Biophysical Journal

Article	Citations
Insights into DNA solvation found in protein-DNA structures	199
Characteristic frequencies of localized stress relaxation in scaling-law rheology of living cells	65
A dynamic biomimetic model of the membrane-bound CD4-CD3-TCR complex during pMHC disengagement	56
Centromere and telomere dynamics reveal heterogeneity of the human cell nucleus	56
Open-state structure and pore gating mechanism of the cardiac sodium channel	52
Structural characterization of MH/CCD NTD mutations in skeletal ryanodine receptor by cryo-EM	48
Small-angle x-ray scattering investigation of the integration of free fatty acids in polysorbate 20 micelles	47
Oblique circle method for measuring the curvature and twist of mitotic spindle microtubule bundles	47
Does it stick? Long-term outcomes for biology majors from introductory physics for the life sciences	46
Local interactions and transient secondary structures govern backbone dynamics of intrinsically disordered proteins	43
Unraveling the dance of phosphoproteins at adhesion planes: Modeling YAP phosphorylation by a particle-based stochastic model	43
TMEM16 scramblases thin the membrane to enable lipid scrambling	42
Thank You to Our Reviewers	40
Targeting anti-aggregation and anti-oxidation of amyloid deposits for therapeutic intervention of Alzheimer’s using machine learning-enhanced molecular docking	40
BPS2025 - Functional assessment of recombinant human alpha-cardiac myosin and the effect of atrial arrhythmia mutations	39
BPS2025 - Recovering true FRET efficiencies from smFRET investigations requires triplet state mitigation	39
BPS2025 - Integrated data acquisition and real-time parameter-free reconstruction for cryo-ET	39
BPS2025 - Systematic embedding of biomechanics within dynamical graph grammars with application to actin networks in dendritic spine heads	38
BPS2025 - Activation of TMEM16E scramblase induces ligand-independent growth factor receptor signaling and macropinocytosis for membrane repair	36
BPS2025 - Direct quantification of human αβ-tubulin binding kinetics at microtubule ends reveals nucleotide regulation of end-binding affinity	36
BPS2025 - Generative computational modeling with CellPACK reveals interplay between rules of intracellular organization and geometry in hiPSCs	36
BPS2025 - Deciphering the relationship between form and inherent electrochemical function during the phase transition of Aβ peptides	35
BPS2025 - Optimization of therapeutic T cells through biophysical modeling	35
BPS2025 - On the cooperativity of fold-switching sequences	35
BPS2025 - Deciphering the role of SNARE transmembrane domain palmitoylation in neurotransmitter release	34

BPS2025 - Inhibition of amyloid beta fibrillation by a heparin binding protein Midkine—a combined spectroscopy, microscopy, and proteomics study	33
BPS2025 - Complex DNA effects on polyphosphate condensate growth and architecture	33
BPS2025 - The effects of pH on condensate and cortex formation	33
BPS2025 - RSV fusion protein conformation transition pathway from prefusion to postfusion	33
BPS2025 - Networked interactions in biomolecular condensates formed by disordered proteins reveal structural and dynamic inhomogeneities	33
BPS2025 - Phylogenetic corrections and higher-order sequence statistics in protein families: The Potts model and MSA transformer showdown	33
BPS2025 - High-spatial-resolved heat manipulating membrane heterogeneity alters cellular migration and signaling	33
BPS2025 - Structural dynamics study on mosaic spike heterotrimer provides insights into polyvalent vaccine immunogen display	33
BPS2025 - Dynamics of IDPs in biomolecular condensates from massive all-atom explicit-solvent simulations	33
BPS2025 - Comparison of multi-axes sample handler devices for multiview imaging of lung organoids	32
BPS2025 - Integrating accelerated molecular simulations and AI to elucidate Cas9 specificity factors	32
BPS2025 - GIRK2 drug repurposing screen identifies treatment options for patients suffering from extremely rare diseases	31
BPS2025 - Toxic competitors of phospholamban may contribute to dysregulation of SERCA in heart failure	31
BPS2025 - Electromagnetic dynamics and characterization of cancer cell-magnetic bead interactions	31
BPS2025 - Glycan-mediated regulation of IgG1 Fc-CD16a interactions: Insights from all-atom simulations	30
BPS2025 - Real-time tracking of the structural dynamics of adenylate kinase	28
BPS2025 - Mavacamten and omecamtiv mecarbil modulate the structure of the interacting-heads motif by inducing distinct subfragment-2 conformations	28
BPS2025 - Structure and dynamics of the p53-MDMX-CK1α complex	28
BPS2025 - Cardiotoxic effects of synthetic cannabinoid receptor agonists: Inhibition of hERG and Kv7.1/KCNE1 channels with proposed hERG binding site	28
