Stem Cell Reports

Article	Citations
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2	148
ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update	141
Naive Human Embryonic Stem Cells Can Give Rise to Cells with a Trophoblast-like Transcriptome and Methylome	139
Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease	128
Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology	112
Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids	109
Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development	102
Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids	95
Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids	70
SARS-CoV-2 targets glial cells in human cortical organoids	70
SARS-CoV-2 Infects Human Pluripotent Stem Cell-Derived Cardiomyocytes, Impairing Electrical and Mechanical Function	70
Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro	68
Mesenchymal stromal cell-derived exosomes in cardiac regeneration and repair	64
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice	64
Human embryo research, stem cell-derived embryo models and in vitro gametogenesis: Considerations leading to the revised ISSCR guidelines	63
A conversation with ChatGPT on the role of computational systems biology in stem cell research	63
Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2	61
NGN2 induces diverse neuron types from human pluripotency	57
Gene Therapy of Dominant CRX-Leber Congenital Amaurosis using Patient Stem Cell-Derived Retinal Organoids	57
Rebooting the Epigenomes during Mammalian Early Embryogenesis	55
Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids	55
Opportunities and challenges with stem cell-based embryo models	54
Distinct Phases of Postnatal Skeletal Muscle Growth Govern the Progressive Establishment of Muscle Stem Cell Quiescence	53
Soft Matrix Promotes Cardiac Reprogramming via Inhibition of YAP/TAZ and Suppression of Fibroblast Signatures	53
Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients	53

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation	53
Engineered 3D vessel-on-chip using hiPSC-derived endothelial- and vascular smooth muscle cells	53
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies	51
Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids	50
Engineering spatial-organized cardiac organoids for developmental toxicity testing	50
Basal-like Progenitor Cells: A Review of Dysplastic Alveolar Regeneration and Remodeling in Lung Repair	50
Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format	49
Age-Related Changes in the Inflammatory Status of Human Mesenchymal Stem Cells: Implications for Cell Therapy	49
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition	49
A Manually Curated Database on Clinical Studies Involving Cell Products Derived from Human Pluripotent Stem Cells	47
Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons	47
Gastruloids generated without exogenous Wnt activation develop anterior neural tissues	45
Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons	44
The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research	44
Identifying Therapeutic Agents for Amelioration of Mitochondrial Clearance Disorder in Neurons of Familial Parkinson Disease	43
Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation	43
APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes	43
Pharmacologic therapy for engraftment arrhythmia induced by transplantation of human cardiomyocytes	43
Neurotropic Effects of SARS-CoV-2 Modeled by the Human Brain Organoids	43
Estrogen Receptor β Controls Muscle Growth and Regeneration in Young Female Mice	42
Human Intestinal Organoids Recapitulate Enteric Infections of Enterovirus and Coronavirus	42
Efficient conversion of human induced pluripotent stem cells into microglia by defined transcription factors	41
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids	40
Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells	39
Generation and Differentiation of Adult Tissue-Derived Human Thyroid Organoids	39
Gli1+ Cells Couple with Type H Vessels and Are Required for Type H Vessel Formation	38
Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells	38
Imaging Transplanted Photoreceptors in Living Nonhuman Primates with Single-Cell Resolution	37
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection	37
Gastruloid Development Competence Discriminates Different States of Pluripotency	36
Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization	36
Non-human primates as a model for human development	36
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2	36
Induced Fetal Human Muscle Stem Cells with High Therapeutic Potential in a Mouse Muscular Dystrophy Model	34
Robotic high-throughput biomanufacturing and functional differentiation of human pluripotent stem cells	34
Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy	34
Homozygous might be hemizygous: CRISPR/Cas9 editing in iPSCs results in detrimental on-target defects that escape standard quality controls	34
Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs	33
Allele-specific gene editing to rescue dominant CRX-associated LCA7 phenotypes in a retinal organoid model	33
Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells	33
Damaged Myofiber-Derived Metabolic Enzymes Act as Activators of Muscle Satellite Cells	33
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species	32
Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells	32
A Scalable Suspension Platform for Generating High-Density Cultures of Universal Red Blood Cells from Human Induced Pluripotent Stem Cells	31
Human Aging Alters the Spatial Organization between CD34+ Hematopoietic Cells and Adipocytes in Bone Marrow	31
Arachidonic Acid Promotes Intestinal Regeneration by Activating WNT Signaling	31
