Biology of Reproduction

Article	Citations
Inflammation and reproductive function in women with polycystic ovary syndrome	55
Age-associated changes in cumulus cells and follicular fluid: the local oocyte microenvironment as a determinant of gamete quality	55
Oocyte mitochondria—key regulators of oocyte function and potential therapeutic targets for improving fertility	45
Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†	45
The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization†	44
Macrophages: an indispensable piece of ovarian health	41
Role of zinc in female reproduction	38
Epigenetic transgenerational inheritance, gametogenesis and germline development†	38
Sperm migration, selection, survival, and fertilizing ability in the mammalian oviduct	37
Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells	34
NAD+ deficiency and mitochondrial dysfunction in granulosa cells of women with polycystic ovary syndrome‡	33
Mysteries and unsolved problems of mammalian fertilization and related topics	32
Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis	32
Developmental programming of the female reproductive system—a review	32
Microvesicles and exosomes released by amnion epithelial cells under oxidative stress cause inflammatory changes in uterine cells†	31
Single-cell analysis of prostaglandin E2-induced human decidual cell in vitro differentiation: a minimal ancestral deciduogenic signal	31
Male fertility preservation and restoration strategies for patients undergoing gonadotoxic therapies	28
The effects of assisted reproduction technologies on metabolic health and disease†	28
The PRAME family of cancer testis antigens is essential for germline development and gametogenesis	27
Male hybrid sterility in the cattle-yak and other bovines: a review	27
Igf3: a novel player in fish reproduction	27
Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights	27
Sirt1 and Nrf2: regulation of Leydig cell oxidant/antioxidant intracellular environment and steroid formation†	26
Anatomical and cellular heterogeneity in the mouse oviduct—its potential roles in reproduction and preimplantation development	26
Generation and characterization of human Fetal membrane and Decidual cell lines for reproductive biology experiments	26

Sex differences in innate and adaptive immunity impact fetal, placental, and maternal health	24
Successful in vitro fertilization in the horse: production of blastocysts and birth of foals after prolonged sperm incubation for capacitation	24
Negative impact of high doses of follicle-stimulating hormone during superovulation on the ovulatory follicle function in small ovarian reserve dairy heifers	23
Single-cell RNA sequencing analysis of mouse follicular somatic cells	23
AASRA: an anchor alignment-based small RNA annotation pipeline†	22
The effects of vitrification on oocyte quality	22
The molecular mechanisms underlying acrosome biogenesis elucidated by gene-manipulated mice†	22
Iodoacetic acid affects estrous cyclicity, ovarian gene expression, and hormone levels in mice	22
NOTCH signaling pathway is required for bovine early embryonic development	21
HOXA10 improves endometrial receptivity by upregulating E-cadherin	21
Approaches to oocyte meiotic arrest in vitro and impact on oocyte developmental competence	21
The ruminant placental trophoblast binucleate cell: an evolutionary breakthrough	21
The anatomy, movement, and functions of human sperm tail: an evolving mystery	21
Impaired decidualization of human endometrial stromal cells from women with adenomyosis†	20
Overview of extracellular vesicles in the pathogenesis of preeclampsia	20
Differences in the proteome of stallion spermatozoa explain stallion-to-stallion variability in sperm quality post-thaw†	20
The impact of bisphenol A on the placenta	20
Loss of ITGB3 in ovine conceptuses decreases conceptus expression of NOS3 and SPP1: implications for the developing placental vasculature†	19
The future of assessing bull fertility: Can the ‘omics fields identify usable biomarkers?	19
METTL3-mediated m6A methylation negatively modulates autophagy to support porcine blastocyst development‡	19
Glucose metabolism characterization during mouse in vitro maturation identifies alterations in cumulus cells†	19
Comparing effects and action mechanisms of BPA and BPS on HTR-8/SVneo placental cells	19
Modeling human peri-implantation placental development and function	19
The influence of COVID-19 infection-associated immune response on the female reproductive system	18
Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction	18
Oxidative stress promotes cellular damages in the cervix: implications for normal and pathologic cervical function in human pregnancy	18
Early life stress affects the miRNA cargo of epididymal extracellular vesicles in mouse	18
Exposure to nivalenol declines mouse oocyte quality via inducing oxidative stress-related apoptosis and DNA damage	18
