Biochemistry

Article	Citations
Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag	95
Modulating α-Synuclein Liquid–Liquid Phase Separation	93
Genetic Code Expansion: A Brief History and Perspective	81
Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates	72
Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic	70
Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies: Structurally Adaptable Allosteric Communication Hotspots Define Spike Si	68
The Biochemical Landscape of Riboswitch Ligands	61
Ligandability of E3 Ligases for Targeted Protein Degradation Applications	59
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation	56
Principles Governing the Phase Separation of Multidomain Proteins	56
Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity	54
Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation	52
Exploring the Mechanism of Covalent Inhibition: Simulating the Binding Free Energy of α-Ketoamide Inhibitors of the Main Protease of SARS-CoV-2	50
Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors	49
Cryo-EM Structure of the Rhodobacter sphaeroides Light-Harvesting 2 Complex at 2.1 Å	44
Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria	40
Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences	36
Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability and Activity	36
Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design	33
Fast and Specific Peroxygenase Reactions Catalyzed by Fungal Mono-Copper Enzymes	32
Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils	31
Functional Roles of Chelated Magnesium Ions in RNA Folding and Function	31
Dynamic Connection between Enzymatic Catalysis and Collective Protein Motions	31
The Origin of Lipid Rafts	30
Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening	30

Improved Bst DNA Polymerase Variants Derived via a Machine Learning Approach	29
Enabling Role of Ligand-Driven Conformational Changes in Enzyme Evolution	29
Mechanisms of O2 Activation by Mononuclear Non-Heme Iron Enzymes	29
Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists	28
Targeted Degradation of the Oncogenic Phosphatase SHP2	28
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen	28
Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo	27
Effect of Surface Modification with Hydrocarbyl Groups on the Exocytosis of Nanoparticles	27
Protein Substrates Engage the Lumen of O-GlcNAc Transferase’s Tetratricopeptide Repeat Domain in Different Ways	27
Direct Mapping of Higher-Order RNA Interactions by SHAPE-JuMP	27
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode	26
Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum	26
Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life	25
How Sugars Protect Dry Protein Structure	25
Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering Toolbox	24
Pulse EPR Spectroscopic Characterization of the S3 State of the Oxygen-Evolving Complex of Photosystem II Isolated from Synechocystis	24
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates	24
A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster	23
Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery	23
Reframing the Protein Folding Problem: Entropy as Organizer	22
Targeted Protein Degradation via Lysosomes	22
Polyamines Mediate Folding of Primordial Hyperacidic Helical Proteins	22
Mechanism of Oxygen Evolution and Mn4CaO5 Cluster Restoration in the Natural Water-Oxidizing Catalyst	22
Progress, Challenges, and Opportunities with Artificial Metalloenzymes in Biosynthesis	22
The m6A Consensus Motif Provides a Paradigm of Epitranscriptomic Studies	22
Midazolam as a Probe for Drug–Drug Interactions Mediated by CYP3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation	22
HDAC6 ZnF UBP as the Modifier of Tau Structure and Function	22
Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force	21
Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)	21
Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport	21
Correlated Motions in Structural Biology	21
Insertions and Deletions (Indels): A Missing Piece of the Protein Engineering Jigsaw	21
The 2-Aminopyridine Nucleobase Improves Triple-Helical Recognition of RNA and DNA When Used Instead of Pseudoisocytosine in Peptide Nucleic Acids	21
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2	20
The Structure of the Dimeric State of IscU Harboring Two Adjacent [2Fe–2S] Clusters Provides Mechanistic Insights into Cluster Conversion to [4Fe–4S]	20
SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers	20
Discovery of a New, Recurrent Enzyme in Bacterial Phosphonate Degradation: (R)-1-Hydroxy-2-aminoethylphosphonate Ammonia-lyase	20
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator	20
Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin	19
Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity	19
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases	19
Engineering Fe(II)/α-Ketoglutarate-Dependent Halogenases and Desaturases	19
Buffers, Especially the Good Kind	19
Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain	18
The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme	18
Identifying Distinct Structural Features of the SARS-CoV-2 Spike Protein Fusion Domain Essential for Membrane Interaction	18
Enhanced Cholesterol-Dependent Hemifusion by Internal Fusion Peptide 1 of SARS Coronavirus-2 Compared to Its N-Terminal Counterpart	18
Peptidase Activation by a Leader Peptide-Bound RiPP Recognition Element	18
Lipoprotein Particles Interact with Membranes and Transfer Their Cargo without Receptors	18
Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin	18

Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization	17
The Interaction between PsbT and the DE Loop of D1 in Photosystem II Stabilizes the Quinone–Iron Electron Acceptor Complex	17
Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca2+Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic	17
Estimation of Effective Concentrations Enforced by Complex Linker Architectures from Conformational Ensembles	17
An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways	17
One-Enzyme Reverse Transcription qPCR Using Taq DNA Polymerase	17
Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products	17
Structural Robustness Affects the Engineerability of Aminoacyl-tRNA Synthetases for Genetic Code Expansion	17
How to Recruit a Promiscuous Enzyme to Serve a New Function	16
Long-Acting Cabotegravir for HIV/AIDS Prophylaxis	16
Dried Protein Structure Revealed at the Residue Level by Liquid-Observed Vapor Exchange NMR	16
Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in Escherichia coli	16
Protein–Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory	16
New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products	16
Bioinformatic Expansion of Borosins Uncovers Trans-Acting Peptide Backbone N-Methyltransferases in Bacteria	15
Annexins A1 and A2 Accumulate and Are Immobilized at Cross-Linked Membrane–Membrane Interfaces	15
Fatty Acid Photodecarboxylase Is an Interfacial Enzyme That Binds to Lipid–Water Interfaces to Access Its Insoluble Substrate	15
Hyperphosphorylation of Human Osteopontin and Its Impact on Structural Dynamics and Molecular Recognition	15
Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, th	15
X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10	15
Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence	15
The Zinc and Iron Binuclear Transport Center of ZupT, a ZIP Transporter from Escherichia coli	15
Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications	15
Water’s Variable Role in Protein Stability Uncovered by Liquid-Observed Vapor Exchange NMR	15
Cryo-Electron Microscopy Structures of Yeast Alcohol Dehydrogenase	15
Live and Let Dye	15
Leveraging a Structural Blueprint to Rationally Engineer the Rieske Oxygenase TsaM	14
Biosynthesis of d-glycero-l-gluco-Heptose in the Capsular Polysaccharides of Campylobacter jejuni	14
An Extended DNA Binding Domain of the Estrogen Receptor Alpha Directly Interacts with RNAs in Vitro	14
De Novo-Designed β-Sheet Heme Proteins	14
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B	14
Electrostatic Drivers of GPx4 Interactions with Membrane, Lipids, and DNA	14
Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir	14
Insights into Cerebral Amyloid Angiopathy Type 1 and Type 2 from Comparisons of the Fibrillar Assembly and Stability of the Aβ40-Iowa and Aβ40-Dutch Peptides	14
Uncoupling Amphipathicity and Hydrophobicity: Role of Charge Clustering in Membrane Interactions of Cationic Antimicrobial Peptides	14
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay	14
Advances in the Treatment of Chronic Pain by Targeting GPCRs	14
Analysis of Tagged Proteins Using Tandem Affinity-Buffer Exchange Chromatography Online with Native Mass Spectrometry	13
Structure of a Stable Interstrand DNA Cross-Link Involving a β-N-Glycosyl Linkage Between an N6-dA Amino Group and an Abasic Site	13
