Biochemical Pharmacology

Article	Citations
ALKBH7 mediates the mitigative effect of bismuth drug against cisplatin-induced acute kidney injury	307
Editorial Board	264
Editorial Board	236
Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells	176
Diabetes and the fabkin complex: A dual-edged sword	163
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy	151
Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex	148
Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models	133
PGC‐1α activation ameliorates cancer-induced bone pain via inhibiting apoptosis of GABAergic interneurons	127
Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis	122
Unveiling ODP4: A breakthrough in PCOS treatment via BAT transplantation	122
Butyrolactone I from Aspergillus fungi blocks neutrophil FPR1 to alleviate acute respiratory distress syndrome	108
Metformin exhibits inhibitory effects on ferroptosis and alleviates chondrocyte metabolic imbalance in osteoarthritis models, as well as Erastin-induced ferroptosis, through the modulation of the P53/	102
Ammonium tetrathiomolybdate attenuates acetaminophen-induced acute liver failure by inhibiting the TRPV4/Calcium/NF-κB signaling pathway	99
Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases	96
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy	95
A novel L-shaped ortho-quinone analog as PLK1 inhibitor blocks prostate cancer cells in G2 phase	94
Growth factor receptor-bound protein 2-mediated corneal epithelial injury drives depression-associated dry eye disease	93
Corrigendum to “Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells” [Biochem. Pharmacol. 176 (2020) 113902]	88
Corrigendum to “Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis” [Biochem. Pharmacol. 232 (2025) 116711]	83
PXR as the tipping point between innate immune response, microbial infections, and drug metabolism	82
Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib	80
Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies	77
Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis	71
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis	70

Ultraviolet-treated riboflavin alleviates atopic dermatitis by inhibiting NLRP3 inflammasome activation and M1 macrophage polarization via histone lactylation	68
Recent trends in fragment-based anticancer drug design strategies against different targets: A mini-review	67
Renoprotective effect of Nesfatin-1 in Adenine-Induced Chronic kidney Disease: An in vitro and in vivo study	66
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis	64
IP3R-dependent Ca2+ signaling in the endoplasmic reticulum is required for deoxynivalenol-induced intestinal stem cell injury	62
ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling	62
Evidence for the contribution of vasopressin V1B receptors in the pathophysiology of depression	61
Indole selectively suppresses aldosterone overproduction via binding to the catalytic site of CYP11B2	61
RNA-binding protein GIGYF2 promotes colorectal cancer progression through activation of the METTL3/SERP1/STAT3 axis in an m6A-IGF2BP2-dependent manner	60
Peptide GLP-1 receptor agonists: From injection to oral delivery strategies	60
Melatonin protects vascular homeostasis by restoring PVAT redox balance in arterial hypertension	59
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway	59
The potent role of Src kinase-regulating glucose metabolism in cancer	58
ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization	58
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway	58
Restoring mitochondria–endoplasmic reticulum–synapse axis: a proteomic dissection of Rhein’s multi-pathway antidepressant mechanism	57
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain	57
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex	55
Emerging role of m6A modification in fibrotic diseases and its potential therapeutic effect	55
Methionine cycle in nonalcoholic fatty liver disease and its potential applications	55
Bile acids and bile acid activated receptors in the treatment of Covid-19	54
Cellular crosstalk in doxorubicin-induced cardiotoxicity: underlying mechanisms and therapeutic strategies	53
Exploring the mechanism of nonylphenol-induced myocardial fibrosis based on TGF-β1/Smads signaling pathway	52
EP3 promotes macrophage M1-polarization to play a critical role in diabetic renal injury	52