BPS2025 - TMEM175 chronicles: A journey from high throughput screening to lysosome	28
BPS2025 - Molecular pharmacology of human P2X7 receptor ligands visualized by cryo-EM	28
BPS2025 - Protein intrinsically disordered regions have nonrandom, modular architectures that influence conformation and function	28
BPS2025 - Phospholipase D-derived phosphatidic acid regulates multivesicular body fusion	27
BPS2025 - Cryoprotectant-free lamella preparation of plant and animal tissue for cryo-electron tomography	27
BPS2025 - Monitoring conformational dynamics and interactions of p53-TAD via an MspA nanopore	27
BPS2025 - Studying the interaction of Kv1.3-specific inhibitors with Kv1.3-Kv1.x heterotetrameric ion channels	26
BPS2025 - Characterization of seven new K+ channel blocker peptides of Centruroides bonito revealed that α-KTx 2.24 has a picomolar affinity for Kv1.2	26
BPS2025 - Investigating the modulation of Kv1.3 channel inactivation by KCNE4	26
BPS2025 - Anticooperative substrate binding in the yeast BC1 complex	25
BPS2025 - Differential modulation of beta-cardiac myosin conformations by cardiomyopathy-associated mutations in the converter domain	25
BPS2025 - Synthetic intrinsically disordered proteins that exhibit phase separation	25
BPS2025 - Calcium-mediated structural dynamics and zinc sequestration in S100A12: Insights from NMR and molecular dynamics studies	25
BPS2025 - Developing a model to study iPSC-CM integration with human heart tissue	25
BPS2025 - Native structure of mosquito salivary protein complexes unveils molecular mechanisms of malaria transmission	24
BPS2025 - Developing an adaptable toolbox for measuring ion channel stoichiometry using stepwise photobleaching	24
BPS2025 - Molecular dynamics insights into lipid and nucleotide modulation of P-glycoprotein transport cycle	24
BPS2025 - The inaugural flatiron heterogeneity community challenge	24
BPS2025 - Regulated confinement patterns elicit the organized collective migration of rear cells	24
BPS2025 - Single-molecule measurements of p44-enhanced XPD helicase activity	23
BPS2025 - A tool for determining the release rate and number of mRNA molecules released from lipid nanoparticles in cells based on fluorescence readout and simulation	23
BPS2025 - Molecular mechanisms of keratin-based polymer materials for bioengineering applications	23
BPS2025 - Replication organelles of arboviruses through the lens of a cryo-electron microscope	23
BPS2025 - Entropically generated SNARE linker forces maintain a maximally fusogenic, partially unzippered state and drive fusion	23
BPS2025 - COBY: An advanced tool for accurate creation of coarse-grained simulation systems	23
BPS2025 - Minimal protein components for chromatin replication-coupled symmetric histone recycling	23
BPS2025 - Simulation of biopolymerization on surfaces—implications for biogenesis	23
BPS2025 - Time-resolved fluorometry reveals novel insights into small molecule drug interactions with the HCN channel voltage sensor	23
BPS2025 - Investigation of microtubule-CRMP2-isoforms interaction using high-speed atomic force microscopy	23
BPS2025 - Ultrafast fluorescence lifetimes of NADH via FLIM	23
BPS2025 - Mechanisms underlying distinct cardiac arrhythmia phenotypes caused by calmodulin mutation D132E in Calm2 and Calm3 genes	22

Reversing aberrant phase transitions of ALS-linked disease protein FUS with RNA	22
β-Barrel formation examined through β-hairpin interactions with lipid vesicles	22
BPS2025 - Effective charge of RNA in a fully packaged viral particle	22
Cryo-EM structures of nanodisc reconstituted ligand-gated ion channel GLIC in various conformations reveal state-dependent protein-lipid interactions and gating mechanism	22
Druggable and allosteric pocket prints of G-protein coupled receptors	22
BPS2025 - Characterizing the potassium binding site in human excitatory amino acid transporter	22
BPS2025 - Cryo-EM structures of mitochondrial RNA editing catalytic complexes from Trypanosoma brucei	22
Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation	22
Spelunking with potassium: Functional analysis of the water tunnel in the potassium pump KdpFABC	21
Comparing photosynthetic metabolite free energy and permeability across bacterial microcompartment shell proteins	21
Regulatory mechanisms of kinesin function at varying pH	21
A structural model of TCR-pMHC catch bonding	21
Phase separation of myosin-15 and centrin-2 contributes to stereocilia tip density formation	21
Self-organization of ovarian cancer organoids revealed by 3D image segmentation and phase-field model	21
Multi-GPU-powered UNRES package for physics-based coarse-grained simulations of structure, dynamics, and thermodynamics of protein systems at biological size- and timescales	21
