Biochemistry

Article	Citations
Why Are Lopinavir and Ritonavir Effective against the Newly Emerged Coronavirus 2019? Atomistic Insights into the Inhibitory Mechanisms	176
Emerging Approaches to Functionalizing Cell Membrane-Coated Nanoparticles	97
Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3	88
Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag	77
Modulating α-Synuclein Liquid–Liquid Phase Separation	67
Genetic Code Expansion: A Brief History and Perspective	64
Comparative Perturbation-Based Modeling of the SARS-CoV-2 Spike Protein Binding with Host Receptor and Neutralizing Antibodies: Structurally Adaptable Allosteric Communication Hotspots Define Spike Si	61
Clustering of Aromatic Residues in Prion-like Domains Can Tune the Formation, State, and Organization of Biomolecular Condensates	58
Targeting Lipid Metabolism in Liver Cancer	57
Site-Specific Steric Control of SARS-CoV-2 Spike Glycosylation	50
Ligandability of E3 Ligases for Targeted Protein Degradation Applications	47
Exploring the Mechanism of Covalent Inhibition: Simulating the Binding Free Energy of α-Ketoamide Inhibitors of the Main Protease of SARS-CoV-2	46
The Biochemical Landscape of Riboswitch Ligands	45
Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic	43
Principles Governing the Phase Separation of Multidomain Proteins	43
Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity	40
High-Throughput Screening at the Membrane Interface Reveals Inhibitors of Amyloid-β	39
Cryo-EM Structure of the Rhodobacter sphaeroides Light-Harvesting 2 Complex at 2.1 Å	39
How Do Branched Detergents Stabilize GPCRs in Micelles?	38
Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors	37
Mechanism of Catalysis by l-Asparaginase	35
Natural Products for the Treatment of Pain: Chemistry and Pharmacology of Salvinorin A, Mitragynine, and Collybolide	35
Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation	33
Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria	31
Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences	30

Hydration and Dynamics of Full-Length Tau Amyloid Fibrils Investigated by Solid-State Nuclear Magnetic Resonance	29
Biosynthesis of Metal Nanoparticles from Leaves of Ficus palmata and Evaluation of Their Anti-inflammatory and Anti-diabetic Activities	29
Dimerization Induced by C-Terminal 14–3–3 Binding Is Sufficient for BRAF Kinase Activation	29
Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases	29
Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists	29
Fast and Specific Peroxygenase Reactions Catalyzed by Fungal Mono-Copper Enzymes	29
Improving the Treatment of Acute Lymphoblastic Leukemia	29
Effect of Molecular Crowding on the Stability of RNA G-Quadruplexes with Various Numbers of Quartets and Lengths of Loops	28
Enzyme Stabilization by Virus-Like Particles	28
Probing CRISPR-Cas12a Nuclease Activity Using Double-Stranded DNA-Templated Fluorescent Substrates	28
Bicarbonate-Mediated CO2 Formation on Both Sides of Photosystem II	28
Sequence Characterization and Molecular Modeling of Clinically Relevant Variants of the SARS-CoV-2 Main Protease	28
Solving the Conundrum: Widespread Proteins Annotated for Urea Metabolism in Bacteria Are Carboxyguanidine Deiminases Mediating Nitrogen Assimilation from Guanidine	27
The NBDY Microprotein Regulates Cellular RNA Decapping	26
Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo	25
Revealing the Specificity of a Range of Antimicrobial Peptides in Lipid Nanodiscs by Native Mass Spectrometry	25
Glycine-Rich Peptides from FUS Have an Intrinsic Ability to Self-Assemble into Fibers and Networked Fibrils	25
Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators	25
Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design	25
The Origin of Lipid Rafts	24
Direct Mapping of Higher-Order RNA Interactions by SHAPE-JuMP	24
