Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice164
Characterization of a natural model of adult mice with different rate of aging111
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT104
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease100
The role of cytokines/chemokines in an aging skin immune microenvironment96
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs90
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy83
Strategies for late phase preclinical and early clinical trials of senolytics79
Phenolic acid metabolites of polyphenols act as inductors for hormesis in C. elegans74
Brain aging mechanisms with mechanical manifestations73
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study70
Impact of age and gender on glioblastoma onset, progression, and management66
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases61
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress61
Sex differences in neuroimmunoendocrine communication. Involvement on longevity54
Editorial Board54
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review53
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years51
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe46
The role of mitochondria in cytokine and chemokine signalling during ageing45
Age-related alterations and senescence of mesenchymal stromal cells: Implications for regenerative treatments of bones and joints42
Editorial: Aging and osteoporosis41
Molecular mechanisms and potential interventions during aging-associated sarcopenia41
Senescence of skeletal stem cells and their contribution to age-related bone loss40
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl40
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways37
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways37
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis37
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity36
Recent advances in the discovery of senolytics36
Vascular participation in bone healing: Implications related to advancing age and morbidity35
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role34
Towards defining optimal concentrations of micronutrients in adults to optimize health34
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M33
Living in endemic area for infectious diseases accelerates epigenetic age31
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response30
Decreased oxidative stress response and oxidant detoxification of skin during aging29
Editorial Board29
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling29
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging28
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease28
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of28
Inflammaging: The lesson of COVID-19 pandemic28
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]27
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory27
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox27
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients26
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus26
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts26
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury26
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder26
The link between obesity and aging - insights into cardiac energy metabolism25
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project25
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans25
A novel platform for precise senolysis25
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives24
Improving intestinal inflammaging to delay aging? A new perspective23
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses23
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections23
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data23
MicroRNA profiles of human peripheral arteries and abdominal aorta in normal conditions: MicroRNAs-27a-5p, -139-5p and -155-5p emerge and in atheroma too22
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites22
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 122
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age21
Ferulic acid and hormesis: Biomedical and environmental implications21
Evaluation of senescent cells in intervertebral discs by lipofuscin staining21
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?20
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction20
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?20
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila20
Editorial Board19
Editorial Board19
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue19
A quantile frailty index without dichotomization18
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder18
The adult lifespan of the female honey bee (Apis mellifera): Metabolic rate, AGE pigment and the effect of dietary fatty acids18
Risks and rewards of targeting NAD+ homeostasis in the brain18
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice17
Lipids and the hallmarks of ageing: From pathology to interventions17
Genistein, a tool for geroscience17
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues17
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy17
Fatty acid desaturation is essential for C. elegans longevity at high temperature17
Editorial Board17
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez616
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]16
Fecal microbiota transplantation holds the secret to youth16
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors16
Signs of diastolic dysfunction are graded by serum testosterone levels in aging C57BL/6 male mice15
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome15
The influence of inflammation and frailty in the aging continuum15
The emerging importance of lymphangiogenesis in aging and aging-associated diseases15
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment15
EDITORIAL Special Issue: The influence of biological sex in ageing15
Senolytic drugs: Beyond the promise and the hype15
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’15
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