Origins of Ca2+ Imaging with Fluorescent Indicators	13
Rhodium Complexes Targeting DNA Mismatches as a Basis for New Therapeutics in Cancers Deficient in Mismatch Repair	13
Biosynthesis of Oxetanocin-A Includes a B12-Dependent Radical SAM Enzyme That Can Catalyze both Oxidative Ring Contraction and the Demethylation of SAM	13
Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs)	13
Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?	13
Convergent Evolution of Multiple Mutations Improves the Viral Fitness of SARS-CoV-2 Variants by Balancing Positive and Negative Selection	13
RNA–Ligand Interactions Quantified by Surface Plasmon Resonance with Reference Subtraction	13
Cholesterol Asymmetrically Modulates the Conformational Ensemble of the Nucleotide-Binding Domains of P-Glycoprotein in Lipid Nanodiscs	13
Phenoxazinone Synthase-like Activity of Rationally Designed Heme Enzymes Based on Myoglobin	13
PCNA Monoubiquitination Is Regulated by Diffusion of Rad6/Rad18 Complexes along RPA Filaments	13
Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets	13
Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity	13
Polyanions Cause Protein Destabilization Similar to That in Live Cells	13
Purification of Recombinant α-synuclein: A Comparison of Commonly Used Protocols	12
Danio rerio Oocytes for Eukaryotic In-Cell NMR	12
Alteration of the O2-Producing Mn4Ca Cluster in Photosystem II by the Mutation of a Metal Ligand	12
TAT Rhodopsin Is an Ultraviolet-Dependent Environmental pH Sensor	12
Long Range Communication between the Drug-Binding Sites and Nucleotide Binding Domains of the Efflux Transporter ABCB1	12
The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam	12
Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzym	12
Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level	12
A Structural View of Alkyl-Coenzyme M Reductases, the First Step of Alkane Anaerobic Oxidation Catalyzed by Archaea	12
Probing Metal-Dependent Phosphate Binding for the Catalysis of the 17E DNAzyme	12
A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands	12
The Crystal Structures of Bacillithiol Disulfide Reductase Bdr (YpdA) Provide Structural and Functional Insight into a New Type of FAD-Containing NADPH-Dependent Oxidoreductase	12
Cross-Binding of Four Adenosine/ATP Aptamers to Caffeine, Theophylline, and Other Methylxanthines	12
Protonation-Dependent Sequencing of 5-Formylcytidine in RNA	12
Strongly Hydrogen-Bonded Schiff Base and Adjoining Polyene Twisting in the Retinal Chromophore of Schizorhodopsins	12
Novel Mechanisms of Molecular Glue-Induced Protein Degradation	12
Structural Insights into Binding of Remdesivir Triphosphate within the Replication–Transcription Complex of SARS-CoV-2	12
Engineering Catalytically Self-Sufficient P450s	12
Variable Autoinhibition among Deafness-Associated Variants of Diaphanous 1 (DIAPH1)	12
Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range	12
H1.0 C Terminal Domain Is Integral for Altering Transcription Factor Binding within Nucleosomes	12
On the Track of Long-Range Electron Transfer in B-Type Dye-Decolorizing Peroxidases: Identification of a Tyrosyl Radical by Computational Prediction and Electron Paramagnetic Resonance Spectroscopy	12
New Mechanism of Gemcitabine and Its Phosphates: DNA Polymerization Disruption via 3′–5′ Exonuclease Inhibition	12
Membrane-Catalyzed Aggregation of Islet Amyloid Polypeptide Is Dominated by Secondary Nucleation	12
Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms	12
Calorimetric Analysis of the Interplay between Synthetic Tn Antigen-Presenting MUC1 Glycopeptides and Human Macrophage Galactose-Type Lectin	12
Metabolic Processing of Selenium-Based Bioisosteres of meso-Diaminopimelic Acid in Live Bacteria	11
Opposing Effects of PhoPQ and PmrAB on the Properties of Salmonella enterica serovar Typhimurium: Implications on Resistance to Antimicrobial Peptides	11

Biochemical Characterization and NMR Study of a PET-Hydrolyzing Cutinase from Fusarium solani pisi	11
Local Electric Field Changes during the Photoconversion of the Bathy Phytochrome Agp2	11
The DNA-Binding High-Mobility Group Box Domain of Sox Family Proteins Directly Interacts with RNA In Vitro	11
Characterization of the High-Affinity Fuzzy Complex between the Disordered Domain of the E7 Oncoprotein from High-Risk HPV and the TAZ2 Domain of CBP	11
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay	11
