OOIR: Observatory of International Research

Papers

(The H4-Index of Biochemical Pharmacology is 52. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Editorial Board	338
Editorial Board	304
Diabetes and the fabkin complex: A dual-edged sword	276
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy	176
PGC‐1α activation ameliorates cancer-induced bone pain via inhibiting apoptosis of GABAergic interneurons	142
Unveiling ODP4: A breakthrough in PCOS treatment via BAT transplantation	131
A novel L-shaped ortho-quinone analog as PLK1 inhibitor blocks prostate cancer cells in G2 phase	122
Corrigendum to “Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells” [Biochem. Pharmacol. 176 (2020) 113902]	118
Corrigendum to “Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis” [Biochem. Pharmacol. 232 (2025) 116711]	112
Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies	111
Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases	107
Histone deacetylase 6 modulates autophagy through HIF-1α/BNIP3 signaling in lung cancer	106
AMPK-activation by catecholamines induces autophagy and cell proliferation in cardiac fibroblasts	103
Corrigendum to “Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways” [Biochem. Pharmacol. 223 (2024) 116132]	99
HDAC6 is involved in diabetic nephropathy by regulating TGFβ/Smads and NF-κB signaling pathways	98
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain	86
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex	82
RNA-binding protein GIGYF2 promotes colorectal cancer progression through activation of the METTL3/SERP1/STAT3 axis in an m6A-IGF2BP2-dependent manner	82
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway	80
Melatonin protects vascular homeostasis by restoring PVAT redox balance in arterial hypertension	76
Renoprotective effect of Nesfatin-1 in Adenine-Induced Chronic kidney Disease: An in vitro and in vivo study	75
IP3R-dependent Ca2+ signaling in the endoplasmic reticulum is required for deoxynivalenol-induced intestinal stem cell injury	71
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis	71
Indole selectively suppresses aldosterone overproduction via binding to the catalytic site of CYP11B2	67
Tspan4+ fibroblasts facilitate the development of NECSO in myocardial ischemia reperfusion through migrasomes-mediated Tnf-α autocrine and cardiomyocytes aldosterone generation	66

CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis	66
KLF2-Mediated Modulation of oxidative stress and pyroptosis by Vanillic acid in intervertebral disc degeneration	66
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights	66
ALKBH7 mediates the mitigative effect of bismuth drug against cisplatin-induced acute kidney injury	66
Butyrolactone I from Aspergillus fungi blocks neutrophil FPR1 to alleviate acute respiratory distress syndrome	65
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease	63
Growth factor receptor-bound protein 2-mediated corneal epithelial injury drives depression-associated dry eye disease	62
Fangchinoline derivative LYY-34 suppresses TNBC by inhibiting BLM DNA helicase from unfolding of c-MYC promoter G-quadruplex DNA	61
Tucatinib alleviates postmenopausal osteoporosis by suppressing osteoclast differentiation via regulating the DRP1/NFATc1/CTSK signaling pathway	60
The rare bile acid isoallolithocholic acid (IALCA) is an EphA2 antagonist sparing FXR and TGR5 receptors	59
Exploring the mechanism of nonylphenol-induced myocardial fibrosis based on TGF-β1/Smads signaling pathway	59
Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis	58
Recent trends in fragment-based anticancer drug design strategies against different targets: A mini-review	58
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway	58
Restoring mitochondria–endoplasmic reticulum–synapse axis: a proteomic dissection of Rhein’s multi-pathway antidepressant mechanism	57
Sodium aescinate induces renal cell ferroptosis through the ATF4/CTH/SQOR axis	57
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure	57
Targeting purinergic signaling and MTAP-associated metabolism in cancer: A functional immunometabolic convergence framework	56
Diving into AA9-mediated transglutaminase 2 inhibition reveals ferroptosis as driver of anticancer effects	56
ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization	54
Evidence for the contribution of vasopressin V1B receptors in the pathophysiology of depression	54
Cellular crosstalk in doxorubicin-induced cardiotoxicity: underlying mechanisms and therapeutic strategies	54
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy	54
Bromodomain containing protein 4 (BRD4) and cancer therapy: A glimpse at dual-target drug development	54
Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis	52
The relationship between tumor metabolism and 5-fluorouracil resistance	52
The potent role of Src kinase-regulating glucose metabolism in cancer	52