Understanding the Link between Lipid Diversity and the Biophysical Properties of the Neuronal Plasma Membrane	23
Pulse EPR Spectroscopic Characterization of the S3 State of the Oxygen-Evolving Complex of Photosystem II Isolated from Synechocystis	23
Enabling Role of Ligand-Driven Conformational Changes in Enzyme Evolution	23
Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability and Activity	23
Effect of Surface Modification with Hydrocarbyl Groups on the Exocytosis of Nanoparticles	23
Targeted Degradation of the Oncogenic Phosphatase SHP2	22
Mechanisms of O2 Activation by Mononuclear Non-Heme Iron Enzymes	22
Protein Substrates Engage the Lumen of O-GlcNAc Transferase’s Tetratricopeptide Repeat Domain in Different Ways	22
Functional Roles of Chelated Magnesium Ions in RNA Folding and Function	22
Energetics of Ionized Water Molecules in the H-Bond Network near the Ca2+ and Cl– Binding Sites in Photosystem II	22
Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum	22
Structural Insight into the Substrate Scope of Viperin and Viperin-like Enzymes from Three Domains of Life	21
Human γS-Crystallin–Copper Binding Helps Buffer against Aggregation Caused by Oxidative Damage	21
Global Profiling of Cellular Substrates of Human Dcp2	21
Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode	21
Position-Dependent Effect of Guanine Base Damage and Mutations on Telomeric G-Quadruplex and Telomerase Extension	21
The Inflection Point Hypothesis: The Relationship between the Temperature Dependence of Enzyme-Catalyzed Reaction Rates and Microbial Growth Rates	21
In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2	20
Predicting Antiviral Resistance Mutations in SARS-CoV-2 Main Protease with Computational and Experimental Screening	20
Midazolam as a Probe for Drug–Drug Interactions Mediated by CYP3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation	20
Improved Bst DNA Polymerase Variants Derived via a Machine Learning Approach	20
HDAC6 ZnF UBP as the Modifier of Tau Structure and Function	20
A Spectroscopic Marker for Structural Transitions Associated with Amyloid-β Aggregation	20
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen	20
Mapping the Neuroanatomy of ABHD16A, ABHD12, and Lysophosphatidylserines Provides New Insights into the Pathophysiology of the Human Neurological Disorder PHARC	19
Reframing the Protein Folding Problem: Entropy as Organizer	19
Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway	19
The czcD (NiCo) Riboswitch Responds to Iron(II)	19
Structural Studies of the Methylosinus trichosporium OB3b Soluble Methane Monooxygenase Hydroxylase and Regulatory Component Complex Reveal a Transient Substrate Tunnel	19

Humanin Blocks the Aggregation of Amyloid-β Induced by Acetylcholinesterase, an Effect Abolished in the Presence of IGFBP-3	19
Probing the Conformational Changes Associated with DNA Binding to PARP1	19
Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery	19
Metal Sequestration and Antimicrobial Activity of Human Calprotectin Are pH-Dependent	19
Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force	18
Enhanced Cholesterol-Dependent Hemifusion by Internal Fusion Peptide 1 of SARS Coronavirus-2 Compared to Its N-Terminal Counterpart	18
The 2-Aminopyridine Nucleobase Improves Triple-Helical Recognition of RNA and DNA When Used Instead of Pseudoisocytosine in Peptide Nucleic Acids	18
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates	18
A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster	18
Correlated Motions in Structural Biology	18
Dynamic Connection between Enzymatic Catalysis and Collective Protein Motions	18
Lipoprotein Particles Interact with Membranes and Transfer Their Cargo without Receptors	18
Discovery of a New, Recurrent Enzyme in Bacterial Phosphonate Degradation: (R)-1-Hydroxy-2-aminoethylphosphonate Ammonia-lyase	18
Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain	17
Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2	17
A Complete Survey of RhoGDI Targets Reveals Novel Interactions with Atypical Small GTPases	17
The m6A Consensus Motif Provides a Paradigm of Epitranscriptomic Studies	17
The Structure of the Dimeric State of IscU Harboring Two Adjacent [2Fe–2S] Clusters Provides Mechanistic Insights into Cluster Conversion to [4Fe–4S]	17
Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport	17
Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases	17
Polyamines Mediate Folding of Primordial Hyperacidic Helical Proteins	17
Can Selenoenzymes Resist Electrophilic Modification? Evidence from Thioredoxin Reductase and a Mutant Containing α-Methylselenocysteine	17
Estimation of Effective Concentrations Enforced by Complex Linker Architectures from Conformational Ensembles	17
Intermolecular and Intramolecular Interactions of the Arabidopsis Plasma Membrane Proton Pump Revealed Using a Mass Spectrometry Cleavable Cross-Linker	16
Mechanism of Oxygen Evolution and Mn4CaO5 Cluster Restoration in the Natural Water-Oxidizing Catalyst	16
Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin	16
Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin	16
Progress, Challenges, and Opportunities with Artificial Metalloenzymes in Biosynthesis	16
An Ambidextrous Polyphenol Glycosyltransferase PaGT2 from Phytolacca americana	16
One-Enzyme Reverse Transcription qPCR Using Taq DNA Polymerase	16
RNA G-Quadruplexes Facilitate RNA Accumulation in G-Rich Repeat Expansions	16
Flexible Synthetic Carbohydrate Receptors as Inhibitors of Viral Attachment	16
Genome-wide DNA Methylation Signatures Are Determined by DNMT3A/B Sequence Preferences	16
Protein Sequence Selection Method That Enables Full Consensus Design of Artificial l-Threonine 3-Dehydrogenases with Unique Enzymatic Properties	16
Hidden Conformational States and Strange Temperature Optima in Enzyme Catalysis	16
Crystal Structure of TCPTP Unravels an Allosteric Regulatory Role of Helix α7 in Phosphatase Activity	16
Specific Binding of snoRNAs to PARP-1 Promotes NAD+-Dependent Catalytic Activation	16
An Early Association between the α-Helix of the TEAD Binding Domain of YAP and TEAD Drives the Formation of the YAP:TEAD Complex	16
Identifying Distinct Structural Features of the SARS-CoV-2 Spike Protein Fusion Domain Essential for Membrane Interaction	16
Hyperphosphorylation of Human Osteopontin and Its Impact on Structural Dynamics and Molecular Recognition	15
Engineering of a Brighter Variant of the FusionRed Fluorescent Protein Using Lifetime Flow Cytometry and Structure-Guided Mutations	15
The Interaction between PsbT and the DE Loop of D1 in Photosystem II Stabilizes the Quinone–Iron Electron Acceptor Complex	15
Mimicking Functions of Native Enzymes or Photosynthetic Reaction Centers by Nucleoapzymes and Photonucleoapzymes	15
ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease	15
Buffers, Especially the Good Kind	15
Protein–Ligand Interactions in the STING Binding Site Probed by Rationally Designed Single-Point Mutations: Experiment and Theory	15
Lycopene-Family Carotenoids Confer Thermostability on Photocomplexes from a New Thermophilic Purple Bacterium	15
Significance of the Protein Interface Configuration for Allostery in Imidazole Glycerol Phosphate Synthase	15
SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers	14
A Chemoenzymatic Synthesis of the (RP)-Isomer of the Antiviral Prodrug Remdesivir	14
An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways	14
Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1	14
KLR-70: A Novel Cationic Inhibitor of the Bacterial Hsp70 Chaperone	14
Leveraging Peptide Sequence Modification to Promote Assembly of Chiral Helical Gold Nanoparticle Superstructures	14