Multiomics analysis of male infertility	18
Obesity alters the ovarian proteomic response to zearalenone exposure	18
Transcriptome and proteome dynamics of cervical remodeling in the mouse during pregnancy	18
Metabolic changes in female rats exposed to intrauterine hyperglycemia and postweaning consumption of high-fat diet	18
Current progress, challenges, and future prospects of testis organoids†	17
Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriage	17
Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth	17
Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy†	17
Five questions toward mRNA degradation in oocytes and preimplantation embryos: when, who, to whom, how, and why?	17
Melatonin alleviates deoxynivalenol-induced apoptosis of human granulosa cells by reducing mutually accentuated FOXO1 and ER stress	16
Loss of Nobox prevents ovarian differentiation from juvenile ovaries in zebrafish	16
Extracellular vesicle research in reproductive science: Paving the way for clinical achievements	16
C1QTNF6 participates in the pathogenesis of PCOS by affecting the inflammatory response of granulosa cells	16
Metabolomic signature of spermatozoa established during holding time is responsible for differences in boar sperm freezability	16
Metabolo-epigenetics: the interplay of metabolism and epigenetics during early germ cells development†	16
Heritable consequences of paternal nicotine exposure: from phenomena to mechanisms†	16
Toxicant effects on mammalian oocyte mitochondria†	16
Polyploid giant cancer cells and ovarian cancer: new insights into mitotic regulators and polyploidy	16
Conceptus interferon gamma is essential for establishment of pregnancy in the pig	16
Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells†	16
Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells	15
State of assisted reproduction technology in the coronavirus disease 2019 era and consequences on human reproductive system	15

Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss	15
Rbm46, a novel germ cell-specific factor, modulates meiotic progression and spermatogenesis	15
Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells	14
Two distinct Sertoli cell states are regulated via germ cell crosstalk†	14
SPP1 expression in the mouse uterus and placenta: implications for implantation†	14
Spatial transcriptomic profiles of mouse uterine microenvironments at pregnancy day 7.5	14
Self-renewal and differentiation of rat epididymal basal cells using a novel in vitro organoid model	14
Preserving Oocytes in Oncofertility	14
Endometrial receptivity and embryo implantation in carnivores—commonalities and differences with other mammalian species	14
Igf3 is essential for ovary differentiation in zebrafish†	14
Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases	14
Present state and future outlook for the application of in vitro oocyte maturation in human infertility treatment	14
Leptin and Its Signaling Are Not Involved in Zebrafish Puberty Onset	13
Hypoxia-induced alteration of RNA modifications in the mouse testis and sperm	13
Cross talk: trafficking and functional impact of maternal exosomes at the feto-maternal interface under normal and pathologic states	13
Phthalates and alternative plasticizers differentially affect phenotypic parameters in gonadal somatic and germ cell lines	13
Non-invasive oocyte quality assessment	13
The alarmin S100A12 causes sterile inflammation of the human chorioamniotic membranes as well as preterm birth and neonatal mortality in mice	13
The sperm-specific form of lactate dehydrogenase is required for fertility and is an attractive target for male contraception (a review)	13
Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice	13
Vaginal mucus in mice: developmental and gene expression features of epithelial mucous cells during pregnancy	12
Roles ofStra8andTcerg1lin retinoic acid induced spermatogonial differentiation in mouse	12
Chemerin as a modulator of angiogenesis and apoptosis processes in the corpus luteum of pigs: an in vitro study	12
Novel mineral regulatory pathways in ovine pregnancy: I. phosphate, klotho signaling, and sodium-dependent phosphate transporters	12
Is human labor at term an inflammatory condition?	12
Risk of pathogenic virus transmission by somatic cell nuclear transfer: implications for xenotransplantation	12
Prenatal stress, anxiety and depression alter transcripts, proteins and pathways associated with immune responses at the maternal-fetal interface	12
Germ cells of the mammalian female: A limited or renewable resource?	12
Transcriptomic analysis of equine placenta reveals key regulators and pathways involved in ascending placentitis†	12
Whole-exome sequencing reveals potential germline and somatic mutations in 60 malignant ovarian germ cell tumors	12
Activation of angiotensin type 2 receptor attenuates testosterone-induced hypertension and uterine vascular resistance in pregnant rats	12
