OOIR: Observatory of International Research

Papers

(The H4-Index of Biochemical Pharmacology is 48. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis	364
Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans	173
PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy	165
Effects of heme oxygenase 1 in the molecular changes and neuropathy associated with type 2 diabetes in mice	142
The potent role of Src kinase-regulating glucose metabolism in cancer	136
Diabetes and the fabkin complex: A dual-edged sword	129
Evidence for the contribution of vasopressin V1B receptors in the pathophysiology of depression	117
Corrigendum to “Dose-dependent regulation of mitochondrial function and cell death pathway by sorafenib in liver cancer cells” [Biochem. Pharmacol. 176 (2020) 113902]	116
Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells	115
A novel L-shaped ortho-quinone analog as PLK1 inhibitor blocks prostate cancer cells in G2 phase	109
Editorial Board	105
Corrigendum to “Sulfasalazine alleviates neuropathic pain hypersensitivity in mice through inhibition of SGK-1 in the spinal cord” [Biochem. Pharmacol. 185 (2021) 114411]	100
An organogold compound impairs Leishmania amazonensis amastigotes survival and delays lesion progression in murine cutaneous leishmaniasis: Mechanistic insights	99
Bile acids and bile acid activated receptors in the treatment of Covid-19	95
Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies	87
Sleep during COVID-19 lockdown: A cross-cultural study investigating job system relevance	83
Design, synthesis and anti-tumor activity of novel benzothiophenonaphthalimide derivatives targeting mitochondrial DNA (mtDNA) G-quadruplex	82
Renoprotective effect of Nesfatin-1 in Adenine-Induced Chronic kidney Disease: An in vitro and in vivo study	82
Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis	80
ALA-PDT augments intense inflammation in the treatment of acne vulgaris by COX2/TREM1 mediated M1 macrophage polarization	78
Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy	75
ALDH1A1 confers resistance to RAF/MEK inhibitors in melanoma cells by maintaining stemness phenotype and activating PI3K/AKT signaling	72
Excess glucocorticoid exposure contributes to adipose tissue fibrosis which involves macrophage interaction with adipose precursor cells	69
CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis	68
Recent trends in fragment-based anticancer drug design strategies against different targets: A mini-review	66

Corrigendum to “Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis” [Biochem. Pharmacol. 232 (2025) 116711]	66
Interplay between the renin angiotensin system and oxidative stress contributes to alcohol addiction by stimulating dopamine accumulation in the mesolimbic pathway	65
Identification of a dual JAK3/TEC family kinase inhibitor for atopic dermatitis therapy	65
Peptide GLP-1 receptor agonists: From injection to oral delivery strategies	64
Methionine cycle in nonalcoholic fatty liver disease and its potential applications	63
Roles of microglia in Alzheimer’s disease and impact of new findings on microglial heterogeneity as a target for therapeutic intervention	63
LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway	62
PXR as the tipping point between innate immune response, microbial infections, and drug metabolism	62
Pharmacological inhibition of HDAC6 suppresses NLRP3 inflammasome-mediated IL-1β release	61
PGC‐1α activation ameliorates cancer-induced bone pain via inhibiting apoptosis of GABAergic interneurons	59
CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis	57
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models	56
Exploring tryptophan metabolism: The transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases	55
Decreased HMGB1 expression contributed to cutaneous toxicity caused by lapatinib	55
MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway	55
The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity	54
The relationship between tumor metabolism and 5-fluorouracil resistance	52
Cytochrome P450 2E1 gene knockout or inhibition prevents obesity induced by high-fat diet via regulating energy expenditure	52
Emerging role of m6A modification in fibrotic diseases and its potential therapeutic effect	52
Neuroanatomical distribution of fluorophores within adult RXFP3 Cre-tdTomato/YFP mouse brain	51
Alisol A 24-Acetate combats Methicillin-Resistant Staphylococcus aureus infection by targeting the mevalonate biosynthesis	49
Modulation of contextual fear acquisition and extinction by acute and chronic relaxin-3 receptor (RXFP3) activation in the rat retrosplenial cortex	49
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease	48
Luteolin binds Src, promotes STAT3 protein ubiquitination and exerts anti-melanoma effects in cell and mouse models	48