Biochemistry

Papers
(The TQCC of Biochemistry is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)
ArticleCitations
Molecular Insights into the Inhibition of Dialysis-Related β2m Amyloidosis Orchestrated by a Bispidine Peptidomimetic Analogue123
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Two-Component System Sensor Kinase Inhibitors Target the ATP-Lid of PmrB to Disrupt Colistin Resistance in Acinetobacter baumannii82
Computational Approaches for Development of Engineered Therapeutics against SARS-CoV-276
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Distinguishing Different Hydrogen-Bonded Helices in Proteins by Efficient 1H-Detected Three-Dimensional Solid-State NMR58
Contrasting Mechanisms of Aromatic and Aryl-Methyl Substituent Hydroxylation by the Rieske Monooxygenase Salicylate 5-Hydroxylase54
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AmorProt: Amino Acid Molecular Fingerprints Repurposing-Based Protein Fingerprint47
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Determining the Sequence Dependency of Self-Assembly of Elastin-Like Peptides Using Short Peptide Analogues with Shuffled Repetitive Sequences44
Transient Prenyltransferase–Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase43
RNA Polymerase Ribozyme That Recognizes the Template–Primer Complex through Tertiary Interactions41
Signal Transmission in Escherichia coli Cyclic AMP Receptor Protein for Survival in Extreme Acidic Conditions40
Structure and Mechanism of a Cold-Adapted Bacterial Lipase39
Modification of the 4Fe-4S Cluster Charge Transport Pathway Alters RNA Synthesis by Yeast DNA Primase38
Advancing the Biosynthetic and Chemical Understanding of the Carcinogenic Risk Factor Colibactin and Its Producers38
Genome Engineering for Next-Generation Cellular Immunotherapies37
C3- and C3/C5-Epimerases Required for the Biosynthesis of the Capsular Polysaccharides from Campylobacter jejuni36
Transient-State Kinetic Analysis of the RNA Polymerase II Nucleotide Incorporation Mechanism36
13C Electron Nuclear Double Resonance Spectroscopy-Guided Molecular Dynamics Computations Reveal the Structure of the Enzyme–Substrate Complex of an Active, N-Linked Glycosylated Lip35
Identification of Filamin A Mechanobinding Partner III: SAV1 Specifically Interacts with Filamin A Mechanosensitive Domain 2135
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay32
Biochemical, Bioinformatic, and Structural Comparisons of Transketolases and Position of Human Transketolase in the Enzyme Evolution32
A Novel Gene Alignment in Dorea sp. AM58-8 Produces 7-Dehydroxy-3β Bile Acids from Primary Bile Acids32
Modifying the Basicity of the dNTP Leaving Group Modulates Precatalytic Conformational Changes of DNA Polymerase β32
Electrostatic Interactions Dictate Bile Salt Hydrolase Substrate Preference31
Interaction of the Influenza A Virus NS1 Protein with the 5′-m7G-mRNA·eIF4E·eIF4G1 Complex31
Inside-Out Design of Zinc-Binding Proteins with Non-Native Backbones31
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Human Translesion Synthesis Polymerases polκ and polη Perform Error-Free Replication across N2-dG Methyleugenol and Estragole DNA Adducts29
Hysteresis in Hepatitis B Virus (HBV) Requires Assembly of Near-Perfect Capsids28
Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation27
Modulating α-Synuclein Liquid–Liquid Phase Separation27
Glycerol 3-Phosphate Dehydrogenase Catalyzed Hydride Transfer: Enzyme Activation by Cofactor Pieces27
Parameterizing the Binding Properties of XNA Aptamers Isolated from a Low Stringency Selection27
Targeting Scaffolding Functions of Enzymes Using PROTAC Approaches27
Buffers, Especially the Good Kind26
A High-Throughput Screening Pipeline to Identify Methyltransferase and Exonuclease Inhibitors of SARS-CoV-2 NSP1426
Putative Protein Interactome of the Rhomboid Protease RHBDL426
The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa25
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Phase Separation in Cell Polarity24
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Pre-Steady-State Reactivity of Peptidylglycine Monooxygenase Implicates Ascorbate in Substrate Triggering of the Active Conformer23
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Structure–Function Analysis of the A1 Subunit of Shiga Toxin 2 with Peptides That Target the P-Stalk Binding Site and Inhibit Activity23
Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy22
Phosphonoacetate Modifications Enhance the Stability and Editing Yields of Guide RNAs for Cas9 Editors22
Importance of Asparagine 202 in Manipulating Active Site Structure and Substrate Preference for Human CYP17A122
Anionic Lipids Confine Cytochrome c2 to the Surface of Bioenergetic Membranes without Compromising Its Interaction with Redox Partners22
Mechanism of the Clinically Relevant E305G Mutation in Human P450 CYP17A122
Menaquinone Biosynthesis: New Strategies to Trap Radical Intermediates in the MqnE-Catalyzed Reaction21
How Sugars Protect Dry Protein Structure21
New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products20
Drug–Membrane Interactions: Effects of Virus-Specific RNA-Dependent RNA Polymerase Inhibitors Remdesivir and Favipiravir on the Structure of Lipid Bilayers20
Chemical Logic of Peptide Branching by Iterative Nonlinear Nonribosomal Peptide Synthetases20
Glycerol-3-Phosphate Dehydrogenase: The K120 and K204 Side Chains Define an Oxyanion Hole at the Enzyme Active Site20
Kinetic and Structural Analysis of Two Linkers in the Tautomerase Superfamily: Analysis and Implications20
Antimalarial Delivery with a Ferritin-Based Protein Cage: A Step toward Developing Smart Therapeutics against Malaria20
Kinetic Regulation of the Mammalian Sterile 20-like Kinase 2 (MST2)19
Conformational Selection Governs Carrier Domain Positioning in Staphylococcus aureus Pyruvate Carboxylase19
Molecular Mechanism of Protein Arginine Deiminase 2: A Study Involving Multiple Microsecond Long Molecular Dynamics Simulations19
Serine-Carboxyl Peptidases, Sedolisins: From Discovery to Evolution19
Energetic Diversity in the Electron-Transfer Pathways of Type I Photosynthetic Reaction Centers18
Structural Insights into the Substrate Range of a Bacterial Monoamine Oxidase18
Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk18
What Drives Chorismate Mutase to Top Performance? Insights from a Combined In Silico and In Vitro Study18
Conserved Residues at the Mtr4 C-Terminus Coordinate Helicase Activity and Exosome Interactions18
Comparative Analysis of Corrinoid Profiles across Host-Associated and Environmental Samples18
Substrate Electronics Dominate the Rate of Reductive Dehalogenation Promoted by the Flavin-Dependent Iodotyrosine Deiodinase18
Identification and Characterization of a Bacterial Periplasmic Solute Binding Protein That Binds l-Amino Acid Amides18
Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics17
“Just in Time”: The Role of Cryo-Electron Microscopy in Combating Recent Pandemics17
Activation of the Influenza B M2 Proton Channel (BM2)17
Decoding Substrate Selectivity of an Archaeal RlmCD-like Methyltransferase Through Its Salient Traits17
Identification of an Intrinsically Disordered Region (IDR) in Arginyltransferase 1 (ATE1)17
Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity17
Collagen Alpha 1(XI) Amino-Terminal Domain Modulates Type I Collagen Fibril Assembly16
Structural Dynamics of the Methyl-Coenzyme M Reductase Active Site Are Influenced by Coenzyme F430 Modifications16
Membrane-Catalyzed Aggregation of Islet Amyloid Polypeptide Is Dominated by Secondary Nucleation16
Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag16
Role of Ribosomal Protein bS1 in Orthogonal mRNA Start Codon Selection16
CUP1 Metallothionein from HealthySaccharomyces cerevisiaeColocalizes to the Cytosol and Mitochondrial Intermembrane Space16
Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis16
Identification of 2-Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay15
Strong Protection by 4-Hydroxyestrone against Erastin-Induced Ferroptotic Cell Death in Estrogen Receptor-Negative Human Breast Cancer Cells: Evidence for Protein Disulfide Isomerase as a Mechanistic 15
2′-Deoxy Guanosine Nucleotides Alter the Biochemical Properties of Ras15
Mitochondrial Dynamics of Bcl-2 Family Proteins during 17-β-Estradiol-Induced Apoptosis Correlate with the Malignancy of Endometrial Cancer Cells15
RNA–Ligand Interactions Quantified by Surface Plasmon Resonance with Reference Subtraction15
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Targeting Polymeric Nanoparticles to Specific Cell Populations in the Liver15
Contrasting Effects of Temperature on Human Arylamine N-Acetyltransferase and Acetyl Coenzyme A Hydrolase Activities15
Incorporation and Assembly of a Light-Emitting Enzymatic Reaction into Model Protein Condensates15
Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins15
Genome Editing: The Future Begins!15
A Kinetic Investigation of the Early Steps in Cytochrome c Nitrite Reductase (ccNiR)-Catalyzed Reduction of Nitrite15
Structural, Spectroscopic, and Computational Insights from Canavanine-Bound and Two Catalytically Compromised Variants of the Ethylene-Forming Enzyme14
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Adenylate Kinase-Catalyzed Reactions of AMP in Pieces: Specificity for Catalysis at the Nucleoside Activator and Dianion Catalytic Sites14
ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics14
Origins of Ca2+ Imaging with Fluorescent Indicators14
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Insights into the Activation and Self-Association of Arrestin-114
The Fragile X Protein Disordered Regions Bind a Novel RNA Target14
Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization14
Inter-domain Flexibility of Human Ser/Arg-Rich Splicing Factor 1 Allows Variable Spacer Length in Cognate RNA’s Bipartite Motifs14
A Soluble, Minimalistic Glycosylphosphatidylinositol Transamidase (GPI-T) Retains Transamidation Activity14
Structural Motifs at the Telomeres and Their Role in Regulatory Pathways14
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DNA Minor Groove-Induced cistrans Isomerization of a Near-Infrared Fluorescent Probe14
Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport14
Structural Framework for Analysis of CD4+ T-Cell Epitope Dominance in Viral Fusion Proteins14
Correlating Conformational Equilibria with Catalysis in the Electron Bifurcating EtfABCX of Thermotoga maritima14
Kinetic and Structural Characterization of a Flavin-Dependent Putrescine N-Hydroxylase from Acinetobacter baumannii14
Electrostatic Contribution to 19F Chemical Shifts in Fluorotryptophans in Proteins14
Slow Dissociation from the PARP1–HPF1 Complex Drives Inhibitor Potency14
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Kinetic Studies of the Hydrogen Atom Transfer in a Hypoxia-Sensing Enzyme, FIH-1: KIE and O2 Reactivity14
Human Archaea and Associated Metabolites in Health and Disease14
Functional Role of an Unusual Transmembrane Acidic Residue in the Calcium Pump Regulator Myoregulin13
Biochemical Analysis of the Regulatory Role of Gαo in the Conformational Transitions of Drosophila Pins13
Kinetic and Mechanistic Studies of Human Oligoadenylate Synthetase 113
Bioinformatic, Enzymatic, and Structural Characterization of Trichuris suis Hexosaminidase HEX-213
Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides of Campylobacter jejuni13
Role of Hydration and Amino Acid Interactions on the Ion Permeation Mechanism in the hNaV1.5 Channel13
Revisiting the Burden Borne by Fumarase: Enzymatic Hydration of an Olefin13
Role of the Palmitoyl Group and of the Amphipathic α Helix in the Membrane Binding of the C-Terminus of G-Protein Receptor Kinase 4α/β13
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DNA Sequence Specificity Reveals a Role of the HLTF HIRAN Domain in the Recognition of Trinucleotide Repeats12
Mechanisms of Peptide Agonist Dissociation and Deactivation of Adhesion G-Protein-Coupled Receptors12
Chemical Identification of [Fe(III)(OH)(H2O)]2+ Complex Ion at the Ferroxidase Active Site in Cryo-EM Maps12
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Protein Engineering in the Design of Protein–Protein Interactions: SARS-CoV-2 Inhibitors as a Test Case12
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Bisubstrate Analog Inhibitors of DXP Synthase Show Species Specificity12
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Activation of Dithiolopyrrolone Antibiotics by Cellular Reductants12
Structure of the LarB–Substrate Complex and Identification of a Reaction Intermediate during Nickel-Pincer Nucleotide Cofactor Biosynthesis12
Biochemical and Mutational Analysis of Radical S-Adenosyl-L-Methionine Adenosylhopane Synthase HpnH from Zymomonas mobilis Reveals that the Conserved Residue Cysteine-106 Reduces a Radic11
The RNA-Binding Domain of hnRNP U Extends beyond the RGG/RG Motifs11
AQP4-DARPin1: A Chimeric Antigen Based on Scaffold Protein DARPin for Efficient Detection of AQP4-IgG in NMOSD11
Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes11
Insights into the Structure and Dynamics of Proteins from 19F Solution NMR Spectroscopy11
