Neural Regeneration Research

Article	Citations
Microglia regulation of synaptic plasticity and learning and memory	154
Pathological mechanisms and therapeutic strategies for Alzheimer’s disease	146
Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease	86
Oxidative stress factors in Parkinson’s disease	82
Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4	80
Astrocytes: a double-edged sword in neurodegenerative diseases	75
Promising drug targets and associated therapeutic interventions in Parkinson’s disease	73
Research trends, hot spots and prospects for necroptosis in the field of neuroscience	68
Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke	66
Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies	62
Microglia in neurodegenerative diseases	59
Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis	51
Apelin-13 inhibits apoptosis and excessive autophagy in cerebral ischemia/reperfusion injury	50
The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson’s disease?	48
Targeting the core of neurodegeneration: FoxO, mTOR, and SIRT1	45
Mesenchymal stem cell treatment for peripheral nerve injury: a narrative review	45
Targeting neuroinflammation in Alzheimer’s disease: from mechanisms to clinical applications	41
Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders	40
Lineage tracing of direct astrocyte-to-neuron conversion in the mouse cortex	40
Association between inflammatory bowel diseases and Parkinson’s disease: systematic review and meta-analysis	39
Mitochondrial dysfunctions in neurodegenerative diseases: role in disease pathogenesis, strategies for analysis and therapeutic prospects	38
Mechanisms of neuroplasticity and brain degeneration: strategies for protection during the aging process	38
Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy	38
Inflammation induces zebrafish regeneration	36
A multi-channel collagen scaffold loaded with neural stem cells for the repair of spinal cord injury	36

Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury	35
Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation	35
Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation	35
Cortical plasticity and nerve regeneration after peripheral nerve injury	34
The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury	34
Oral frailty and neurodegeneration in Alzheimer’s disease	32
The future of retinal gene therapy: evolving from subretinal to intravitreal vector delivery	32
Interaction between Schwann cells and other cells during repair of peripheral nerve injury	31
Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease	31
Prospects for intelligent rehabilitation techniques to treat motor dysfunction	31
Electroacupuncture improves learning and memory functions in a rat cerebral ischemia/reperfusion injury model through PI3K/Akt signaling pathway activation	31
Progress in clinical trials of cell transplantation for the treatment of spinal cord injury: how many questions remain unanswered?	30
SARS-CoV-2 involvement in central nervous system tissue damage	30
Abnormal characterization of dynamic functional connectivity in Alzheimer’s disease	30
Regulation of neuroimmune processes by damage- and resolution-associated molecular patterns	29
Therapeutic potential of trehalose in neurodegenerative diseases: the knowns and unknowns	29
The Yin-Yang of osteopontin in nervous system diseases: damage versus repair	29
TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyroptosis and ischemic brain damage	28
The interaction of stem cells and vascularity in peripheral nerve regeneration	28
Low-dose lipopolysaccharide as an immune regulator for homeostasis maintenance in the central nervous system through transformation to neuroprotective microglia	28
Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage	28
Liposome based drug delivery as a potential treatment option for Alzheimer’s disease	28
Delving into the recent advancements of spinal cord injury treatment: a review of recent progress	28
Quercetin protects against diabetic retinopathy in rats by inducing heme oxygenase-1 expression	28
Urolithin A alleviates blood-brain barrier disruption and attenuates neuronal apoptosis following traumatic brain injury in mice	27
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons	27
Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure	27
Epidural electrical stimulation for spinal cord injury	27
Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke	27
P2X7 receptor activation aggravates NADPH oxidase 2-induced oxidative stress after intracerebral hemorrhage	27
Pro- and anti-epileptic roles of microglia	26
Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases	26
Physiopathology of ischemic stroke and its modulation using memantine: evidence from preclinical stroke	26
Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases	26
Potential therapeutic effects of polyphenols in Parkinson's disease: in vivo and in vitro pre-clinical studies	26
Application of modern neuroimaging technology in the diagnosis and study of Alzheimer's disease	26
Motor tract reorganization after acute central nervous system injury: a translational perspective	25
The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease	25
Insights into stem cell therapy for diabetic retinopathy: a bibliometric and visual analysis	25
Potential neuroprotection by Dendrobium nobile Lindl alkaloid in Alzheimer’s disease models	25
LncRNA Airsci increases the inflammatory response after spinal cord injury in rats through the nuclear factor kappa B signaling pathway	25
