Cell Reports

Article	Citations
Leave no sister behind	354
Deneddylation of ribosomal proteins promotes synergy between MLN4924 and chemotherapy to elicit complete therapeutic responses	295
Combinatorial Developmental Controls on Striatonigral Circuits	270
Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy	241
Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase	241
Regulation of RNA localization during oocyte maturation by dynamic RNA-ER association and remodeling of the ER	214
The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing	213
Enforced activation of the CREB/KDM2B axis prevents alcohol-induced embryonic developmental delay	212
Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner	200
Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection	171
DRD1 signaling modulates TrkB turnover and BDNF sensitivity in direct pathway striatal medium spiny neurons	167
High plasticity of ribosomal DNA organization in budding yeast	159
OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase	159
The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1	158
Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV	151
Neutralization fingerprinting technology for characterizing polyclonal antibody responses to dengue vaccines	147
Actin-dependent astrocytic infiltration is a key step for axon defasciculation during remodeling	146
Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer	144
Memory trace imbalance in reinforcement and punishment systems can reinforce implicit choices leading to obsessive-compulsive behavior	139
Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues	138
Cortical mechanisms of visual brightness	138
Systematic analysis of human antibody response to ebolavirus glycoprotein shows high prevalence of neutralizing public clonotypes	136
Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons	136
Loss of neuronal heterogeneity in epileptogenic human tissue impairs network resilience to sudden changes in synchrony	134
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors	133

Development of pial collaterals by extension of pre-existing artery tips	132
The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma	130
HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation	127
Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction	125
Direct type I interferon signaling in hepatocytes controls malaria	121
Failure of digit tip regeneration in the absence of Lmx1b suggests Lmx1b functions disparate from dorsoventral polarity	121
Phosphoproteomic profiling of influenza virus entry reveals infection-triggered filopodia induction counteracted by dynamic cortactin phosphorylation	121
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression	120
A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis	119
Fibroblast diversification is an embryonic process dependent on muscle contraction	119
The structural basis of Salmonella A2B5 toxin neutralization by antibodies targeting the glycan-receptor binding subunits	118
Regionally defined proteomic profiles of human cerebral tissue and organoids reveal conserved molecular modules of neurodevelopment	117
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle	116
Single-cell RNA-seq analysis identifies the atlas of lymph fluid and reveals a sepsis-related T cell subset	114
Q&A with Bin Cao	114
PIX is an N-terminal delivery domain that defines a class of polymorphic T6SS effectors in Enterobacterales	114
Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection	113
Endophytic mycobiont provides growth benefits via a phenylpropanoid-auxin axis in host plants	112
The m C methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism	111
EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes	111
The architecture of silk-secreting organs during the final larval stage of silkworms revealed by single-nucleus and spatial transcriptomics	110
A type III-Dv CRISPR-Cas system is controlled by the transcription factor RpaB and interacts with the DEAD-box RNA helicase CrhR	108
Tyzzerella nexilis strains enriched in mobile genetic elements are involved in progressive multiple sclerosis	108
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells	107
Santa-maria is a glial phagocytic receptor that acts with SIMU to recognize and engulf apoptotic neurons	106
CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells	104
An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma	104
The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis	103
Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts	102
Deep ancestry of Bornean hunter-gatherers supports long-term local ancestry dynamics	100
Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model	100
Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration	100
EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release	99
An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike	99
β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4	99
Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells	99
SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones	98
A synaptic molecular dependency network in knockdown of autism- and schizophrenia-associated genes revealed by multiplexed imaging	98
Acetylation-dependent regulation of BRAF oncogenic function	97
Cell context-dependent CFI-1/ARID3 functions control neuronal terminal differentiation	97
A robot-rodent interaction arena with adjustable spatial complexity for ethologically relevant behavioral studies	96
Hierarchical behavioral analysis framework as a platform for standardized quantitative identification of behaviors	96
Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression	96
The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells	94
A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner	93
Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia	93
Amino acids in cancer: Understanding metabolic plasticity and divergence for better therapeutic approaches	92
Supercoiling-mediated feedback rapidly couples and tunes transcription	91
Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response	91
A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth	91

Mechanosensitive Notch-Dll4 and Klf2-Wnt9 signaling pathways intersect in guiding valvulogenesis in zebrafish	90
Food-induced dopamine signaling in AgRP neurons promotes feeding	90
Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation	89
53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication	88
Mitochondrial cristae architecture protects against mtDNA release and inflammation	87
In vivo partial cellular reprogramming enhances liver plasticity and regeneration	87
Unique potential of immature adult-born neurons for the remodeling of CA3 spatial maps	86
