Biology of Reproduction

Article	Citations
Absence of 2019 novel coronavirus in semen and testes of COVID-19 patients†	200
ACE2 receptor expression in testes: implications in coronavirus disease 2019 pathogenesis†	71
Metabolic changes in mouse sperm during capacitation†	49
Inflammation and reproductive function in women with polycystic ovary syndrome	42
The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization†	40
Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality	40
Cytoplasmic maturation in human oocytes: an ultrastructural study †	39
Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†	34
Epigenetic transgenerational inheritance, gametogenesis and germline development†	33
Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†	33
In vitro models of the human endometrium: evolution and application for women’s health+	33
Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells	31
Sperm migration, selection, survival, and fertilizing ability in the mammalian oviduct	31
Macrophages: an indispensable piece of ovarian health	31
Role of zinc in female reproduction	30
In vitro ovarian follicle growth: a comprehensive analysis of key protocol variables†	29
Microvesicles and exosomes released by amnion epithelial cells under oxidative stress cause inflammatory changes in uterine cells†	28
Oocyte mitochondria—key regulators of oocyte function and potential therapeutic targets for improving fertility	26
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis	26
Dux facilitates post-implantation development, but is not essential for zygotic genome activation†	26
Developmental programming of the female reproductive system—a review	25
The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications†	25
Igf3: a novel player in fish reproduction	25
The effects of assisted reproduction technologies on metabolic health and disease†	25
Loss of RBBP4 results in defective inner cell mass, severe apoptosis, hyperacetylated histones and preimplantation lethality in mice†	24

Progesterone receptor membrane components: key regulators of fetal membrane integrity	24
MicroRNA-21 as a regulator of human cumulus cell viability and its potential influence on the developmental potential of the oocyte	24
CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity	24
Mysteries and unsolved problems of mammalian fertilization and related topics	24
Engineering monoclonal antibody-based contraception and multipurpose prevention technologies†	23
Single-cell analysis of prostaglandin E2-induced human decidual cell in vitro differentiation: a minimal ancestral deciduogenic signal	23
The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception†	23
Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†	22
MiRNA-155 regulates cumulus cells function, oocyte maturation, and blastocyst formation	22
NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome‡	22
Fatty acid induced lipolysis influences embryo development, gene expression and lipid droplet formation in the porcine cumulus cells†	22
Maternal high fat diet-induced obesity affects trophoblast differentiation and placental function in mice†	22
Sirt1 and Nrf2: regulation of Leydig cell oxidant/antioxidant intracellular environment and steroid formation†	21
Generation and characterization of human Fetal membrane and Decidual cell lines for reproductive biology experiments	21
Prss55 but not Prss51 is required for male fertility in mice†	21
Iodoacetic acid affects estrous cyclicity, ovarian gene expression, and hormone levels in mice	21
Male hybrid sterility in the cattle-yak and other bovines: a review	21
Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes†	21
Single-cell RNA sequencing analysis of mouse follicular somatic cells	21
Retinoic acid receptor antagonists for male contraception: current status†	20
Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapies	20
AASRA: an anchor alignment-based small RNA annotation pipeline†	20
Tmprss12 is required for sperm motility and uterotubal junction migration in mice†	19
Pig conceptuses secrete interferon gamma to recruit T cells to the endometrium during the peri-implantation period	19
CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction†	19
Overview of extracellular vesicles in the pathogenesis of preeclampsia	19
Effect of mitophagy in oocytes and granulosa cells on oocyte quality†	19
The PRAME family of cancer testis antigens is essential for germline development and gametogenesis	19
Anatomical and cellular heterogeneity in the mouse oviduct—its potential roles in reproduction and preimplantation development	19
Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights	19
Modeling human peri-implantation placental development and function	19
Impaired decidualization of human endometrial stromal cells from women with adenomyosis†	19
Bisphenol A and 17α-ethinylestradiol-induced transgenerational gene expression differences in the brain–pituitary–testis axis of medaka, Oryzias latipes†	19
Comparing effects and action mechanisms of BPA and BPS on HTR-8/SVneo placental cells	18
Successful in vitro fertilization in the horse: production of blastocysts and birth of foals after prolonged sperm incubation for capacitation	18
Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception†	18
Hypoxia-inducible factor (HIF1alpha) inhibition modulates cumulus cell function and affects bovine oocyte maturation in vitro†	18
Severity of prepregnancy diabetes on the fetal malformations and viability associated with early embryos in rats†	18
Experimentally Induced Endometritis Impairs the Developmental Capacity of Bovine Oocytes†	18
Loss of ITGB3 in ovine conceptuses decreases conceptus expression of NOS3 and SPP1: implications for the developing placental vasculature†	17
Interactions of circulating estradiol and progesterone on changes in endometrial area and pituitary responsiveness to GnRH†	17
Negative impact of high doses of follicle-stimulating hormone during superovulation on the ovulatory follicle function in small ovarian reserve dairy heifers	17
NOTCH signaling pathway is required for bovine early embryonic development	17
Glucose metabolism characterization during mouse in vitro maturation identifies alterations in cumulus cells†	17
Early life stress affects the miRNA cargo of epididymal extracellular vesicles in mouse	17
Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration†	17
METTL3-mediated m6A methylation negatively modulates autophagy to support porcine blastocyst development‡	16
Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy	16
Differences in the proteome of stallion spermatozoa explain stallion-to-stallion variability in sperm quality post-thaw†	16
Peripheral action of kisspeptin at reproductive tissues—role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review	16

Endometrial Organoids: A New Model for the Research of Endometrial-Related Diseases†	16
The future of assessing bull fertility: Can the ‘omics fields identify usable biomarkers?	16
Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy†	15
Mesenchymal stromal cell-derived extracellular vesicle therapy prevents preeclamptic physiology through intrauterine immunomodulation†	15
Loss of myosin VI expression affects acrosome/acroplaxome complex morphology during mouse spermiogenesis†	15
Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†	15
Nesfatin-1-like peptide suppresses hypothalamo–pituitary–gonadal mRNAs, gonadal steroidogenesis, and oocyte maturation in fish†	15
Approaches to oocyte meiotic arrest in vitro and impact on oocyte developmental competence	15
Role of DNA damage and repair mechanisms in uterine fibroid/leiomyomas: a review	15
Metabolic changes in female rats exposed to intrauterine hyperglycemia and postweaning consumption of high-fat diet	15
Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction	14
Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis	14
Preclinical contraceptive development for men and women	14
Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells†	14
The effects of vitrification on oocyte quality	14
Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth	14
MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium†	14
Is there a definite relationship between placental mTOR signaling and fetal growth?	14
The influence of COVID-19 infection-associated immune response on the female reproductive system	14
Metabolo-epigenetics: the interplay of metabolism and epigenetics during early germ cells development†	14
Toxicant effects on mammalian oocyte mitochondria†	14
Seminal plasma AnnexinA2 protein is a relevant biomarker for stallions which require removal of seminal plasma for sperm survival upon refrigeration†	13
Analysis of expression of candidate genes for polycystic ovary syndrome in adult and fetal human and fetal bovine ovaries†	13
Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss	13
The molecular mechanisms underlying acrosome biogenesis elucidated by gene-manipulated mice†	13
Extracellular vesicle research in reproductive science: Paving the way for clinical achievements	13
Towards a roadmap to advance non-hormonal contraceptive multipurpose prevention technologies: strategic insights from key stakeholders†	13
The anatomy, movement, and functions of human sperm tail: an evolving mystery	13
C1QTNF6 participates in the pathogenesis of PCOS by affecting the inflammatory response of granulosa cells	13
Transcriptome and proteome dynamics of cervical remodeling in the mouse during pregnancy	13
Five questions toward mRNA degradation in oocytes and preimplantation embryos: when, who, to whom, how, and why?	13
Conceptus interferon gamma is essential for establishment of pregnancy in the pig	13
Roles of aryl hydrocarbon receptor in endothelial angiogenic responses†	13
The sperm-specific form of lactate dehydrogenase is required for fertility and is an attractive target for male contraception (a review)	13
Polyploid giant cancer cells and ovarian cancer: new insights into mitotic regulators and polyploidy	13
HOXA10 improves endometrial receptivity by upregulating E-cadherin	13
Loss of Nobox prevents ovarian differentiation from juvenile ovaries in zebrafish	13
Obesity alters the ovarian proteomic response to zearalenone exposure	12
Progesterone receptor membrane component 1 is required for mammary gland development†	12
Self-renewal and differentiation of rat epididymal basal cells using a novel in vitro organoid model	12
