Biophysical Journal

Article	Citations
Dynamics of asymmetric membranes and interleaflet coupling as intermediates in membrane fusion	180
Insights into DNA solvation found in protein-DNA structures	152
Characteristic frequencies of localized stress relaxation in scaling-law rheology of living cells	143
A dynamic biomimetic model of the membrane-bound CD4-CD3-TCR complex during pMHC disengagement	74
Supracellular measurement of spatially varying mechanical heterogeneities in live monolayers	62
Properties of a tardigrade desiccation-tolerance protein aerogel	59
Centromere and telomere dynamics reveal heterogeneity of the human cell nucleus	59
Inertial artifact in viscoelastic measurements of striated muscle: Modeling and experimental results	55
Open-state structure and pore gating mechanism of the cardiac sodium channel	54
Measurement of the specific and non-specific binding energies of Mg2+ to RNA	54
Structural characterization of MH/CCD NTD mutations in skeletal ryanodine receptor by cryo-EM	51
Oblique circle method for measuring the curvature and twist of mitotic spindle microtubule bundles	44
Calculation of solvation force in molecular dynamics simulation by deep-learning method	44
Small-angle x-ray scattering investigation of the integration of free fatty acids in polysorbate 20 micelles	43
Does it stick? Long-term outcomes for biology majors from introductory physics for the life sciences	42
Peptide diffusion in biomolecular condensates	41
Blocking uncertain mispriming errors of PCR	39
Local interactions and transient secondary structures govern backbone dynamics of intrinsically disordered proteins	39
Unraveling the dance of phosphoproteins at adhesion planes: Modeling YAP phosphorylation by a particle-based stochastic model	39
Syntaxin clusters and cholesterol affect the mobility of Syntaxin1a	39
Modulating Ca2+ influx into adrenal chromaffin cells with short-duration nanosecond electric pulses	39
TMEM16 scramblases thin the membrane to enable lipid scrambling	37
Thank You to Our Reviewers	36
Targeting anti-aggregation and anti-oxidation of amyloid deposits for therapeutic intervention of Alzheimer’s using machine learning-enhanced molecular docking	36
BPS2025 - Recovering true FRET efficiencies from smFRET investigations requires triplet state mitigation	36

Active learning model for extracting elastic modulus of cell on substrate	36
BPS2025 - Integrated data acquisition and real-time parameter-free reconstruction for cryo-ET	35
BPS2025 - Systematic embedding of biomechanics within dynamical graph grammars with application to actin networks in dendritic spine heads	34
BPS2025 - Functional assessment of recombinant human alpha-cardiac myosin and the effect of atrial arrhythmia mutations	34
BPS2025 - Direct quantification of human αβ-tubulin binding kinetics at microtubule ends reveals nucleotide regulation of end-binding affinity	34
BPS2025 - Generative computational modeling with CellPACK reveals interplay between rules of intracellular organization and geometry in hiPSCs	34
BPS2025 - Activation of TMEM16E scramblase induces ligand-independent growth factor receptor signaling and macropinocytosis for membrane repair	33
BPS2025 - DNA nanotechnology for large-scale hybrid nanopore integration	33
BPS2025 - On the cooperativity of fold-switching sequences	32
BPS2025 - Deciphering the role of SNARE transmembrane domain palmitoylation in neurotransmitter release	31
BPS2025 - Deciphering the relationship between form and inherent electrochemical function during the phase transition of Aβ peptides	31
BPS2025 - Optimization of therapeutic T cells through biophysical modeling	31
BPS2025 - Inhibition of amyloid beta fibrillation by a heparin binding protein Midkine—a combined spectroscopy, microscopy, and proteomics study	30
BPS2025 - Networked interactions in biomolecular condensates formed by disordered proteins reveal structural and dynamic inhomogeneities	30
BPS2025 - Structural dynamics study on mosaic spike heterotrimer provides insights into polyvalent vaccine immunogen display	30
BPS2025 - Dynamics of IDPs in biomolecular condensates from massive all-atom explicit-solvent simulations	30
BPS2025 - High-spatial-resolved heat manipulating membrane heterogeneity alters cellular migration and signaling	30
BPS2025 - RSV fusion protein conformation transition pathway from prefusion to postfusion	30
BPS2025 - Complex DNA effects on polyphosphate condensate growth and architecture	30
BPS2025 - The effects of pH on condensate and cortex formation	29
BPS2025 - Comparison of multi-axes sample handler devices for multiview imaging of lung organoids	29
BPS2025 - Phylogenetic corrections and higher-order sequence statistics in protein families: The Potts model and MSA transformer showdown	29
