OOIR: Observatory of International Research

Papers

(The H4-Index of Biochemical Pharmacology is 45. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-02-01 to 2025-02-01.)

Article	Citations
miR-146a-5p/TXNIP axis attenuates intestinal ischemia-reperfusion injury by inhibiting autophagy via the PRKAA/mTOR signaling pathway	300
JOSD2 promotes breast cancer metastasis by deubiquitinating and stabilizing SMAD4	134
A current overview of RhoA, RhoB, and RhoC functions in vascular biology and pathology	120
The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a protective role in sepsis-induced lung injury by targeting TAK1-mediated MAPK and NF-κB signaling	112
Ceramide de novo synthesis in non-alcoholic fatty liver disease: Pathogenic mechanisms and therapeutic perspectives	105
Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro	103
Unraveling HDAC11: Epigenetic orchestra in different diseases and structural insights for inhibitor design	96
Exosomes: Powerful weapon for cancer nano-immunoengineering	95
Orodispersible films – Recent developments and new applications in drug delivery and therapy	94
Bim transfer between Bcl-2-like protein and Hsp70 underlines Bcl-2/Hsp70 crosstalk to regulate apoptosis	91
Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex	82
Carbon monoxide and β-cell function: Implications for type 2 diabetes mellitus	79
Berberine induces anti-atopic dermatitis effects through the downregulation of cutaneous EIF3F and MALT1 in NC/Nga mice with atopy-like dermatitis	76
Attenuation of growth hormone production at the fetal stage is critical for dioxin-induced developmental disorder in rat offspring	72
Dahl salt-resistant rats are protected against angiotensin II-induced hypertension	72
The orphan GPR50 receptor interacting with TβRI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells	70
miR-29c-3p promotes alcohol dehydrogenase gene cluster expression by activating an ADH6 enhancer	69
Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice	64
PPARGC1A affects inflammatory responses in photodynamic therapy (PDT)-treated inflammatory bowel disease (IBD)	63
Neratinib is a TFEB and TFE3 activator that potentiates autophagy and unbalances energy metabolism in ERBB2+ breast cancer cells	63
Challenging and target-based shifting strategies for heart failure treatment: An update from the last decades	63
The magic of a methyl group: Biochemistry at the service of medicine	62
Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV pathogen box	60
Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARα	60
Cpd-0225 attenuates renal fibrosis via inhibiting ALK5	59

Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges	56
Pterostilbene-isothiocyanate inhibits breast cancer metastasis by selectively blocking IKK-β/NEMO interaction in cancer cells	55
Highly potent and selective 5-lipoxygenase inhibition by new, simple heteroaryl-substituted catechols for treatment of inflammation	55
P2X7 receptors in the central nervous system	54
Spider and scorpion knottins targeting voltage-gated sodium ion channels in pain signaling	54
Gelsevirine improves age-related and surgically induced osteoarthritis in mice by reducing STING availability and local inflammation	53
Activation of FXR by ganoderic acid A promotes remyelination in multiple sclerosis via anti-inflammation and regeneration mechanism	53
Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases	53
sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity	53
MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway	53
Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models	51
A racemosin B derivative, C25, suppresses breast cancer growth via lysosomal membrane permeabilization and inhibition of autophagic flux	50
A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease	49
Modulating MGMT expression through interfering with cell signaling pathways	47
Melatonin regulates the immune response and improves Sjögren’s syndrome-like symptoms in NOD/Ltj Mice	47
Prolonged cultured human hepatocytes as an in vitro experimental system for the evaluation of potency and duration of activity of RNA therapeutics: Demonstration of prolonged duration of gene silencin	47
MiR-146a-5p enrichment in small-extracellular vesicles of relapsed pediatric ALCL patients promotes macrophages infiltration and differentiation	47
Short-term rapamycin treatment increases life span and attenuates aortic aneurysm in a murine model of Marfan-Syndrome	47
Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs	46
Securinine inhibits the tumor growth of human bladder cancer cells by suppressing Wnt/β-catenin signaling pathway and activating p38 and JNK signaling pathways	45