Investigating how the anionic lipid, BMP, plays a crucial role in the initation of SARS-CoV-2 fusion	21
Structural insights into a new class of noncovalent, potent, and highly selective G protein-coupled receptor kinase 5 inhibitors	21
De novo design of a DNA-binding protein capable of multi-site recognition	20
Structural studies of connexin 32 gap junction channels by cryo-EM	20
Graded cleavage of elastic titin in living mouse hearts reveals the role of titin stiffness for cardiac contractility	20
Elucidating the spatial distribution of genomic and epigenetic lamina-associated domains implicated in adipocyte differentiation and hypertrophy	20
Temperature dependence of α-crystallin membrane binding	20
BAG3 differentially responds to acute and chronic stress via a post-transcriptional mechanism	20
Computational analyses of SERCA, phospholamban, and sarcolipin complexes	20
Quantification of NINJ1-mediated membrane rupture	20
Engineering inducible dipoles to develop better fluorescent biosensors	20
Mapping the tension-gated transition of the bacterial MscS with MD simulations	19
X-ray single molecule observations using SR and laboratory source	19
Quantifying water rigidization near protein surfaces	19
Machine learning for prediction of protein function and elucidation of enzyme function and control	19
Co-VET: Correlative-voltage imaging and cryo-electron tomography	19
Enhancing sarcomere function and length-dependent activation in engineered human myocardium via triiodothyronine and dexamethasone treatment	19
Allosteric mechanisms of transcriptional control in FXR	19
Conformational preferences of disordered proteins in biomolecular condensates	19
Membrane composition affects binding and insertion of the influenza virus fusion peptide	19
Molecular kinetics of polycomb body formation during development	19
Metabolic regulation by enzyme polymerization	19
Molecular insights into the role of SNX1-SNX5 heterodimer in endosomal trafficking	19
NMR studies of the complex between the small GTPase Arf1 and segmentally labeled ARFGAP ASAP1 at the membrane surface of nanodiscs	18
Investigating the presence of carbon quantum dots in the inhalable aerosol from electronic cigarettes	18
Student usage and perceptions of ChatGPT: The good, the bad, and the ugly	18
Unique molecular features in the activation of the AT1 receptor by chemical and mechanical stimuli	18
Quantitative views of protein dynamics through the computational microscope	18
Action at a distance along the microtubule couples kinesin motors	18
High throughput mechanotyping via flow cytometry and DNA sequencing	18
Insights on plasma membrane asymmetry from studies of asymmetric model membranes	18
The cancer mucin barrier plays a multifunctional role in providing sustained physical resistance to natural killer cell attack	18
Characterizing salt and humidity induced 3D electrospun matrices	18
Structural basis of closed groove scrambling by a TMEM16 protein	18
The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM	18
The Piezo1 channel interacts with the transmembrane channel Tmc1 to exert mechanoelectrical transducer (MET) functions	18
Optimal efficacy in mosquito-host interaction inhibition by 35-60 kHz animal sounds for malaria control	18
Quantitative fret studies of EphA2-Lyn interactions	18
Biochemical signaling encoded in emergent properties	18
The N-terminus is not the Ca2+-regulated gate in CALHM1 channels	18
Spatial distribution of adhesion force generation in human cardiomyocytes	18
Active-learning-guided and high-throughput synthesis of membrane proteins	18
Measuring the effects of infection on disordered viral proteins	18
Bind-and-bend model for DNA looping	18
Engineering of the high-affinity chemokine CXCL13 to screen CXCR5 antagonists to treat cancer and autoimmune diseases	18
Drug discovery for heart failure: Targeting the myosin-binding protein C interactions with actin	18
Storm imaging provides nanodomain-lengthscale observation of coordination between Arabidopsis root hair membrane proteins	18
Probing synaptic distribution and arrangement of native surface AMPAR in mouse brain slices with 3D super-resolution microscopy	17
Compounds specifically enhance IKs by modulating VSD-pore coupling	17
Sequence adaptation in various environments across organisms; similar yet different superoxide dismutase	17
RNA structure controls composition and network dynamics of condensates	17
Investigation of G-protein specificity and biased agonism at the beta-2 adrenergic receptor (β2AR)	17
Solution structure of poly(UG) RNA reveals a new fold that drives gene silencing	17
2-d liquid-liquid phase separation of GM130 Golgin protein bound to supported bilayer	17
RTK-integrin interactions universally modulate αVβ3 integrin-mediated cell adhesion	17