BPS2025 - Integrating accelerated molecular simulations and AI to elucidate Cas9 specificity factors	28
BPS2025 - Electromagnetic dynamics and characterization of cancer cell-magnetic bead interactions	27
BPS2025 - GIRK2 drug repurposing screen identifies treatment options for patients suffering from extremely rare diseases	27
BPS2025 - Glycan-mediated regulation of IgG1 Fc-CD16a interactions: Insights from all-atom simulations	27
BPS2025 - Toxic competitors of phospholamban may contribute to dysregulation of SERCA in heart failure	27
BPS2025 - Real-time tracking of the structural dynamics of adenylate kinase	26
BPS2025 - Molecular pharmacology of human P2X7 receptor ligands visualized by cryo-EM	26
BPS2025 - Cardiotoxic effects of synthetic cannabinoid receptor agonists: Inhibition of hERG and Kv7.1/KCNE1 channels with proposed hERG binding site	26
BPS2025 - Monitoring conformational dynamics and interactions of p53-TAD via an MspA nanopore	25
BPS2025 - TMEM175 chronicles: A journey from high throughput screening to lysosome	25
BPS2025 - Structure and dynamics of the p53-MDMX-CK1α complex	25
BPS2025 - Mavacamten and omecamtiv mecarbil modulate the structure of the interacting-heads motif by inducing distinct subfragment-2 conformations	25
BPS2025 - Protein intrinsically disordered regions have nonrandom, modular architectures that influence conformation and function	25
BPS2025 - Investigating the modulation of Kv1.3 channel inactivation by KCNE4	24
BPS2025 - Studying the interaction of Kv1.3-specific inhibitors with Kv1.3-Kv1.x heterotetrameric ion channels	24
BPS2025 - Phospholipase D-derived phosphatidic acid regulates multivesicular body fusion	24
BPS2025 - Characterization of seven new K+ channel blocker peptides of Centruroides bonito revealed that α-KTx 2.24 has a picomolar affinity for Kv1.2	24
BPS2025 - Cryoprotectant-free lamella preparation of plant and animal tissue for cryo-electron tomography	24
BPS2025 - Synthetic intrinsically disordered proteins that exhibit phase separation	23
BPS2025 - Calcium-mediated structural dynamics and zinc sequestration in S100A12: Insights from NMR and molecular dynamics studies	23
BPS2025 - Anticooperative substrate binding in the yeast BC1 complex	23
BPS2025 - Developing a model to study iPSC-CM integration with human heart tissue	23
BPS2025 - Differential modulation of beta-cardiac myosin conformations by cardiomyopathy-associated mutations in the converter domain	23
BPS2025 - Regulated confinement patterns elicit the organized collective migration of rear cells	22
BPS2025 - The inaugural flatiron heterogeneity community challenge	22
BPS2025 - A tool for determining the release rate and number of mRNA molecules released from lipid nanoparticles in cells based on fluorescence readout and simulation	22
BPS2025 - Developing an adaptable toolbox for measuring ion channel stoichiometry using stepwise photobleaching	22
BPS2025 - Native structure of mosquito salivary protein complexes unveils molecular mechanisms of malaria transmission	22

BPS2025 - Time-resolved fluorometry reveals novel insights into small molecule drug interactions with the HCN channel voltage sensor	22
BPS2025 - Molecular dynamics insights into lipid and nucleotide modulation of P-glycoprotein transport cycle	22
BPS2025 - Investigation of microtubule-CRMP2-isoforms interaction using high-speed atomic force microscopy	21
BPS2025 - Minimal protein components for chromatin replication-coupled symmetric histone recycling	21
BPS2025 - Single-molecule measurements of p44-enhanced XPD helicase activity	21
BPS2025 - COBY: An advanced tool for accurate creation of coarse-grained simulation systems	21
BPS2025 - Molecular mechanisms of keratin-based polymer materials for bioengineering applications	21
BPS2025 - Replication organelles of arboviruses through the lens of a cryo-electron microscope	21
BPS2025 - Characterizing the potassium binding site in human excitatory amino acid transporter	21
BPS2025 - Enhancing the AMBER ff19SB-BSC1-OPC force field for improved molecular dynamics simulations of proteins, nucleic acids, and their complexes	21
BPS2025 - Ultrafast fluorescence lifetimes of NADH via FLIM	21
BPS2025 - Simulation of biopolymerization on surfaces—implications for biogenesis	21
BPS2025 - Entropically generated SNARE linker forces maintain a maximally fusogenic, partially unzippered state and drive fusion	21
Multi-GPU-powered UNRES package for physics-based coarse-grained simulations of structure, dynamics, and thermodynamics of protein systems at biological size- and timescales	20
Discovering inhibitors against human norovirus protein target 3CLpro using ligand-protein docking	20
BPS2025 - Cryo-EM structures of mitochondrial RNA editing catalytic complexes from Trypanosoma brucei	20