Modification of histidine repeat proteins by inorganic polyphosphate	86
EWSR1 maintains centromere identity	86
Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy	85
The medial entorhinal cortex encodes multisensory spatial information	85
SRSF3-mediated regulation of N6-methyladenosine modification-related lncRNA ANRIL splicing promotes resistance of pancreatic cancer to gemcitabine	85
FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis	85
CD84 as a therapeutic target for breaking immune tolerance in triple-negative breast cancer	85
Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo	84
Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex	84
MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis	84
PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA	84
TGF-β Determines the Pro-migratory Potential of bFGF Signaling in Medulloblastoma	83
Gamma synchronization between the medial temporal lobe and medial frontal cortex for goal-directed visual attention in humans	83
Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3′ untranslated region mutations	83
The human placenta shapes the phenotype of decidual macrophages	83
Direction selectivity of inhibitory interneurons in mouse barrel cortex differs between interneuron subtypes	83
A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution	83
Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning	82
UQCRC1 engages cytochrome c for neuronal apoptotic cell death	82
Chemical-induced epigenome resetting for regeneration program activation in human cells	82
Atg15 is a vacuolar phospholipase that disintegrates organelle membranes	82
Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins	82
Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity	81
Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment	81
Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity	81
Extracellular vesicle-mediated trafficking of molecular cues during human brain development	81
A synthetic chlorophagy receptor promotes plant fitness by mediating chloroplast microautophagy	80
LKB1 prevents ILC2 exhaustion to enhance antitumor immunity	80
Spatiotemporal patterns of neuronal subtype genesis suggest hierarchical development of retinal diversity	79
SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification	79
PAMless SpRY exhibits a preference for the seed region for efficient targeting	79
MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC	79
Q&A with Hao Gu	79
Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain	79
CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection	79
Sugar detection in 3D: Structure of an insect gustatory receptor	79
Secretory IgA in breast milk protects against asthma through modulation of the gut microbiota	78
AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia	78
Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus	78
Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females	78
SoxD genes are required for adult neural stem cell activation	78
Stereotyped goal-directed manifold dynamics in the insular cortex	78
Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange	77
Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation	77
Multimodal CRISPR screens uncover DDX39B as a global repressor of A-to-I RNA editing	77
Cross-species communication via agr controls phage susceptibility in Staphylococcus aureus	76
Chlorophyll biosynthesis under the control of arginine metabolism	76
MYB68 regulates radial endodermal differentiation and suberin patterning	76
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols	76
Coupling to Pam16 differentially controls the dual role of Pam18 in protein import and respiratory chain formation	75
Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors	75
Laminar mechanisms of saccadic suppression in primate visual cortex	75
Genome restructuring and lineage diversification of Cryptococcus neoformans during chronic infection of human hosts	74
Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts	74
PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth	74
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A	74
A trans-kingdom T6SS RNase effector targeting both prokaryotic and host cells for pathogenesis	74
piRNA-guided intron removal from pre-mRNAs regulates density-dependent reproductive strategy	74
Coordinated expression of retained introns and poison exons in renal cell carcinoma	73
Organization of hippocampal CA3 into correlated cell assemblies supports a stable spatial code	73
Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity	73
An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity	72
Evaluating the impact of age on immune checkpoint therapy biomarkers	72
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity	72
HuR promotes triglyceride synthesis and intestinal fat absorption	72
Piezo1 senses hyphae and initiates host defense against pathogenic fungi	72
HNF4A modulates glucocorticoid action in the liver	72
Cytoskeletal activation of NHE1 regulates mechanosensitive cell volume adaptation and proliferation	72
FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress	71
YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation	71
Exploring the pan-cancer landscape of posttranscriptional regulation	71
Genome-wide fetalization of enhancer architecture in heart disease	71
Compartmentalized PGRP expression along the dipteran Bactrocera dorsalis gut forms a zone of protection for symbiotic bacteria	70

Gestationally dependent immune organization at the maternal-fetal interface	70
DNA replication is highly resilient and persistent under the challenge of mild replication stress	70
Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP	70
Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis	69
Gasdermin D restricts anti-tumor immunity during PD-L1 checkpoint blockade	69
Mapping the evolution of T cell states during response and resistance to adoptive cellular therapy	69
Critical roles of the miR-17∼92 family in thymocyte development, leukemogenesis, and autoimmunity	68
The T cell receptor sequence influences the likelihood of T cell memory formation	68
Structural basis of ligand specificity and channel activation in an insect gustatory receptor	68
Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus	68
The OsbHLH002/OsICE1-OSH1 module orchestrates secondary cell wall formation in rice	67
Epitopes in the capsular polysaccharide and the porin OmpK36 receptors are required for bacteriophage infection of Klebsiella pneumoniae	67
PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model	67
CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance	67
Salmonella enterica serovar Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance	67