Effects of LPXRFamide peptides on chub mackerel gonadotropin secretion	11
A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells	11
Depletion of high-mobility group box 2 causes seminiferous tubule atrophy via aberrant expression of androgen and estrogen receptors in mouse testis	11
Attainment and maintenance of pubertal cyclicity may predict reproductive longevity in beef heifers	11
Mitochondrial transfer from induced pluripotent stem cells rescues developmental potential of in vitro fertilized embryos from aging females†	11
Conceptus metabolomic profiling reveals stage-specific phenotypes leading up to pregnancy recognition in cattle†	11
Ancestral smoking and developmental outcomes: a review of publications from a population birth cohort	11
Reversing complete mechanical transzonal projections disruption during mouse in vitro follicle culture with unaltered oocyte competence	11
The functions ofWt1in mouse gonad development and somatic cells differentiation	11
Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism†	11
Long non-coding RNA NRSN2-AS1 facilitates tumorigenesis and progression of ovarian cancer via miR-744-5p/PRKX axis	11
Differences in the sperm metabolomes of smoking and nonsmoking men	11
The impact of perfluoroalkyl substances on pregnancy, birth outcomes, and offspring development: a review of data from mouse models	11
Environmentally relevant mixtures of phthalates and phthalate metabolites differentially alter the cell cycle and apoptosis in mouse neonatal ovaries†	11
Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes	11
Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats	11
Sperm–oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site	10
ESR1 mediates estrogen-induced feminization of genetic male Chinese soft-shelled turtle	10
Spatial transcriptomics analysis of uterine gene expression in enhancer of zeste homolog 2 conditional knockout mice†	10
The mystery of the life tree: the placentas	10
The combined impact of testosterone and Western-style diet on endometriosis severity and progression in rhesus macaques	10
Excessive follicle-stimulating hormone during ovarian stimulation of cattle may induce premature luteinization of most ovulatory-size follicles	10
A central role for cAMP/EPAC/RAP/PI3K/AKT/CREB signaling in LH-induced follicular Pgr expression at medaka ovulation	10
Use of anti-inhibin monoclonal antibody for increasing the litter size of mouse strains and its application to in vivo-genome editing technology	10
Vaginal microbiota differences associated with pelvic organ prolapse risk during late gestation in commercial sows	10
Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling	10
Exposures during the prepuberty period and future offspring’s health: evidence from human cohort studies†	10
Biochemical and molecular characterization of sialylated cervical mucins in sheep	10
ZC3H4—a novel Cys-Cys-Cys-His-type zinc finger protein—is essential for early embryogenesis in mice†	10
SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy	10
miR-26a-5p and miR-125b-5p affect trophoblast genes and cell functions important during early pregnancy	10
Recapitulating folliculogenesis and oogenesis outside the body: encapsulated in vitro follicle growth	10
Novel mineral regulatory pathways in ovine pregnancy: II. Calcium-binding proteins, calcium transporters, and vitamin D signaling	10
Aging and oxidative stress alter DNA repair mechanisms in male germ cells of superoxide dismutase-1 null mice	10
Identification of novel genes and pathways regulated by the orphan nuclear receptor COUP-TFII in mouse MA-10 Leydig cells	10
Gestational diabetes mellitus suppresses fetal testis development in mice	9
Elongating porcine conceptuses can utilize glutaminolysis as an anaplerotic pathway to maintain the TCA cycle	9
Chronic overload of concentration-dependent iron exerts different effects on ovarian function in C57BL/6J mice	9
Galectin-1 induces gene and protein expression related to maternal-conceptus immune tolerance in bovine endometrium	9
Influence of estradiol on bovine trophectoderm and uterine gene transcripts around maternal recognition of pregnancy	9
L-amino acid oxidase 1 in sperm is associated with reproductive performance in male mice and bulls	9
Comparing the maternal-fetal microbiome of humans and cattle: a translational assessment of the reproductive, placental, and fetal gut microbiomes	9
Research progress and application prospects of stable porcine pluripotent stem cells	9
Attenuated monoamine oxidase a impairs endometrial receptivity in women with adenomyosis via downregulation of FOXO1	9
Chemerin effect on transcriptome of the porcine endometrium during implantation determined by RNA-sequencing	9
Dynamic zinc fluxes regulate meiotic progression in Caenorhabditis elegans	9
CXCR4 signaling at the fetal–maternal interface may drive inflammation and syncytia formation during ovine pregnancy†	9