Bromodomain containing protein 4 (BRD4) and cancer therapy: A glimpse at dual-target drug development	52
HDAC6 is involved in diabetic nephropathy by regulating TGFβ/Smads and NF-κB signaling pathways	51
SEMA7A orchestrates the colorectal cancer tumor microenvironment via PlexinC1: coordinating angiogenesis and macrophage M2 polarization	51
The relationship between tumor metabolism and 5-fluorouracil resistance	49
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models	49
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease	49
CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease	49
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights	47
Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release	47
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure	46
Histone deacetylase 6 modulates autophagy through HIF-1α/BNIP3 signaling in lung cancer	46
Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases	46
Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice	45
The rare bile acid isoallolithocholic acid (IALCA) is an EphA2 antagonist sparing FXR and TGR5 receptors	45
AMPK-activation by catecholamines induces autophagy and cell proliferation in cardiac fibroblasts	45
Editorial Board	45
GRHL3 drives radiotherapy resistance and blocks the anti-tumor response of NK and CD4+ T cells in lung squamous cell carcinoma via RNF2	44
Serum-derived extracellular vesicles mediate acquired multidrug resistance of MCF-7 breast cancer cells induced by chemotherapeutic drugs	44
Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro	44
Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo	43
Targeting non-coding RNAs and N6-methyladenosine modification in hepatocellular carcinoma	43
Sleep deprivation exacerbates experimental colitis via down-regulating the clock gene Per2	43
Exploring the glycation association with dyslipidaemia: Novel approach for diabetic nephropathy	43
Treatment with S-adenosylmethionine ameliorates irinotecan-induced intestinal barrier dysfunction and intestinal microbial disorder in mice	43
ACE1-targeting peptide Acein ameliorates UV-induced skin damage and aging in vivo and in vitro via downregulation of the pro-aging factor CLEC4G	43
DEC1 deficiency promotes osteoclastic activity by augmenting NFATc1 signaling via transactivation and the Ca2+/calcineurin pathway	42

Decoding the roles of CCL11 in human malignancies and clinical implications	42
Systematic review and synthesis without meta-analysis (SWiM) reveals lack of clinical studies and weak preclinical evidence for interaction between glucose regulating drugs and environmental contamina	42
ALOX5 promotes autophagy-dependent ferroptosis by activating the AMPK/mTOR pathway in melanoma	42
Immunometabolic attributes and mitochondria-associated signaling of Tumor-Associated Macrophages in tumor microenvironment modulate cancer progression	41
Dexmedetomidine alleviates anxiety-like behavior in mice following peripheral nerve injury by reducing the hyperactivity of glutamatergic neurons in the anterior cingulate cortex	41
Epigallocatechin gallate relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages	41
Tumor Cells-derived exosomal CircRNAs: Novel cancer drivers, molecular mechanisms, and clinical opportunities	40
Editorial Board	40
Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines	39
Understanding resistance acquisition by Pseudomonas aeruginosa and possible pharmacological approaches in palliating its pathogenesis	39
A modern approach to glioblastoma using temozolomide and nanoparticles carrier drug: a standard care of combination therapy and treatment	39
Corrigendum to “Almonertinib inhibits liver cancer progression by triggering autophagy-dependent ferroptosis through inhibition of the PI3K/Akt1/mTOR pathway”. [Biochem. Pharmacol. 245 (2026) 117628]	39
Macrophage scavenger receptor A1 antagonizes abdominal aortic aneurysm via upregulating IRG1	39
Modulating UNC-51-like kinase 1 (ULK1) to treat diseases: A perspective from autophagic initiator to druggable target	38
SMURF1 leads to the β-catenin signaling-mediated progression of esophageal squamous carcinoma by losing PATZ1-induced CCNG2 transcription	38
Astragaloside IV as a potent vWbp inhibitor: An innovative strategy to mitigate foodborne Staphylococcus aureus infections	37
Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products	37
6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model	37
FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression	36
The value of neck adipose tissue as a predictor for metabolic risk in health and type 2 diabetes	36
Rosavidin protects against PM2.5-induced lung toxicity via inhibition of NLRP3 inflammasome-mediated pyroptosis by activating the PI3K/AKT pathway	36
Mast cell activation induced by tamoxifen citrate via MRGPRX2 plays a potential adverse role in breast cancer treatment	36
Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction	36
Pyroptosis as a molecular bridge: linking gasdermin activation to enhanced anti-tumor immunity in immunotherapy	35
GPR55: Physiological functions and therapeutic potential in depression	35
Combination of two Na+ channel-inhibiting anticonvulsants lacosamide and phenytoin: An additive, synergistic, or antagonistic effect?	35
Immunomodulatory effects of antiangiogenic tyrosine kinase inhibitors in renal cell carcinoma models: Impact on following anti-PD-1 treatments	35
The role of metabolic reprogramming in inflammatory bone diseases	35
Knockdown of Galectin-9 alleviates rheumatoid arthritis through suppressing TNF-α-induced activation of fibroblast-like synoviocytes	35
Carbon monoxide in cell signaling and potential therapeutics	35
Inhibition of CXCR2 improves motor coordination through attenuating white matter lesions in Parkinson’s disease models	34
KDM6B knockdown alleviates sleep deprivation-induced cerebrovascular lesions in APP/PS1 mice by inhibiting PARP16 expression	34
Circadian oscillator NPAS2 regulates diurnal expression and activity of CYP1A2 in mouse liver	34
Peroxisome proliferator-activated receptor (PPAR) agonists as a potential therapy for inherited metabolic disorders	34
Chrysophanol prevents IL-1β-Induced inflammation and ECM degradation in osteoarthritis via the Sirt6/NF-κB and Nrf2/NF-κB axis	34
Identifying inhibitors of Trypanosoma cruzi nucleoside diphosphate kinase 1 as potential repurposed drugs for Chagas’ disease	33
Combining Sorafenib, Se-methylselenocysteine, and α-Ketoacid for synergistic cytotoxicity in Hepatocellular carcinoma cell lines	33
Melatonin alleviates brain injury in copper-laden rats: Underlying benefits for Wilson’s disease	33
Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders	33
The dual targeting effects of KD025 on casein kinase 2 and ROCK2 in a mouse model of diet-induced obesity	33
Effect of pharmacological heart failure drugs and gene therapy on Danon's cardiomyopathy	32
Viral Vectors, Exosomes, and Vexosomes: Potential armamentarium for delivering CRISPR/Cas to cancer cells	32
Icaritin enhances the antitumor efficacy of irinotecan by dual-targeting carboxylesterase 2 and p53 in vitro and in vivo	32
Methyl-oxazolomycin A: A novel oxazolomycin analog with potent selective estrogen receptor degrading activity in breast cancer cells	32
Oleoylethanolamide alleviates hyperlipidaemia-mediated vascular calcification via attenuating mitochondrial DNA stress triggered autophagy-dependent ferroptosis by activating PPARα	31
Sirtuin1-p53: A potential axis for cancer therapy	31
Dual-specificity tyrosine phosphorylation-regulated kinase 1A promotes the inclusion of amyloid precursor protein exon 7	31
LILRB4 as a novel immunotherapeutic target for multiple diseases	31
Reynoutrin targets EphB4 to ameliorate hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus	31
The short-chain fatty acid acetate modulates orexin/hypocretin neurons: A novel mechanism in gut-brain axis regulation of energy homeostasis and feeding	31
Regulation of OTULIN ubiquitination by RNF6 alleviates asthma via mitigating epithelial-mesenchymal transition‑like phenotypic changes	31
Potential small effector molecules restoring cellular defects due to sialic acid biosynthetic enzyme deficiency: Pathological relevance to GNE myopathy	31
PPARα/δ dual agonist H11 alleviates diabetic kidney injury by improving the metabolic disorders of tubular epithelial cells	31
Sonic Hedgehog pathway: molecular mechanisms and therapeutic potentials in ischemic stroke recovery	31
Physiological and pharmacological overview of the gonadotropin releasing hormone	30
