OOIR: Observatory of International Research

Papers

(The TQCC of Amino Acids is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
Impact of non-proteinogenic amino acids in the discovery and development of peptide therapeutics	84
Nutrition and metabolism of glutamate and glutamine in fish	67
Multiple sclerosis and myelin basic protein: insights into protein disorder and disease	57
Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease	49
Effects of dietary starch and lipid levels on the protein retention and growth of largemouth bass (Micropterus salmoides)	48
The serum amino acid profile in COVID-19	43
Use of alternative protein sources for fishmeal replacement in the diet of largemouth bass (Micropterus salmoides). Part I: effects of poultry by-product meal and soybean meal on growth, feed utilizat	43
SARS-CoV-2 receptor ACE2 gene expression in small intestine correlates with age	37
Proline metabolism and redox; maintaining a balance in health and disease	37
Effects of dietary protein and lipid levels on the growth performance, feed utilization, and liver histology of largemouth bass (Micropterus salmoides)	35
Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function	35
Analytical methods for amino acid determination in organisms	33
Proline metabolism in cancer	33
The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review	32
Oxidation of energy substrates in tissues of largemouth bass (Micropterus salmoides)	30
Amino acid metabolism as a therapeutic target in cancer: a review	30
Identification of chia seed (Salvia hispanica L.) peptides with enzyme inhibition activity towards skin-aging enzymes	30
Hydroxyproline in animal metabolism, nutrition, and cell signaling	30
Hunting the main protease of SARS-CoV-2 by plitidepsin: Molecular docking and temperature-dependent molecular dynamics simulations	29
Proline metabolism and transport in retinal health and disease	28
Protein carbonylation in food and nutrition: a concise update	27
Glycine regulates mucosal immunity and the intestinal microbial composition in weaned piglets	25
The role of posttranslational modification in moonlighting glyceraldehyde-3-phosphate dehydrogenase structure and function	25
Proteomic comparison of different synaptosome preparation procedures	25
Use of alternative protein sources for fishmeal replacement in the diet of largemouth bass (Micropterus salmoides). Part II: effects of supplementation with methionine or taurine on growth, feed utili	24

Tailor-made amino acid-derived pharmaceuticals approved by the FDA in 2019	24
d-Amino acids in mammalian endocrine tissues	23
Theoretical elucidation of the amino acid interaction with graphene and functionalized graphene nanosheets: insights from DFT calculation and MD simulation	22
PYCR, a key enzyme in proline metabolism, functions in tumorigenesis	21
Novel formulation of antimicrobial peptides enhances antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA)	20
Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target	19
Human cell receptors: potential drug targets to combat COVID-19	19
The effects of taurine supplementation on glycemic control and serum lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial	19
Direct chromatographic methods for enantioresolution of amino acids: recent developments	19
Cystine reduces tight junction permeability and intestinal inflammation induced by oxidative stress in Caco-2 cells	18
Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies	18
Methionine sulfoxide and the methionine sulfoxide reductase system as modulators of signal transduction pathways: a review	18
Paleoproteomic profiling of organic residues on prehistoric pottery from Malta	18
Oxidative testicular injury: effect of l-leucine on redox, cholinergic and purinergic dysfunctions, and dysregulated metabolic pathways	18
The tea-bag protocol for comparison of Fmoc removal reagents in solid-phase peptide synthesis	18
Protective effects of glycine against lipopolysaccharide-induced intestinal apoptosis and inflammation	17
Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization	17
The involvement of polyamine uptake and synthesis pathways in the proliferation of neonatal astrocytes	17
Post-translational formation of hypusine in eIF5A: implications in human neurodevelopment	17
Cortisol enhances citrulline synthesis from proline in enterocytes of suckling piglets	17
Disruption of kynurenine pathway reveals physiological importance of tryptophan catabolism in Henosepilachna vigintioctopunctata	16
