertoire	12
BPS2026 – Regulation of inositol 1,4,5-trisphosphate receptors: Controlling Ca2+ signals in time and space	12
BPS2026 – High resolution electron density of protein-ligand complexes from solution scattering	12
BPS2026 – Polymersome membrane disruption mediated by plasmonic nanoparticles under pulsed laser irradiation	12
BPS2026 – GMO-based cubic phase lipid nanoparticles facilitate gene delivery to adipocytes	12
BPS2026 – Uncovering regulation of bifunctional enzymes with opposing activities	12
BPS2026 – A machine learning framework for predicting CD4+ T cell receptors’ therapeutic efficacy from structural and dynamical features	12