Clonal gametogenesis is triggered by intrinsic stimuli in the hybrid’s germ cells but is dependent on sex differentiation	9
Glycyrrhizin ameliorates impaired glucose metabolism and ovarian dysfunction in a polycystic ovary syndrome mouse model	9

Comparing mRNA and sncRNA profiles during the maternal-to-embryonic transition in bovine IVF and scNT embryos	9
HDL mediates reverse cholesterol transport from ram spermatozoa and induces hyperactivated motility	9
KIF3B gene silent variant leading to sperm morphology and motility defects and male infertility	9
Meiotic chromosome organization and crossover patterns	9
Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism	9
Synergistic action of estradiol and PGE2 on endometrial transcriptome in vivo resembles pregnancy effects better than estradiol alone†	9
MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis	9
Regulation of mouse primordial follicle formation by signaling through the PI3K pathway	9
Peri-estrus ovarian, uterine, and hormonal variables determine the uterine luminal fluid metabolome in beef heifers	9
The placenta as a target of opioid drugs	9
Seasonal reproduction and gonadal function: a focus on humans starting from animal studies	9
Zp4 is completely dispensable for fertility in female rats	9
Ovarian follicles are resistant to monocyte perturbations—implications for ovarian health with immune disruption	8
Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†	8
Neither gonadotropin nor cumulus cell expansion is needed for the maturation of competent porcine oocytes in vitro†	8
Conditional knockout of leptin receptor in the female reproductive tract reduces fertility due to parturition defects in mice	8
Berberine alleviates LPS-induced apoptosis, oxidation, and skewed lineages during mouse preimplantation development	8
The gut microbiota: a double-edged sword in endometriosis	8
Hyperandrogenism diminishes maternal–fetal fatty acid transport by increasing FABP4-mediated placental lipid accumulation	8
Irisin reduces the abnormal reproductive and metabolic phenotypes of PCOS by regulating the activity of brown adipose tissue in mice	8
Pattern recognition receptor-initiated innate immune responses in mouse prostatic epithelial cells	8
Recent progress of proteomic analysis on spermatogenesis	8
Glutamate can act as a signaling molecule in mouse preimplantation embryos	8
Kisspeptin-54 injection induces a physiological luteinizing hormone surge and ovulation in mice	8
Prolonging photoperiod promotes testosterone synthesis of Leydig cells by directly targeting local melatonin system in rooster testes	8
Design of novel oocyte activation methods: the role of zinc	8
VEGFA165 can rescue excess steroid secretion, inflammatory markers, and follicle arrest in the ovarian cortex of High A4 cows	8
An evo-devo perspective of the female reproductive tract	8
Low glucose and high pyruvate reduce the production of 2-oxoaldehydes, improving mitochondrial efficiency, redox regulation, and stallion sperm function†	8
Decreased B7-H3 promotes unexplained recurrent miscarriage via RhoA/ROCK2 signaling pathway and regulates the secretion of decidual NK cells	8
Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice	8
Pyometra and estrous cycle modulate the uterine expression of the kisspeptin system and angiogenic and immune factors in cats	8
High-content imaging analyses of the effects of bisphenols and organophosphate esters on TM4 mouse Sertoli cells	8
Male fetal sex affects uteroplacental angiogenesis in growth restriction mouse model†	8
RNF8 is not required for histone-to-protamine exchange in spermiogenesis	8
Effect of natural pre-luteolytic prostaglandin F2α pulses on the bovine luteal transcriptome during spontaneous luteal regression†	8
Evidence of intergenerational transmission of diethylstilbestrol health effects: hindsight and insight	8
Effects of the endocrine disruptor vinclozolin in male reproduction: a systematic review and meta-analysis†	8
Niclosamide’s potential direct targets in ovarian cancer	8
Sex differences in microRNA expression in first and third trimester human placenta	8
The requirement of ubiquitin C-terminal hydrolase L1 in mouse ovarian development and fertility	8
Glucagon-like peptide-1 receptor agonists decrease hyperinsulinemia and hyperandrogenemia in dehydroepiandrosterone-induced polycystic ovary syndrome mice and are associated with mitigating inflammati	8
Anex vivoovulation system enables the discovery of novel ovulatory pathways and nonhormonal contraceptive candidates	8
Gaps in the knowledge of thyroid hormones and placental biology	8
Phosphoproteomics for the identification of new mechanisms of cryodamage: the role of SPATA18 in the control of stallion sperm function	8
Identification of pathogenic mutations from nonobstructive azoospermia patients	8
Characterization of transcriptional activity during ZGA in mammalian SCNT embryo	8
