OOIR: Observatory of International Research

Papers

(The TQCC of Acta Neuropathologica is 21. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-07-01 to 2024-07-01.)

Article	Citations
Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology	313
The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics	233
Plasma p-tau181 accurately predicts Alzheimer’s disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline	217
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis	201
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease	179
Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease	166
Periphery and brain, innate and adaptive immunity in Parkinson’s disease	152
CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas	129
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease	126
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains	125
Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study	119
Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology	114
Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607	114
Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change	106
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function	101
The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models	98
Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology	90
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy	88
Tau strains shape disease	87
Brain arteriolosclerosis	86
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis	82
Lesion stage-dependent causes for impaired remyelination in MS	80
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology	78
The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer’s disease	78
Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19	77

Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts	75
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy	72
Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol	70
The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis	67
Analyzing microglial phenotypes across neuropathologies: a practical guide	66
Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis	61
TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma	60
Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme	60
Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease	59
Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter	59
Pyroptosis in Alzheimer’s disease: cell type-specific activation in microglia, astrocytes and neurons	57
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential	57
Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders	55
Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex	55
Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis	54
Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases	53
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons	52
Structure of Tau filaments in Prion protein amyloidoses	51
LATE-NC staging in routine neuropathologic diagnosis: an update	50
White matter microglia heterogeneity in the CNS	50
Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases	50
Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration	50
Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood–brain barrier	49
R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils	49
Infratentorial IDH-mutant astrocytoma is a distinct subtype	49
Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology	49
The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer’s disease	48
Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation	46
Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers	45
Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study	45
Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts	45
Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates	45
Selective vulnerability of inhibitory networks in multiple sclerosis	44
C9orf72 loss-of-function: a trivial, stand-alone or additive mechanism in C9 ALS/FTD?	43
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood–brain barrier in acute ischemic stroke	43
Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1)	42
Subgroup and subtype-specific outcomes in adult medulloblastoma	41
Supratentorial ependymoma in childhood: more than just RELA or YAP	39
Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia	39
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo	38
Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors	38
Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases	37
Post-mortem analyses of PiB and flutemetamol in diffuse and cored amyloid-β plaques in Alzheimer’s disease	37
Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation	37
Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy	37
The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer’s disease	36
Making sense of missense variants in TTN-related congenital myopathies	36
PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum	36
Cryo-EM structures of prion protein filaments from Gerstmann–Sträussler–Scheinker disease	36
Seizure-mediated iron accumulation and dysregulated iron metabolism after status epilepticus and in temporal lobe epilepsy	35

Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases	34
Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites	34
BTK inhibition limits B-cell–T-cell interaction through modulation of B-cell metabolism: implications for multiple sclerosis therapy	34
A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease	34
Non-IDH1-R132H IDH1/2 mutations are associated with increased DNA methylation and improved survival in astrocytomas, compared to IDH1-R132H mutations	33
Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1	33
Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory	33
Retinal pathological features and proteome signatures of Alzheimer’s disease	32
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders	32
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics	32
Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders	31
The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease	31
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains	31
Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43	30
Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease	30
Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging	30
Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature	30
Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy	29
APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology	29
Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus–pericoerulear complex by three-dimensional imaging	29
Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay	29
Altered oligodendroglia and astroglia in chronic traumatic encephalopathy	28
Glioblastomas with primitive neuronal component harbor a distinct methylation and copy-number profile with inactivation of TP53, PTEN, and RB1	28
Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis	28
Malignant transformation of a polymorphous low grade neuroepithelial tumor of the young (PLNTY)	28
HnRNP K mislocalisation is a novel protein pathology of frontotemporal lobar degeneration and ageing and leads to cryptic splicing	27
Necrotic reshaping of the glioma microenvironment drives disease progression	27
Tau immunotherapy is associated with glial responses in FTLD-tau	27
Physiological β-amyloid clearance by the liver and its therapeutic potential for Alzheimer’s disease	26
Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia	26
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids	26
Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease	26
CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles	25
Phenotypic diversity of genetic Creutzfeldt–Jakob disease: a histo-molecular-based classification	25
Epigenomic, genomic, and transcriptomic landscape of schwannomatosis	25
ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer’s disease	24
Oligodendroglia heterogeneity in the human central nervous system	24
The oncogenic fusion landscape in pediatric CNS neoplasms	24
Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study	24
Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis	24
Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains	24
Wolframin is a novel regulator of tau pathology and neurodegeneration	24
Patterns of amygdala region pathology in LATE-NC: subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies	24
Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome	24
miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease	24
Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling	24
FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease	23
Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ	23
Heterogeneity of white matter astrocytes in the human brain	23
Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD	23
Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes	23
Vagus nerve inflammation contributes to dysautonomia in COVID-19	23
Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations	22
TDP-43 drives synaptic and cognitive deterioration following traumatic brain injury	22
Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex	22
Association of small vessel disease with tau pathology	22
Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patterns	21
Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy	21
A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer’s disease	21
DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner	21
Alzheimer disease neuropathology in a patient previously treated with aducanumab	21
Dominant-acting CSF1R variants cause microglial depletion and altered astrocytic phenotype in zebrafish and adult-onset leukodystrophy	21
Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions	21
MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis	21
Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges	21