Biochemical Pharmacology

Article	Citations
miR-146a-5p/TXNIP axis attenuates intestinal ischemia-reperfusion injury by inhibiting autophagy via the PRKAA/mTOR signaling pathway	300
JOSD2 promotes breast cancer metastasis by deubiquitinating and stabilizing SMAD4	134
A current overview of RhoA, RhoB, and RhoC functions in vascular biology and pathology	120
The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a protective role in sepsis-induced lung injury by targeting TAK1-mediated MAPK and NF-κB signaling	112
Ceramide de novo synthesis in non-alcoholic fatty liver disease: Pathogenic mechanisms and therapeutic perspectives	105
Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro	103
Unraveling HDAC11: Epigenetic orchestra in different diseases and structural insights for inhibitor design	96
Exosomes: Powerful weapon for cancer nano-immunoengineering	95
Orodispersible films – Recent developments and new applications in drug delivery and therapy	94
Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis	91
Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex	82
Carbon monoxide and β-cell function: Implications for type 2 diabetes mellitus	79
Berberine induces anti-atopic dermatitis effects through the downregulation of cutaneous EIF3F and MALT1 in NC/Nga mice with atopy-like dermatitis	76
Dahl salt-resistant rats are protected against angiotensin II-induced hypertension	72
Attenuation of growth hormone production at the fetal stage is critical for dioxin-induced developmental disorder in rat offspring	72
The orphan GPR50 receptor interacting with TβRI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells	70
miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer	69
Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice	64
PPARGC1A affects inflammatory responses in photodynamic therapy (PDT)-treated inflammatory bowel disease (IBD)	63
Neratinib is a TFEB and TFE3 activator that potentiates autophagy and unbalances energy metabolism in ERBB2+ breast cancer cells	63
Challenging and target-based shifting strategies for heart failure treatment: An update from the last decades	63
The magic of a methyl group: Biochemistry at the service of medicine	62
Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV pathogen box	60
Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARα	60
Cpd-0225 attenuates renal fibrosis via inhibiting ALK5	59

Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges	56
Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells	55
Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation	55
P2X7 receptors in the central nervous system	54
Spider and scorpion knottins targeting voltage-gated sodium ion channels in pain signaling	54
Gelsevirine improves age-related and surgically induced osteoarthritis in mice by reducing STING availability and local inflammation	53
Activation of FXR by ganoderic acid A promotes remyelination in multiple sclerosis via anti-inflammation and regeneration mechanism	53
Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases	53
sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity	53
MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway	53
Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models	51
A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux	50
A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease	49
MiR-146a-5p enrichment in small-extracellular vesicles of relapsed pediatric ALCL patients promotes macrophages infiltration and differentiation	47
Short-term rapamycin treatment increases life span and attenuates aortic aneurysm in a murine model of Marfan-Syndrome	47
Modulating MGMT expression through interfering with cell signaling pathways	47
Melatonin regulates the immune response and improves Sjögren’s syndrome-like symptoms in NOD/Ltj Mice	47
Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencin	47
Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs	46
Securinine inhibits the tumor growth of human bladder cancer cells by suppressing Wnt/β-catenin signaling pathway and activating p38 and JNK signaling pathways	45
Sensitization of cancer cells to paclitaxel-induced apoptosis by canagliflozin	44
Suppression of NSCLC progression via the co-administration of Danusertib, an AURK inhibitor, and KRIBB11, an HSF1 inhibitor	43
Introduction to the Special Issue “Angiotensin Receptors”	43
Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2/HO-1 pathway activation	42
Dapagliflozin ameliorates hepatic steatosis via suppressing LXRα-mediated synthesis of lipids and bile acids	41
Impact of the redox-active MnTnHex-2-PyP5+ and cisplatin on the metabolome of non-small cell lung cancer cells	41
Diabetes and the fabkin complex: A dual-edged sword	41
Bifunctional iRGD-Exo-DOX crosses the blood-brain barrier to target central nervous system lymphoma	41
Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies	40