Efficient Exploration of Sequence Space by Sequence-Guided Protein Engineering and Design	11
Mechanistic Insights into Nitrogenase FeMo-Cofactor Catalysis through a Steady-State Kinetic Model	11
Conformational Changes and H-Bond Rearrangements during Quinone Release in Photosystem II	11
Photoreaction Dynamics of a Full-Length Protein YtvA and Intermolecular Interaction with RsbRA	11
The RNA Polymerase α Subunit Recognizes the DNA Shape of the Upstream Promoter Element	11
Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes	11
Characterization of Enzymes Catalyzing the Formation of the Nonproteinogenic Amino Acid l-Dap in Capreomycin Biosynthesis	11
Acetylated Ubiquitin Modulates the Catalytic Activity of the E1 Enzyme Uba1	11
Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway	10
Revealing Donor Substrate-Dependent Mechanistic Control on DXPS, an Enzyme in Bacterial Central Metabolism	10
Transition Metals Induce Quenching of Monomeric Near-Infrared Fluorescent Proteins	10
Insights into Binding of Single-Stranded Viral RNA Template to the Replication–Transcription Complex of SARS-CoV-2 for the Priming Reaction from Molecular Dynamics Simulations	10
Heterogeneous Composition of Oxygen-Evolving Complexes in Crystal Structures of Dark-Adapted Photosystem II	10
Soluble Methane Monooxygenase Component Interactions Monitored by 19F NMR	10
A Spectroscopically Validated Computational Investigation of Viable Reaction Intermediates in the Catalytic Cycle of the Reductive Dehalogenase PceA	10
Quantitative NMR Study of Insulin-Degrading Enzyme Using Amyloid-β and HIV-1 p6 Elucidates Its Chaperone Activity	10
Oxygen-Induced Conformational Changes in the PAS-Heme Domain of the Pseudomonas aeruginosa Aer2 Receptor	10
Comparative Analysis of Corrinoid Profiles across Host-Associated and Environmental Samples	10
Characterization of the β-KDO Transferase KpsS, the Initiating Enzyme in the Biosynthesis of the Lipid Acceptor for Escherichia coli Polysialic Acid	10
An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9, and LDLR in Hepatocytes	10
Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation	10
Ganglioside-Enriched Phospholipid Vesicles Induce Cooperative Aβ Oligomerization and Membrane Disruption	10
Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis	10
Discovery and Mechanism of Small Molecule Inhibitors Selective for the Chromatin-Binding Domains of Oncogenic UHRF1	10
In vitro-Constructed Ribosomes Enable Multi-site Incorporation of Noncanonical Amino Acids into Proteins	10
Incorporation and Assembly of a Light-Emitting Enzymatic Reaction into Model Protein Condensates	10
Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A	10
Design of a Superpositively Charged Enzyme: Human Carbonic Anhydrase II Variant with Ferritin Encapsulation and Immobilization	10
In vitro Tau Aggregation Inducer Molecules Influence the Effects of MAPT Mutations on Aggregation Dynamics	10
Protonation State of a Key Histidine Ligand in the Iron–Quinone Complex of Photosystem II as Revealed by Light-Induced ATR-FTIR Spectroscopy	10
Protein Condensate Formation via Controlled Multimerization of Intrinsically Disordered Sequences	10
Bacterial Responses to Iron Withholding by Calprotectin	10
Mechanistic Insight into Lipid Binding to Yeast Niemann Pick Type C2 Protein	10
Structural Insights into Microbial One-Carbon Metabolic Enzymes Ni–Fe–S-Dependent Carbon Monoxide Dehydrogenases and Acetyl-CoA Synthases	10
ATR-FTIR Spectroelectrochemical Study on the Mechanism of the pH Dependence of the Redox Potential of the Non-Heme Iron in Photosystem II	10
The Acyl-CoA Specificity of Human Lysine Acetyltransferase KAT2A	10
Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6	9
α-Carboxysome Size Is Controlled by the Disordered Scaffold Protein CsoS2	9
A Novel Gene Alignment in Dorea sp. AM58-8 Produces 7-Dehydroxy-3β Bile Acids from Primary Bile Acids	9
Oligomerization of Sticholysins from Förster Resonance Energy Transfer	9
Orthogonal Bioluminescent Probes from Disubstituted Luciferins	9
Pinpoint Dual Chemical Cross-Linking Explores the Structural Dynamics of the Ubiquinone Reaction Site in Mitochondrial Complex I	9
Common Pitfalls and Recommendations for Using a Turbidity Assay to Study Protein Phase Separation	9
Translesion Synthesis Past 5-Formylcytosine-Mediated DNA–Peptide Cross-Links by hPolη Is Dependent on the Local DNA Sequence	9
