Cell Stem Cell

Article	Citations
Regrowing the heart, one TREE at a time	497
Prolonged 3D culture unlocks black box of primate embryogenesis	264
Cut out that YAPping: Mechanisms to reduce scar formation	213
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	202
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	199
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	197
Tissue morphology influences the temporal program of human brain organoid development	190
Successful organoid-mediated generation of iPSC-derived CAR-T cells	186
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	183
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	169
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	167
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	165
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	151
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	141
Oscillation steers differentiation	140
Brain organoids restore cortical damage	139
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	138
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	136
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	135
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	130
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	129
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	125
Paul S. Frenette (1965–2021)	124
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	124
From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony	123

Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	123
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	122
Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	122
IRF6 hits the sweet spot	122
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	121
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	121
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	120
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	120
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	119
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	119
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	118
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	118
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	116
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	112
Human biliary epithelial cells for regenerative medicine	110
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	110
Perceiving the brain like never before	109
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	107
An oncogenic enhancer encodes selective selenium dependency in AML	107
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	107
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	106
Enchanted by the earliest stages of human life	106
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	100
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	100
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	99
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	97
Progress in multicellular human cardiac organoids for clinical applications	97
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	95
Early human development and stem cell-based human embryo models	95
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	91
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	91
Human Down syndrome microglia are up for a synaptic feast	89
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	89
Mini kidney organoids deliver maximal drug screening impact	87
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	87
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	87
Video, ergo sum: The search for response to natural light	87
Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging	85
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	82
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	82
A human pluripotent stem cell-based somitogenesis model using microfluidics	81
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	80
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	79
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	79
Rebuilding and rebooting immunity with stem cells	78
Organ function is preserved despite reorganization of niche architecture in the hair follicle	76
Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	76
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	76
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	75
Epigenetic regulation of early human embryo development	75

A reference human induced pluripotent stem cell line for large-scale collaborative studies	74
Advancing cell therapy for neurodegenerative diseases	74
Human hematopoietic stem cells expand beyond cytokines	73
Maturation for regeneration	73
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	73
iPSC model of congenital heart disease predicts disease outcome	73
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	72
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	72
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	72
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	72
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	72
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	71
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	70
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	69
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	69
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	68
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	68
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	68
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	68
Face off: Stem cell therapy versus the immune system	68
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	68
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	68
The clones have STRACK: Tracing responses to leukemic mutations	67
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	67
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	66
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	66
Rewinding cells to reverse disease	65
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	65
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	65
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	64
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	64
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease	64
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	64
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	63
New evidence for adult beta cell neogenesis	62
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	62
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	61
Chemical reprogramming takes the fast lane	61
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	60
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	60
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	60
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	60
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	59
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	59
Capybara: A computational tool to measure cell identity and fate transitions	59
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	58
Hallmarks of stem cell aging	58
Patient-derived micro-organospheres enable clinical precision oncology	57
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	57
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	56
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	56
Can’t touch this: Stromal-mediated ductal proliferation	56
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	56
Human blastoids 3.0	56
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	56
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	55
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	55
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	54
Beyond transplantation: Gene-edited pig liver supports function in a human host	54
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	53
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	53
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	53
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	53
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	52
Acetate to the rescue: Acetyl-CoA facilitates placental development	52
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	52
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	51
Human brain organoids assemble functionally integrated bilateral optic vesicles	50
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	50
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	49
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	49
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	49
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	48
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	48
Lung repair and regeneration: Advanced models and insights into human disease	48
MDS/AML with del5q: An acquired “laminopathy”?	48
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	47
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	47
The eyeball’s connected to the brain ball	47
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	47

Generation of human alveolar epithelial type I cells from pluripotent stem cells	46
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	46
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	46
Mapping of clonal lineages across developmental stages in human neural differentiation	46
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	46
Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	46
Hallmarks of stemness in mammalian tissues	46
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	45
Anniversary reflections: Inspiring discoveries and the future of the field	45
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages	44
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling	44
Hair follicle stem cells feel the pressure	44
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine	44
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	43
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites	43
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs	43
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk	43
Hallmarks of regeneration	42
Effective regulatory responses to predatory stem cell markets in Australia and Canada	42
From stem cells to regulatory T cells: A tale of plasticity	42
Setting the stage for embryo segmentation	42
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip	42
Generating human neural diversity with a multiplexed morphogen screen in organoids	41
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation	41
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction	41
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia	41
Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence	40
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo	40
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells	40
3D ECM-rich environment sustains the identity of naive human iPSCs	40
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids	40
Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques	40
Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis	40
Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis	40
Establishment, maintenance, and recall of inflammatory memory	39
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion	39
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds	39
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development	38
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming	38
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells	37
The difficult translational pathway from animal models to patients	37
Human pluripotent stem cell-derived organoids repair damaged bowel in vivo	37
Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas	36
From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP	36
Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies	34
Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei	34
tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche	34
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions	34
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration	34
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy	33
20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis	33
Spatiotemporal single-cell roadmap of human skin wound healing	33
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease	32
Quickly moving too slowly: Interneuron migration in Timothy Syndrome	32
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells	32
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche	32
Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells	32
An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier	31
Maternal gut microbiota influence stem cell function in offspring	31
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation	31
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance	31
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming	30
Empowering human lung development	30
Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells	30
Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy	29
A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer	29
Alveolar regeneration by airway secretory-cell-derived p63+ progenitors	29
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids	28
Forward steps in organoid-based forward screening	27
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages	27
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation	26
Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease	26
Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches	26
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury	26
Bioprinted platform for parallelized screening of engineered microtissues in vivo	26
Amniogenesis occurs in two independent waves in primates	25
Generating high-fidelity cochlear organoids from human pluripotent stem cells	25
Multipotent stromal cells: One name, multiple identities	25
A time- and single-cell-resolved model of murine bone marrow hematopoiesis	24
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells	24
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice	24
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy	24
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	24
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	24
Breathing-induced forces influence lung cell fate	24
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing	24
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	24
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration	23
A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells	23
Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients	23
Stem cell-derived β cells go in monkeys	23
Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis	23
ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum	23
T cell development made EZ	23
Androgens increase excitement in brain organoid research	23