Biomedicine & Pharmacotherapy

Article	Citations
The emerging role of ferroptosis in inflammation	349
Cancer immunotherapy: Pros, cons and beyond	329
Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management	295
The role of IL-1β and TNF-α in intervertebral disc degeneration	278
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols	261
Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases	256
Type II diabetes mellitus: a review on recent drug based therapeutics	247
Adipose tissue and insulin resistance in obese	240
EMT, cancer stem cells and autophagy; The three main axes of metastasis	228
Isorhamnetin: A review of pharmacological effects	216
New understanding of the damage of SARS-CoV-2 infection outside the respiratory system	212
5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition	205
An update on β-sitosterol: A potential herbal nutraceutical for diabetic management	194
ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19	174
Lipase Inhibitors for Obesity: A Review	171
WNT/β-catenin signaling in the development of liver cancers	170
The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators	163
Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease	162
Anticancer activities of TCM and their active components against tumor metastasis	161
Role of lncRNA LUCAT1 in cancer	160
Antiviral activities of flavonoids	159
Myricetin: A review of the most recent research	156
Natural carbon-based quantum dots and their applications in drug delivery: A review	153
Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation	153
Antiproliferative and palliative activity of flavonoids in colorectal cancer	152

The role of curcumin in aging and senescence: Molecular mechanisms	148
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms	144
Resveratrol (RV): A pharmacological review and call for further research	140
Puerarin inhibits inflammation and oxidative stress in dextran sulfate sodium-induced colitis mice model	139
Role of microbiota-derived short-chain fatty acids in cancer development and prevention	135
Oxindole and its derivatives: A review on recent progress in biological activities	132
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role	129
Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice	128
Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake	127
Role of the NLRP3 inflammasome in autoimmune diseases	124
Immune boosting functional foods and their mechanisms: A critical evaluation of probiotics and prebiotics	120
The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review	119
Lipocalin-2: Structure, function, distribution and role in metabolic disorders	118
Monoclonal antibody as a potential anti-COVID-19	117
A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications	116
The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway	116
MicroRNA: A signature for cancer progression	115
Immune defence to invasive fungal infections: A comprehensive review	115
Mechanistic insights and perspectives involved in neuroprotective action of quercetin	113
Natural history of COVID-19 and current knowledge on treatment therapeutic options	111
Probiotics for cancer alternative prevention and treatment	107
Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and Akt signaling pathways	106
Role of microbiota-derived short-chain fatty acids in nervous system disorders	106
New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities	103
Investigation of gut microbiome changes in type 1 diabetic mellitus rats based on high-throughput sequencing	102
Innate and adaptive immune responses against coronavirus	102
Pleotropic Effects of Polyphenols in Cardiovascular System	101
Flavonoids against the SARS-CoV-2 induced inflammatory storm	101
AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation	98
Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence	97
NF-κB inhibitors in treatment and prevention of lung cancer	96
Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents	95
Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2	95
CAR-macrophage: A new immunotherapy candidate against solid tumors	95
Mechanisms of BCG in the treatment of bladder cancer-current understanding and the prospect	94
A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects	92
Potential inhibitory effect of lycopene on prostate cancer	92
Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming	91
Mechanisms of blue light-induced eye hazard and protective measures: a review	90
Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease	90
Standardized extract of ginger ameliorates liver cancer by reducing proliferation and inducing apoptosis through inhibition oxidative stress/ inflammation pathway	89
Novel advances in inhibiting advanced glycation end product formation using natural compounds	89
Gestational diabetes mellitus - A metabolic and reproductive disorder	89
Progress of exosomes in the diagnosis and treatment of lung cancer	88
A comprehensive review on Pueraria: Insights on its chemistry and medicinal value	88
STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress	87
The links between gut microbiota and obesity and obesity related diseases	86
Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential	86
Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms	85
Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment	85

Traditional Chinese medicine and lung cancer——From theory to practice	84
Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages	84
Polymer-hybrid nanoparticles: Current advances in biomedical applications	84
Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives	83
Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC)	83
Pharmacological basis and new insights of taxifolin: A comprehensive review	82
Polysaccharides from Polygonatum kingianum improve glucose and lipid metabolism in rats fed a high fat diet	81
Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway	81
EF24 induces ferroptosis in osteosarcoma cells through HMOX1	81
The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling	80
Onion (Allium cepa L.) peels: A review on bioactive compounds and biomedical activities	79
Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis	79
Pharmacological insights and prediction of lead bioactive isolates of Dita bark through experimental and computer-aided mechanism	79
Emerging role of NRF2 in ROS-mediated tumor chemoresistance	78
Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets	78
Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway	77