Maraviroc promotes recovery from traumatic brain injury in mice by suppression of neuroinflammation and activation of neurotoxic reactive astrocytes	25
Progress in clinical trials of stem cell therapy for cerebral palsy	25
The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke	24
Spinal cord injury-induced cognitive impairment: a narrative review	24
Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up	24
Graphene oxide-composited chitosan scaffold contributes to functional recovery of injured spinal cord in rats	24
Role of vitamin B12 deficiency in ischemic stroke risk and outcome	24
Current application and future directions of photobiomodulation in central nervous diseases	24
Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year	24

Parkinson’s disease and diabetes mellitus: common mechanisms and treatment repurposing	24
Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity	23
Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer’s disease: a meta-analysis and systematic review	23
Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity	23
Neutrophil-to-lymphocyte ratio in sporadic amyotrophic lateral sclerosis	23
Neuroregeneration and functional recovery after stroke: advancing neural stem cell therapy toward clinical application	23
Phytochemicals as inhibitors of tumor necrosis factor alpha and neuroinflammatory responses in neurodegenerative diseases	23
Initial failures of anti-tau antibodies in Alzheimer’s disease are reminiscent of the amyloid-β story	23
Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy	23
Adipose tissue, systematic inflammation, and neurodegenerative diseases	22
Axonal regeneration and sprouting as a potential therapeutic target for nervous system disorders	22
Circulating extracellular vesicles: friends and foes in neurodegeneration	22
Retinal regeneration requires dynamic Notch signaling	22
Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease	22
GDNF to the rescue: GDNF delivery effects on motor neurons and nerves, and muscle re-innervation after peripheral nerve injuries	22
Exosomes derived from bone marrow mesenchymal stem cells inhibit neuroinflammation after traumatic brain injury	22
Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury	22
Repetitive transcranial magnetic stimulation for lower extremity motor function in patients with stroke: a systematic review and network meta-analysis	22
Diabetes mellitus and Parkinson’s disease: dangerous liaisons between insulin and dopamine	21
Analysis of corneal nerve plexus in corneal confocal microscopy images	21
Degenerative and regenerative processes in amyotrophic lateral sclerosis: motor reserve, adaptation and putative compensatory changes	21
Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers	21
Baicalin attenuates blood-spinal cord barrier disruption and apoptosis through PI3K/Akt signaling pathway after spinal cord injury	21
Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model	21
Corneal neuromediator profiles following laser refractive surgery	21
Role of apoptosis-inducing factor in perinatal hypoxic-ischemic brain injury	21
Neuronal reprogramming in treating spinal cord injury	21
Lithium beyond psychiatric indications: the reincarnation of a new old drug	21
Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive	21
Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury	21
Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury	21
Collagen/heparan sulfate porous scaffolds loaded with neural stem cells improve neurological function in a rat model of traumatic brain injury	20
Hydrogel-based local drug delivery strategies for spinal cord repair	20
Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease	20
Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage	20
Ultrasonic vocalizations in mice: relevance for ethologic and neurodevelopmental disorders studies	20
The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline	20
The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke: a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessme	20
Temporal changes in inflammatory mitochondria-enriched microRNAs following traumatic brain injury and effects of miR-146a nanoparticle delivery	20
VX-765 reduces neuroinflammation after spinal cord injury in mice	20
Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage	20
Neuroinflammation as a mechanism linking hypertension with the increased risk of Alzheimer’s disease	20
Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy	20
Neuroimaging mechanisms of high-frequency repetitive transcranial magnetic stimulation for treatment of amnestic mild cognitive impairment: a double-blind randomized sham-controlled trial	19
Microglial depletion impairs glial scar formation and aggravates inflammation partly by inhibiting STAT3 phosphorylation in astrocytes after spinal cord injury	19
Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer’s disease	19
Neuroprotective effects of naturally sourced bioactive polysaccharides: an update	19
Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury	19
Connexin therapeutics: blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions	19
Interleukin-4 promotes microglial polarization toward a neuroprotective phenotype after retinal ischemia/reperfusion injury	19
Exploration of the mechanism by which icariin modulates hippocampal neurogenesis in a rat model of depression	19
The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders	19
Hypoxia in Alzheimer's disease: effects of hypoxia inducible factors	19
Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration	18