PGE2 receptors in detrusor muscle: Drugging the undruggable for urgency	40
Long non-coding RNAs in gastrointestinal cancers: Implications for protein phosphorylation	39
Multiple ligand recognition sites in free fatty acid receptor 2 (FFA2R) direct distinct neutrophil activation patterns	39
Brain histamine improves colonic hyperpermeability through the basal forebrain cholinergic neurons, adenosine A2B receptors and vagus nerve in rats	38
Tanshinone IIA acts as a regulator of lipogenesis to overcome osimertinib acquired resistance in lung cancer	38
Cardiac glycoside neriifolin exerts anti-cancer activity in prostate cancer cells by attenuating DNA damage repair through endoplasmic reticulum stress	37
Developing insulin-like peptide 5-based antagonists for the G protein-coupled receptor, RXFP4	37
Renoprotective effect of Nesfatin-1 in Adenine-Induced Chronic kidney Disease: An in vitro and in vivo study	37
The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice	37
Human P2X7 receptors – Properties of single ATP-gated ion channels	36
From molecular pathogenesis to therapy: Unraveling non-coding RNAs/DNMT3A axis in human cancers	36
A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells	36
Cellular senescence signaling in cancer: A novel therapeutic target to combat human malignancies	35
EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post- transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis	35
Angiopoietin-like proteins 8 knockout reduces intermittent hypoxia-induced vascular remodeling in a murine model of obstructive sleep apnea	35
Editorial Board	34
Ocular surface complications in diabetes: The interrelationship between insulin and enkephalin	34
Effect of 7-ketocholesterol incorporation on substrate binding affinity and turnover rate of the organic cation transporter 2 (OCT2)	34
Eltrombopag inhibits Type I interferon-mediated antiviral signaling by decreasing cellular iron	34
Excess glucocorticoid exposure contributes to adipose tissue fibrosis which involves macrophage interaction with adipose precursor cells	33
IL-23p19 deficiency reduces M1 macrophage polarization and improves stress-induced cardiac remodeling by alleviating macrophage ferroptosis in mice	33

Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells	33
Physiopathological mechanisms involved in the development of hypertension associated with gut dysbiosis and the effect of nutritional/pharmacological interventions	32
Regulation of cardiac ion channels by transcription factors: Looking for new opportunities of druggable targets for the treatment of arrhythmias	32
Preserved oxytocin-induced myometrium contraction and sensitivity to progesterone inhibition following rat uterus thermal insult. Impact on fertility	32
Editor’s Note	31
Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability	31
Editorial Board	31
The potent role of Src kinase-regulating glucose metabolism in cancer	31
Zoledronate repositioning as a potential trypanocidal drug. Trypanosoma cruzi HPRT an alternative target to be considered	31
Editorial Board	30
Unlocking the protective potential of the angiotensin type 2 receptor (AT2R) in acute lung injury and age-related pulmonary dysfunction	30
Editorial Board	30
Exploring cell competition for the prevention and therapy of esophageal squamous cell carcinoma	30
Circadian, sleep-wake dependent or both? A preface to the special issue “Circadian rhythm and sleep-wake dependent regulation of behavior and brain function”	30
Sevelamer reverses liver fibrosis by deactivation of hepatic stellate cells	30
Targeted and functional genomics approaches to the mechanism of action of lagunamide D, a mitochondrial cytotoxin from marine cyanobacteria	30
Impact of endocrine disrupting chemicals on health and disease	30
Pharmacological options in the treatment of osteogenesis imperfecta: A comprehensive review of clinical and potential alternatives	29
Bleomycin restricts the glycolysis of lymphatic endothelial cells by inhibiting dimeric PKM2 formation: A novel mechanism for lymphatic malformation treatment	29
Acknowledgment	29
Editorial Board	29
Editorial Board	29
Neuronal differentiation reporter mice as a new methodology for detecting in vivo developmental neurotoxicity	29
Adaptive changes in tumor cells in response to reductive stress	28
The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity	28
Editorial Board	28
SKCa- and Kv1-type potassium channels and cancer: Promising therapeutic targets?	28
The C-terminal cleavage of angiotensin II and III is mediated by prolyl carboxypeptidase in human umbilical vein and aortic endothelial cells	27
Discovery and functional characterization of N-(thiazol-2-yl)-benzamide analogs as the first class of selective antagonists of the Zinc-Activated Channel (ZAC)	27
Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists	27
Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles	27