Structural Insights into the Advances and Mechanistic Understanding of Human Dicer11
More Pieces of the Puzzle: Transient State Analysis of Dihydroorotate Dehydrogenase B from Lactoccocus lactis11
Structural Plasticity Allows Calumenin-1 to Moonlight as a Ca2+-Independent Chaperone: Pb2+ Enables Probing Alternate Inhibitory Conformation11
Differential Interactions of the Proteasome Inhibitor PI31 with Constitutive and Immuno-20S Proteasomes11
Peptide-Based Strategies: Combating Alzheimer’s Amyloid β Aggregation through Ergonomic Design and Fibril Disruption11
C-Terminal Basic Region of Troponin T Alters the Ca2+-Dependent Changes in Troponin I Interactions11
4,4-Difluoroproline as a Unique 19F NMR Probe of Proline Conformation11
Alternative Role of B/b Knob–Hole Interactions in the Fibrin Assembly11
Discovery and Functional Characterization of a Clandestine ATP-Dependent Amidoligase in the Biosynthesis of the Capsular Polysaccharide from Campylobacter jejuni11
The Biochemical Impact of Extracting an Embedded Adenylate Kinase Domain Using Circular Permutation11
Reaction Mechanism of the Terminal Plastoquinone QB in Photosystem II as Revealed by Time-Resolved Infrared Spectroscopy11
Catalytic Activity of the Archetype from Group 4 of the FTR-like Ferredoxin:Thioredoxin Reductase Family Is Regulated by Unique S = 7/2 and S = 1/2 [4Fe–4S] Clusters11
Biochemical Characterization of GacI, a Bifunctional Glycosyltransferase–Phosphatase Enzyme Involved in Acarbose Biosynthesis in Streptomyces glaucescens GLA.O11
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Contribution of Proteorhodopsin to Light-Dependent Biological Responses in Hymenobacter nivis P3T Isolated from Red Snow in Antarctica10
Exploring the Heterogeneous Structural Dynamics of Class II Lanthipeptide Synthetases with Hydrogen–Deuterium Exchange Mass Spectrometry (HDX-MS)10
Atomistic Insights into Sequence-Mediated Spontaneous Association of Short RNA Chains10
New Insights into the Mechanism of Action of L-681,217, a Medicinally Promising Polyketide Inhibitor of Bacterial Protein Translation10
Enzyme-Mediated Proximity Labeling Identifies Small RNAs in the Endoplasmic Reticulum Lumen10
The Chaperone-Active State of HdeB at pH 4 Arises from Its Conformational Rearrangement and Enhanced Stability Instead of Surface Hydrophobicity10
The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme10
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Negative Cooperativity in the Mechanism of Prenylated-Flavin-Dependent Ferulic Acid Decarboxylase: A Proposal for a “Two-Stroke” Decarboxylation Cycle10
Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes10
HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase10
Functional Validation of SAM Riboswitch Element A from Listeria monocytogenes10
Using Biotinylated myo-Inositol Hexakisphosphate to Investigate Inositol Pyrophosphate–Protein Interactions with Surface-Based Biosensors10
Protein Condensate Formation via Controlled Multimerization of Intrinsically Disordered Sequences10
Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening10
Alteration of the O2-Producing Mn4Ca Cluster in Photosystem II by the Mutation of a Metal Ligand10
Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation10
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Introducing the 60th Anniversary of Biochemistry Special Issue10
Sequence Divergence in the Arginase Domain of Ornithine Decarboxylase/Arginase in Fusobacteriacea Leads to Loss of Function in Oral Associated Species10
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The Engineered Hexosaminidase TtOGA-D120N Is an Efficient O-/N-/S-Glycoligase That Also Catalyzes Formation and Release of Oxazoline Donors for Cascade Syntheses with Glyco10
LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface10
Cosolvent Dimethyl Sulfoxide Influences Protein–Ligand Binding Kinetics via Solvent Viscosity Effects: Revealing the Success Rate of Complex Formation Following Diffusive Protein–Ligand Encounter10
A Biparatopic Intrabody Renders Vero Cells Impervious to Ricin Intoxication9
Coupling Subunit-Specific States to Allosteric Regulation in Homodimeric Cyclooxygenase-29
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Dissecting the Interaction between Cryptochrome and Timeless Reveals Underpinnings of Light-Dependent Recognition9
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Conformation-Dependent Reversible Interaction of Ca2+/Calmodulin-Dependent Protein Kinase Kinase with an Inhibitor, TIM-0639