A vascular-associated fibroblastic cell controls pancreatic islet immunity	66
Association of B cell profile and receptor repertoire with the progression of Alzheimer’s disease	66
Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins	66
Tumor-derived Jagged1 promotes cancer progression through immune evasion	66
Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly	65
APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation	65
Oviduct epithelial cells constitute two developmentally distinct lineages that are spatially separated along the distal-proximal axis	65
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids	64
p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP	64
Autocleavage of separase suppresses its premature activation by promoting binding to cyclin B1	64
Documenting the diversity of the Namibian Ju|’hoansi intestinal microbiome	64
Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation	64
Hippocampal and medial prefrontal ensemble spiking represents episodes and rules in similar task spaces	64
Human antibodies in Mexico and Brazil neutralizing tick-borne flaviviruses	64
Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity	64
Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic	64
T-type Ca2+ and persistent Na+ currents synergistically elevate ventral, not dorsal, entorhinal cortical stellate cell excitability	64
Bodies in motion: Unraveling the distinct roles of motion and shape in dynamic body responses in the temporal cortex	63
Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3	63
CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart	63
T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103+ intestine-resident memory CD8+ T cells	63
Active APPL1 sequestration by Plasmodium favors liver-stage development	63
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages	62
A tug of war between DCC and ROBO1 signaling during commissural axon guidance	62
Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer	62
Bioengineering for robust tolerance against cold and drought stresses via co-overexpressing three Cu-miRNAs in major food crops	62
Nucleus accumbens local circuit for cue-dependent aversive learning	62
The cellular basis of mechanosensation in mammalian tongue	62
Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1	61
Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell types	61
Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels	61
Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1	61
EPH receptor tyrosine kinases phosphorylate the PAR-3 scaffold protein to modulate downstream signaling networks	61
Loss of the proton-activated chloride channel in neurons impairs AMPA receptor endocytosis and LTD via endosomal hyper-acidification	61
Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors	61
A rice protein modulates endoplasmic reticulum homeostasis and coordinates with a transcription factor to initiate blast disease resistance	61
Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD	61
Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication	61
Laminar and dorsoventral organization of layer 1 interneuronal microcircuitry in superficial layers of the medial entorhinal cortex	60
NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells	60
Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration	60
Selective targeting of mu opioid receptors to primary cilia	59
Subcellular localization shapes the fate of RNA polymerase III	59
Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3	59
Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination	59
METTL3 regulates cartilage development and homeostasis by affecting Lats1 mRNA stability in an m6A-YTHDF2-dependent manner	59
The Chlamydia effector IncE employs two short linear motifs to reprogram host vesicle trafficking	59
Cell-substrate distance fluctuations of confluent cells enable fast and coherent collective migration	59
Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions	59
Phospholipids can regulate complex I assembly independent of their role in maintaining mitochondrial membrane integrity	59
Stromal cell and B cell dialogue potentiates IL-33-enriched lymphoid niches to support eosinophil recruitment and function during type 2 immunity	59
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia	58
Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways	58
Mammalian milk glycomes: Connecting the dots between evolutionary conservation and biosynthetic pathways	58
Acute neuroinflammation leads to disruption of neuronal chloride regulation and consequent hyperexcitability in the dentate gyrus	58
Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of intestinal stemness	58
Mitochondrial transplantation rescues Ca2+ homeostasis imbalance and myocardial hypertrophy in SLC25A3-related hypertrophic cardiomyopathy	58
Automated live-cell single-molecule tracking in enteroid monolayers reveals transcription factor dynamics probing lineage-determining function	58
SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells	58
Gene-regulatory programs that specify age-related differences during thymocyte development	58
TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria	58
Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis	58
Age-dependent glial heterogeneity and traumatic injury responses in a vertebrate brain structure	58
Reverse engineering neuron-type-specific and type-orthogonal splicing-regulatory networks using diverse cellular transcriptomes	58
Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4+ T cell immunity	57
Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes	57
Dynamic chromatin remodeling in cycling human endometrium at single-cell level	57
Midbrain dopamine neurons signal phasic and ramping reward prediction error during goal-directed navigation	57
Redefining sensorimotor mismatch selectivity in the visual cortex	57
Parallel processing in active dendrites during periods of intense spiking activity	57
A neural circuit integrates pharyngeal sensation to control feeding	57
Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway	57
PP2A licenses the FANCD2/FANCI complex for chromosome loading	57
Identification of the viral and cellular microRNA interactomes during SARS-CoV-2 infection	56
Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration	56
Randomly barcoded transposon mutant libraries for gut commensals II: Applying libraries for functional genetics	56
Encoding of acquired sound-sequence salience by auditory cortical offset responses	56
Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia	56
Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase	56
Mechanistic insight into the induction of liver tissue-resident memory CD8+ T cells by glycolipid-peptide vaccination	56