Altered microRNA expression in animal models of Huntington’s disease and potential therapeutic strategies	18
Stress increases MHC-I expression in dopaminergic neurons and induces autoimmune activation in Parkinson's disease	18
Acupuncture enhances brain function in patients with mild cognitive impairment: evidence from a functional-near infrared spectroscopy study	18
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease	18
Exosomes derived from human induced pluripotent stem cell-derived neural progenitor cells protect neuronal function under ischemic conditions	18
Topical delivery of nerve growth factor for treatment of ocular and brain disorders	18
Cathepsins in neuronal plasticity	18
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway	18
Pentadecapeptide BPC 157 and the central nervous system	18
Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases	18
Rutin pretreatment promotes microglial M1 to M2 phenotype polarization	18
Alterations in gut microbiota are related to metabolite profiles in spinal cord injury	17
Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease: two triggers, one disease	17
Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke	17
Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease	17
From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases	17
Efficacy of Lycium barbarum polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study	17
The mechanisms through which auricular vagus nerve stimulation protects against cerebral ischemia/reperfusion injury	17
The plasminogen activating system in the pathogenesis of Alzheimer’s disease	17
Dental pulp stem cells stimulate neuronal differentiation of PC12 cells	17
Evaluation of the combined activity of benzimidazole arylhydrazones as new anti-Parkinsonian agents: monoamine oxidase-B inhibition, neuroprotection and oxidative stress modulation	17
One ring is sufficient to inhibit α-synuclein aggregation	17
Nerve bundle formation during the promotion of peripheral nerve regeneration: collagen VI-neural cell adhesion molecule 1 interaction	17
Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer’s disease	17
The role of peptidase neurolysin in neuroprotection and neural repair after stroke	17
MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing	17

Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke	16
Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives	16
Exogenous platelet-derived growth factor improves neurovascular unit recovery after spinal cord injury	16
TLR2 and TLR4-mediated inflammation in Alzheimer’s disease: self-defense or sabotage?	16
Microglial activation and adult neurogenesis after brain stroke	16
Diabetic retinopathy: neurovascular disease requiring neuroprotective and regenerative therapies	16
SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses	16
Lithium promotes recovery after spinal cord injury	16
Neuron-fibrous scaffold interfaces in the peripheral nervous system: a perspective on the structural requirements	16
Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke	16
MicroRNAs as biomarkers in glaucoma and potential therapeutic targets	16
Axonal remodeling of the corticospinal tract during neurological recovery after stroke	16
Promoting axon regeneration in the central nervous system by increasing PI3-kinase signaling	16
M1-type microglia can induce astrocytes to deposit chondroitin sulfate proteoglycan after spinal cord injury	16
Aquaporin 4 deficiency eliminates the beneficial effects of voluntary exercise in a mouse model of Alzheimer’s disease	16
Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury	16
miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation	16
Hippo signaling: bridging the gap between cancer and neurodegenerative disorders	16
Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder	16
Pannexin 1, a large-pore membrane channel, contributes to hypotonicity-induced ATP release in Schwann cells	16
Oligodendrocyte precursor cell maturation: role of adenosine receptors	15
P2X4 receptor participates in autophagy regulation in Parkinson's disease	15
Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice	15
Promise of metformin for preventing age-related cognitive dysfunction	15
Functional repertoire of protein kinases and phosphatases in synaptic plasticity and associated neurological disorders	15
Dynamic changes in the systemic immune responses of spinal cord injury model mice	15
Brain delivering RNA-based therapeutic strategies by targeting mTOR pathway for axon regeneration after central nervous system injury	15
Construction and imaging of a neurovascular unit model	15
Melatonin, circadian rhythms and glaucoma: current perspective	15
Mens sana in corpore sano: lifestyle changes modify astrocytes to contain Alzheimer’s disease	15
Olfactory ensheathing cell transplantation alters the expression of chondroitin sulfate proteoglycans and promotes axonal regeneration after spinal cord injury	15
Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy	15
MicroRNAs as diagnostic and prognostic biomarkers of age-related macular degeneration: advances and limitations	15
Vimentin as a potential target for diverse nervous system diseases	15
Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury: focus on the visual system	15
Reduced graphene oxide-embedded nerve conduits loaded with bone marrow mesenchymal stem cell-derived extracellular vesicles promote peripheral nerve regeneration	15
Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases: new perspectives	15
From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson’s disease?	15