Substrate-Dependent Mobile Loop Conformational Changes in Alkanesulfonate Monooxygenase from Accelerated Molecular Dynamics	14
Heterologous Expression, Purification, and Functional Analysis of the Plasmodium falciparum Phosphatidylinositol 4-Kinase IIIβ	14
Thermodynamic Stability and Aggregation Kinetics of EF Helix and EF Loop Variants of Transthyretin	14
Dried Protein Structure Revealed at the Residue Level by Liquid-Observed Vapor Exchange NMR	13
Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets	13
Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Selective Cytotoxicity	13
Biosynthesis of d-glycero-l-gluco-Heptose in the Capsular Polysaccharides of Campylobacter jejuni	13
Discovery of Diverse CRISPR-Cas Systems and Expansion of the Genome Engineering Toolbox	13
Monitoring Protein–Protein Interactions in the Cyanobacterial Circadian Clock in Real Time via Electron Paramagnetic Resonance Spectroscopy	13
Biosynthesis of Oxetanocin-A Includes a B12-Dependent Radical SAM Enzyme That Can Catalyze both Oxidative Ring Contraction and the Demethylation of SAM	13
HD-[HD-GYP] Phosphodiesterases: Activities and Evolutionary Diversification within the HD-GYP Family	13
Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, th	13
A Phosphorylated Intermediate in the Activation of WNK Kinases	13
Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications	13
Annexins A1 and A2 Accumulate and Are Immobilized at Cross-Linked Membrane–Membrane Interfaces	13
Structural Robustness Affects the Engineerability of Aminoacyl-tRNA Synthetases for Genetic Code Expansion	13
Insertions and Deletions (Indels): A Missing Piece of the Protein Engineering Jigsaw	13
Activity Mapping the Acyl Carrier Protein: Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis	13
Engineering Fe(II)/α-Ketoglutarate-Dependent Halogenases and Desaturases	13
Residue-Specific Binding Mechanisms of Thioflavin T to a Surface of Flat β-Sheets within a Peptide Self-Assembly Mimic	13
X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10	13
Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products	13
mRNA Therapies: New Hope in the Fight against Melanoma	13
Convergent Evolution of Multiple Mutations Improves the Viral Fitness of SARS-CoV-2 Variants by Balancing Positive and Negative Selection	12
Rhodium Complexes Targeting DNA Mismatches as a Basis for New Therapeutics in Cancers Deficient in Mismatch Repair	12
Structural Insights into Binding of Remdesivir Triphosphate within the Replication–Transcription Complex of SARS-CoV-2	12

Advances in the Treatment of Chronic Pain by Targeting GPCRs	12
Fatty Acid Photodecarboxylase Is an Interfacial Enzyme That Binds to Lipid–Water Interfaces to Access Its Insoluble Substrate	12
Live and Let Dye	12
High-Resolution In Situ NMR Spectroscopy of Bacterial Envelope Proteins in Outer Membrane Vesicles	12
Targeted Protein Degradation via Lysosomes	12
Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir	12
Polyanions Cause Protein Destabilization Similar to That in Live Cells	12
Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)	12
Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca2+Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic	12
Structure and Role of BCOR PUFD in Noncanonical PRC1 Assembly and Disease	12
Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B	12
Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in Escherichia coli	12
Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzym	12
Cholesterol Asymmetrically Modulates the Conformational Ensemble of the Nucleotide-Binding Domains of P-Glycoprotein in Lipid Nanodiscs	12
De Novo-Designed β-Sheet Heme Proteins	12
Long-Acting Cabotegravir for HIV/AIDS Prophylaxis	12
Lifetimes of the Aglycone Substrates of Specifier Proteins, the Autonomous Iron Enzymes That Dictate the Products of the Glucosinolate-Myrosinase Defense System in Brassica Plants	12
