Mechanisms of Ageing and Development

Papers
(The TQCC of Mechanisms of Ageing and Development is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)
ArticleCitations
The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs181
Characterization of a natural model of adult mice with different rate of aging104
Effects of exosomal miRNAs in the diagnosis and treatment of Alzheimer’s disease81
Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practice77
Strategies for late phase preclinical and early clinical trials of senolytics76
Electrical brain activity in Centenarians: Neurophysiological EEG markers in resilient brain ageing67
Polypharmacy is differentially associated with 20-year mortality among community-dwelling elderly women and men: The Israel Glucose Intolerance, Obesity and Hypertension cohort study61
The role of cytokines/chemokines in an aging skin immune microenvironment57
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy56
Characteristics of geriatric rehabilitation inpatients based on their frailty severity and change in frailty severity during admission: RESORT49
REDD1 knockdown ameliorates endothelial cell senescence through repressing TXNIP-mediated oxidative stress49
Brain aging mechanisms with mechanical manifestations44
Impact of age and gender on glioblastoma onset, progression, and management42
Mosaic loss of Y chromosome and the association to mortality in Danish men aged 56–100 years41
Mitochondrial microRNAs (mitomiRs) in human ageing and diseases40
Sex differences in neuroimmunoendocrine communication. Involvement on longevity39
Dietary ingredients inducing cellular senescence in animals and humans: A systematic review37
The role of mitochondria in cytokine and chemokine signalling during ageing37
In reviewing the emerging biomarkers of human inflammatory bowel disease (IBD): Endothelial progenitor cells (EPC) and their vesicles as potential biomarkers of cardiovascular manifestations and targe33
Molecular mechanisms and potential interventions during aging-associated sarcopenia32
Mechanism of FTO-mediated m6A demethylation regulation of YAP1 in nucleus pulposus cell senescence32
Editorial: Aging and osteoporosis31
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways30
Klotho ameliorates angiotension-II-induced endothelial senescence via restoration of autophagy by inhibiting Wnt3a/GSK-3β/mTOR signaling: A potential mechanism involved in prognostic performance of Kl29
B cells from old mice induce the generation of inflammatory T cells through metabolic pathways29
Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity29
Effect of a lifestyle intervention on telomere length: A systematic review and meta-analysis29
Senescence of skeletal stem cells and their contribution to age-related bone loss28
Recent advances in the discovery of senolytics28
Living in endemic area for infectious diseases accelerates epigenetic age27
Vascular participation in bone healing: Implications related to advancing age and morbidity27
Artesunate delays the dysfunction of age-related intestinal epithelial barrier by mitigating endoplasmic reticulum stress/unfolded protein response27
Decreased oxidative stress response and oxidant detoxification of skin during aging26
Towards defining optimal concentrations of micronutrients in adults to optimize health26
Expression of concern: Regulation of β-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer’s disease26
ELN regulates cellular senescence: Emerging hypothesis for a non-canonical role26
Amyloid fil rouge from invertebrate up to human ageing: A focus on Alzheimer disease26
Corrigendum to “Association of cytomegalovirus serostatus with ELOVL2 methylation: Implications for lipid metabolism, inflammation, DNA damage, and repair capacity in the MARK-AGE study population” [M26
Inflammaging: The lesson of COVID-19 pandemic26
Functional significance of extracellular vesicles as mediators of cardiometabolic and cardiorenal diseases upon aging25
Prenatal glucocorticoid exposure and congenital abdominal wall defects: Involvement of CXCR4 – SDF-1 signaling24
Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of24
Editorial Board24
The effect of the demographic history on the evolution of senescence: A potential new test of the mutation accumulation theory23
Corrigendum to “CAR, mGPS and hs-mGPS: Which of these is the best gero-biomarker for age-related diseases? And for what clinical application?” [Mech. Aging Dev. 220 (2024) 111952]23
p53/HIF-1α regulates neuronal aging and autophagy in spinal cord ischemia/reperfusion injury23
Comprehensive variant analysis of phospholipase A2 superfamily genes in large Chinese Parkinson’ s disease cohorts23
A novel platform for precise senolysis22
The abundance change of age-regulated secreted proteins affects lifespan of C. elegans22
Potential prevention and treatment of neurodegenerative disorders by olive polyphenols and hidrox21
Local cannabinoid receptor type-1 regulates glial cell activity and insulin-like growth factor-1 receptor signaling in the mediobasal hypothalamus21
Genetic susceptibility to telomere shortening through the rs2293607 polymorphism is associated with a greater risk of alcohol use disorder21
Improving intestinal inflammaging to delay aging? A new perspective20
Association between vitamin D status and physical performance in COVID-19 survivors: Results from the Gemelli against COVID-19 post-acute care project20
The link between obesity and aging - insights into cardiac energy metabolism20
IRF1-RIG-I signaling defects in the aged alveolar epithelial cells may contribute to decreased pulmonary antiviral immune responses19
The effect of torque teno virus (TTV) infection on clinical outcomes, genomic integrity, and mortality in COPD patients19
CAR, mGPS and hs-mGPS: What is among them the best gero-biomarker for age-related diseases? And for what clinical application?19
Resveralogues protect HepG2 cells against cellular senescence induced by hepatotoxic metabolites18
Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data18
VhaAC39-1 regulates gut homeostasis and affects the health span in Drosophila17
ANRIL modulates endothelial senescence and angiogenesis through SASP-driven miR146a regulation in age-related vascular dysfunction17
Mitochondrial dysfunction plays an essential role in remodeling aging adipose tissue17
Interspecific interactions and aging: Prediction of gerogenic bacteria and critical human protein targets of microbial infections17
Protective effects and bioinformatic analysis of narciclasine on vascular aging via cross-talk between inflammation and metabolism through inhibiting skeletal muscle-specific ceramide synthase 117
The role of longevity-related genetic variant interactions as predictors of survival after 85 years of age17
Ageing, metabolomics and palaeoanthropology: What can the fields learn from each other?17
Editorial Board16
Genistein, a tool for geroscience16
Editorial Board16
Circulating microRNAs and cross sectional and longitudinal measurements of physical functioning and frailty: An explorative study in older twins16
Lipids and the hallmarks of ageing: From pathology to interventions16
Fatty acid desaturation is essential for C. elegans longevity at high temperature16
Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice15
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not proteolysis of BACE1 substrates Sez6 and Sez615
Cycloastragenol activation of telomerase improves β-Klotho protein level and attenuates age-related malfunctioning in ovarian tissues15
Metformin to treat Huntington disease: A pleiotropic drug against a multi-system disorder15
Editorial Board14
Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome14
Corrigendum to “Evaluation of senescent cells in intervertebral discs by lipofuscin staining” [Mech. Ageing Dev. 199 (2021) 1–9/111564]14
Spatiotemporal monitoring of NAD+ metabolism with fluorescent biosensors14
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy14
Hutchinson-Gilford progeria syndrome: Cardiovascular manifestations and treatment13
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus13
Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice13
Senolytic drugs: Beyond the promise and the hype13
Fecal microbiota transplantation holds the secret to youth13
Sex differences in adult lifespan and aging rate across mammals: A test of the ‘Mother Curse hypothesis’13
EDITORIAL Special Issue: The influence of biological sex in ageing13
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