Free-amino acid metabolic profiling of visceral adipose tissue from obese subjects	16
Transglutaminase 2: a novel therapeutic target for idiopathic pulmonary fibrosis using selective small molecule inhibitors	16
PepQSAR: a comprehensive data source and information platform for peptide quantitative structure–activity relationships	16
Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats	16
Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?	16
Lyophilization and homogenization of biological samples improves reproducibility and reduces standard deviation in molecular biology techniques	15
N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations	15
Novel antimicrobial cruzioseptin peptides extracted from the splendid leaf frog, Cruziohyla calcarifer	15
LEAP2 has antagonized the ghrelin receptor GHSR1a since its emergence in ancient fish	15
Monitoring peptide tyrosine nitration by spectroscopic methods	14
Effect of weight-loss diet combined with taurine supplementation on body composition and some biochemical markers in obese women: a randomized clinical trial	14
Taurine protects dopaminergic neurons in paraquat-induced Parkinson’s disease mouse model through PI3K/Akt signaling pathways	14
Feeding intact proteins, peptides, or free amino acids to monogastric farm animals	14
Determination of amino acids in human biological fluids by high-performance liquid chromatography: critical review	14
Development, validation of a GC–MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special empha	14
Biological macromolecule binding and anticancer activity of synthetic alkyne-containing l-phenylalanine derivatives	14
Oxidation of amino acids, glucose, and fatty acids as metabolic fuels in enterocytes of developing pigs	14
Increasing l-lysine production in Corynebacterium glutamicum by engineering amino acid transporters	14
Functional roles of polyamines and their metabolite acrolein in eukaryotic cells	14
Efficient synthesis of amino acids capped gold nanoparticles from easily reducible aryldiazonium tetrachloroaurate(III) salts for cellular uptake study	14
Alarin alleviated cardiac fibrosis via attenuating oxidative stress in heart failure rats	14
High performance liquid chromatography determination of l-glutamate, l-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer’s disease	13
Physicochemical stability study of protein–benzoic acid complexes using molecular dynamics simulations	13
Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology—part I	13
Creatine metabolism in the uterus: potential implications for reproductive biology	13
Chemical synthesis and characterisation of the complement C5 inhibitory peptide zilucoplan	13
Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent	13
Apoptosis-mediated anticancer activity in prostate cancer cells of a chestnut honey (Castanea sativa L.) quinoline–pyrrolidine gamma-lactam alkaloid	12
Isocyanide-based consecutive Bargellini/Ugi reactions: an efficient method for the synthesis of pseudo-peptides containing three amide bonds	12

The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer	12
Oxygen reactivity with pyridoxal 5′-phosphate enzymes: biochemical implications and functional relevance	12
Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis	12
Effects of N-acetylcysteine supplementation on disease activity, oxidative stress, and inflammatory and metabolic parameters in rheumatoid arthritis patients: a randomized double-blind placebo-control	12
Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women	12
Perspectives, past, present and future: the proline cycle/proline-collagen regulatory axis	12
Dual effects of the tryptophan-derived bacterial metabolite indole on colonic epithelial cell metabolism and physiology: comparison with its co-metabolite indoxyl sulfate	12
Taurine ameliorates axonal damage in sciatic nerve of diabetic rats and high glucose exposed DRG neuron by PI3K/Akt/mTOR-dependent pathway	12
Proline dehydrogenase in cancer: apoptosis, autophagy, nutrient dependency and cancer therapy	12
Enhanced neural differentiation of neural stem cells by sustained release of Shh from TG2 gene-modified EMSC co-culture in vitro	12
Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs	11
Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats	11
Dietary supplementation with monosodium glutamate enhances milk production by lactating sows and the growth of suckling piglets	11
Chiral resolution of plasma amino acids reveals enantiomer-selective associations with organ functions	11