Activation Microswitches in Adenosine Receptor A2A Function as Rheostats in the Cell Membrane	11
Cryo-Electron Microscopy Structures of Yeast Alcohol Dehydrogenase	11
Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase	11
Characterization of Enzymes Catalyzing the Formation of the Nonproteinogenic Amino Acid l-Dap in Capreomycin Biosynthesis	11
Expression and In Vivo Characterization of the Antimicrobial Peptide Oncocin and Variants Binding to Ribosomes	11
Long Range Communication between the Drug-Binding Sites and Nucleotide Binding Domains of the Efflux Transporter ABCB1	11
Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions	11
Water’s Variable Role in Protein Stability Uncovered by Liquid-Observed Vapor Exchange NMR	11
NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex	11
Evidence of Allosteric Coupling between Substrate Binding and Adx Recognition in the Vitamin D Carbon-24 Hydroxylase CYP24A1	11
Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer’s Disease	11
Epitope Mapping for a Preclinical Bevacizumab (Avastin) Biosimilar on an Extended Construct of Vascular Endothelial Growth Factor A Using Millisecond Hydrogen–Deuterium Exchange Mass Spectrometry	11
Danio rerio Oocytes for Eukaryotic In-Cell NMR	11
Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?	11
On the Track of Long-Range Electron Transfer in B-Type Dye-Decolorizing Peroxidases: Identification of a Tyrosyl Radical by Computational Prediction and Electron Paramagnetic Resonance Spectroscopy	11
The Crystal Structures of Bacillithiol Disulfide Reductase Bdr (YpdA) Provide Structural and Functional Insight into a New Type of FAD-Containing NADPH-Dependent Oxidoreductase	11
Determinants of Enantiospecificity in Limonene Synthases	11
Light-Driven Catalytic Regulation of Enzymes at the Interface with Plasmonic Nanomaterials	11
The Positively Charged C-Terminal Region of Human Skeletal Troponin T Retards Activation and Decreases Calcium Sensitivity	11
The Siderophore Synthetase IucA of the Aerobactin Biosynthetic Pathway Uses an Ordered Mechanism	11
Bioinformatic Expansion of Borosins Uncovers Trans-Acting Peptide Backbone N-Methyltransferases in Bacteria	11
The Two Deubiquitinating Enzymes from Chlamydia trachomatis Have Distinct Ubiquitin Recognition Properties	11
Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence	11
Analysis of Tagged Proteins Using Tandem Affinity-Buffer Exchange Chromatography Online with Native Mass Spectrometry	11
cGAMP as an Adjuvant in Antiviral Vaccines and Cancer Immunotherapy	11
The Zinc and Iron Binuclear Transport Center of ZupT, a ZIP Transporter from Escherichia coli	11
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator	11
Uncoupling Amphipathicity and Hydrophobicity: Role of Charge Clustering in Membrane Interactions of Cationic Antimicrobial Peptides	11
Thermodynamic and Kinetic Studies of the Interaction of Nuclear Receptor Coactivator-4 (NCOA4) with Human Ferritin	11
Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance	11
New Role for Radical SAM Enzymes in the Biosynthesis of Thio(seleno)oxazole RiPP Natural Products	11
Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases	11
The Human Fragile X Mental Retardation Protein Inhibits the Elongation Step of Translation through Its RGG and C-Terminal Domains	11
PET Polymer Recycling	10
Local Electric Field Changes during the Photoconversion of the Bathy Phytochrome Agp2	10
H1.0 C Terminal Domain Is Integral for Altering Transcription Factor Binding within Nucleosomes	10
Origins of Ca2+ Imaging with Fluorescent Indicators	10
Tuning Enzyme Thermostability via Computationally Guided Covalent Stapling and Structural Basis of Enhanced Stabilization	10
Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity	10
Staphylococcus aureus Glucose-Induced Biofilm Accessory Protein A (GbaA) Is a Monothiol-Dependent Electrophile Sensor	10