Treatment with anti-Hsp90 antibody mitigates fibronectin-related cardiac fibrosis induced by pressure overload in mice	30
Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae)	30
Recent advances in studies on FtsZ inhibitors	30
Translational potential of targeting Anoctamin-1-Encoded Calcium-Activated chloride channels in hypertension	30
Nodosin alleviates cholestatic liver injury by activation of SIRT1/FXR signaling pathway and inhibition of hepatic inflammation	30
Inhibition of γ-secretase/Notch pathway as a potential therapy for reversing cancer drug resistance	30
Itaconate alleviates β2-microglobulin-induced cognitive impairment by enhancing the hippocampal amino-β-carboxymuconate-semialdehyde-decarboxylase/picolinic acid pathway	29
Mitomycin induced the senescence of alveolar epithelial cells by targeting peroxiredoxin I	29
Immunometabolism: Is cyanide a missing link between metabolic pathways and immune function?	29
Ifosfamide alleviates autoimmune toxicity and enhances antitumor efficacy in melanoma immunotherapy	29
Activation of the Nrf2/HO-1/GPX4 pathway by cGAMP Mitigates oxidative stress and ferroptosis in ischaemic stroke	29
Editorial Board	29
Targeting hematopoietic progenitor kinase 1 (HPK1) for tumor immunotherapy: advances in small molecule inhibitors	29
Leptin impairs the therapeutic efficacy of adipose-derived mesenchymal stem cells by inducing apoptosis through NLRP3 inflammasomes activation	29
Emerging roles of senolytics/senomorphics in HIV-related co-morbidities	29
Acyclovir resistance in herpes simplex viruses: Prevalence and therapeutic alternatives	29
Cytarabine-induced destabilization of MCL1 mRNA and protein triggers apoptosis in leukemia cells	29
Circadian rhythm disturbance induces osteoarthritis in mice: Involvement of Clock and Bmal1 dysregulation and Pdgfa inhibition	29
Rational two-round modification for developing isopeptide bond-containing antimicrobial peptide with enhanced stability and potent activity against multidrug-resistant gram-negative bacteria	28
Protein prenylation in islet β-cell function in health and metabolic stress	28
Inhibiting Cytosine-Adenine-Guanine (CAG) repeat expansions as a therapeutic strategy for Huntington’s disease	28
MiR-466b-3p/HDAC7 meditates transgenerational inheritance of testicular testosterone synthesis inhibition induced by prenatal dexamethasone exposure	28
SIRT6 regulates endothelium-dependent relaxation by modulating nitric oxide synthase 3 (NOS3)	28
Targeting PIM1 ameliorates sepsis-associated acute kidney injury through inhibiting ferroptosis	28
Pharmacological inhibition of JNK-MAPK disrupts cigarette smoke-induced RUNX2/Galectin-3 -driven EMT and cancer stemness in lung adenocarcinoma cells	28

IOX-1 suppresses metastasis of osteosarcoma by upregulating histone H3 lysine trimethylation	28
A rational foundation for micheliolide-based combination strategy by targeting redox and metabolic circuit in cancer cells	28
Corrigendum to “DOCK2 contributes to endotoxemia-induced acute lung injury in mice by activating proinflammatory macrophages” [Biochem. Pharmacol. 184 (2021) 114399]	27
Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles	27
Macrophage-derived human resistin promotes perivascular adipose tissue dysfunction in experimental inflammatory arthritis	27
Mefunidone ameliorates acute liver failure in mice by inhibiting MKK4-JNK pathway	27
xCT/Slc7a11 promotes pulmonary arterial hypertension by disrupting AMPKα suppression of mTOR activation	27
Detailed resume of S-methyltransferases: Categories, structures, biological functions and research advancements in related pathophysiology and pharmacotherapy	27
Corrigendum to “Effects of 5-aminoisoquinolinone, a water-soluble, potent inhibitor of the activity of poly (ADP-ribose) polymerase, in a rodent model of lung injury“ [Biochem. Pharmacol. 63(1) (2002)	27
Maladaptive regeneration and metabolic dysfunction associated steatotic liver disease: Common mechanisms and potential therapeutic targets	27
Positive programming of the GC-IGF1 axis mediates adult osteoporosis susceptibility in male offspring rats induced by prenatal dexamethasone exposure	27
Role of sirtuins in hepatocellular carcinoma progression and multidrug resistance: Mechanistical and pharmacological perspectives	27
Recent progress in developing ATR inhibitors as anticancer agents	27