Inflammation and retinal degenerative diseases	15
Transcranial magnetic stimulation in animal models of neurodegeneration	15
Angiogenesis and nerve regeneration induced by local administration of plasmid pBud-coVEGF165-coFGF2 into the intact rat sciatic nerve	15
Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury	15
Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer’s disease	14
CircLphn3 protects the blood-brain barrier in traumatic brain injury	14
Non-coding RNAs and other determinants of neuroinflammation and endothelial dysfunction: regulation of gene expression in the acute phase of ischemic stroke and possible therapeutic applications	14
Cerebellar pathology in motor neuron disease: neuroplasticity and neurodegeneration	14
Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury	14
Brain ischemia as a bridge to Alzheimer’s disease	14
Role of circular RNA expression in the pathological progression after spinal cord injury	14
Oxidative stress battles neuronal Bcl-xL in a fight to the death	14
Challenges in developing therapeutic strategies for mild neonatal encephalopathy	14
The Alzheimer’s disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation	14
Production of chitosan scaffolds by lyophilization or electrospinning: which is better for peripheral nerve regeneration?	14
A hyaluronic acid granular hydrogel nerve guidance conduit promotes regeneration and functional recovery of injured sciatic nerves in rats	14
Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching	14
The gut microbiome: implications for neurogenesis and neurological diseases	14
Regulated upon activation, normal T cell expressed and secreted (RANTES) levels in the peripheral blood of patients with Alzheimer’s disease	14
Brain-derived neurotrophic factor protects against acrylamide-induced neuronal and synaptic injury via the TrkB-MAPK-Erk1/2 pathway	14
Neuroimmune connections between corticotropin-releasing hormone and mast cells: novel strategies for the treatment of neurodegenerative diseases	14
Ruxolitinib attenuates secondary injury after traumatic spinal cord injury	14
Alzheimer’s disease: a tale of two diseases?	14
Exploring magneto-electric nanoparticles (MENPs): a platform for implanted deep brain stimulation	13
Laminin-coated multifilament entubulation, combined with Schwann cells and glial cell line-derived neurotrophic factor, promotes unidirectional axonal regeneration in a rat model of thoracic spinal co	13
Elevated intraspinal pressure in traumatic spinal cord injury is a promising therapeutic target	13
Apolipoprotein A1, the neglected relative of Apolipoprotein E and its potential role in Alzheimer’s disease	13
Melatonin, tunneling nanotubes, mesenchymal cells, and tissue regeneration	13
Mitochondrial inorganic polyphosphate (polyP): the missing link of mammalian bioenergetics	13
Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins	13
Significance of mitochondrial activity in neurogenesis and neurodegenerative diseases	13
Oligodendrocyte pathology in fetal alcohol spectrum disorders	13
Deletion of Krüppel-like factor-4 promotes axonal regeneration in mammals	13
Emerging roles of GPR109A in regulation of neuroinflammation in neurological diseases and pain	13
What do we know about the role of lncRNAs in multiple sclerosis?	13
Bioinformatics analysis of ferroptosis in spinal cord injury	13
The role of NLRP3 inflammasome for microglial response to peripheral inflammation	13
Dying by fire: noncanonical functions of autophagy proteins in neuroinflammation and neurodegeneration	13
The neurosphere assay: an effective in vitro technique to study neural stem cells	13
HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson's disease cell and mouse models	13
Anxiety, depression, and quality of life in Parkinson’s disease: the implications of multidisciplinary treatment	13
Probiotics, prebiotics and their role in Alzheimer’s disease	13
Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson's disease	13
Transcriptomic analysis reveals essential microRNAs after peripheral nerve injury	13
Hippocampal insulin resistance and the Sirtuin 1 signaling pathway in diabetes-induced cognitive dysfunction	13
Brain plasticity after peripheral nerve injury treatment with massage therapy based on resting-state functional magnetic resonance imaging	13
Preventive electroacupuncture reduces cognitive deficits in a rat model of D-galactose-induced aging	13
Leukocyte telomere length and plasma interleukin-1β and interleukin-18 levels in mild cognitive impairment and Alzheimer’s disease: new biomarkers for diagnosis and disease progression?	12
Transcranial focused ultrasound stimulation reduces vasogenic edema after middle cerebral artery occlusion in mice	12
Long non-coding RNA MEG3 regulates autophagy after cerebral ischemia/reperfusion injury	12
Gene-modified leucoconcentrate for personalized ex vivo gene therapy in a mini pig model of moderate spinal cord injury	12
The neuroprotective effects of oxygen therapy in Alzheimer’s disease: a narrative review	12
Combination of epidural electrical stimulation with ex vivo triple gene therapy for spinal cord injury: a proof of principle study	12
Downregulation of miR-491-5p promotes neovascularization after traumatic brain injury	12
Roles of the ocular pressure, pressure-sensitive ion channel, and elasticity in pressure-induced retinal diseases	12
Neuroglobin and neuroprotection: the role of natural and synthetic compounds in neuroglobin pharmacological induction	12
Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease	12