Evidence that human and equine erythrocytes could have significant roles in the transport and delivery of amino acids to organs and tissues	11
Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women	11
Anti-inflammatory effect of l-cysteine (a semi-essential amino acid) on 5-FU-induced oral mucositis in hamsters	11
A mix of functional amino acids and grape polyphenols promotes the growth of piglets, modulates the gut microbiota in vivo and regulates epithelial homeostasis in intestinal organoids	11
Effects of dietary protein intake on the oxidation of glutamate, glutamine, glucose and palmitate in tissues of largemouth bass (Micropterus salmoides)	11
C-terminus amidation influences biological activity and membrane interaction of maculatin 1.1	11
Polyamine synthesis from arginine and proline in tissues of developing chickens	10
Effects of long-term taurine supplementation on age-related changes in skeletal muscle function of Sprague–Dawley rats	10
The introduction of l-phenylalanine into antimicrobial peptide protonectin enhances the selective antibacterial activity of its derivative phe-Prt against Gram-positive bacteria	10
Effect of l-Carnosine as adjunctive therapy in the management of children with autism spectrum disorder: a randomized controlled study	10
Molecular targets for antifungals in amino acid and protein biosynthetic pathways	10
Impact of probiotic Limosilactobacillus reuteri DSM 17938 on amino acid metabolism in the healthy newborn mouse	10
Factors associated with elevated plasma phenylalanine in patients with heart failure	10
Taurine chloramine selectively regulates neutrophil degranulation through the inhibition of myeloperoxidase and upregulation of lactoferrin	10
Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides	10
ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions	9
The use of BCAA to decrease delayed-onset muscle soreness after a single bout of exercise: a systematic review and meta-analysis	9
Dietary supplementation with l-arginine between days 14 and 25 of gestation enhances NO and polyamine syntheses and the expression of angiogenic proteins in porcine placentae	9
Metabolomics and correlation network analyses of core biomarkers in type 2 diabetes	9
Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy	9
IHEC_RAAC: a online platform for identifying human enzyme classes via reduced amino acid cluster strategy	9
Tryptophan regulates bile and nitrogen metabolism in two pig gut lactobacilli species in vitro based on metabolomics study	9
Current status of PTMs structural databases: applications, limitations and prospects	9
Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults	8
Interference of dietary polyphenols with potentially toxic amino acid metabolites derived from the colonic microbiota	8
Effects of different branched-chain amino acids supplementation protocols on the inflammatory response of LPS-stimulated RAW 264.7 macrophages	8
Plasma amino acids indicate glioblastoma with ATRX loss	8
Bioactive peptide apelin rescues acute kidney injury by protecting the function of renal tubular mitochondria	8
Carnosine and skeletal muscle dysfunction in a rodent multiple sclerosis model	8
Targeted metabolomics analysis of serum amino acid profiles in patients with Moyamoya disease	8
Comparing activity, toxicity and model membrane interactions of Jelleine-I and Trp/Arg analogs: analysis of peptide aggregation	8
Rational design of stapled antimicrobial peptides	8
A chiral GC–MS method for analysis of secondary amino acids after heptafluorobutyl chloroformate & methylamine derivatization	8
Synthetic analogues of memantine as neuroprotective and influenza viral inhibitors: in vitro and physicochemical studies	8
Dietary L-arginine supplementation during days 14–25 of gestation enhances aquaporin expression in the placentae and endometria of gestating gilts	8
Age-related decline in the taurine content of the skin in rodents	8
Highly efficient and enantioselective syntheses of (2S,3R)-3-alkyl- and alkenylglutamates from Fmoc-protected Garner’s aldehyde	8
Complex relationship between amino acids, fitness and food intake in Bombus terrestris	8
Scope and limitations of pseudoprolines as individual amino acids in peptide synthesis	8
Attenuation of doxorubicin-induced oxidative damage in rat brain by regulating amino acid homeostasis with Astragali Radix	8
Structure–activity relationship study on new hemorphin-4 analogues containing steric restricted amino acids moiety for evaluation of their anticonvulsant activity	8