The role of Interleukin 6 inhibitors in therapy of severe COVID-19	77
Strategies and perspectives to develop SARS-CoV-2 detection methods and diagnostics	77
MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets	77
Tumor-infiltrating lymphocytes: Warriors fight against tumors powerfully	77
Silica nanoparticles: Biomedical applications and toxicity	77
Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines	76
Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects	76
Safety profile of the antiviral drug remdesivir: An update	76
Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system	76
Recent progress in TGF-β inhibitors for cancer therapy	76
Traditional Chinese medicine combined with pulmonary drug delivery system and idiopathic pulmonary fibrosis: Rationale and therapeutic potential	75
Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial	74
Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement	74
The role of miRNAs in colorectal cancer progression and chemoradiotherapy	74
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size	73
Prospective multifunctional roles and pharmacological potential of dietary flavonoid narirutin	73
Therapeutic targets of neuroprotection and neurorestoration in ischemic stroke: Applications for natural compounds from medicinal herbs	73
The emerging roles of artificial intelligence in cancer drug development and precision therapy	72
Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family	72
Gene therapy clinical trials, where do we go? An overview	71
Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression	71
A review on development of MUC1-based cancer vaccine	71
SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role	71
The antioxidant potential of different edible and medicinal mushrooms	70
Dual role of microbiota-derived short-chain fatty acids on host and pathogen	70
Principles of RNA methylation and their implications for biology and medicine	70
Uric acid aggravates myocardial ischemia–reperfusion injury via ROS/NLRP3 pyroptosis pathway	70
The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19	69
Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential	69
Non-coding RNAs participate in the ischemia-reperfusion injury	69
Role of miRNA and lncRNAs in organ fibrosis and aging	69
Essential oils as anticancer agents: Potential role in malignancies, drug delivery mechanisms, and immune system enhancement	68
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis	68
Anti prostate cancer therapy: Aptamer-functionalized, curcumin and cabazitaxel co-delivered, tumor targeted lipid-polymer hybrid nanoparticles	68
The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment	67
Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota	67
Oxidative stress – Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders	67
Curcumin regulates the differentiation of naïve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice	66
Mutations in SARS-CoV-2: Insights on structure, variants, vaccines, and biomedical interventions	66
Exploring the multifocal role of phytochemicals as immunomodulators	66
Small rodent models of atherosclerosis	66
Curcumin and cardiovascular diseases: Focus on cellular targets and cascades	65
CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis	65
Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation	65
Engineering of the current nucleoside-modified mRNA-LNP vaccines against SARS-CoV-2	65
Diets and drugs for weight loss and health in obesity – An update	64
Aptamers used for biosensors and targeted therapy	63
Natural components in sunscreens: Topical formulations with sun protection factor (SPF)	63
Traditional Chinese medicine formulas, extracts, and compounds promote angiogenesis	63
An updated role of astragaloside IV in heart failure	63
The potential of photodynamic therapy in current breast cancer treatment methodologies	63
The effects of metformin on autophagy	62
When science goes viral: The research response during three months of the COVID-19 outbreak	62
N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability	62
Nanotechnology-based drug delivery for central nervous system disorders	62
Link between microbiota and hypertension: Focus on LPS/TLR4 pathway in endothelial dysfunction and vascular inflammation, and therapeutic implication of probiotics	62
Botany, traditional uses, phytochemistry, analytical methods, processing, pharmacology and pharmacokinetics of Bupleuri Radix: A systematic review	62
Nanomedicines: Redefining traditional medicine	61
Inhibition of Wnt/β-catenin pathway reverses multi-drug resistance and EMT in Oct4+/Nanog+ NSCLC cells	61
HDAC11: a rising star in epigenetics	61
Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment	61
Plant-derived bioactive compounds in colon cancer treatment: An updated review	61
Natural therapeutics and nutraceuticals for lung diseases: Traditional significance, phytochemistry, and pharmacology	61
G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy	60

Update on targeted cancer therapies, single or in combination, and their fine tuning for precision medicine	60
Chicory ameliorates hyperuricemia via modulating gut microbiota and alleviating LPS/TLR4 axis in quail	60
Emerging pharmacotherapies for COVID-19	60
Early use of non-steroidal anti-inflammatory drugs in COVID-19 might reverse pathogenesis, prevent complications and improve clinical outcomes	60
The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges	60
RNA-based pharmacotherapy for tumors: From bench to clinic and back	60
The role of a ceRNA regulatory network based on lncRNA MALAT1 site in cancer progression	60
Exploring the plant-derived bioactive substances as antidiabetic agent: An extensive review	60
The emerging molecular mechanism of m6A modulators in tumorigenesis and cancer progression	60
The effect of Berberine on weight loss in order to prevent obesity: A systematic review	60
The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases	59
Macrophages in pancreatitis: Mechanisms and therapeutic potential	59
Targeting SARS-CoV2 Spike Protein Receptor Binding Domain by Therapeutic Antibodies	59
Glyoxalase system: A systematic review of its biological activity, related-diseases, screening methods and small molecule regulators	59
Protective effect of quercetin on streptozotocin-induced diabetic peripheral neuropathy rats through modulating gut microbiota and reactive oxygen species level	59
Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety	59
Extraction, structure, and activity of polysaccharide from Radix astragali	59