Characterizing the APOBEC3B closed to open pathway with weighted ensemble	17
Physical determinants of multiphase organisation in multi-component protein/RNA condensates	17
Nascent-chain interaction networks and their effect on the bacterial ribosome	17
Functional impact of the interaction between S1 segment and KCNE subunit in the modulation of KCNQ1 channels	17
Cataracts and copper: A spectroscopic perspective of copper-induced aggregation of betaB2-crystallin	17
Quantum-enabled ghost imaging for non-invasive imaging of plants	17
Single-molecule dynamics of ribonuclease H enzymes in Bacillus subtilis	17
Analysis and comparison of amorphous & amyloid aggregates of the tumor suppressor p53	17
Empagliflozin and ROS-CaMKII-late sodium current signaling in heart failure with preserved ejection fraction	16
Lipids and microparticles, physical characterization as a lung-contamination model	16

Myosin-I facilitates symmetry breaking and promotes the growth of actin ‘comet tails’	16
How lipids modulate association of proteins in lipid membranes	16
Single molecule evidence for linker histone H1 DNA sliding and nucleosomal bypassing regulated by the C-terminal disordered domain	16
Dissecting metabotropic glutamate receptor activation by single molecule FRET using minimally invasive labeling strategies	16
Diversity and molecular mechanisms of channelrhodopsins	16
Measurements of cholesterol chemical potential constrain models of cholesterol-phosphatidylcholine interactions	16
Differential nuclear translocation of STAT6 regulates the mechanosensitive immune cell activation	16
Modulation of potassium channels preserves temporal fidelity in auditory network models	16
Disease mutations of human α3 Na+/K+-ATPase define extracellular Na+ binding/occlusion kinetics at ion binding site III	16
Amplification-free rapid detection of viral genomes at single molecule level	16
“Helicase” activity promoted through dynamic interactions between a ssDNA translocase and a diffusing SSB protein	16
Investigation of nonselective cation permeation through CNGA1 channels by MD simulations	16
Examining HIV-1 envelope conformational transitions at high temporal resolution	16
Bacterial brains: How bacteria use electrochemical potentials to solve complex problems	15
Intrinsic stiffening and dynamic softening by cholesterol	15
Visualizing both nucleosome disassembly and reassembly during FACT chaperone activity	15
Treatment of osteoarthritis by salvianolic acid derivatives	15
The rigidization of water dynamics around proteins: A molecular dynamics study	15
Dynamic association of an assembly platform subcomplex of the bacterial type two secretion system	15
Experimental methods and mathematical modeling quantify and predict DUSP1 RNA expression dynamics in response to dexamethasone	15
Method for direct measuring antibody affinity in biological sample	15
Long-range regulation of cytochrome c binding to bc1 complex	15
FkpA enhances outer membrane protein folding using an extensive interaction surface	15
Inter-domain coordination essential for dengue virus non-structural (5) NS5 interaction with stem loop a (SLA)	15
Expansion microscopy through mechanical force	15
Novel biomolecular fingerprint using graph convolutional networks	15
Sarcomere dynamics simulations to uncover mechanisms in hypertrophic cardiomyopathy	15
Novel approaches to understand function and explore inhibition within protein-membrane interfaces	15
A multi-view reflector microscope visualizes six-dimensional single-molecule translational and rotational dynamics with isotropic nanoscale resolution	15
NFATC1 modulation of atrial excitability in zebrafish	15
Origins of protein concentration noise in mitochondria	15
Investigating Dnase1L3's role in inflammation and redesigning the enzyme to be used as a therapeutic	15
Unraveling the molecular basis of protein search on ssDNA track and binding specificity of the ssDNA sequences	15
Fluctuating diffusivity of intrinsically disordered proteins	15
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family	15
cryo-EM structure of tarantula myosin filament: Implications for analysis of myopathy mutations	15
Myosin binding protein-C: Everything, everywhere, all at once	15
Mechanically induced conformational transition of spectrin in the mammalian cell cortex	15
Structural basis for the intracellular regulation of ferritin degradation	14
Collective functionalities emerging in microbial active matter	14
Solution NMR studies reveal novel CLIC4 chaperone activity with respect to profilin-1	14
Using HDX-MS to probe the dynamics and denatured state of GlpG, a helical membrane protein	14
Alchemical free-energy simulations support the formation of the sarco-endoplasmic reticulum calcium pump (SERCA) inhibitory complex from the phospholamban pentamer	14