Structural Origins of Altered Spectroscopic Properties upon Ligand Binding in Proteins Containing a Fluorescent Noncanonical Amino Acid9
Correction to “Axial Heme Coordination by the Tyr-His Motif in the Extracellular Hemophore HasAp Is Critical for the Release of Heme to the HasR Receptor of Pseudomonas aeruginosa9
Identification of Kazal Inhibitor Scaffolds with Identical Canonical Binding Loops and Their Effects on Binding Properties9
Mutational Analysis of (+)-Limonene Synthase9
Glycerol 3-Phosphate Dehydrogenase: Role of the Protein Conformational Change in Activation of a Readily Reversible Enzyme-Catalyzed Hydride Transfer Reaction9
Comparative Biochemical Studies of Disease-Associated Human Dicer Mutations on Processing of a Pre-microRNA and snoRNA9
Pathway Specific Unbinding Free Energy Profiles of Ritonavir Dissociation from HIV-1 Protease9
Phosphonate and α-Fluorophosphonate Analogues of d-Glucose 6-Phosphate as Active-Site Probes of 1l-myo-Inositol 1-Phosphate Synthase9
Functional Characterization of Two Polymerizing Glycosyltransferases for the Addition of N-Acetyl-d-galactosamine to the Capsular Polysaccharide of Campylobacter jejuni9
Membrane Binding and Cholesterol Sensing Motif in Mycoplasma genitalium FtsZ: A Novel Mode of Membrane Recruitment for Bacterial FtsZ9
Increasing the Soluble Expression and Whole-Cell Activity of the Plastic-Degrading Enzyme MHETase through Consensus Design9
Assessing Interferon Regulatory Factor 4 Complex Formation: Differential Behavior of Homocomplexes Versus Heterocomplexes Induced by Mutations9
Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding9
Aldol Cleavage in Water and the Power of Citrate Lyase as a Catalyst9
Hydrogen Bonding Compensation on the Convex Solvent-Exposed Helical Face of IA3, an Intrinsically Disordered Protein9
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Recent Advances in Double-Strand Break-Free Kilobase-Scale Genome Editing Technologies9
Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP+-Dependent Malic Enzyme 19
Sortase-Mediated Fluorescent Labeling of eIF4E for Investigating Translation Initiation Mechanisms9
Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins9
Transcription Regulation of Flagellins: A Structural Perspective9
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Slow Conformational Exchange between Partially Folded and Near-Native States of Ubiquitin: Evidence for a Multistate Folding Model9
Live and Let Dye9
Engineered Chimeras Unveil Swappable Modular Features of Fatty Acid and Polyketide Synthase Acyl Carrier Proteins9
Crystal Structure of Caryolan-1-ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction9
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Biophysical Characterization of Nucleolin Domains Crucial for Interaction with Telomeric and TERRA G-Quadruplexes9
Phenoxazinone Synthase-like Activity of Rationally Designed Heme Enzymes Based on Myoglobin9
Biosynthesis of UDP-β-l-Arabinofuranoside for the Capsular Polysaccharides of Campylobacter jejuni9
Mammalian Commensal Streptococci Utilize a Rare Family of Class VI Lanthipeptide Synthetases to Synthesize Miniature Lanthipeptide-type Ribosomal Peptide Natural Products9
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Dynamic Nuclear Polarization Illuminates Key Protein–Lipid Interactions in the Native Bacterial Cell Envelope9
Molecular Glues: A New Approach to Modulating GPCR Signaling Bias8
PARP1 Incises Abasic Sites and Covalently Cross-links to 3′-DNA Termini via Cysteine Addition Not Reductive Amination8
Peptide-Dependent Growth in Yeast via Fine-Tuned Peptide/GPCR-Activated Essential Gene Expression8
Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques8
Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis8
A Closed Form Model for Molecular Ratchet-Type Chemically Induced Dimerization Modules8
Delivery Aspects for Implementing siRNA Therapeutics for Blood Diseases8
Initial Steps in Methanobactin Biosynthesis: Substrate Binding by the Mixed-Valent Diiron Enzyme MbnBC8
The Huntingtin Transport Complex8
BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease8
Inactivation of CYP2D6 by Berberrubine and the Chemical Mechanism8
Characterization of a Nitro-Forming Enzyme Involved in Fosfazinomycin Biosynthesis8
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