OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Neuropathologica is 47. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Neuropathology of COVID-19: a spectrum of vascular and acute disseminated encephalomyelitis (ADEM)-like pathology	383
Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology	282
The physiological roles of tau and Aβ: implications for Alzheimer’s disease pathology and therapeutics	219
Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies	215
Distribution patterns of tau pathology in progressive supranuclear palsy	210
Plasma p-tau181 accurately predicts Alzheimer’s disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline	205
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis	179
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease	161
Cerebral blood flow decrease as an early pathological mechanism in Alzheimer's disease	151
The structural differences between patient-derived α-synuclein strains dictate characteristics of Parkinson’s disease, multiple system atrophy and dementia with Lewy bodies	145
Periphery and brain, innate and adaptive immunity in Parkinson’s disease	133
CDKN2A/B homozygous deletion is associated with early recurrence in meningiomas	116
APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease	115
Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology	114
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains	110
Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study	103
Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607	96
The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models	92
Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change	89
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function	83
Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology	79
Brain arteriolosclerosis	79
Tau strains shape disease	78
Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19	76
α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy	75

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis	74
The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer’s disease	72
Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology	71
Lesion stage-dependent causes for impaired remyelination in MS	68
Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease	67
Frequency of LATE neuropathologic change across the spectrum of Alzheimer’s disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts	67
Analyzing microglial phenotypes across neuropathologies: a practical guide	65
Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol	64
The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy	63
The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis	60
Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme	59
TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma	56
Inhibition of Bruton’s tyrosine kinase interferes with pathogenic B-cell development in inflammatory CNS demyelinating disease	56
Evidence of distinct α-synuclein strains underlying disease heterogeneity	53
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential	53
Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter	53
Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis	53
Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis	51
TDP-43 transports ribosomal protein mRNA to regulate axonal local translation in neuronal axons	50
Physiological and pathological functions of TMEM106B: a gene associated with brain aging and multiple brain disorders	50
Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition	49
Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis	47
Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex	47
White matter microglia heterogeneity in the CNS	47
Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology	47