Druggable and allosteric pocket prints of G-protein coupled receptors	20
β-Barrel formation examined through β-hairpin interactions with lipid vesicles	20
Spelunking with potassium: Functional analysis of the water tunnel in the potassium pump KdpFABC	20
Regulatory mechanisms of kinesin function at varying pH	20
Investigating how the anionic lipid, BMP, plays a crucial role in the initation of SARS-CoV-2 fusion	20
BPS2025 - Mechanisms underlying distinct cardiac arrhythmia phenotypes caused by calmodulin mutation D132E in Calm2 and Calm3 genes	20
Cryo-EM structures of nanodisc reconstituted ligand-gated ion channel GLIC in various conformations reveal state-dependent protein-lipid interactions and gating mechanism	20
Comparing photosynthetic metabolite free energy and permeability across bacterial microcompartment shell proteins	20
Phase separation of myosin-15 and centrin-2 contributes to stereocilia tip density formation	20
Structural insights into a new class of noncovalent, potent, and highly selective G protein-coupled receptor kinase 5 inhibitors	20
BPS2025 - Effective charge of RNA in a fully packaged viral particle	20
Reversing aberrant phase transitions of ALS-linked disease protein FUS with RNA	20
Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation	20
A structural model of TCR-pMHC catch bonding	20
De novo design of a DNA-binding protein capable of multi-site recognition	19
Fluorescent drug analogs to study drug-target interactions in intact cells	19
Structural studies of connexin 32 gap junction channels by cryo-EM	19
BAG3 differentially responds to acute and chronic stress via a post-transcriptional mechanism	19
Self-organization of ovarian cancer organoids revealed by 3D image segmentation and phase-field model	19
Computational analyses of SERCA, phospholamban, and sarcolipin complexes	19
Engineering inducible dipoles to develop better fluorescent biosensors	19
Temperature dependence of α-crystallin membrane binding	19
Quantification of NINJ1-mediated membrane rupture	19
Elucidating the spatial distribution of genomic and epigenetic lamina-associated domains implicated in adipocyte differentiation and hypertrophy	19
Graded cleavage of elastic titin in living mouse hearts reveals the role of titin stiffness for cardiac contractility	19
Quantifying water rigidization near protein surfaces	18
Conformational preferences of disordered proteins in biomolecular condensates	18
Active-learning-guided and high-throughput synthesis of membrane proteins	18
Enhancing sarcomere function and length-dependent activation in engineered human myocardium via triiodothyronine and dexamethasone treatment	18
X-ray single molecule observations using SR and laboratory source	18
Metabolic regulation by enzyme polymerization	18
Molecular insights into the role of SNX1-SNX5 heterodimer in endosomal trafficking	18
Structural basis of closed groove scrambling by a TMEM16 protein	18
Membrane composition affects binding and insertion of the influenza virus fusion peptide	18
Molecular kinetics of polycomb body formation during development	18
Machine learning for prediction of protein function and elucidation of enzyme function and control	18
Tyrosine fluorescence as an intrinsic probe for protein aggregation	18
Investigating the presence of carbon quantum dots in the inhalable aerosol from electronic cigarettes	18
Allosteric mechanisms of transcriptional control in FXR	18
Mapping the tension-gated transition of the bacterial MscS with MD simulations	18
Co-VET: Correlative-voltage imaging and cryo-electron tomography	18
The cancer mucin barrier plays a multifunctional role in providing sustained physical resistance to natural killer cell attack	17
Characterizing salt and humidity induced 3D electrospun matrices	17
NMR studies of the complex between the small GTPase Arf1 and segmentally labeled ARFGAP ASAP1 at the membrane surface of nanodiscs	17
The Piezo1 channel interacts with the transmembrane channel Tmc1 to exert mechanoelectrical transducer (MET) functions	17
Unique molecular features in the activation of the AT1 receptor by chemical and mechanical stimuli	17
Student usage and perceptions of ChatGPT: The good, the bad, and the ugly	17
Spatial distribution of adhesion force generation in human cardiomyocytes	17
Bind-and-bend model for DNA looping	17
Biochemical signaling encoded in emergent properties	17
The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM	17
The N-terminus is not the Ca2+-regulated gate in CALHM1 channels	17
Measuring the effects of infection on disordered viral proteins	17
Insights on plasma membrane asymmetry from studies of asymmetric model membranes	17
Quantitative views of protein dynamics through the computational microscope	16