Long-term glucocorticoid exposure persistently impairs CD4+ T cell biology by epigenetically modulating the mTORC1 pathway	26
Activin receptors in human cancer: Functions, mechanisms, and potential clinical applications	26
Editorial Board	26
Sleep during COVID-19 lockdown: A cross-cultural study investigating job system relevance	26
A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo	26
PGC‐1α activation ameliorates cancer-induced bone pain via inhibiting apoptosis of GABAergic interneurons	26
Increased Ca2+-dependent intrinsic tone and arterial stiffness in mesenteric microvessels of hypertensive pregnant rats	26
CXCL13 promotes TNF-α synthesis in rheumatoid arthritis through activating ERK/p38 pathway and inhibiting miR-330-3p generation	26
JAK inhibition as a new treatment strategy for patients with COVID-19	26
mTORC2 is an important target for simvastatin-associated toxicity in C2C12 cells and mouse skeletal muscle – Roles of Rap1 geranylgeranylation and mitochondrial dysfunction	25
CaMK4: Structure, physiological functions, and therapeutic potential	25
Abscisic acid, an evolutionary conserved hormone: Biosynthesis, therapeutic and diagnostic applications in mammals	25
Peptide GLP-1 receptor agonists: From injection to oral delivery strategies	25
Tankyrase1/2 inhibitor XAV-939 reverts EMT and suggests that PARylation partially regulates aerobic activities in human hepatocytes and HepG2 cells	25
Targeting cancer stem cells with antibiotics inducing mitochondrial dysfunction as an alternative anticancer therapy	25
The functional subclasses of AT1 receptor autoantibody in patients with coronary heart disease	25
An inducible sphingosine kinase 1 in hepatic stellate cells potentiates liver fibrosis	25
Corrigendum to “Liraglutide attenuates angiotensin II-induced aortic dissection and aortic aneurysm via inhibiting M1 macrophage polarization in APOE -/- mice” [Biochem. Pharmacol. 223 (2024) 116170]	25
miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway	25
Chicago sky blue 6B (CSB6B), an allosteric inhibitor of macrophage migration inhibitory factor (MIF), suppresses osteoclastogenesis and promotes osteogenesis through the inhibition of the NF-κB signal	25
Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library	25
Unveiling the protective potential of mirabegron against thioacetamide-induced hepatic encephalopathy in rats: Insights into cAMP/PPAR-γ/p-ERK1/2/p S536 NF-κB p 65 and p-CREB/BDNF/TrkB in parallel wit	25
The ‘ABC’ of split-nanoluciferase HIF heterodimerization bioassays: Applications, Benefits & Considerations	25
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights	25
Ketamine – An Imperfect Wonder Drug?	25
Caffeic acid phenethyl ester targets ubiquitin-specific protease 8 and synergizes with cisplatin in endometrioid ovarian carcinoma cells	24
Early evolutionary history (from bacteria to hemichordata) of the omnipresent purinergic signalling: A tribute to Geoff Burnstock inquisitive mind	24
Quercetin protects cardiomyoblasts against hypertonic cytotoxicity by abolishing intracellular Ca2+ elevations and mitochondrial depolarisation	24
The combination of gemcitabine and albumin-bound paclitaxel effectively inhibits de novo lipogenesis in pancreatic cancer cells by targeting the AMPK/SREBP1 pathway	24
Serine/Threonine kinase 16 phosphorylates STAT3 and confers a JAK2-Inhibition resistance phenotype in triple-negative breast cancer	24
Gold nanostructures as mediators of hyperthermia therapies in breast cancer	24
Biological insights from the direct measurement of purine release	24
Use of knockout mice to explore CNS effects of adenosine	24
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain	24
A chemically adjustable BMP6-IL6 axis in mesenchymal stem cells drives acute myeloid leukemia cell differentiation	24
Mitochondria and the permeability transition pore in cancer metabolic reprogramming	24
Comments on “Clinically relevant therapeutic approaches against acetaminophen (APAP) hepatotoxicity and acute liver failure”	24
Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition	24
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex	24
Isopropyl 3-(3,4-dihydroxyphenyl) 2-hydroxypropanoate protects septic myocardial injury via regulating GAS6/Axl-AMPK signaling pathway	23
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury	23
Cancer treatment-related cardiovascular disease: Current status and future research priorities	23
PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3	23
MicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells	23
Neratinib exerts dual effects on cartilage degradation and osteoclast production in Osteoarthritis by inhibiting the activation of the MAPK/NF-κB signaling pathways	23
Angiotensin-(1–9) in hypertension	23
Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal Hypoxic-Ischemic encephalopathy Diseases	23