Addressing Transcriptional Dysregulation in Cancer through CDK9 Inhibition	9
A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry	9
Mutagenesis, Hydrogen–Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase	9
Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD+	9
Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c	9
Structural, Dynamic, and Functional Characterization of a DnaX Mini-intein Derived from Spirulina platensis Provides Important Insights into Intein-Mediated Catalysis of Protein Splicing	9
Transient-State Kinetic Analysis of the RNA Polymerase II Nucleotide Incorporation Mechanism	9
Direct Visualization of a 26 kDa Protein by Cryo-Electron Microscopy Aided by a Small Scaffold Protein	9
Structure and Mechanism of a Cold-Adapted Bacterial Lipase	9
Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2	9
Comparison of the Forward and Reverse Photocycle Dynamics of Two Highly Similar Canonical Red/Green Cyanobacteriochromes Reveals Unexpected Differences	9
Bisindolylmaleimide Ligands Stabilize c-MYC G-Quadruplex DNA Structure and Downregulate Gene Expression	9
C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni	9
Chemoproteomic Analysis of Microbiota Metabolite–Protein Targets and Mechanisms	9
Functional Characterization of Two PLP-Dependent Enzymes Involved in Capsular Polysaccharide Biosynthesis from Campylobacter jejuni	9
Controlled and Stable Patterning of Diverse Inorganic Nanocrystals on Crystalline Two-Dimensional Protein Arrays	9
In Vitro Synthesis and Reconstitution Using Mammalian Cell-Free Lysates Enables the Systematic Study of the Regulation of LINC Complex Assembly	9
Structural Determinants of Flavin Dynamics in a Class B Monooxygenase	9
Phase Separation Properties in Transcriptional Organization	9
Replication Protein A Utilizes Differential Engagement of Its DNA-Binding Domains to Bind Biologically Relevant ssDNAs in Diverse Binding Modes	9
Lipid Nanoparticles Deliver mRNA to the Brain after an Intracerebral Injection	9
Formation of the Metal-Binding Core of the ZRT/IRT-like Protein (ZIP) Family Zinc Transporter	9
Mutations in Dynamic Structural Elements Alter the Kinetics and Fidelity of the Multifunctional Class II Lanthipeptide Synthetase, HalM2	9
Phosphomimetic Mutations Impact Huntingtin Aggregation in the Presence of a Variety of Lipid Systems	9
Chemoenzymatic Synthesis of Chito-oligosaccharides with Alternating N-d-Acetylglucosamine and d-Glucosamine	9
Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine–Guanine Phosphoribosyltransferases	9
Evaluation of the Inhibition Potency of Nirmatrelvir against Main Protease Mutants of SARS-CoV-2 Variants	9
Global Mapping of Metalloproteomes	9
Asymmetric Roles of Two Histidine Residues in Streptococcus pyogenes Cas9 Catalytic Domains upon Chemical Rescue	9
Conserved Trigger Loop Histidine of RNA Polymerase II Functions as a Positional Catalyst Primarily through Steric Effects	9
Enterococcus NlpC/p60 Peptidoglycan Hydrolase SagA Localizes to Sites of Cell Division and Requires Only a Catalytic Dyad for Protease Activity	9
Mutation of βGln114 to Ala Alters the Stabilities of Allosteric States in Tryptophan Synthase Catalysis	9
Optogenetic Analysis of Allosteric Control in Protein Tyrosine Phosphatases	8
Rationally Guided Improvement of NOV1 Dioxygenase for the Conversion of Lignin-Derived Isoeugenol to Vanillin	8
Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers	8
Structural Dynamics of Cytochrome P450 3A4 in the Presence of Substrates and Cytochrome P450 Reductase	8
From the Three-Dimensional Structure of Phosphotriesterase	8
Tertiary Base Triple Formation in the SRV-1 Frameshifting Pseudoknot Stabilizes Secondary Structure Components	8
Structural Ensemble of the Insulin Monomer	8
A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination	8
Exploring the Conformational Landscape of a Lanthipeptide Synthetase Using Native Mass Spectrometry	8
Accumulation and Pulse Electron Paramagnetic Resonance Spectroscopic Investigation of the 4-Oxidobenzyl Radical Generated in the RadicalS-Adenosyl-l-methionine Enzyme HydG	8
The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability	8
Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii	8
Effects of Familial Alzheimer’s Disease Mutations on the Assembly of a β-Hairpin Peptide Derived from Aβ16–36	8
Effects of Stromal and Lumenal Side Perturbations on the Redox Potential of the Primary Quinone Electron Acceptor QA in Photosystem II	8