Prokineticin 1–prokineticin receptor 1 signaling promotes angiogenesis in the porcine endometrium during pregnancy†	12
The effects of the phthalate DiNP on reproduction†	12
Serine protease inhibitor disrupts sperm motility leading to reduced fertility in female mice†	12
The impact of bisphenol A on the placenta	12
Metabolomic signature of spermatozoa established during holding time is responsible for differences in boar sperm freezability	12
Risk of pathogenic virus transmission by somatic cell nuclear transfer: implications for xenotransplantation	12
The alarmin S100A12 causes sterile inflammation of the human chorioamniotic membranes as well as preterm birth and neonatal mortality in mice	12
The ruminant placental trophoblast binucleate cell: an evolutionary breakthrough	12
Heritable consequences of paternal nicotine exposure: from phenomena to mechanisms†	12
Oocytes suppress FOXL2 expression in cumulus cells in mice†	12
Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†	12
Exposure to nivalenol declines mouse oocyte quality via inducing oxidative stress-related apoptosis and DNA damage	12
The microRNA-200 cluster on chromosome 23 is required for oocyte maturation and ovulation in zebrafish†	12
CCL20-CCR6 axis directs sperm–oocyte interaction and its dysregulation correlates/associates with male infertility‡	12
Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception†	12
Ephrin and Eph receptor signaling in female reproductive physiology and pathology†	12
Cross talk: trafficking and functional impact of maternal exosomes at the feto-maternal interface under normal and pathologic states	12
Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells	12
Generation of chimeric mice with spermatozoa fully derived from embryonic stem cells using a triple-target CRISPR method forNanos3†	12
Effects of LPXRFamide peptides on chub mackerel gonadotropin secretion	11
A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells	11
Igf3 is essential for ovary differentiation in zebrafish†	11
Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism†	11
Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stress†	11
Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females†	11
The new contraceptive revolution: developing innovative products outside of industry†,‡	11
High-fat-diet induced obesity increases the proportion of linoleic acyl residues in dam serum and milk and in suckling neonate circulation	11
Current progress, challenges, and future prospects of testis organoids†	11
Multiomics analysis of male infertility	11
The actions of resveratrol in decidualizing endometrium: acceleration or inhibition?†	11
Vaginal mucus in mice: developmental and gene expression features of epithelial mucous cells during pregnancy	11
Transforming growth factor beta signaling and decidual integrity in mice†	11
Melatonin alleviates deoxynivalenol-induced apoptosis of human granulosa cells by reducing mutually accentuated FOXO1 and ER stress	11
State of assisted reproduction technology in the coronavirus disease 2019 era and consequences on human reproductive system	11
SPP1 expression in the mouse uterus and placenta: implications for implantation†	11
Present state and future outlook for the application of in vitro oocyte maturation in human infertility treatment	11
Aging and oxidative stress alter DNA repair mechanisms in male germ cells of superoxide dismutase-1 null mice	10
Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriage	10
Phosphorylation of Yes-associated protein impairs trophoblast invasion and migration: implications for the pathogenesis of fetal growth restriction†	10
Roles ofStra8andTcerg1lin retinoic acid induced spermatogonial differentiation in mouse	10

miR-26a-5p and miR-125b-5p affect trophoblast genes and cell functions important during early pregnancy	10
Phthalates and alternative plasticizers differentially affect phenotypic parameters in gonadal somatic and germ cell lines	10
Long non-coding RNA NRSN2-AS1 facilitates tumorigenesis and progression of ovarian cancer via miR-744-5p/PRKX axis	10
Endometrial receptivity and embryo implantation in carnivores—commonalities and differences with other mammalian species	10
Differences in the sperm metabolomes of smoking and nonsmoking men	10
Melatonergic systems of AANAT, melatonin, and its receptor MT2 in the corpus luteum are essential for reproductive success in mammals†	10
Chemerin as a modulator of angiogenesis and apoptosis processes in the corpus luteum of pigs: an in vitro study	10
Hyaluronidase-based swim-up for semen selection in patients with human papillomavirus semen infection	10
Ancestral smoking and developmental outcomes: a review of publications from a population birth cohort	10
Spatial transcriptomic profiles of mouse uterine microenvironments at pregnancy day 7.5	10
Whole-exome sequencing reveals potential germline and somatic mutations in 60 malignant ovarian germ cell tumors	10
Spatial transcriptomics analysis of uterine gene expression in enhancer of zeste homolog 2 conditional knockout mice†	10
Interleukin-13 receptor subunit alpha-2 is a target of progesterone receptor and steroid receptor coactivator-1 in the mouse uterus†	9
