Cell Stem Cell

Article	Citations
Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis	467
Induction of Multipotential Hematopoietic Progenitors from Human Pluripotent Stem Cells via Respecification of Lineage-Restricted Precursors	261
Regrowing the heart, one TREE at a time	219
Prolonged 3D culture unlocks black box of primate embryogenesis	207
T cell immunotherapy for cardiac fibrosis: mRNA starts the CAR	199
Oscillation steers differentiation	190
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts	187
Engineered heart tissue patches: A milestone in cardiac regenerative medicine	185
Successful organoid-mediated generation of iPSC-derived CAR-T cells	184
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development	178
Cut out that YAPping: Mechanisms to reduce scar formation	177
Stem cell-based islet replacement therapy in diabetes: A road trip that reached the clinic	170
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes	166
Brain organoids restore cortical damage	163
hPSCs-derived Schwann cells serve for disease modeling and drug discovery	151
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis	147
Tissue morphology influences the temporal program of human brain organoid development	137
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate	136
An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer	134
Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model	132
Stage-specific H3K9me3 occupancy ensures retrotransposon silencing in human pre-implantation embryos	132
Principles of signaling pathway modulation for enhancing human naive pluripotency induction	131
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis	130
Refined transcriptional blueprint of human preimplantation embryos	128
Paul S. Frenette (1965–2021)	124

IRF6 hits the sweet spot	124
Hypoimmune CD19 CAR T cells evade allorejection in patients with cancer and autoimmune disease	121
Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination	120
Retraction Notice to: Efficient Derivation of Functional Floor Plate Tissue from Human Embryonic Stem Cells	119
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis	119
Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors	119
Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero	118
In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells	118
Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development	116
C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells	115
A post-middle-age crisis for CD47 and THBS1 that turns into a vicious cycle	115
Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment	114
Human biliary epithelial cells for regenerative medicine	114
The single-cell and spatial transcriptional landscape of human gastrulation and early brain development	113
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease	113
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD	113
Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells	112
Perceiving the brain like never before	111
Healing takes nerve	108
Enchanted by the earliest stages of human life	108
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease	108
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering	107
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids	107
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	106
An oncogenic enhancer encodes selective selenium dependency in AML	104
Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification	103
Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion	102
Sustained NF-κB activation allows mutant alveolar stem cells to co-opt a regeneration program for tumor initiation	101
Preclinical efficacy and safety of encapsulated proliferating human hepatocyte organoids in treating liver failure	98
Progress in multicellular human cardiac organoids for clinical applications	97
Early human development and stem cell-based human embryo models	95
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging	93
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates	92
Human Down syndrome microglia are up for a synaptic feast	91
Video, ergo sum: The search for response to natural light	91
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models	88
Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas	88
Mini kidney organoids deliver maximal drug screening impact	87
Rebuilding and rebooting immunity with stem cells	86
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress	84
Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model	83
Organ function is preserved despite reorganization of niche architecture in the hair follicle	83
Retraction Notice to: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development	82
Revolutionizing islet transplantation with a preconditioning boost for beta cell survival	82
Cognitive impairment in epilepsy progression: Adult neurogenesis loss at critical window	80
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons	79
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation	77
A reference human induced pluripotent stem cell line for large-scale collaborative studies	76
Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons	76
A human pluripotent stem cell-based somitogenesis model using microfluidics	76

Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells	76
Advancing cell therapy for neurodegenerative diseases	76
Epigenetic regulation of early human embryo development	74
iPSC model of congenital heart disease predicts disease outcome	74
Human hematopoietic stem cells expand beyond cytokines	73
Maturation for regeneration	73
PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1	72
The nuclear receptor THRB facilitates differentiation of human PSCs into more mature hepatocytes	72
Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids	72
The clones have STRACK: Tracing responses to leukemic mutations	71
3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T cells	71
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation	70
Construction of multilayered small intestine-like tissue by reproducing interstitial flow	69
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease	69
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia	69
Human embryo models made from pluripotent stem cells are not synthetic; they aren’t embryos, either	69
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes	68
Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing	67
Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis	67
Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction	67
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment	67
TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice	66
Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity	66
Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors	65
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution	65
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	65
Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells	65
PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia	64
Therapeutic intersections: Expanding benefits of CD19 CAR T cells from cancer to autoimmunity	64
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells	64
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins	64
Rewinding cells to reverse disease	64
An erythroid-biased FOShi hematopoietic multipotent progenitor subpopulation contributes to adaptation to chronic hypoxia	63
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease	63
Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1	63
Too little, too soon: Japan’s experiment in regenerative medicine deregulation	62
In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration	62
Remodeling ceramide homeostasis promotes functional maturation of human pluripotent stem cell-derived β cells	61
Embryonic macrophages support endocrine commitment during human pancreatic differentiation	61
Hallmarks of stem cell aging	60
Capybara: A computational tool to measure cell identity and fate transitions	60
Chemical reprogramming takes the fast lane	60
New evidence for adult beta cell neogenesis	60
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases	59
Hiding from allogeneic NK cells and macrophages by a synthetic receptor	59
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells	59
Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair	58
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate	58
Multilayer omics analysis reveals a non-classical retinoic acid signaling axis that regulates hematopoietic stem cell identity	57
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal	57
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise	56
Patient-derived glioblastoma organoids as real-time avatars for assessing responses to clinical CAR-T cell therapy	56
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation	54
A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease	54
Patient-derived micro-organospheres enable clinical precision oncology	54
The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells	54
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity	53
Human blastoids 3.0	53
Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia	53
Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures	53
Human brain organoids assemble functionally integrated bilateral optic vesicles	53
Can’t touch this: Stromal-mediated ductal proliferation	53
Beyond transplantation: Gene-edited pig liver supports function in a human host	52
Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain	52
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength	52
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3	51
Acetate to the rescue: Acetyl-CoA facilitates placental development	51
Mobility mediates maturation: Synthetic substrates to enhance neural differentiation	50
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models	50
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation	49
Engineered hiPSC-derived vascular graft brings hope for thrombosis-free vascular therapy	49
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients	48
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis	48
Lung repair and regeneration: Advanced models and insights into human disease	48
TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate	47
Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells	47
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity	47
Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells	47
Vascular architecture regulates mesenchymal stromal cell heterogeneity via P53-PDGF signaling in the mouse incisor	46
The eyeball’s connected to the brain ball	46

