OOIR: Observatory of International Research

Papers

(The H4-Index of Biochemical Pharmacology is 50. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
ALKBH7 mediates the mitigative effect of bismuth drug against cisplatin-induced acute kidney injury	316
Editorial Board	272
Editorial Board	243
Diabetes and the fabkin complex: A dual-edged sword	158
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy	155
PGC‐1α activation ameliorates cancer-induced bone pain via inhibiting apoptosis of GABAergic interneurons	133
Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis	128
Unveiling ODP4: A breakthrough in PCOS treatment via BAT transplantation	125
Ammonium tetrathiomolybdate attenuates acetaminophen-induced acute liver failure by inhibiting the TRPV4/Calcium/NF-κB signaling pathway	112
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy	105
A novel L-shaped ortho-quinone analog as PLK1 inhibitor blocks prostate cancer cells in G2 phase	102
Corrigendum to “Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells” [Biochem. Pharmacol. 176 (2020) 113902]	98
Corrigendum to “Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis” [Biochem. Pharmacol. 232 (2025) 116711]	97
Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib	96
Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies	95
Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis	86
Renoprotective effect of Nesfatin-1 in Adenine-Induced Chronic kidney Disease: An in vitro and in vivo study	85
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis	81
IP3R-dependent Ca2+ signaling in the endoplasmic reticulum is required for deoxynivalenol-induced intestinal stem cell injury	79
ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling	73
Indole selectively suppresses aldosterone overproduction via binding to the catalytic site of CYP11B2	72
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights	70
Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex	69
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models	66
Emerging role of m6A modification in fibrotic diseases and its potential therapeutic effect	66

PXR as the tipping point between innate immune response, microbial infections, and drug metabolism	64
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis	64
Metformin exhibits inhibitory effects on ferroptosis and alleviates chondrocyte metabolic imbalance in osteoarthritis models, as well as Erastin-induced ferroptosis, through the modulation of the P53/	63
Ultraviolet-treated riboflavin alleviates atopic dermatitis by inhibiting NLRP3 inflammasome activation and M1 macrophage polarization via histone lactylation	62
Growth factor receptor-bound protein 2-mediated corneal epithelial injury drives depression-associated dry eye disease	62
Peptide GLP-1 receptor agonists: From injection to oral delivery strategies	61
Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models	60
Histone deacetylase 6 modulates autophagy through HIF-1α/BNIP3 signaling in lung cancer	60
Dual roles of Makorin ring finger protein 1 in ubiquitination and RNA biology: regulatory mechanisms and therapeutic implications in human diseases	60
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure	59
CDP-choline modulates cholinergic signaling and gut microbiota to alleviate DSS-induced inflammatory bowel disease	58
AMPK-activation by catecholamines induces autophagy and cell proliferation in cardiac fibroblasts	58
Corrigendum to “Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways” [Biochem. Pharmacol. 223 (2024) 116132]	58
Bromodomain containing protein 4 (BRD4) and cancer therapy: A glimpse at dual-target drug development	57
Bile acids and bile acid activated receptors in the treatment of Covid-19	57
HDAC6 is involved in diabetic nephropathy by regulating TGFβ/Smads and NF-κB signaling pathways	56
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain	55
Restoring mitochondria–endoplasmic reticulum–synapse axis: a proteomic dissection of Rhein’s multi-pathway antidepressant mechanism	55
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex	54
Methionine cycle in nonalcoholic fatty liver disease and its potential applications	54
RNA-binding protein GIGYF2 promotes colorectal cancer progression through activation of the METTL3/SERP1/STAT3 axis in an m6A-IGF2BP2-dependent manner	53
The potent role of Src kinase-regulating glucose metabolism in cancer	52
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway	52
Melatonin protects vascular homeostasis by restoring PVAT redox balance in arterial hypertension	52
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease	51
SEMA7A orchestrates the colorectal cancer tumor microenvironment via PlexinC1: coordinating angiogenesis and macrophage M2 polarization	50
Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release	50