Engineering of the high-affinity chemokine CXCL13 to screen CXCR5 antagonists to treat cancer and autoimmune diseases	16
RTK-integrin interactions universally modulate αVβ3 integrin-mediated cell adhesion	16
Single-molecule dynamics of ribonuclease H enzymes in Bacillus subtilis	16
Optimal efficacy in mosquito-host interaction inhibition by 35-60 kHz animal sounds for malaria control	16
Storm imaging provides nanodomain-lengthscale observation of coordination between Arabidopsis root hair membrane proteins	16
Quantitative fret studies of EphA2-Lyn interactions	16
Quantum-enabled ghost imaging for non-invasive imaging of plants	16
Investigation of G-protein specificity and biased agonism at the beta-2 adrenergic receptor (β2AR)	16
Drug discovery for heart failure: Targeting the myosin-binding protein C interactions with actin	16

High throughput mechanotyping via flow cytometry and DNA sequencing	16
Sequence adaptation in various environments across organisms; similar yet different superoxide dismutase	16
Characterizing the APOBEC3B closed to open pathway with weighted ensemble	16
Action at a distance along the microtubule couples kinesin motors	16
Nascent-chain interaction networks and their effect on the bacterial ribosome	15
Physical determinants of multiphase organisation in multi-component protein/RNA condensates	15
2-d liquid-liquid phase separation of GM130 Golgin protein bound to supported bilayer	15
Intrinsic stiffening and dynamic softening by cholesterol	15
How lipids modulate association of proteins in lipid membranes	15
Differential nuclear translocation of STAT6 regulates the mechanosensitive immune cell activation	15
Structural studies of human serum albumin using cryo-EM up to 0.38 nm resolution	15
“Helicase” activity promoted through dynamic interactions between a ssDNA translocase and a diffusing SSB protein	15
Solution structure of poly(UG) RNA reveals a new fold that drives gene silencing	15
Cataracts and copper: A spectroscopic perspective of copper-induced aggregation of betaB2-crystallin	15
Empagliflozin and ROS-CaMKII-late sodium current signaling in heart failure with preserved ejection fraction	15
Probing synaptic distribution and arrangement of native surface AMPAR in mouse brain slices with 3D super-resolution microscopy	15
Measurements of cholesterol chemical potential constrain models of cholesterol-phosphatidylcholine interactions	15
Novel biomolecular fingerprint using graph convolutional networks	15
Myosin-I facilitates symmetry breaking and promotes the growth of actin ‘comet tails’	15
Lipids and microparticles, physical characterization as a lung-contamination model	15
Functional impact of the interaction between S1 segment and KCNE subunit in the modulation of KCNQ1 channels	15
Amplification-free rapid detection of viral genomes at single molecule level	15
Dissecting metabotropic glutamate receptor activation by single molecule FRET using minimally invasive labeling strategies	15
RNA structure controls composition and network dynamics of condensates	15
Analysis and comparison of amorphous & amyloid aggregates of the tumor suppressor p53	15
Diversity and molecular mechanisms of channelrhodopsins	15
Unraveling the molecular basis of protein search on ssDNA track and binding specificity of the ssDNA sequences	15
Modulation of potassium channels preserves temporal fidelity in auditory network models	15
Examining HIV-1 envelope conformational transitions at high temporal resolution	15
Single molecule evidence for linker histone H1 DNA sliding and nucleosomal bypassing regulated by the C-terminal disordered domain	15
Disease mutations of human α3 Na+/K+-ATPase define extracellular Na+ binding/occlusion kinetics at ion binding site III	15
Investigation of nonselective cation permeation through CNGA1 channels by MD simulations	15
Compounds specifically enhance IKs by modulating VSD-pore coupling	15
Dynamic association of an assembly platform subcomplex of the bacterial type two secretion system	14
Method for direct measuring antibody affinity in biological sample	14
Long-range regulation of cytochrome c binding to bc1 complex	14
Sarcomere dynamics simulations to uncover mechanisms in hypertrophic cardiomyopathy	14
Fluctuating diffusivity of intrinsically disordered proteins	14
Solution NMR studies reveal novel CLIC4 chaperone activity with respect to profilin-1	14
Novel approaches to understand function and explore inhibition within protein-membrane interfaces	14
FkpA enhances outer membrane protein folding using an extensive interaction surface	14
NFATC1 modulation of atrial excitability in zebrafish	14
Treatment of osteoarthritis by salvianolic acid derivatives	14
A multi-view reflector microscope visualizes six-dimensional single-molecule translational and rotational dynamics with isotropic nanoscale resolution	14