Kinetic and Spectroscopic Characterization of the Catalytic Ternary Complex of Tryptophan 2,3-Dioxygenase	10
Photoreaction Dynamics of a Full-Length Protein YtvA and Intermolecular Interaction with RsbRA	10
Discovery, Design, and Structural Characterization of Alkane-Producing Enzymes across the Ferritin-like Superfamily	10
High-Affinity Binding of LDL Receptor-Related Protein 1 to Matrix Metalloprotease 1 Requires Protease:Inhibitor Complex Formation	10
Purification of Recombinant α-synuclein: A Comparison of Commonly Used Protocols	10
Ligand- and pH-Induced Structural Transition of Gypsy Moth Lymantria dispar Pheromone-Binding Protein 1 (LdisPBP1)	10
Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis	10
Spectroscopic Investigation of Cysteamine Dioxygenase	10
ATR-FTIR Spectroelectrochemical Study on the Mechanism of the pH Dependence of the Redox Potential of the Non-Heme Iron in Photosystem II	10
The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam	10
Insight into the Selectivity of Kir3.2 toward Phosphatidylinositides	10
Strongly Hydrogen-Bonded Schiff Base and Adjoining Polyene Twisting in the Retinal Chromophore of Schizorhodopsins	10
Novel Mechanisms of Molecular Glue-Induced Protein Degradation	10
The Organization of Active Site Side Chains of Glycerol-3-phosphate Dehydrogenase Promotes Efficient Enzyme Catalysis and Rescue of Variant Enzymes	10
Ganglioside-Enriched Phospholipid Vesicles Induce Cooperative Aβ Oligomerization and Membrane Disruption	10
Cytoskeletal Drugs Modulate Off-Target Protein Folding Landscapes Inside Cells	10
Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs)	10
The Crystal Structure of Cysteamine Dioxygenase Reveals the Origin of the Large Substrate Scope of This Vital Mammalian Enzyme	10
Selection of High-Affinity RNA Aptamers That Distinguish between Doxycycline and Tetracycline	10
Electrostatic Drivers of GPx4 Interactions with Membrane, Lipids, and DNA	10
An Extended DNA Binding Domain of the Estrogen Receptor Alpha Directly Interacts with RNAs in Vitro	10
Structure and Function of BorB, the Type II Thioesterase from the Borrelidin Biosynthetic Gene Cluster	10
Dynamics and Mechanism of Binding of Androstenedione to Membrane-Associated Aromatase	10
Insights into Binding of Single-Stranded Viral RNA Template to the Replication–Transcription Complex of SARS-CoV-2 for the Priming Reaction from Molecular Dynamics Simulations	10
Hepatocellular Carcinoma and Statins	10
Variable Autoinhibition among Deafness-Associated Variants of Diaphanous 1 (DIAPH1)	10
The RNA Polymerase α Subunit Recognizes the DNA Shape of the Upstream Promoter Element	10
Characterization of the High-Affinity Fuzzy Complex between the Disordered Domain of the E7 Oncoprotein from High-Risk HPV and the TAZ2 Domain of CBP	9
Bacterial Responses to Iron Withholding by Calprotectin	9
Protonation State of a Key Histidine Ligand in the Iron–Quinone Complex of Photosystem II as Revealed by Light-Induced ATR-FTIR Spectroscopy	9
Discovery of an Allosteric, Inactive Conformation-Selective Inhibitor of Full-Length HPK1 Utilizing a Kinase Cascade Assay	9
Design of a Superpositively Charged Enzyme: Human Carbonic Anhydrase II Variant with Ferritin Encapsulation and Immobilization	9
Comparison of the Forward and Reverse Photocycle Dynamics of Two Highly Similar Canonical Red/Green Cyanobacteriochromes Reveals Unexpected Differences	9
Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level	9
Membrane-Catalyzed Aggregation of Islet Amyloid Polypeptide Is Dominated by Secondary Nucleation	9
Chemoenzymatic Synthesis of Chito-oligosaccharides with Alternating N-d-Acetylglucosamine and d-Glucosamine	9
Metabolic Processing of Selenium-Based Bioisosteres of meso-Diaminopimelic Acid in Live Bacteria	9
Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms	9