Activation of bovine oocytes by protein synthesis inhibitors: new findings on the role of MPF/MAPKs†	8
Epigenetic regulation of cell fate transition: learning from early embryo development and somatic cell reprogramming	8
A critical appraisal of the circulating levels of differentially expressed microRNA in endometriosis	8
Oocyte quality following in vitro follicle development	8
Role of ceRNAs in non-tumor female reproductive diseases	7
Glutathione deficiency decreases lipid droplet stores and increases reactive oxygen species in mouse oocytes	7
The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility	7
Sperm selection by the oviduct: perspectives for male fertility and assisted reproductive technologies	7
Notch1 is crucial for decidualization and maintaining the first pregnancy in the mouse†	7
Loss of mouse Y chromosome geneZfy1andZfy2leads to spermatogenesis impairment, sperm defects, and infertility	7
Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes	7
Sphingosine-1-phosphate and its mimetic FTY720 do not protect against radiation-induced ovarian fibrosis in the nonhuman primate†	7
Evolutionary, proteomic, and experimental investigations suggest the extracellular matrix of cumulus cells mediates fertilization outcomes†	7
Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis	7
Endometrial and luteal responses to a prostaglandin F2alpha pulse: a comparison between heifers and mares	7
Efficient cell chatting between embryo and uterus ensures embryo implantation	7
Placental expression of estrogen-related receptor gamma is reduced in fetal growth restriction pregnancies and is mediated by hypoxia	7
Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse.	7
Neuroanatomical basis of the nerve growth factor ovulation–induction pathway in llamas†	7
Prophylactic and therapeutic vaccination protects sperm health from Chlamydia muridarum-induced abnormalities	7
Characterization of different oligomeric forms of CRISP2 in the perinuclear theca versus the fibrous tail structures of boar spermatozoa†	7
Decoding the transcriptome of pre-granulosa cells during the formation of primordial follicles in the mouse	7
Insights into the lipidome and primary metabolome of the uterus from day 14 cyclic and pregnant sheep	7
Proteomic analysis of spermatozoa reveals caseins play a pivotal role in preventing short-term periods of subfertility in stallions	7
TBC1D21 is an essential factor for sperm mitochondrial sheath assembly and male fertility	7
Myostatin increases human trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 signaling	7
Neurotensin: a neuropeptide induced by hCG in the human and rat ovary during the periovulatory period	7
Delayed parenthood and its influence on offspring health: what have we learned from the mouse model	7
Actin-related protein ACTL7B ablation leads to OAT with multiple morphological abnormalities of the flagellum and male infertility in mice	7
Dynamic erectile responses of a novel penile organ model utilizing TPEM†	7
Downregulating HK2 inhibits proliferation of endometrial stromal cells through a noncanonical pathway involving phosphorylation of signal transducer and activator of transcription 1 in endometriosis	7
Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian follicles†	7
Temporal and spatial expression of adrenomedullin and its receptors in the porcine uterus and peri-implantation conceptuses	7
Functional evaluation of the cystic fibrosis transmembrane conductance regulator in the endocervix	7
Evidence and manipulation of O-GlcNAcylation in granulosa cells of bovine antral follicles†	7
Insulin-like growth factor 2 is produced by antral follicles and promotes preantral follicle development in macaques†	7
Dnmt2-null sperm block maternal transmission of a paramutant phenotype†	6
Tauroursodeoxycholic acid/TGR5 signaling promotes survival and early development of glucose-stressed porcine embryos	6
Pregnancy-induced changes in the transcriptome of the bovine corpus luteum during and after embryonic interferon-tau secretion†	6
Kisspeptin/Kiss1r system and angiogenic and immunological mediators at the maternal-fetal interface of domestic cats	6
Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in rats	6
Proteomic determinants of uterine receptivity for pregnancy in early and mid-postpartum dairy cows	6
Metabolomic markers of biological fluid in women with reproductive failure: a systematic review of current literatures	6
Role of autocrine bone morphogenetic protein signaling in trophoblast stem cells	6
Paternally expressed retrotransposon Gag-like 1 gene, RTL1, is one of the crucial elements for placental angiogenesis in horses	6
Current understanding in deciphering trophoblast cell differentiation during human placentation	6
Genetically engineered birds; pre-CRISPR and CRISPR era	6
MicroRNAs in amniotic fluid and maternal blood plasma associated with sex determination and early gonad differentiation in cattle	6