Targeting fibroblast activation protein with chimeric antigen receptor macrophages	27
Overview of the therapeutic strategies for ER positive breast cancer	27
Corrigendum to “Geraniol ameliorates acute liver failure induced by lipopolysaccharide/D-galactosamine via regulating macrophage polarization and NLRP3 inflammasome activation by PPAR-γ methylation Ge	27
PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction	27
CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis	27
Mitochondrial elongation confers protection against doxorubicin-induced cardiotoxicity	27
Targeting regulated chondrocyte death in osteoarthritis therapy	26
Non-covalent mTOR inhibition suppresses NLRP3-GSDMD inflammasome-mediated pyroptosis	26
Finding new analgesics: Computational pharmacology faces drug discovery challenges	26
Lactylation in colorectal cancer: From mechanism to clinical application	26
Chronic kidney disease-induced muscle atrophy: Molecular mechanisms and promising therapies	26
Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators	26
Ponatinib exacerbate renal injury in systemic lupus erythematosus mouse model through PDGFR-PI3K/AKT pathway	26
Antibody-drug conjugates for non-small cell lung cancer: Advantages and challenges in clinical translation	26
Preclinical evaluation of new drug-drug interactions of lomitapide: A proposal for novel mechanism of interaction associated with lipid metabolic changes	25
Unraveling the glioblastoma (GBM) tumor microenvironment: future perspective on targeted immunotherapy	25
A review on tumor-targeting liposomes: Fabrication, mechanism and applications	25
A review on the effect of COX-2-mediated mechanisms on development and progression of gastric cancer induced by nicotine	25
BMAL1 plays a crucial role in immune homeostasis during sepsis-induced acute lung injury	25
Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV-induced hepatitis: Opportunities for developing novel therapeutics	25
P4HA3 depletion induces ferroptosis and inhibits colorectal cancer growth by stabilizing ACSL4 mRNA	25
Discovery of a novel selective small molecule interleukin-36 receptor antagonist for inflammation and cancer	25
Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology	25
Eicosanoids and Inflammation: A delicate balance of Pro-Inflammatory and Pro-Resolving mediators	25
Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses	25
Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes	24
Editorial Board	24
Editorial Board	24
Targeting TDP-43-activated GRP78/endoplasmic reticulum stress axis suppresses triple-negative breast cancer progression	24
Coffee for the liver: a mechanistic approach	24
Therapeutic of a white adipose tissue-specific bivalent aptamer in obesity	24
Citrulline activates adenosine receptors: New insight into metabolic pathways interaction	24
LncRNA SNHG14 drives angiotensin-induced abdominal aortic aneurysm progression by regulating autophagy via the miR-27b-3p/Wnt/β-catenin/c-Myc axis	24
Enhanced thermogenesis in PAS Kinase-deficient male mice	24
Selpercatinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway	24
PACS2 deficiency ameliorates hepatic steatosis via inhibition of the JNK signaling pathway in diabetic mice	24
The critical roles of STING in mitochondrial homeostasis	24
Design and characterization of a triazole-based growth hormone secretagogue receptor modulator inhibiting the glucoregulatory and feeding actions of ghrelin	24
Circ_0057582 inhibits breast cancer progression via hnRNPF/YAP/SOX9 axis and M2 polarization in TAMs by autophagic degradation of ISG15	24
Harmine suppresses pancreatic cancer through DYRK1A-mediated hyper-activated RAS/MAPK inhibition	24
G-protein coupled receptors in neuroinflammation, neuropharmacology, and therapeutics	23
Extracellular nucleotides in smooth muscle contraction	23
Activated microglia secretome and proinflammatory cytokines increase neuronal mu-opioid receptor signalling and expression	23
Delineating the tumour-regulatory roles of EYA4	23
Corrigendum to “Cardioprotective effects of melatonin and metformin against doxorubicin-induced cardiotoxicity in rats are through preserving mitochondrial function and dynamics” [Biochem. Pharmacol.	23
Triflupromazine and tranylcypromine alleviate primary cisplatin resistance in lung adenocarcinoma by promoting LDHA-mediated AMBRA1 ubiquitination	23
