OOIR: Observatory of International Research

Papers

(The H4-Index of Acta Neuropathologica is 41. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD	147
A novel subtype of sporadic Creutzfeldt–Jakob disease with PRNP codon 129MM genotype and PrP plaques	136
Assessment of PABPN1 nuclear inclusions on a large cohort of patients and in a human xenograft model of oculopharyngeal muscular dystrophy	129
The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers	122
Capillary basement membrane reduplication in myositis patients with mild clinical features of systemic sclerosis supports the concept of ‘scleromyositis’	115
Regulated cell death and its role in Alzheimer’s disease and amyotrophic lateral sclerosis	114
Macrophages and endothelial cells in the neurovascular unit	103
Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer’s disease	99
Comprehensive assessment of TDP-43 neuropathology data in the National Alzheimer’s Coordinating Center database	91
Wolframin is a novel regulator of tau pathology and neurodegeneration	89
Identification of high-performing antibodies for the reliable detection of Tau proteoforms by Western blotting and immunohistochemistry	84
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma	83
BTK inhibition limits microglia-perpetuated CNS inflammation and promotes myelin repair	74
SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility	73
Cryptic exon detection and transcriptomic changes revealed in single-nuclei RNA sequencing of C9ORF72 patients spanning the ALS-FTD spectrum	71
A familial missense variant in the Alzheimer’s disease gene SORL1 impairs its maturation and endosomal sorting	70
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation	68
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS	67
Metabologenomic characterization uncovers a clinically aggressive IDH mutant glioma subtype	62
Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics	60
Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases	59
Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination	59
TREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia	56
TDP-43 pathology in the retina of patients with frontotemporal lobar degeneration	53
Detection of blood–brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2	52

The Alzheimer’s disease GWAS risk alleles in the ABCA7 promoter and 5’ region reduce ABCA7 expression	52
Multi-level profiling unravels mitochondrial dysfunction in myotonic dystrophy type 2	51
TBK1 haploinsufficiency in ALS and FTD compromises membrane trafficking	51
Cell-specific MAPT gene expression is preserved in neuronal and glial tau cytopathologies in progressive supranuclear palsy	51
From metabolomics to proteomics: understanding the role of dopa decarboxylase in Parkinson’s disease. Scientific commentary on: “Comprehensive proteomics of CSF, plasma, and urine identify DDC and oth	50
Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma	50
Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges	50
Tau seeding in chronic traumatic encephalopathy parallels disease severity	49
Expanding the spectrum of amyloid-β plaque pathology: the Down syndrome associated ‘bird-nest plaque’	45
Neuropathological associations of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) differ between the oldest-old and younger-old	45
Jorge Cervós-Navarro 1930–2021	45
Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy	45
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis	44
Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau	43
Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson’s disease-related fibril polymorphism	42
Variants in DTNA cause a mild, dominantly inherited muscular dystrophy	41