OOIR: Observatory of International Research

Papers

(The TQCC of Mechanisms of Ageing and Development is 14. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Characterization of a natural model of adult mice with different rate of aging	172
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease	109
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study	105
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT	98
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice	79
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress	75
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy	64
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs	62
Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing	58
The role of cytokines/chemokines in an aging skin immune microenvironment	55
Impact of age and gender on glioblastoma onset, progression, and management	55
Brain aging mechanisms with mechanical manifestations	49
Strategies for late phase preclinical and early clinical trials of senolytics	47
Editorial Board	42
Molecular mechanisms and potential interventions during aging-associated sarcopenia	42
The role of mitochondria in cytokine and chemokine signalling during ageing	42
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases	41
Sex differences in neuroimmunoendocrine communication. Involvement on longevity	39
Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence	38
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review	38
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe	38
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years	37
Human astrocytes from healthy individuals and Alzheimer’s patients respond differently to Aβ1-42 oligomers, triggering distinct paths of reactivity and senescence	37
Senescence of skeletal stem cells and their contribution to age-related bone loss	35
Editorial: Aging and osteoporosis	34

Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity	33
Recent advances in the discovery of senolytics	32
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways	31
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis	30
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways	29
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role	29
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl	29
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M	28
Living in endemic area for infectious diseases accelerates epigenetic age	28
Towards defining optimal concentrations of micronutrients in adults to optimize health	28
Vascular participation in bone healing: Implications related to advancing age and morbidity	28
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response	28
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling	27
Decreased oxidative stress response and oxidant detoxification of skin during aging	27
Editorial Board	26
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of	26
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease	26
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]	26
Inflammaging: The lesson of COVID-19 pandemic	26
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging	26
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory	25
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts	24
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus	23
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury	23
The link between obesity and aging - insights into cardiac energy metabolism	23
A novel platform for precise senolysis	22
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients	22
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans	22
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder	21
Improving intestinal inflammaging to delay aging? A new perspective	21
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox	21
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data	20
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project	20
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses	20
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections	20
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives	20
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 1	19
Evaluation of senescent cells in intervertebral discs by lipofuscin staining	18
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?	18
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age	18
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?	18
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins	18
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites	18
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction	18
Lipids and the hallmarks of ageing: From pathology to interventions	17
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids	17
Editorial Board	17
Editorial Board	17
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues	16
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue	16

Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice	16
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila	16
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder	16
A quantile frailty index without dichotomization	16
Editorial Board	15
Genistein, a tool for geroscience	15
Fecal microbiota transplantation holds the secret to youth	15
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors	15
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez6	15
Fatty acid desaturation is essential for C. elegans longevity at high temperature	15
Senolytic drugs: Beyond the promise and the hype	14
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy	14
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome	14
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment	14
EDITORIAL Special Issue: The influence of biological sex in ageing	14
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]	14