Targeted delivery of a colchicine analogue provides synergy with ATR inhibition in cancer cells	23
Quassinoid analogs exert potent antitumor activity via reversible protein biosynthesis inhibition in human colorectal cancer	23
Curing childhood cancer the “Natural” Way: Nature as the source of chemotherapy agents	23
Resolvin D3 improves the impairment of insulin signaling in skeletal muscle and nonalcoholic fatty liver disease through AMPK/autophagy-associated attenuation of ER stress	23
FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy	23
Editorial Board	23
Eicosatrienoic acid inhibits estradiol synthesis through the CD36/FOXO1/CYP19A1 signaling pathway to improve PCOS in mice	23
Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies	23
Canonical DDR activation by EMT inducing agent 5-Fluorouracil is modulated by a cannabinoid based combinatorial approach via inducing autophagy and suppression of vimentin expression	23
Omega-3 polyunsaturated fatty acids alleviate hyperuricemic nephropathy by inhibiting renal pyroptosis through GPR120	23
Ubiquitin ligase TRIM63 regulates HOXA10 expression to mediate fatty acid β-oxidation and suppress lung adenocarcinoma metastasis	23
Inhibition of soluble epoxide hydrolase relieves adipose inflammation via modulating M1/M2 macrophage polarization to alleviate airway inflammation and hyperresponsiveness in obese asthma	23
The V-ATPase a3 subunit deficiency affects osteoarthritis via mTOR-Mediated autophagy levels in subchondral bone	23
A systematic review and meta-analysis of environmental contaminant exposure impacts on weight loss and glucose regulation during calorie-restricted diets in preclinical studies: Persistent organic pol	23
Development of 6-methyl-4,5-dihydropyrazolo[3,4-d]pyrimidin-4-one derivatives as lead sigma-1 receptor inhibitor: synthesis and biological evaluation via MSI	23
Mst1 inhibition mitigates steroid-induced femoral head osteonecrosis by modulating autophagy in bone microvascular endothelial cells	23
1,2,4-Trimethoxybenzene alleviates cognitive dysfunction in type 2 diabetes model rats by inhibiting NLRP3 inflammasome and restoring gut microbiota disorders	23
5-O-Methylvisammioside, a novel inhibitor of CNT2, improves hyperuricemia by inhibiting intestinal purine nucleoside absorption with a safe profile	22
Oridonin combined with cisplatin synergistically induces apoptosis by activating the NOXA-BCL2 axis in esophageal squamous cell carcinoma	22
Mechanotransduction and the extracellular matrix: Key drivers of lung pathologies and drug responsiveness	22
Cardiac human bitter taste receptors contain naturally occurring variants that alter function	22
Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects	22
An A-ring substituted evodiamine derivative with potent anticancer activity against human non-small cell lung cancer cells by targeting heat shock protein 70	22
Targeting the DYNLL2-PAK1 axis inhibits caspase-11-dependent pyroptosis to alleviate sepsis	22
Cancer stem cells: Recent insights and therapies	22
AdipoRon and ADP355, adiponectin receptor agonists, in Metabolic-associated Fatty Liver Disease (MAFLD) and Nonalcoholic Steatohepatitis (NASH): A systematic review	22
Novel molecular insights into the role of CRH type 1 receptor in the pathophysiology of depression	22
Enterogastric and enterohepatic recycling of dendrobine in rats: a novel disposition mechanism responsible for pharmacokinetic multiple peaks	22
Integrated metabolomics and transcriptomics reveal the neuroprotective effect of nervonic acid on LPS-induced AD model mice	22
Anti-inflammatory mechanism of the MLKL inhibitor necrosulfonamide in LPS- or poly(I:C)-induced neuroinflammation and necroptosis	22
Selective activation of cannabinoid receptors by cannabis terpenes	22
Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches to attenuate re	22
The role of taurine through endoplasmic reticulum in physiology and pathology	22
Iron supplementation protects against renal ischemia–reperfusion injury by enhancing mitochondrial respiratory complex assembly	22
PPARγ activation by fisetin mitigates vascular smooth muscle cell senescence via the mTORC2-FoxO3a-autophagy signaling pathway	22
A novel GSH depletor for simultaneous ferroptosis and cuproptosis Activation in hepatocellular carcinoma	22