OOIR: Observatory of International Research

Papers

(The H4-Index of Frontiers in Pharmacology is 81. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic	861
Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications	342
The Bone Extracellular Matrix in Bone Formation and Regeneration	331
Advances in Oral Drug Delivery	287
Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application	274
Perceptions of healthcare professionals and patients on the role of the pharmacist in TB management in Pakistan: A qualitative study	267
Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors	257
Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models	252
Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review	225
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action	224
Advances in Oral Drug Delivery for Regional Targeting in the Gastrointestinal Tract - Influence of Physiological, Pathophysiological and Pharmaceutical Factors	219
Comparative effectiveness of individualized longer and standardized shorter regimens in the treatment of multidrug resistant tuberculosis in a high burden country	215
Nanocurcumin: A Promising Candidate for Therapeutic Applications	208
Modeling Parkinson’s Disease With the Alpha-Synuclein Protein	193
Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety	181
COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?	168
PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer’s Disease and Parkinson’s Disease	167
DNA Repair Pathways in Cancer Therapy and Resistance	166
Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer	161
The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action	148
From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery	145
Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective	145
Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation	145
Discovering Anti-Cancer Drugs via Computational Methods	144
A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic	142

SIRT1 Activation by Natural Phytochemicals: An Overview	141
The Role of the CXCL12/CXCR4/CXCR7 Chemokine Axis in Cancer	140
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy	140
Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis	138
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence	137
Comprehensive Analysis of Cuproptosis-Related Genes in Immune Infiltration and Prognosis in Melanoma	135
PD-1/PD-L1 Checkpoint Inhibitors in Tumor Immunotherapy	133
Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia	132
Phytosterols: From Preclinical Evidence to Potential Clinical Applications	131
Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19	130
Response to the Novel Corona Virus (COVID-19) Pandemic Across Africa: Successes, Challenges, and Implications for the Future	128
Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes	123
Medicinal Plants as Sources of Active Molecules Against COVID-19	121
Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review	118
AKT Inhibitors: New Weapons in the Fight Against Breast Cancer?	113
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments	113
Knowledge Mapping of Drug-Induced Liver Injury: A Scientometric Investigation (2010–2019)	112
A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective	108
The Pharmacological Action of Kaempferol in Central Nervous System Diseases: A Review	108
Neurodegenerative Disease and the NLRP3 Inflammasome	108
Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research	107
Clinically-Relevant ABC Transporter for Anti-Cancer Drug Resistance	105
Oral Curcumin With Piperine as Adjuvant Therapy for the Treatment of COVID-19: A Randomized Clinical Trial	105
Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice	105
P2X7 in Cancer: From Molecular Mechanisms to Therapeutics	103
Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention	103
Cellular Mechanisms of Liver Fibrosis	100
Mesenchymal Stem Cell–Derived Exosomes: A Promising Biological Tool in Nanomedicine	99
Novel and Emerging Therapies for Inflammatory Bowel Disease	99
Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)	99
Heavy Metal Contaminations in Herbal Medicines: Determination, Comprehensive Risk Assessments, and Solutions	97
Combination of Ruxolitinib and Eculizumab for Treatment of Severe SARS-CoV-2-Related Acute Respiratory Distress Syndrome: A Controlled Study	97
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment	97
Challenges for Drug Repurposing in the COVID-19 Pandemic Era	96
Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19	94
Pharmacogenetics Guidelines: Overview and Comparison of the DPWG, CPIC, CPNDS, and RNPGx Guidelines	94
Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy	94
Current Prevention of COVID-19: Natural Products and Herbal Medicine	92
Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies	92
A Review on the Potential Use of Medicinal Plants From Asteraceae and Lamiaceae Plant Family in Cardiovascular Diseases	92
The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging	91
Drug Shortage: Causes, Impact, and Mitigation Strategies	91
G Protein-Coupled Receptors in Taste Physiology and Pharmacology	90
A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin	90
Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits	90
Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis	89
Passiflora edulis: An Insight Into Current Researches on Phytochemistry and Pharmacology	88
Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease	88
The Drug Repurposing for COVID-19 Clinical Trials Provide Very Effective Therapeutic Combinations: Lessons Learned From Major Clinical Studies	88
Repurposing Drugs, Ongoing Vaccine, and New Therapeutic Development Initiatives Against COVID-19	86

Advanced Approaches to Breast Cancer Classification and Diagnosis	86
Immunosuppressive Drugs and COVID-19: A Review	85
Immune Checkpoint Inhibitor-Related Cytokine Release Syndrome: Analysis of WHO Global Pharmacovigilance Database	84
Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent	84
Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation	82
Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens	82
Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application	81