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells	30
Efficient ssODN-Mediated Targeting by Avoiding Cellular Inhibitory RNAs through Precomplexed CRISPR-Cas9/sgRNA Ribonucleoprotein	30
Derivation of Peripheral Nociceptive, Mechanoreceptive, and Proprioceptive Sensory Neurons from the same Culture of Human Pluripotent Stem Cells	30
Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression	30

Photobiomodulation therapy for hair regeneration: A synergetic activation of β-CATENIN in hair follicle stem cells by ROS and paracrine WNTs	29
Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors	29
A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders	29
Progress in Modeling and Targeting Inner Ear Disorders with Pluripotent Stem Cells	28
Organs-on-chip: The way forward	28
Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells	28
WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche	28
Modulation by DREADD reveals the therapeutic effect of human iPSC-derived neuronal activity on functional recovery after spinal cord injury	28
Androgen Maintains Intestinal Homeostasis by Inhibiting BMP Signaling via Intestinal Stromal Cells	27
Mthfd2 Modulates Mitochondrial Function and DNA Repair to Maintain the Pluripotency of Mouse Stem Cells	27
Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: Altered mitochondrial and energy metabolism	27
Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency	27
All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models	27
Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells	27
Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy	27
Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer	27
Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium	26
Novel synthetic biology approaches for developmental systems	26
Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart Fails	26
Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer	26
Bioengineering in vitro models of embryonic development	26
Aging of intestinal stem cells	26
Iron accumulation induces oxidative stress, while depressing inflammatory polarization in human iPSC-derived microglia	26
Engineered models of the human heart: Directions and challenges	26
Isogenic Sets of hiPSC-CMs Harboring Distinct KCNH2 Mutations Differ Functionally and in Susceptibility to Drug-Induced Arrhythmias	25
Patients' perspectives on the derivation and use of organoids	25
Restoration of hippocampal neural precursor function by ablation of senescent cells in the aging stem cell niche	25
Unproven stem cell interventions: A global public health problem requiring global deliberation	25
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes	25
Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation	25
Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin	25
CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell	25
FGFR3 in Periosteal Cells Drives Cartilage-to-Bone Transformation in Bone Repair	25
SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids	24
Modulating adult neurogenesis affects synaptic plasticity and cognitive functions in mouse models of Alzheimer's disease	24
An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development	24
Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3	24
ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts	23
Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells	23
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation	23
UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters	23
Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis	23
Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells	23
Assessing donor-to-donor variability in human intestinal organoid cultures	23
Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets	23
Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions	23
Molecular Mechanisms Underlying Ascl1-Mediated Astrocyte-to-Neuron Conversion	23
Increased Expression of Interleukin-1 Receptor Characterizes Anti-estrogen-Resistant ALDH+ Breast Cancer Stem Cells	23
Generation of anti-GD2 CAR macrophages from human pluripotent stem cells for cancer immunotherapies	23
Inhibition of Apoptosis Reduces Diploidization of Haploid Mouse Embryonic Stem Cells during Differentiation	23
Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells	23
A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4	23
Genomic Safe Harbor Expression of PAX7 for the Generation of Engraftable Myogenic Progenitors	22
Low Immunogenicity and Immunosuppressive Properties of Human ESC- and iPSC-Derived Retinas	22
Mammalian Germ Cell Development: From Mechanism to In Vitro Reconstitution	22
Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics	22
A Single Radioprotective Dose of Prostaglandin E2 Blocks Irradiation-Induced Apoptotic Signaling and Early Cycling of Hematopoietic Stem Cells	22
Biomanufacturing in low Earth orbit for regenerative medicine	22
Insulin Promotes Mitochondrial Respiration and Survival through PI3K/AKT/GSK3 Pathway in Human Embryonic Stem Cells	21
Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease	21
Novel Lineage-Tracing System to Identify Site-Specific Ectopic Bone Precursor Cells	21
A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients	21
Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury	21
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration	21
Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders	21
Conserved features of non-primate bilaminar disc embryos and the germline	21
Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids	21
EBiSC best practice: How to ensure optimal generation, qualification, and distribution of iPSC lines	21
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells	21
One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2	21