Open software for analyzing lipid-resolved mechanics of complex bilayers	14
Elucidation of a dynamic interplay between beta-adrenergic receptors, its agonists, and stimulatory G protein	14
Extracting conformational heterogeneity from 2D and 3D cryo-EM data	14
Extreme-value analysis of intracellular cargo transport by motor proteins	14
Critical regulation of the voltage-gated sodium channel, Nav1.4, by PIP2	14
Modeling toxin effects on sodium channels in neurons using real-time dynamic clamp	14
Distinct spatiotemporal dynamics of calmodulin genes in cardiac myocytes under beta-adrenergic stimulation	14
From loops to stacks: Early steps in the DNA folding pathway by protamine	14
Cardiac dysfunction in a mouse model of colon cancer cachexia is due to sarcomeric changes	14
Understanding transport processes with simulation	14
The plasma membrane as an emulsion: A rational basis for “rafts,” and a different look at them	14
Regioselective metabolism of cannabinoids by cytochrome P450 2J2	14
Stress-induced BAG3 cleavage and its effects on sarcomere contractile functions	14
Configuring extracellular matrix architectures with dynamic forces	14
Towards revealing functionally relevant conformational dynamics of the C-terminal tail of β-arrestin	14
Dissecting ER stress signaling with live-cell single-molecule imaging and optogenetics	14
Computational study of inhibitory mechanisms for Janus iron oxide nanoparticles on amyloid aggregations	13
Molecular mechanisms of the mitochondrial calcium uniporter part II: evidence against MICU1 as a uniporter potentiator	13
Mechano-chemo-electric signaling in heart: how local blood flow is regulated	13
Exploring kinetically controlled protein solubility under physiologically relevant conditions	13
DNA-RNA hybrid G-quadruplex tends to form near the 3′ end of telomere overhang	13
Sensing membrane voltage by reorientation of dipolar transmembrane peptides	13
Structural basis of distinct signaling kinetics of calcitonin-like receptor peptide ligands	13
In situ detection of single microRNA molecules by transient hybridization utilizing FRET-based probes	13
Modulation of membrane fusion using a novel fusogenic system composition	13
Structure, dynamics and nanomechanics of wild-type and alpha-variant SARS-CoV-2 virions	13
Impact of mutations near the SARS-CoV-2 furin-cleavage site on viral infectivity	13
Molecular dynamics modeling of polystyrene functionalized carbon nanotubes	13
Disparate effects of CaM N- and C-lobe CPVT-linked mutations on SK channel-CaM assembly	13
Orthogonal control of DNA nanoswitches with mixed physical and biochemical cues	13
Revisiting lipid II binding by teixobactin oligomers using membrane MD simulations	13
Single-molecule dissection of coupling mechanisms between cofactor binding and folding of a complex protein	13
Kv3.1 channel expression determines the spike waveform in vocal-motor neurons	13
Nanoscale organization of ryanodine receptor distribution and phosphorylation pattern determines the dynamics of calcium sparks	13
Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels	13
Intramembrane serine protease catalysis in different physical environments	13
Elucidating the role of membrane tension in cellular processes using continuum modeling	13
Integrative structural dynamics of calmodulin showcases sequence-to-function	13
Subunit conformation modulates the concentration of CO2 in the active site of the most efficient carboxylase	13
The effects of biomolecular crowding on the behaviour of polymyxin antibiotics within the E. coli cell envelope	13
Analysis of PI(4,5)P2 metabolism from the perspective of different cell types	13
Measuring the barrier function of skeletal muscle in individuals with muscular dystrophy	13
A disordered linker with “something” on its N-terminus drives the allostery in the urokinase-type plasminogen activator (uPA)	13
Perm-waved human hair: a thermorheologically complex shape memory composite	13
The multiple dimensions of lncRNAS: how 3D structure determines meg3 function	13
Ion-specific partition energies in a heparan sulfate glycocalyx model	13
Superresolution imaging of native surface AMPA receptors in brain tissue	13
Phosphomimetic mutations in the C-terminal basic region of troponin T increases actin filament activity	13
Cell invasion involves membrane-active and calmodulin-binding properties of the CyaA toxin translocation domain	13
Functional and structural characterization of a novel pH-modulated open state of a pentameric ligand-gated ion channel	12
Effect of cigarette smoke on immune response to pollen allergen in the lung	12
Comparison of left versus right ventricular contraction profile in failing and non-failing isolated human myocardium	12