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia	46
PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms	46
HBO1 functions as an epigenetic barrier to hepatocyte plasticity and reprogramming during liver injury	46
MDS/AML with del5q: An acquired “laminopathy”?	46
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons	46
Generation of human alveolar epithelial type I cells from pluripotent stem cells	45
Mapping of clonal lineages across developmental stages in human neural differentiation	45
The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells	44
Hallmarks of stemness in mammalian tissues	44
Dynamic reprogramming of H3K9me3 at hominoid-specific retrotransposons during human preimplantation development	44
Anniversary reflections: Inspiring discoveries and the future of the field	44
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling	44
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes	43
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk	43
From stem cells to regulatory T cells: A tale of plasticity	43
Effective regulatory responses to predatory stem cell markets in Australia and Canada	43
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip	43
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease	43
Setting the stage for embryo segmentation	43
Hair follicle stem cells feel the pressure	42
Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction	42
SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling	42
Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages	41
Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites	41
Generating human neural diversity with a multiplexed morphogen screen in organoids	41
iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia	40
Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis	40
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs	40
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine	40
Expanding the precision oncology toolkit with micro-organospheres for early cancer diagnosis	40
Hallmarks of regeneration	40
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation	40
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells	39
Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids	39
3D ECM-rich environment sustains the identity of naive human iPSCs	39
Controlling genetic heterogeneity in gene-edited hematopoietic stem cells by single-cell expansion	39
Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence	39
Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds	39
Parasympathetic neurons derived from human pluripotent stem cells model human diseases and development	38
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo	38
Highly efficient and rapid generation of human pluripotent stem cells by chemical reprogramming	38
Long-term engraftment and maturation of autologous iPSC-derived cardiomyocytes in two rhesus macaques	38
The difficult translational pathway from animal models to patients	37
Establishment, maintenance, and recall of inflammatory memory	37
20-αHydroxycholesterol, an oxysterol in human breast milk, reverses mouse neonatal white matter injury through Gli-dependent oligodendrogenesis	37
From symbiote to bad neighbor: The intestinal microbiome as a driver of CHIP	36
tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche	35
Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells	35
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration	35
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease	35
Reprogramming reactive glia into interneurons reduces chronic seizure activity in a mouse model of mesial temporal lobe epilepsy	35
Response to Magenheim et al.: Ductal Ngn3-expressing progenitors contribute to adult beta cell neogenesis in the pancreas	35
Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche	34
Human pluripotent stem cell-derived organoids repair damaged bowel in vivo	33
Human stem cell-derived embryo models: Toward ethically appropriate regulations and policies	33
Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification	32
Neural stem cell quiescence and activation dynamics are regulated by feedback input from their progeny under homeostatic and regenerative conditions	32
Generation of human region-specific brain organoids with medullary spinal trigeminal nuclei	32
Two is better than one: Advancing gene therapy protocols for enhanced safety and efficacy	31
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells	31
Quickly moving too slowly: Interneuron migration in Timothy Syndrome	31
An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrier	31
Spatiotemporal single-cell roadmap of human skin wound healing	31
Maternal gut microbiota influence stem cell function in offspring	30
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming	30
Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance	30
Alveolar regeneration by airway secretory-cell-derived p63+ progenitors	30
Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells	29
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids	29
Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells	28
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages	28
Empowering human lung development	28
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation	27
Forward steps in organoid-based forward screening	27
A distinct metabolic and epigenetic state drives trained immunity in HSC-derived macrophages from autoimmune mice	26
Inflation comes before the fall: How epithelial stretch drives crypt fission	26
Bioprinted platform for parallelized screening of engineered microtissues in vivo	25
Shaping intestinal organoids: Engineering crypt curvature to guide stem cell niches	25
Generating high-fidelity cochlear organoids from human pluripotent stem cells	25
A time- and single-cell-resolved model of murine bone marrow hematopoiesis	25
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization	25
Mesenchymal stromal cells: Putative microenvironmental modulators become cell therapy	24
Amniogenesis occurs in two independent waves in primates	24
Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson’s disease	24
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury	24
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair	24
A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery	24
Lymphatics act as a signaling hub to regulate intestinal stem cell activity	24
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation	23
Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing	23
Androgens increase excitement in brain organoid research	23
Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells	23
Multipotent stromal cells: One name, multiple identities	23
Breathing-induced forces influence lung cell fate	22
Stem cell-derived β cells go in monkeys	22