Stem Cell Reports

Article	Citations
Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells	200
A versatile in vivo platform for reversible control of transgene expression in adult tissues	102
Dissecting the impact of differentiation stage, replicative history, and cell type composition on epigenetic clocks	101
Insertion/deletion and microsatellite alteration profiles in induced pluripotent stem cells	101
Ribosomal proteins regulate 2-cell-stage transcriptome in mouse embryonic stem cells	98
Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies	94
YAP signaling in horizontal basal cells promotes the regeneration of olfactory epithelium after injury	86
Reconstruction of dynamic regulatory networks reveals signaling-induced topology changes associated with germ layer specification	76
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes	72
MSCohi-O lenses for long-term retention of mesenchymal stem cells on ocular surface as a therapeutic approach for chronic ocular graft-versus-host disease	69
Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs	66
Deriving waveform parameters from calcium transients in human iPSC-derived cardiomyocytes to predict cardiac activity with machine learning	61
Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling	61
Putting Science into Standards workshop on standards for organ-on-chip	61
Pen-2 regulates glial homeostasis by coordinating self-renewal and transdifferentiation programs in oligodendrocyte precursor cells	57
Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers	57
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development	53
Plasticity of ocular surface epithelia: Using a murine model of limbal stem cell deficiency to delineate metaplasia and transdifferentiation	52
Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research	52
DOT1L regulates lung developmental epithelial cell fate and adult alveolar stem cell differentiation after acute injury	52
Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes	49
Single-cell approaches define two groups of mammalian oligodendrocyte precursor cells and their evolution over developmental time	47
Functionally redundant roles of ID family proteins in spermatogonial stem cells	46
Human spinal GABA neurons survive and mature in the injured nonhuman primate spinal cord	46
Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture	46

IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock	45
Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids	45
Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium	45
Discovery of NANOG enhancers and their essential roles in self-renewal and differentiation in human embryonic stem cells	42
Connie Eaves (1944–2024)	40
Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironment	39
Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects	39
Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory	38
In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline	38
H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency	37
GP2-enriched pancreatic progenitors give rise to functional beta cells in vivo and eliminate the risk of teratoma formation	37
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation	37
Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids	36
Medium acidosis drives cardiac differentiation during mesendoderm cell fate specification from human pluripotent stem cells	36
Lessons learnt, and still to learn, in first in human stem cell trials	35
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis	35
DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome	35
Response to: SARS-CoV-2 and type I interferon signaling in brain endothelial cells: Blurring the lines between friend or foe	34
Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation	34
DPPA2, DPPA4, and other DPPA factor epigenomic functions in cell fate and cancer	34
Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis	33
Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome	33
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming	32
What does “appropriate scientific justification” mean for the review of human pluripotent stem cell, embryo, and related research?	32
Aged human serum induces vascular changes in an isogenic co-culture venule model	32
Human fetal tissue is critical for biomedical research	32
Glutamine boosts intestinal stem cell-mediated small intestinal epithelial development during early weaning: Involvement of WNT signaling	31
MEF2C/p300-mediated epigenetic remodeling promotes the maturation of induced cardiomyocytes	31
Ependymal and neural stem cells are close relatives	31
UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells	31
Neutrophils as regulators of macrophage-induced inflammation in a setting of allogeneic bone marrow transplantation	31
Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids	31
Human neuronal networks on micro-electrode arrays are a highly robust tool to study disease-specific genotype-phenotype correlations in vitro	31
Generation of highly pure pluripotent stem cell-derived myogenic progenitor cells and myotubes	30
Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3	30
Searching for information about stem cells online in an age of artificial intelligence: How should the stem cell community respond?	30
Public perceptions and expectations: Disentangling the hope and hype of organoid research	30
Engineered models of the human heart: Directions and challenges	30
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells	29
Human iPSC model reveals a central role for NOX4 and oxidative stress in Duchenne cardiomyopathy	29