The role of SQSTM1 (p62) in mitochondrial function and clearance in human cortical neurons	21
Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone	20
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes	20
Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1	20
GATA6-AS1 Regulates GATA6 Expression to Modulate Human Endoderm Differentiation	20
Pluripotent stem cell derived dopaminergic subpopulations model the selective neuron degeneration in Parkinson’s disease	20
Survey Says: “COVID-19 Lockdown Hits Young Faculty and Clinical Trials”	20
Cell-to-Cell Adhesion and Neurogenesis in Human Cortical Development: A Study Comparing 2D Monolayers with 3D Organoid Cultures	20
Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response	20
Entropy sorting of single-cell RNA sequencing data reveals the inner cell mass in the human pre-implantation embryo	20

Pluripotent stem cell–derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty	20
Organoids are not organs: Sources of variation and misinformation in organoid biology	20
Generation of Human-Induced Pluripotent Stem Cell-Derived Functional Enterocyte-Like Cells for Pharmacokinetic Studies	19
Sestrins regulate muscle stem cell metabolic homeostasis	19
A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells	19
Two Functional Axes of Feedback-Enforced PRC2 Recruitment in Mouse Embryonic Stem Cells	19
The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19	19
In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment	19
Machine learning-assisted high-content analysis of pluripotent stem cell-derived embryos in vitro	19
Retinoic Acid Accelerates the Specification of Enteric Neural Progenitors from In-Vitro-Derived Neural Crest	19
Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome	18
Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons	18
Physiological calcium combined with electrical pacing accelerates maturation of human engineered heart tissue	18
Broad-Spectrum Anti-coronavirus Vaccines and Therapeutics to Combat the Current COVID-19 Pandemic and Future Coronavirus Disease Outbreaks	18
Direct Comparison of Four Hematopoietic Differentiation Methods from Human Induced Pluripotent Stem Cells	18
From embryos to embryoids: How external signals and self-organization drive embryonic development	18
Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes	18
Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic Stem Cells	18
Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage	18
Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3	18
In Vitro Meiosis of Male Germline Stem Cells	18
ISSCR standards for the use of human stem cells in basic research	18
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes	18
Deep neural net tracking of human pluripotent stem cells reveals intrinsic behaviors directing morphogenesis	18
Generation of pancreatic progenitors from human pluripotent stem cells by small molecules	17
Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo	17
The chromatin accessibility landscape reveals distinct transcriptional regulation in the induction of human primordial germ cell-like cells from pluripotent stem cells	17
Antioxidant and lipid supplementation improve the development of photoreceptor outer segments in pluripotent stem cell-derived retinal organoids	17
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro	17
Development of human iPSC-derived quiescent hepatic stellate cell-like cells for drug discovery and in vitro disease modeling	17
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy	17
The Median Eminence, A New Oligodendrogenic Niche in the Adult Mouse Brain	17
Splicing Factor SRSF1 Is Essential for Satellite Cell Proliferation and Postnatal Maturation of Neuromuscular Junctions in Mice	17
Agarose microgel culture delineates lumenogenesis in naive and primed human pluripotent stem cells	17
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film	17
YAP1 regulates the self-organized fate patterning of hESC-derived gastruloids	17
Cell position within human pluripotent stem cell colonies determines apical specialization via an actin cytoskeleton-based mechanism	17
Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs	17
Human Stem Cell Resources Are an Inroad to Neandertal DNA Functions	17
Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells	17
Functional genomics and the future of iPSCs in disease modeling	17
Histone Modifications in Stem Cell Development and Their Clinical Implications	17
Chromatin-Associated Membraneless Organelles in Regulation of Cellular Differentiation	17
Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol	17
Reaching into the toolbox: Stem cell models to study neuropsychiatric disorders	16
Human Cerebral Organoids Reveal Early Spatiotemporal Dynamics and Pharmacological Responses of UBE3A	16
Spermatogonial stem cell transplantation into nonablated mouse recipient testes	16
Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition	16
Putting Science into Standards workshop on standards for organ-on-chip	16
H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline	16
Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic iPSCs in 3D vessels on chip	16
Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis	16
Apple Peel and Flesh Contain Pro-neurogenic Compounds	16
A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals	16
Hedgehog Activation Regulates Human Osteoblastogenesis	16
Quick Commitment and Efficient Reprogramming Route of Direct Induction of Retinal Ganglion Cell-like Neurons	16
The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver	16
A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture	16
Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons	16
β-Globin Lentiviral Vectors Have Reduced Titers due to Incomplete Vector RNA Genomes and Lowered Virion Production	16