Peroxisom proliferator-activated receptor-γ coactivator-1α in neurodegenerative disorders: A promising therapeutic target	23
Intestine-specific FXR agonists as potential therapeutic agents for colorectal cancer	23

G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis	23
Kv7.4 channels regulate potassium permeability in neuronal mitochondria	23
CCR5 antagonist treatment inhibits vascular injury by regulating NADPH oxidase 1	23
Aryl hydrocarbon receptor: Its roles in physiology	23
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo	23
Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis	22
Inhibition of PLA2G4A attenuated valproic acid- induced lysosomal membrane permeabilization and restored impaired autophagic flux: Implications for hepatotoxicity	22
Wide awake at bedtime? Effects of caffeine on sleep and circadian timing in male adolescents – A randomized crossover trial	22
Phytochemicals modulate pancreatic islet β cell function through glucagon-like peptide-1-related mechanisms	22
RORγ is a context-specific master regulator of cholesterol biosynthesis and an emerging therapeutic target in cancer and autoimmune diseases	22
Reg2 treatment is protective but the induced Reg2 autoantibody is destructive to the islets in NOD mice	22
Exploration of the urocontrin A scaffold yields new urotensinergic system allosteric modulator and competitive antagonists	22
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy	22
Hepatoprotective potential of alpha-lipoic acid against gliclazide-induced liver injury in high-glucose-exposed human liver cells and experimental type 2 diabetic rats	22
Key links in the physiological regulation of the immune system and disease induction: T cell receptor -CD3 complex	22
The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1	22
Targeting Akt-associated microRNAs for cancer therapeutics	22
Methionine cycle in nonalcoholic fatty liver disease and its potential applications	22
ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats	22
Metformin-conjugated micellar system with intratumoral pH responsive de-shielding for co-delivery of doxorubicin and nucleic acid	21
Increased uterine arterial tone, stiffness and remodeling with augmented matrix metalloproteinase-1 and -7 in uteroplacental ischemia-induced hypertensive pregnancy	21
Induction of mitochondrial toxicity by non-steroidal anti-inflammatory drugs (NSAIDs): The ultimate trade-off governing the therapeutic merits and demerits of these wonder drugs	21
Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases	21
An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges	21
Overexpression of soluble epoxide hydrolase reduces post-ischemic recovery of cardiac contractile function	21
Bile acids and bile acid activated receptors in the treatment of Covid-19	21
Pharmacogene expression during progression of metabolic dysfunction-associated steatotic liver disease: Studies on mRNA and protein levels and their relevance to drug treatment	21
4-octyl itaconate protects against oxidative stress-induced liver injury by activating the Nrf2/Sirt3 pathway through AKT and ERK1/2 phosphorylation	21
Protein arginine methyltransferases (PRMTs): Orchestrators of cancer pathogenesis, immunotherapy dynamics, and drug resistance	21
SHU9119 and MBP10 are biased ligands at the human melanocortin-4 receptor	21
The funnel-web spider venom derived single knot peptide Hc3a modulates acid-sensing ion channel 1a desensitisation	20
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy	20
KCNE4-dependent modulation of Kv1.3 pharmacology	20
Dual allosteric and orthosteric pharmacology of synthetic analog cannabidiol-dimethylheptyl, but not cannabidiol, on the cannabinoid CB2 receptor	20
Ganciclovir attenuates the onset and progression of experimental autoimmune uveitis by inhibiting infiltration of Th17 and inflammatory cells into the retina	20
The aging brain: sleep, the circadian clock and exercise	20
GPR56: A potential therapeutic target for neurological and psychiatric disorders	20
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure	20
Drug and pro-drug substrates and pseudo-substrates of human butyrylcholinesterase	20
A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo	20
ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling	20
Harringtonine: A more effective antagonist for Omicron variant	20
Geniposide effectively safeguards HT22 cells against Aβ-induced damage by activating mitophagy via the PINK1/Parkin signaling pathway	20
Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy	20
Recent trends in fragment-based anticancer drug design strategies against different targets: A mini-review	20
Enhydrin suppresses the malignant phenotype of GBM via Jun/Smad7/TGF-β1 signaling pathway	19
Unveiling therapeutic potential: Adipose tissue-derived mesenchymal stem cells and their exosomes in the management of diabetes mellitus, wound healing, and chronic ulcers	19