The functions ofWt1in mouse gonad development and somatic cells differentiation	9
Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells	9
Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats	9
Prenatal stress, anxiety and depression alter transcripts, proteins and pathways associated with immune responses at the maternal-fetal interface	9
IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mouse†	9
Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†	9
A central role for cAMP/EPAC/RAP/PI3K/AKT/CREB signaling in LH-induced follicular Pgr expression at medaka ovulation	9
Two distinct Sertoli cell states are regulated via germ cell crosstalk†	9
Depletion of high-mobility group box 2 causes seminiferous tubule atrophy via aberrant expression of androgen and estrogen receptors in mouse testis	9
Sex differences in innate and adaptive immunity impact fetal, placental, and maternal health	9
Novel mineral regulatory pathways in ovine pregnancy: I. phosphate, klotho signaling, and sodium-dependent phosphate transporters	9
Conceptus metabolomic profiling reveals stage-specific phenotypes leading up to pregnancy recognition in cattle†	9
Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats	9
Development of human ectocervical tissue models with physiologic endocrine and paracrine signaling†	9
Pleiotropic role of prokineticin 1 in the porcine endometrium during pregnancy establishment and embryo implantation †	9
Exogenous sex steroids regulate genital epithelial barrier function in female rhesus macaques	9
Kisspeptin induces LH release and ovulation in an induced ovulator†	9
Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice	9
Novel mineral regulatory pathways in ovine pregnancy: II. Calcium-binding proteins, calcium transporters, and vitamin D signaling	9
Sirtuin-1 inhibits endothelin-2 expression in human granulosa-lutein cells via hypoxia inducible factor 1 alpha and epigenetic modifications†	9
Exposures during the prepuberty period and future offspring’s health: evidence from human cohort studies†	9
The enigmatic sperm proteins in mammalian fertilization: an overview†	9
Effect of natural pre-luteolytic prostaglandin F2α pulses on the bovine luteal transcriptome during spontaneous luteal regression†	8
Fibrinogen alpha chain promotes the migration and invasion of human endometrial stromal cells in endometriosis through focal adhesion kinase/protein kinase B/matrix metallopeptidase 2 pathway†	8
Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice†	8
Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism	8
Neither gonadotropin nor cumulus cell expansion is needed for the maturation of competent porcine oocytes in vitro†	8
The placenta as a target of opioid drugs	8
Preserving Oocytes in Oncofertility	8
Non-invasive oocyte quality assessment	8
Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism	8
The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques	8
Development of multipurpose technologies products for pregnancy and STI prevention: update on polyphenylene carboxymethylene MPT gel development†	8
Chronic overload of concentration-dependent iron exerts different effects on ovarian function in C57BL/6J mice	8
Sperm–oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site	8
Oocyte quality following in vitro follicle development	8
Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†	8
Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice†	8
Role of AMP-activated protein kinase during postovulatory aging of mouse oocytes†	8
Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases	8
Comparing mRNA and sncRNA profiles during the maternal-to-embryonic transition in bovine IVF and scNT embryos	8
Temporal changes in the corpus luteum during early pregnancy reveal regulation of pathways that enhance steroidogenesis and suppress luteolytic mechanisms†	8
Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression†	8
Hypoxia-induced alteration of RNA modifications in the mouse testis and sperm	8
Germ cells of the mammalian female: A limited or renewable resource?	8
Characterization of transcriptional activity during ZGA in mammalian SCNT embryo	8
Sex differences in microRNA expression in first and third trimester human placenta	8
Transcriptomic analysis of equine placenta reveals key regulators and pathways involved in ascending placentitis†	8
Environmentally relevant mixtures of phthalates and phthalate metabolites differentially alter the cell cycle and apoptosis in mouse neonatal ovaries†	8
Attainment and maintenance of pubertal cyclicity may predict reproductive longevity in beef heifers	8
Removal of peri-ovarian adipose tissue affects follicular development and lipid metabolism†	8
An evo-devo perspective of the female reproductive tract	8
MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancy†	8
Ovarian follicles are resistant to monocyte perturbations—implications for ovarian health with immune disruption	8
Aberrant and constitutive expression of FOXL2 impairs ovarian development and functions in mice	8
The rapamycin analog Everolimus reversibly impairs male germ cell differentiation and fertility in the mouse†	8
Prostaglandin I2 mediates weak vasodilatation in human placental microvessels	8