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family	14
Mechanically induced conformational transition of spectrin in the mammalian cell cortex	14
Expansion microscopy through mechanical force	14
Using HDX-MS to probe the dynamics and denatured state of GlpG, a helical membrane protein	14
Experimental methods and mathematical modeling quantify and predict DUSP1 RNA expression dynamics in response to dexamethasone	14
The rigidization of water dynamics around proteins: A molecular dynamics study	14
Myosin binding protein-C: Everything, everywhere, all at once	14
Origins of protein concentration noise in mitochondria	14
Inter-domain coordination essential for dengue virus non-structural (5) NS5 interaction with stem loop a (SLA)	14
cryo-EM structure of tarantula myosin filament: Implications for analysis of myopathy mutations	14
Regioselective metabolism of cannabinoids by cytochrome P450 2J2	14
Investigating Dnase1L3's role in inflammation and redesigning the enzyme to be used as a therapeutic	14
Bacterial brains: How bacteria use electrochemical potentials to solve complex problems	14
Visualizing both nucleosome disassembly and reassembly during FACT chaperone activity	14
Configuring extracellular matrix architectures with dynamic forces	13
Stress-induced BAG3 cleavage and its effects on sarcomere contractile functions	13
Extreme-value analysis of intracellular cargo transport by motor proteins	13
The plasma membrane as an emulsion: A rational basis for “rafts,” and a different look at them	13
Cryo-electron microscopy structure of human Kir2.1 potassium channel bound to the activator PIP2 reveals its gating mechanism	13
Open software for analyzing lipid-resolved mechanics of complex bilayers	13
Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels	13
Sensing membrane voltage by reorientation of dipolar transmembrane peptides	13
Structural basis of distinct signaling kinetics of calcitonin-like receptor peptide ligands	13
From loops to stacks: Early steps in the DNA folding pathway by protamine	13
Modeling toxin effects on sodium channels in neurons using real-time dynamic clamp	13
Collective functionalities emerging in microbial active matter	13
ERK activation waves are key drivers in the mechanical cell competition that leads to collective onslaught of bacterially infected cells	13
Critical regulation of the voltage-gated sodium channel, Nav1.4, by PIP2	13
Distinct spatiotemporal dynamics of calmodulin genes in cardiac myocytes under beta-adrenergic stimulation	13
Towards revealing functionally relevant conformational dynamics of the C-terminal tail of β-arrestin	13
Kv3.1 channel expression determines the spike waveform in vocal-motor neurons	13
A disordered linker with “something” on its N-terminus drives the allostery in the urokinase-type plasminogen activator (uPA)	13
Elucidation of a dynamic interplay between beta-adrenergic receptors, its agonists, and stimulatory G protein	13
Flexibility of flanking DNA is a key determinant of transcription factor affinity for the core motif	13
Cardiac dysfunction in a mouse model of colon cancer cachexia is due to sarcomeric changes	13
Structural basis for the intracellular regulation of ferritin degradation	13
Understanding transport processes with simulation	13
Alchemical free-energy simulations support the formation of the sarco-endoplasmic reticulum calcium pump (SERCA) inhibitory complex from the phospholamban pentamer	13
Extracting conformational heterogeneity from 2D and 3D cryo-EM data	13
Surface densities prewet a near critical membrane	13
Perm-waved human hair: a thermorheologically complex shape memory composite	13
Probing the mechanisms of low-voltage activation in T-type CaV3.1 calcium channels	13
Dissecting ER stress signaling with live-cell single-molecule imaging and optogenetics	13
Phosphomimetic mutations in the C-terminal basic region of troponin T increases actin filament activity	12
Escherichia coli JM109 in LB as a model bacterial system to study magnetic field effect in recombination of non-correlated pair of biologically relevant radicals nitric oxide and superoxide anion in h	12
Modulation of membrane fusion using a novel fusogenic system composition	12
Impact of mutations near the SARS-CoV-2 furin-cleavage site on viral infectivity	12
Mathematical modeling as a tool to characterize the role of phosphoinositide metabolism for regulation of neuronal action potential firing	12
Intramembrane serine protease catalysis in different physical environments	12
Objective unsupervised learning of behavioral dynamics at the frontier of information bottleneck principles, physics informed priors, and maximum mean discrepancy statistical testing	12
Superresolution imaging of native surface AMPA receptors in brain tissue	12