MicroRNA-15b promotes cardiac ischemia injury by the inhibition of Mitofusin 2/PERK pathway	19
Probiotics as a strategy for addressing helminth infections in low-income countries: Working smarter rather than richer	19
EYA4 reduces chemosensitivity of osteosarcoma to doxorubicin through DNA damage repair	19
Tetrahydroberberrubine exhibits preventive effect on obesity by activating PGC1α-mediated thermogenesis in white and brown adipose tissue	19
Sanggenol L induces ferroptosis in non-small cell lung cancer cells via regulating the miR-26a-1-3p/MDM2/p53 signaling pathway	19
miR-218-5p promotes hepatic lipogenesis through targeting Elovl5 in non-alcoholic fatty liver disease	19
Differential pattern of neurotoxicity induced by the gliadin peptides p31-43 and p57-68 in in vitro model of epilepsy	19
A novel L-shaped ortho-quinone analog as PLK1 inhibitor blocks prostate cancer cells in G2 phase	19
PD184352 exerts anti-inflammatory and antioxidant effects by promoting activation of the Nrf2/HO-1 axis	18
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway	18
Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib	18
Expression and function of VISTA on myeloid cells	18
Verteporfin combined with ROCK inhibitor promotes the restoration of corneal endothelial cell dysfunction in rats	18
Paris saponins Ⅶ inhibits glycolysis of ovarian cancer via the RORC/ACK1 signaling pathway	18
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis	18
Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology	18
Necrosulfonamide ameliorates intestinal inflammation via inhibiting GSDMD-medicated pyroptosis and MLKL-mediated necroptosis	18
A novel aromatic amide derivative SY-65 co-targeted tubulin and histone deacetylase 1 with potent anticancer activity in vitro and in vivo	18
Carbon monoxide mechanism of protection against renal ischemia and reperfusion injury	18
Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation	18
Identification of a novel small-molecule inhibitor targeting TIM-3 for cancer immunotherapy	18
Interplay between purinergic signalling and extracellular vesicles in health and disease	18
Activation of activator protein-1-fibroblast growth factor 21 signaling attenuates Cisplatin hepatotoxicity	18
MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway	18
Mechanisms of cannabinoid tolerance	18
Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention	18
Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1–7)/MasR signaling in normal and hypertensive pregnancy	18
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis	18
The gut microbiota – A vehicle for the prevention and treatment of hepatocellular carcinoma	18
Usefulness of the measurement of neurite outgrowth of primary sensory neurons to study cancer-related painful complications	18
Could hypoxia rehabilitate the osteochondral diseased interface? Lessons from the interplay of hypoxia and purinergic signals elsewhere	18
Targeting the NLRP3 inflammasome in diabetic retinopathy: From pathogenesis to therapeutic strategies	17
Oncogenic FLT3 internal tandem duplication activates E2F1 to regulate purine metabolism in acute myeloid leukaemia	17
Corrigendum to “MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM Mice” [Biochem. Pharmacol. volume (230), Part 2, Published online October 23, 2024/116593]	17
Vitamin D and the risk for cancer: A molecular analysis	17
Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy	17
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway	17
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy	17
Geraniol ameliorates acute liver failure induced by lipopolysaccharide/D-galactosamine via regulating macrophage polarization and NLRP3 inflammasome activation by PPAR-γ methylation Geraniol alleviate	17
Hydrogen sulfide mitigates mitochondrial dysfunction and cellular senescence in diabetic patients: Potential therapeutic applications	17
Perineural invasion: A potential driver of cancer-induced pain	17
S100A16 induces epithelial-mesenchymal transition in human PDAC cells and is a new therapeutic target for pancreatic cancer treatment that synergizes with gemcitabine	17
Characterization of Plasmodium falciparum prohibitins as novel targets to block infection in humans by impairing the growth and transmission of the parasite	17
Characterization of a novel LTA/LPS-binding antimicrobial and anti-inflammatory temporin peptide from the skin of Fejervary limnocharis (Anura: Ranidae)	17
NLRP3 inflammasome in hepatic diseases: A pharmacological target	17
High-throughput screening identifies stevioside as a potent agent to induce apoptosis in bladder cancer cells	17
AMPKα2/HNF4A/BORIS/GLUT4 pathway promotes hepatocellular carcinoma cell invasion and metastasis in low glucose microenviroment	17
SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy	17