RETRACTED: Healing potential of Spirulina platensis for skin wounds by modulating bFGF, VEGF, TGF-ß1 and α-SMA genes expression targeting angiogenesis and scar tissue formation in the rat model	59
Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19	59
Potential effects of SARS-CoV-2 on the gastrointestinal tract and liver	59
Actinidia chinensis Planch prevents proliferation and migration of gastric cancer associated with apoptosis, ferroptosis activation and mesenchymal phenotype suppression	59
Regulation of SIRT3 on mitochondrial functions and oxidative stress in Parkinson’s disease	59
Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy	58
A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds	57
Beneficial effects of polysaccharide-rich extracts from Apocynum venetum leaves on hypoglycemic and gut microbiota in type 2 diabetic mice	57
Recent advances in fructose intake and risk of hyperuricemia	57
The current understanding on the impact of KRAS on colorectal cancer	57
Counteracting role of nuclear factor erythroid 2-related factor 2 pathway in Alzheimer's disease	57
Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K/AKT/mTOR, and ROS pathways	57
Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model	56
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study	56
COVID-19 challenges and its therapeutics	56
Therapeutic potential of CAR T cell in malignancies: A scoping review	56
Phosphodiesterase 5 (PDE5): Structure-function regulation and therapeutic applications of inhibitors	56
Anti-inflammatory action of astaxanthin and its use in the treatment of various diseases	56
Tetramethylpyrazine: A review on its mechanisms and functions	56
Omicron variant (B.1.1.529) and its sublineages: What do we know so far amid the emergence of recombinant variants of SARS-CoV-2?	56
Breakthrough in targeted therapy for non-small cell lung cancer	56
The molecular mechanisms of ferroptosis and its role in cardiovascular disease	56
Research progress of traditional Chinese medicine against COVID-19	55
A cross-talk between gut microbiome, salt and hypertension	55
Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications	55
Potential therapeutic natural products against Alzheimer's disease with Reference of Acetylcholinesterase	54
Advances in the relationship between coronavirus infection and cardiovascular diseases	54
Anti-cerebral ischemia reperfusion injury of polysaccharides: A review of the mechanisms	54
Targets and strategies for vaccine development against SARS-CoV-2	54
The initiation of oxidative stress and therapeutic strategies in wound healing	54
Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review	53
Mitoquinone alleviates vincristine-induced neuropathic pain through inhibiting oxidative stress and apoptosis via the improvement of mitochondrial dysfunction	53
MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients	53
Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review	53
Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia	53
Synergic effect of PD-1 blockade and endostar on the PI3K/AKT/mTOR-mediated autophagy and angiogenesis in Lewis lung carcinoma mouse model	53
Anti-inflammatory phytochemicals for the treatment of diabetes and its complications: Lessons learned and future promise	53
Nanotechnology shaping stem cell therapy: Recent advances, application, challenges, and future outlook	52
The pharmacological properties of chrysophanol, the recent advances	52
Tomato (Solanum lycopersicum L.) seed: A review on bioactives and biomedical activities	52
Anti-inflammatory and immunoregulatory effects of icariin and icaritin	52
Animal models of cerebral ischemia: A review	52
MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration	52
Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids	52
Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway	52
Recent advancements of nanoparticles application in cancer and neurodegenerative disorders: At a glance	52
Evidence and perspectives of cell senescence in neurodegenerative diseases	52
Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke	52
The emerging role of XBP1 in cancer	52
Betulinic acid in the treatment of tumour diseases: Application and research progress	51
Clusterin: Always protecting. Synthesis, function and potential issues	51
Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action	51
Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease	51
Effects of Polygonatum sibiricum saponin on hyperglycemia, gut microbiota composition and metabolic profiles in type 2 diabetes mice	51
Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats	51
Peppermint essential oil: its phytochemistry, biological activity, pharmacological effect and application	51
Recent advances in management of COVID-19: A review	51
Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment	51
The oncogenic role of Jagged1/Notch signaling in cancer	51
Genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine	51
Non-small cell lung cancer combination therapy: Hyaluronic acid modified, epidermal growth factor receptor targeted, pH sensitive lipid-polymer hybrid nanoparticles for the delivery of erlotinib plus	50
Recent advances in heat shock proteins in cancer diagnosis, prognosis, metabolism and treatment	50
Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization	50
Berberine regulates fecal metabolites to ameliorate 5-fluorouracil induced intestinal mucositis through modulating gut microbiota	50
Regulatory role of microRNAs on PTEN signaling	50
HCG18/miR-34a-5p/HMMR axis accelerates the progression of lung adenocarcinoma	50
The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer	50
SARS-CoV-2 neutralizing antibody levels are correlated with severity of COVID-19 pneumonia	50
Cardioprotection of Panax Notoginseng saponins against acute myocardial infarction and heart failure through inducing autophagy	49
Marine-derived drugs: Recent advances in cancer therapy and immune signaling	49
Advances in developing therapeutic strategies for Alzheimer's disease	49
Cellular Red-Ox system in health and disease: The latest update	49
An update review of emerging small-molecule therapeutic options for COVID-19	49
Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights	49
The potential use of simvastatin for cancer treatment: A review	48
Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota	48
Disease-drug and drug-drug interaction in COVID-19: Risk and assessment	48
Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers	48