Low fucosylation defines the glycocalyx of progenitor cells and melanocytes in the human limbal stem cell niche	29
In vitro expanded skeletal myogenic progenitors from pluripotent stem cell-derived teratomas have high engraftment capacity	29
Regeneration of spermatogenesis by mouse germ cell transplantation into allogeneic and xenogeneic testis primordia or organoids	28
Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells	28
Metabolic remodeling in hiPSC-derived myofibers carrying the m.3243A>G mutation	28
Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variants	28
CD49b identifies functionally and epigenetically distinct subsets of lineage-biased hematopoietic stem cells	27
Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment	27
Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming	27
Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation	27

A single cell-based computational platform to identify chemical compounds targeting desired sets of transcription factors for cellular conversion	27
Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology	27
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency	26
Inhibition of N-myristoyltransferase in pluripotent stem cells promotes the naive state in mice and elicits trophectoderm and primitive endoderm markers in humans	26
Titin-truncating variants in hiPSC cardiomyocytes induce pathogenic proteinopathy and sarcomere defects with preserved core contractile machinery	26
Transplantation of human pluripotent stem cell-derived retinal sheet in a primate model of macular hole	26
Critical considerations for public engagement in stem cell-related research	26
DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks	26
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models	25
Fractalkine enhances oligodendrocyte regeneration and remyelination in a demyelination mouse model	25
Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes	25
The trophectoderm acts as a niche for the inner cell mass through C/EBPα-regulated IL-6 signaling	25
Modeling sex differences in humans using isogenic induced pluripotent stem cells	25
Prosaposin maintains adult neural stem cells in a state associated with deep quiescence	24
Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems	24
Elimination of tumorigenic pluripotent stem cells from their differentiated cell therapy products: An important step toward ensuring safe cell therapy	24
AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype	24
Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease	24
Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3	24
Matthias Lutolf, interviewed by Peter Loskill (Vice-Chair of EUROoC, the European-Organ-on-Chip-Society)	24
Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes	23
Aggregation of cryopreserved mid-hindgut endoderm for more reliable and reproducible hPSC-derived small intestinal organoid generation	23
Derivation of functional trophoblast stem cells from primed human pluripotent stem cells	23
Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain	23
Embryonic stem cell ERK, AKT, plus STAT3 response dynamics combinatorics are heterogeneous but NANOG state independent	23
Small-molecule inhibitor cocktail promotes the proliferation of pre-existing liver progenitor cells	23
Mowat-Wilson syndrome factor ZEB2 controls early formation of human neural crest through BMP signaling modulation	23
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors	23
Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models	23
Reconstituted ovaries self-assemble without an ovarian surface epithelium	22
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro	22
A year of engagement and growth: ISSCR’s year-end message from the president 2022–2023	22
Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration	22
CD62L expression level determines the cell fate of myeloid progenitors	22
Deep-supercooling preservation of stem cell spheroids for chondral defect repairment	22
The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development	22
Businesses marketing purported stem cell treatments and exosome therapies for COVID-19: An analysis of direct-to-consumer online advertising claims	22
Fibroblast fate determination during cardiac reprogramming by remodeling of actin filaments	22
Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction	22
Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq	21
Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants	21
Identification of glioblastoma stem cell-associated lncRNAs using single-cell RNA sequencing datasets	21
Defining the nature of human pluripotent stem cell-derived interneurons via single-cell analysis	20
Scalable generation of sensory neurons from human pluripotent stem cells	20
Dual inhibition of MAPK and PI3K/AKT pathways enhances maturation of human iPSC-derived cardiomyocytes	20
Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells	20
MIXL1 activation in endoderm differentiation of human induced pluripotent stem cells	20
Toti: An integrated multi-omics database to decipher the epigenetic regulation of gene expression in totipotent stem cells	20
Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells	20
Ins and outs of HSCs and VEGF-induced vascular remodeling: Toward improved HSC mobilization and engraftment	19
LOTUS overexpression via ex vivo gene transduction further promotes recovery of motor function following human iPSC-NS/PC transplantation for contusive spinal cord injury	19
Generation, genomic characterization, and differentiation of triploid human embryonic stem cells	19
Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells	19
Differentiation of brain and retinal organoids from confluent cultures of pluripotent stem cells connected by nerve-like axonal projections of optic origin	19
The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation	19
Selective elimination of pluripotent stem cells by PIKfyve specific inhibitors	19
Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors	19
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes	19
Inducing human retinal pigment epithelium-like cells from somatic tissue	19
Cell-autonomous and non-cell-autonomous roles of NKCC1 in regulating neural stem cell quiescence in the hippocampal dentate gyrus	19
Argonaute proteins regulate a specific network of genes through KLF4 in mouse embryonic stem cells	19
MAC-1 marks a quiescent and functionally superior HSC subset during regeneration	19
Human microglial cells as a therapeutic target in a neurodevelopmental disease model	19
ER stress and lipid imbalance drive diabetic embryonic cardiomyopathy in an organoid model of human heart development	19
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes	18
Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting	18
Adult hippocampal neurogenesis: New avenues for treatment of brain disorders	18
Pluripotent cell states and unexpected fates	18
Patient-derived parathyroid organoids as a tracer and drug-screening application model	18
Astrocytes originated from neural stem cells drive the regenerative remodeling of pathologic CSPGs in spinal cord injury	18
Long noncoding RNA Lnc530 localizes on R-loops and regulates R-loop formation and genomic stability in mouse embryonic stem cells	18
RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern	18
Graft-derived horizontal cells contribute to host-graft synapses in degenerated retinas after retinal organoid transplantation	18
Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration	18
DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice	18
A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State	17
Subventricular zone adult mouse neural stem cells require insulin receptor for self-renewal	17
Neuroblast migration along cellular substrates in the developing porcine brain	17
Chitinase-like protein 3: A novel niche factor for mouse neural stem cells	17
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes	17

Rescuing human fetal tissue research in the United States: A call for additional regulatory reform	17
An efficient, non-viral arrayed CRISPR screening platform for iPSC-derived myeloid and microglia models	17
ERRγ agonist under mechanical stretching manifests hypertrophic cardiomyopathy phenotypes of engineered cardiac tissue through maturation	17
Seamless and non-destructive monitoring of extracellular microRNAs during cardiac differentiation from human pluripotent stem cells	17
Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells	16
Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration	16
Spatial transcriptomics reveals molecular cues underlying the site specificity of the adult mouse oral mucosa and its stem cell niches	16
Defective autophagy and increased apoptosis contribute toward the pathogenesis of FKRP-associated muscular dystrophies	16
GSK3α negatively regulates GSK3β by decreasing its protein levels and enzymatic activity in mouse embryonic stem cells	16
SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants	16
APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids	16
Accelerated mitochondrial dynamics promote spermatogonial differentiation	16
Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection	16
A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells	16
Retinoic acid signaling in heart development: Application in the differentiation of cardiovascular lineages from human pluripotent stem cells	16
Oligodendrocytes in human induced pluripotent stem cell-derived cortical grafts remyelinate adult rat and human cortical neurons	16
Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitro	16
DOT1L interaction partner AF10 controls patterning of H3K79 methylation and RNA polymerase II to maintain cell identity	15
A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM	15
Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells	15
CD37 regulates the self-renewal of leukemic stem cells via integrin-mediated signaling in acute myeloid leukemia	15
Cell size regulates human endoderm specification through actomyosin-dependent AMOT-YAP signaling	15
Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film	15
Safe CNV removal is crucial for successful hESC-RPE transplantation in wet age-related macular degeneration	15
PBX1-directed stem cell transcriptional program drives tumor progression in myeloproliferative neoplasm	15
Telmisartan is neuroprotective in a hiPSC-derived spinal microtissue model for C9orf72 ALS via inhibition of neuroinflammation	15
PI3Kβ-regulated β-catenin mediates EZH2 removal from promoters controlling primed human ESC stemness and primitive streak gene expression	15
Transcription factor co-expression mediates lineage priming for embryonic and extra-embryonic differentiation	15
Unraveling the impact of ZZZ3 on the mTOR/ribosome pathway in human embryonic stem cells homeostasis	15
AT7867 promotes pancreatic progenitor differentiation of human iPSCs	15
The urgent need for clear and concise regulations on exosome-based interventions	15
Generation of a TPH2-EGFP reporter cell line for purification and monitoring of human serotonin neurons in vitro and in vivo	15
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells	15